Tag: M.W=150-200

Clark, Richard A. F. published the artcile< Oxidative Stress and ""Senescent"" Fibroblasts in Non-Healing Wounds as Potential Therapeutic Targets>, Formula: C7H5BrN2, the main research area is review oxidative stress senescent fibroblast nonhealing wound therapeutic target.

A review. In chronic wounds, fibroblast dysfunctions, such as increased apoptosis, premature senescence, senescence-like phenotype, or poor growth response in the absence of senescence markers, have been reported. Some of these differential dysfunctions may be secondary to differences in patient age or sex, ulcer size or duration, edge vs. base sampling, or culture technique. Nevertheless, the entire spectrum of fibroblast dysfunction may exist and be secondary to, or a response to, different amounts of oxidative stress. Journal of Investigative Dermatol. (2008) 128, 2361-2364. doi:10.1038/jid.2008.257.

Journal of Investigative Dermatology published new progress about Cell aging. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Formula: C7H5BrN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lv, Tengteng; Dai, Fa; Zhuang, Qiuting; Zhao, Xuelin; Shao, Yina; Guo, Ming; Lv, Zhimeng; Li, Chenghua; Zhang, Weiwei published the artcile< Outer membrane protein OmpU is related to iron balance in Vibrio alginolyticus>, Electric Literature of 366-18-7, the main research area is Vibrio outer membrane porin iron; Iron balance; OmpU; Vibrio alginolyticus.

Outer membrane protein U (OmpU) is a major porin from Vibrio alginolyticus and has been considered a vaccine candidate against infection by V. alginolyticus. After pre-incubated with polyclonal antibody against rOmpU, V. alginolyticus showed a 78% decrease in extracellular iron level, suggesting that interruption of OmpU could increase intracellular iron level. The mRNA expression of ompU under iron-limited conditions was determined using real-time reverse transcriptase PCR. The mRNA level of ompU was downregulated to 0.27-, 0.036- and 0.019-fold after the addition of the iron chelator 2,2′-bipyridyl for 10, 30 and 60 min, resp. In addition, the promoter of ompU contained a ferric uptake regulator (Fur) binding site, which revealed the potential regulation of ompU by Fur and iron. Fur from V. alginolyticus was purified and used for electrophoretic mobility shift assay. The result showed that in the absence of Fe2+, purified recombinant Fur could specifically bind to the promoter DNA of ompU, while in the presence of Fe2+, the binding of Fur and the promoter DNA was suppressed. Our study preliminarily explored the function of OmpU in iron balance in V. alginolyticus, and these findings were helpful in understanding iron metabolism in V. alginolyticus.

Microbiological Research published new progress about Major outer membrane porins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yibiao; Huang, Shuo; Liao, Chunshu; Shao, Yan; Chen, Lu published the artcile< Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridines and acetamidine hydrochloride>, Quality Control of 22280-62-2, the main research area is aminopyridine preparation chemoselective green chem; fluoropyridine acetamidine hydrochloride amination.

An efficient method for the synthesis of 2-aminopyridine derivatives I (R = 3-I, 3-Cl-5-I, 5-NO2-6-CH3, etc.; R1 = NH2) through the nucleophilic substitution and hydrolysis of 2-fluoropyridines I (R1 = F) and acetamidine hydrochloride under catalyst-free conditions has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents such as 5-chloro-2,4-difluoropyrimidine and 2-fluoropyrazine can also complete the reaction via these reaction conditions and yield the target products 5-chloro-4-fluoropyrimidin-2-amine and pyrazin-2-amine resp.

Organic & Biomolecular Chemistry published new progress about Amination (chemoselective). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Quality Control of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Demakov, Pavel A.; Ryadun, Alexey A.; Dorovatovskii, Pavel V.; Lazarenko, Vladimir A.; Samsonenko, Denis G.; Brylev, Konstantin A.; Fedin, Vladimir P.; Dybtsev, Danil N. published the artcile< Intense multi-colored luminescence in a series of rare-earth metal-organic frameworks with aliphatic linkers>, Application of C10H8N2, the main research area is rare metal organic framework aliphatic linker multicolored luminescence.

Two series of highly luminescent yttrium(III), europium(III) and terbium(III) metal-organic frameworks containing diimine aromatic ligands and the dicarboxylate linker trans-1,4-cyclohexanedicarboxylate (chdc2-) which can be described by the general formulas [M2(bpy)2(chdc)3], where M = Y3+ (1), Eu3+ (2), and Tb3+ (3) and bpy = 2,2′-bipyridyl, and [M2(phen)2(chdc)3], where M = Y3+ (4), Eu3+ (5), and Tb3+ (6) and phen = 1,10-phenanthroline, were synthesized and characterized. All compounds are based on the same dinuclear {M2(L)2(OOCR)6} building blocks and possess a similar topol. of the 3D framework with narrow pores. The chelate aromatic ligands act as efficient light-harvesting antennas for subsequent energy transfer to the emitting metal center (M = Eu3+, Tb3+) or intraligand photoemission (M = Y3+). As a result, the reported compounds display intense emission in the red (Eu3+), green (Tb3+) or blue (Y3+) regions representing three basic colors (RGB) of visible light. The measured quantum yields (QYs) of the solid-state luminescence for individual compounds were found to be 63% (1), 46% (2), 59% (3), 2.3% (4), 55% (5) and 49% (6). The drastic reduction of the luminescence efficiency for 4 is explained by the strong disorder of phen ligands. The high thermal stability (up to 300 °C) and exceptional moisture resistance of the bpy-based frameworks 1-3 were confirmed by TG and PXRD measurements. Various bimetal or trimetal compositions were also prepared for the bpy-series. The luminescence properties of these mixed-metal compounds depend on both the chem. composition and excitation wavelength (λex). Remarkably, pure white emission with color temperature = 6126 K was achieved for [Y1.68Eu0.08Tb0.24(bpy)2(chdc)3] at λex = 360 nm with QY = 20%. The reported results suggest that the obtained coordination framework series is a convenient platform for the design of highly efficient light emitting materials with tunable properties.

Dalton Transactions published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Santos, Jose L. F.; de Souza, Gabriel L. C. published the artcile< Water hydrogen-bonding effects on the ground and low-lying excited states of dipyridyl isomers>, Computed Properties of 581-47-5, the main research area is dipyridyl water excited state hydrogen bond mol structure.

In this work, we examined the ground and low-lying excited states of six dipyridyl isomers (2,2′-dipyridyl, 2,3′-dipyridyl, 2,4′-dipyridyl, 3,3′-dipyridyl, 3,4′-dipyridyl, and 4,4′-dipyridyl), emphasizing the effects that solvation (water) mols. have on properties such as ground state equilibrium structures, relative energies in terms of conformations and transition states (regarding possible cis-trans interconversions), vertical excitation energies (VEs), generalized oscillator strengths (GOS), and excited state structures. D. functional theory (DFT) and its time-dependent formalism (TD-DFT) were used for determining all the ground state and excited state properties, resp., both being employed with the CAM-B3LYP exchange-correlation functional and the cc-pVTZ basis set. In addition, effects caused by interactions with the solvent environment were probed by means of using two different approaches: (i) the integral equation formalism polarizable continuum model (IEF-PCM) and (ii) a composite solvation model (CSM) through the incorporation of explicit water mols. in combination with the IEF-PCM. In general, a decrease in the relative energies regarding a given cis/trans counterpart is noticed when solvation is considered independently from the model used; all the dipyridyl cis/trans isomers became (practically) isoenergetical due to dipyridyl-H2O hydrogen-bonding interactions. Moreover, the interconversion barriers were also found to be lowered due to solvation effects. For instance, the energy barrier in terms of interconversion of the trans 2,2′-dipyridyl to the cis 2,2′-dipyridyl was determined as (approx.) 67% of the corresponding value obtained in the gas-phase. Although no major differences regarding the values of the VEs associated to a bright state are suggested from the comparison between the results obtained for a given isomer through the consideration of solvation and those corresponding determined in the gas-phase, the GOS are all increased when solvation is considered, suggesting an enhancement in the photoabsorption of all the isomers when in presence of solvent. In addition and in contrast to what was seen previously in the case of the gas-phase, 4,4′-dipyridyl presented a bright state among the five lowest-lying excited singlets (accessible at the UVC energy region), which is located at 5.49 eV (with GOS = 0.4465) at the TD-DFT/CAM-B3LYP/cc-pVTZ level of theory in water (IEF-PCM) and at 5.47 eV (with GOS = 0.5331) at the same level of theory with the CSM. Given that no significant change was noticed in the optimized structures for the excited states, it is possible to infer that all the compounds will decompose through photo decomposition (chem. reaction occurring in the excited state) rather than direct photolysis when in solution

Journal of Molecular Liquids published new progress about Conformation. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Computed Properties of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nakajima, Yutaka; Tojo, Takashi; Morita, Masataka; Hatanaka, Keiko; Shirakami, Shohei; Tanaka, Akira; Sasaki, Hiroshi; Nakai, Kazuo; Mukoyoshi, Koichiro; Hamaguchi, Hisao; Takahashi, Fumie; Moritomo, Ayako; Higashi, Yasuyuki; Inoue, Takayuki published the artcile< Synthesis and evaluation of 1H-pyrrolo[2,3-b]pyridine derivatives as novel immunomodulators targeting Janus kinase 3>, COA of Formula: C8H5ClN2O2, the main research area is pyrrolopyridine preparation Janus kinase inhibitor lipophilicity mol docking pharmacokinetics.

A series of 1H-pyrrolo[2,3-b]pyridine derivatives I [R = H, Me, c-Hex, Ph; R1 = NHCH(CH2CH3)2, piperidin-1-yl, ((1S,2R)-2-methylcyclohexyl)aminyl, cyclohexylaminyl, etc.] as novel immunomodulators targeting JAK3 for use in treating immune diseases such as organ transplantation has been described. In the chem. modification of N-cyclohexyl-N-methyl-1H-pyrrolo[2,3-b]pyridin-4-amine, the introduction of a carbamoyl group to the C5-position and substitution of a cyclohexylamino group at the C4-position of the 1H-pyrrolo[2,3-b]pyridine ring led to a large increase in JAK3 inhibitory activity. Compound I [R = H, R1 = ((1S,2R)-2-methylcyclohexyl)aminyl] was identified as a potent, moderately selective JAK3 inhibitor, and the immunomodulating effect of I [R = H, R1 = ((1S,2R)-2-methylcyclohexyl)aminyl] on interleukin-2-stimulated T cell proliferation was shown. Docking calculations and WaterMap anal. of the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives I were conducted to confirm the substituent effects on JAK3 inhibitory activity.

Chemical & Pharmaceutical Bulletin published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 920966-03-6 belongs to class pyridine-derivatives, and the molecular formula is C8H5ClN2O2, COA of Formula: C8H5ClN2O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Andaloussi, Mounir; Moreau, Emmanuel; Masurier, Nicolas; Lacroix, Jacques; Gaudreault, Rene C.; Chezal, Jean-Michel; El Laghdach, Anas; Canitrot, Damien; Debiton, Eric; Teulade, Jean-Claude; Chavignon, Olivier published the artcile< Novel imidazo[1,2-a]naphthyridinic systems (Part 1): Synthesis, antiproliferative and DNA-intercalating activities>, Safety of 6-Amino-3-nitro-2-picoline, the main research area is imidazonaphthonaphthyridine preparation antiproliferative DNA intercalation.

Novel imidazo[1,2-a]naphthyridine systems were obtained from Friedlaender’s reaction in imidazo[1,2-a]pyridine series. The compounds were evaluated for their antitumor activity in the NCIs in vitro human tumor cell line screening panel. Among them, 7,8-dihydroimidazo[1,2-a]naphtho[2,1-g][1,5]naphthyridine and 8,9-dihydroimidazo[1,2-h]naphtho[1,2-b][1,7]naphthyridine exhibited in vitro activity comparable to anticancer agent such as amsacrine. Their mechanism of cytotoxic action was unrelated to poisoning or inhibiting abilities against topo1. On the contrary, a direct intercalation of the drugs into DNA was observed by electrophoresis on agarose gel.

European Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gu, Jin-Zhong; Wan, Shi-Mao; Dou, Wei; Kirillova, Marina V.; Kirillov, Alexander M. published the artcile< Coordination polymers from an unexplored biphenyl-tricarboxylate linker: hydrothermal synthesis, structural traits and catalytic cyanosilylation>, Safety of 2,2′-Bipyridine, the main research area is coordination polymer biphenyl tricarboxylate linker hydrothermal synthesis catalytic cyanosilylation.

A novel biphenyl-tricarboxylic acid, 3,2′,4′-biphenyl-tricarboxylic acid (H3bta), was used as a versatile linker for preparing a new series of nickel(II), zinc(II), and cadmium(II) coordination polymers (CPs) and complexes, formulated as {[Cd(μ-Hbta)(2,2′-bipy)(H2O)]·3H2O}n (1), {[Ni(μ-Hbta)(4,4′-bipy)(H2O)3]·H2O}n (2), [M2(μ-Hbta)2(4,4′-bipy)2(H2O)2]·2H2O (M = Zn (3) and Cd (4)), {[Cd2(μ4-bta)(μ-Cl)(phen)2]·2H2O}n (5). {[Zn2(μ3-bta)(2,2′-bipy)2(H2O)3][Zn(μ-bta)(2,2′-bipy)(H2O)]·3H2O} (6), {[Cd3(μ4-bta)2(2,2′-bipy)3]·4H2O}n (7), {[Zn3(μ3-bta)2(H2biim)2(μ-H2biim)(H2O)2]·2H2O}n (8), and [Zn3(μ6-bta)2(py)2]n (9). These coordination compounds were hydrothermally assembled from the metal(II) chlorides, H3bta as a principal building block and N-donor ancillary ligands as crystallization mediators (i.e., 2,2′-bipyridine, 2,2′-bipy; 4,4′-bipyridine, 4,4′-bipy; 1,10-phenanthroline, phen; 2,2′-biimidazole, H2biim; or pyridine, py). All the synthesized products 1-9 were characterized by standard solid-state methods including elemental anal., IR spectroscopy, thermogravimetric anal. (TGA), powder X-ray diffraction (PXRD) and single-crystal X-ray diffraction. The structures of 1-9 range from 0D dimers (3 and 4) to 1D coordination polymers (1, 2, 5, and 6) and 2D metal-organic layers (7-9). Such a diversity of structures is explained by the differences in metal(II) centers, deprotonation levels of H3bta, and crystallization mediators. From a topol. perspective, the obtained structures include 2C1 chains (in 1, 2, and 6), pcu H-bonded nets (in 3 and 4), SP 1-periodic nets (in 5), and 4,5L51 (in 7) and hcb (in 8) layers. For compounds 1-9, luminescence properties were also evaluated. Besides, the catalytic behavior of the obtained products was screened in the cyanosilylation of benzaldehydes with trimethylsilyl cyanide to give cyanohydrin products under mild conditions, including an optimization of various reaction parameters and an investigation of the substrate scope. Among the tested compounds, 3 acts as the most efficient and recyclable heterogeneous catalyst with up to 96% product yields. By presenting the unique examples of coordination compounds derived from H3bta, this study introduces its use as a new tricarboxylate linker for assembling functional coordination polymers and metal complexes.

Inorganic Chemistry Frontiers published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brendel, Matthias; Sakhare, Priyanka R.; Dahiya, Gaurav; Subramanian, Parthasarathi; Kaliappan, Krishna P. published the artcile< Serendipitous Synthesis of Pyridoquinazolinones via an Oxidative C-C Bond Cleavage>, Application In Synthesis of 188577-68-6, the main research area is serendipitous synthesis pyridoquinazolinone oxidative carbon carbon bond cleavage.

A direct one-pot copper-catalyzed oxidative C-C bond cleavage route to the synthesis of pyridoquinazolinones is described. This one-pot strategy involves a copper-catalyzed C-N coupling followed by concomitant C(sp3)-H oxidation and amidation via oxidative C-C bond cleavage under an O2 atmosphere to deliver the target mols. in high yields.

Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 188577-68-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4Cl2N2, Application In Synthesis of 188577-68-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thuery, Pierre; Harrowfield, Jack published the artcile< Contrasting Structure-Directing Effects in the Uranyl-Phthalate/Isophthalate Isomer Systems>, Category: pyridine-derivatives, the main research area is crystal growth mol structure directing uranyl phthalate isophthalate isomer.

Reaction of uranyl cations with phthalic (H2pht) or isophthalic (H2ipht) acids under solvohydrothermal conditions was performed in the presence of 3d-block metal cations associated with chelating nitrogen donors to give nine zero-, mono-, and diperiodic complexes. [UO2(pht)2Zn(phen)2]2·4H2O (1), where phen is 1,10-phenanthroline, is a heterometallic, tetranuclear complex, while the counterion separation in [Ni(bipy)3][UO2(pht)(NO3)]2 (2), where bipy is 2,2′-bipyridine, yields a monoperiodic, helical uranyl ion complex crystallizing in a pure enantiomeric form. The diperiodic network in [Ni(phen)3][(UO2)3(O)(pht)3]·6H2O (3) displays pseudotrigonal, cuplike cavities containing part of the bulky counterions. [(UO2)2(O)(pht)2Ni(cyclam)(H2O)]2·H2O (4), where cyclam is 1,4,8,11-tetraazacyclotetradecane, is a discrete, bis(μ3-oxo)-bridged tetranuclear uranyl complex of common geometry, to which two Ni(cyclam)2+ moieties are attached through oxo bonding to uranyl. Separation of the 3d-block metal ion complex in [Ni(cyclam)]2[(UO2)7(pht)8(NO3)2] (5) and [Cu(R,S-Me6cyclam)][(UO2)5(O)2(pht)4(H2O)2]·4H2O (6), where R,S-Me6cyclam is 7(R),14(S)-5,5,7,12,12,14-hexamethylcyclam, results in the formation of quasi-planar diperiodic networks hydrogen bonded to the counterions. The three isophthalate complexes [(UO2)2(ipht)3Cu(bipy)2]·H2O (7), [(UO2)2(ipht)2(HCOO)2Ni(cyclam)] (8), and [(UO2)2(ipht)2(HCOO)2Cu(R,S-Me6cyclam)] (9) crystallize as heterometallic diperiodic species with Cu(bipy)22+ being only decorating in 7, while Ni2+ and Cu2+ in 8 and 9 bridge uranyl-containing chains into a network with a V2O5 topol.

Crystal Growth & Design published new progress about Crystal growth. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem