Tag: M.W=150-200

Eremina, Julia A.; Lider, Elizaveta V.; Samsonenko, Denis G.; Sheludyakova, Liliya A.; Berezin, Alexey S.; Klyushova, Lyubov S.; Ostrovskii, Vladimir A.; Trifonov, Rostislav E. published the artcile< Mixed-ligand copper(II) complexes with tetrazole derivatives and 2,2'-bipyridine, 1,10-phenanthroline: Synthesis, structure and cytotoxic activity>, Category: pyridine-derivatives, the main research area is crystal structure copper phenanthroline bipyridine tetrazole; copper phenanthroline bipyridine phenyltetrazole tetrazole preparation cytotoxicity human.

The [Cu2(2,2′-bipy)2(L1)4] (1), [Cu2(1,10-phen)2(L1)4] (2), [Cu(2,2′-bipy)(L2)2]n (3) and [Cu2(1,10-phen)2(L2)4] (4) complexes, where HL1 – 5-phenyltetrazole, and HL2 – 1H-tetrazole, were synthesized. All complexes were characterized by elemental anal., IR, EPR spectroscopy and x-ray diffraction. The complexes possess distorted tetragonal-pyramidal coordination geometry. Compounds 1, 2, and 4 show μ-5-phenyl-tetrazole/tetrazole bridged dinuclear structures, while compound 3 reveals polymeric structure. The effect of the compounds on viability of the MCF-7 and Hep-2 cell lines was studied in vitro. Tetrazole ligands HL1 and HL2 are nontoxic at tested concentrations (1-50 μM), while 1,10-phen and 2,2′-bipy possess cytotoxicity. All of the complexes exhibit significant dose-dependent cytotoxic effect and have the potential to act as efficient cytotoxic drugs. [Cu(1,10-phen)Cl2] (5) and [Cu(2,2′-bipy)Cl2] (6) also were obtained to establish the influence of insertion of tetrazole ligands in compounds on their cytotoxic properties.

Inorganica Chimica Acta published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ciriano, Miguel A.; Perez-Torrente, Jesus J.; Oro, Luis A. published the artcile< Synthesis and reactivity of binuclear 7-azaindolate complexes of iridium. II. Oxidative-addition reactions of halogens and halocarbons to [{Ir(μ-aza)(CO)2}2]>, COA of Formula: C7H5BrN2, the main research area is azaindolate iridium complex oxidative addition; halogen oxidative addition azaindolate iridium complex; halocarbon oxidative addition azaindolate iridium complex; pyrrolopyridinate iridium complex oxidative addition.

The compound [{Ir(μ-aza)(CO)2}2] (1, aza = 7-azaindolate) is oxidized by AgBF4 in a donor solvent to [{Ir(μ-aza)(CO)2(S)}2]2+ (S = Me2CO, MeCN) and to the neutral complex [{Ir(μ-aza)(CO)2(O2CMe)}2] (2) by silver acetate. The head-to-tail (HT) and the head-to-head (HH) isomers of 1 undergo trans-annular oxidative-addition reactions with a variety of substrates. Halogens (X2) add to 1 giving the diiridium(II) complexes [{Ir(μ-aza)X(CO)2}2] (X = Cl (3), Br, iodo). In addition, bromine selectively attacks position 3 of the five-membered ring in the aza bridges, affording [{Ir(μ-azaBr)Br(CO)2}2] as a single isomer. MeI and polyiodomethanes react with both isomers of 1 to give the iodomethyl complexes [{Ir(μ-aza)(CO)2}2(I)(R)] (R = Me, CH2I, CHI2, or (CH2)3I) as a mixture of isomers. The relative disposition, HH and HT, of the bridging ligands is maintained in these reactions. Complex 1 is a powerful photoreductor that reacts with CHCl3 and CCl4 giving [{Ir(μ-aza)(CO)2}2(Cl)(R)] (R = CHCl2 or CCl3), resp., whereas compound 3 results from reaction with 1,2-dichloroethane. Reactions of complex 1 with di-Et acetylenedicarboxylate and di-Me acetylenedicarboxylate (A) afford the tetranuclear complexes of the type [{Ir(μ-aza)(CO)2}4(A)2].

Journal of Organometallic Chemistry published new progress about Oxidative addition reaction. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, COA of Formula: C7H5BrN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sardaru, Monica-Cornelia; Craciun, Anda Mihaela; Al Matarneh, Cristina-Maria; Sandu, Isabela Andreea; Amarandi, Roxana Maria; Popovici, Lacramioara; Ciobanu, Catalina Ionica; Peptanariu, Dragos; Pinteala, Mariana; Mangalagiu, Ionel I.; Danac, Ramona published the artcile< Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors>, Product Details of C10H8N2, the main research area is indolizine derivative preparation colchicine tubulin polymerization inhibitor cancer; Indolizine; Phenstatin; anticancer; pyridyl; tubulin polymerisation inhibitors.

A potential microtubule destabilizing series of new indolizine derivatives was synthesized and tested for their anticancer activity against a panel of 60 human cancer cell lines. the compounds showed a broad spectrum of growth inhibitory activity against cancer cell lines representing leukemia, melanoma and cancer of lung, colon, central nervous system, ovary, kidney, breast, and prostate. Among them, compound was distinguishable by its excellent cytostatic activity, showing GI50 values in the range of 10-100 nM on 43 cell lines. The less potent compounds and in terms of GI50 values showed a high cytotoxic effect against tested colon cancer, CNS cancer, renal cancer and melanoma cell lines and only on few cell lines from other types of cancer. In vitro assaying revealed tubulin polymerization inhibition by all active compounds Mol. docking showed good complementarity of active compounds with the colchicine binding site of tubulin.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antitumor agents. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Yuncong; Jiang, Shengjie; Xu, Xin published the artcile< Yttrium-Catalyzed ortho-Selective C-H Borylation of Pyridines with Pinacolborane>, Related Products of 581-47-5, the main research area is yttrium catalyzed carbon hydrogen borylation pyridine pinacolborane; crystal mol structure pyridyl boronate; pentamethylcyclopentadienyl yttrium pyridyl boronate intermediate preparation crystal mol structure; Borylation; C−H Activation; Pyridines; Regioselectivity; Yttrium.

This work reports a site-selective C-H borylation of pyridines at the ortho-position with pinacolborane enabled by an yttrocene catalyst. The reaction provides a new family of 2-pyridyl boronates with a broad substrate scope and high atom efficiency. The resultant boronates were able to undergo a variety of transformations, e.g., oxidation, Suzuki-Miyaura coupling, Chan-Lam amination and etherification. Catalytic intermediates, including ortho-C-H metalated and borylated complexes, were isolated from stoichiometric experiments and confirmed by single-crystal x-ray diffraction.

Angewandte Chemie, International Edition published new progress about Amination. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Babaev, Eugene V.; Rybakov, Victor B. published the artcile< Phenacylation of 6-methyl-beta-nitropyridin-2-ones and further heterocyclization of products>, Product Details of C6H7N3O2, the main research area is betanitropyridinone phenacylation; phenacylpyridone heterocyclization; 8-nitro-5-RO-indolizines; Phenacylation of beta-nitropyridin-2-ones; oxazole-pyrrole ring transformation.

Reaction between the derivatives of 6-methyl-beta-nitropyridin-2-one and phenacyl bromides was studied, and the yields observed were extremely low. The pyridones were converted via chloropyridines to methoxyderivatives, which were N-phenacylated. N-Phenacyl derivatives of 4,6-dimethyl-5-nitropyridin-2-one under the action of base gave 5-hydroxy-8-nitroindolizine and under acidic conditions gave 5-methyl-6-nitrooxazole[3,2-a]pyridinium salt, which underwent recyclization with MeONa to 5-methoxy-8-nitroindolizine.

Molecules published new progress about Acylation. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Product Details of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Talik, Tadeusz; Talik, Zofia published the artcile< Synthesis of some sulfo derivatives of pyridine>, Recommanded Product: 2-Fluoro-6-methyl-3-nitropyridine, the main research area is pyridine nitro sulfo; fluoropyridine sulfurization; sulfide pyridyl oxidation.

Fluoropyridine I (R = F, NO2 in 3 or 6 positions, Me in 3,4,5,6-position) were treated with MeSH and EtSH to give I (R = MeS, EtS), which were oxidized to give I (R = MeSO2, EtSO2).

Polish Journal of Chemistry published new progress about 19346-45-3. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Recommanded Product: 2-Fluoro-6-methyl-3-nitropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Dandan; Zhao, Qunfei; Liu, Wen published the artcile< Discovery of caerulomycin/collismycin-type 2,2'-bipyridine natural products in the genomic era>, Reference of 366-18-7, the main research area is review caerulomycin collismycin bipyridine bioactive natural product genomic era; 2,2′-Bipyridine; Caerulomycin; Collismycin; Natural product discovery; Natural products.

A review. 2,2′-Bipyridine (2,2′-BP) is the unique mol. scaffold of the bioactive natural products represented by caerulomycins (CAEs) and collismycins (COLs). CAEs and COLs are highly similar in the chem. structures in which their 2,2′-BP cores typically contain a di- or tri-substituted ring A and an unmodified ring B. Here, we summarize the CAE and COL-type 2,2′-BP natural products known or hypothesized to date: (1) isolated using methods traditional for natural product characterization, (2) created by engineering the biosynthetic pathways of CAEs or COLs, and (3) predicted upon bioinformatics-guided genome mining. The identification of these CAE and COL-type 2,2′-BP natural products not only demonstrates the development of research techniques and methods in the field of natural product chem. but also reflects the general interest in the discovery of CAE and COL-type 2,2′-BP natural products.

Journal of Industrial Microbiology & Biotechnology published new progress about Bioinformatics. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Reference of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Troschuetz, Reinhard; Karger, Alexander published the artcile< Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin>, HPLC of Formula: 21901-29-1, the main research area is deazapteridinediamine preparation; dideazaaminopterin formal total synthesis.

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (I, R =CH2CH2C6H4CO2H-4, R1 = H) and 6-substituted and 5,6-anelated 8-deazapteridine-2,4-diamines I [R = Me, CH2CH2C6H4CO2Me-4, R1 = H; RR1 = (CH2)4] is described. Starting from (H2N)2C:CHNO2 or (H2N)2C:CHCO2Et and RCOCR1:CHNMe2, I can be prepared via functional group transformation of 2-aminopyridines yielding 3-amino-α-picolinonitriles which are cyclocondensed with guanidine.

Journal of Heterocyclic Chemistry published new progress about 21901-29-1. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hasanzadeh Esfahani, Maryam; Iranmanesh, Hasti; Beves, Jonathon E.; Kaur, Manpreet; Jasinski, Jerry P.; Behzad, Mahdi published the artcile< Crystal structures and antibacterial properties of Cu(II) complexes containing an unsymmetrical N2O Schiff base ligand and bidentate N-donor heterocyclic co-ligands>, Safety of 2,2′-Bipyridine, the main research area is copper Schiff propanediamine salicylaldehyde complex preparation; crystal structure copper Schiff propanediamine salicylaldehyde complex.

Three new Cu(II) Schiff base complexes with bidentate N-donor heterocyclic co-ligands, 2,2′-bipyridine (1), 1,10-phenanthroline (2), and 2,9-dimethyl-1,10-phenanthroline (3), were synthesized and characterized by FTIR and UV-visible spectroscopy. Mol. structures of [C20H21CuN4O](ClO4) (1) and [C24H25CuN4O](ClO4) (3) were characterized by single-crystal x-ray crystallog. The Schiff base ligand is an N2O-type ligand, which is the mono-condensed form of the reaction between 1,3-propanediamine and salicylaldehyde. The antibacterial activities of these complexes were studied against one gram pos. and four gram neg. bacteria. Considerable antibacterial activity was obtained against both gram type bacteria. Complexes 2 and 3 with 1,10-phenanthroline and 2,9-dimethyl-1,10-phenanthroline, resp., showed better antibacterial activity compared to which has the 2,2′-bipyridine co-ligand.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, L.; Sirbu, D.; Waddell, P. G.; Tkachenko, N. V.; Probert, M. R.; Benniston, A. C. published the artcile< Hydrogen peroxide assisted photorelease of an anthraquinone-based ligand from [Ru(2,2'-bipyridine)2(9,10-dioxo-9,10-dihydroanthracen-1-olate)]Cl in aqueous solution>, Application In Synthesis of 366-18-7, the main research area is ruthenium hydroxyanthraquinone bipy complex preparation redox potential antitumor CD; crystal structure ruthenium hydroxyanthraquinone bipy complex.

A new class of light-activated ruthenium(II) complex was designed as a potential blocker of biol. functioning, especially for targeting redox reactions within mitochondria under light activation. Based on our concepts the complex [Ru(bipy)2(1-hydroxyanthra-9,10-quinone)]Cl (RU1) was prepared and studied to understand the preliminary reaction mechanisms and its excited state behavior through a series of stability tests, electrochem., UV-Visible kinetics and femtosecond transient absorption spectroscopy experiments Under white light in the presence of H2O2 two different reactions (fast and slow) appear to take place. The complex loses the quinone-based ligand and a resulting Ru(III) or Ru(V) species is produced. The complex RU1 shows potential to consume H2O2 from the one carbon metabolism in mitochondria, and hence may cut the energy cycle pathway of tumor cells.

Dalton Transactions published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application In Synthesis of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem