Tag: M.W=150-200

Wang, Shaohui; Yang, Denghui; Wu, Xiaojun; Yi, Zhengfei; Wang, Yang; Xin, Suhua; Wang, Dong; Tian, Mingxing; Li, Tao; Qi, Jingjing; Ding, Chan; Yu, Shengqing published the artcile< The ferric uptake regulator represses type VI secretion system function by binding directly to the clpV promoter in Salmonella enteric serovar Typhimurium>, Application of C10H8N2, the main research area is Fur; S. Typhimurium; clpV ; regulation; type VI secretion system.

Type VI secretion systems (T6SSs) are highly conserved and complex protein secretion systems that deliver effector proteins into eukaryotic hosts or other bacteria. T6SSs are regulated precisely by a variety of regulatory systems, which enables bacteria to adapt to varied environments. A T6SS within Salmonella pathogenicity island 6 (SPI-6) is activated during infection, and it contributes to the pathogenesis, as well as interbacterial competition, of Salmonella enterica serovar Typhimurium (S. Typhimurium). However, the regulation of the SPI-6 T6SS in S. Typhimurium is not well understood. In this study, we found that the SPI-6 T6SS core gene clpV was significantly upregulated in response to the iron-depleted condition and during infection. The global ferric uptake regulator (Fur) was shown to repress the clpV expression in the iron-replete medium. Moreover, electrophoretic mobility shift and DNase I footprinting assays revealed that Fur binds directly to the clpV promoter region at multiple sites spanning the transcriptional start site. We also observed that the relieving of Fur-mediated repression on clpV contributed to the interbacterial competition activity and pathogenicity of S. Typhimurium. These findings provide insights into the direct regulation of Fur in the expression and functional activity of SPI-6 T6SS in S. Typhimurium and thus help to elucidate the mechanisms of bacterial adaptability and virulence.

Infection and Immunity published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Hongtai; Yang, Yanyan; Wang, Lianxin; Niu, Yuxiang; Guo, Minjie; Ren, Xiangwei; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Slicing and Splicing of Bromodifluoro-N-arylacetamides: Dearomatization and Difunctionalization of Pyridines>, Computed Properties of 22961-45-1, the main research area is copper catalyzed dearomatization functionalization pyridine bromodifluoroarylacetamide; fluoromethyl iminodihydropyridine synthesis.

Copper-catalyzed dearomatization and difunctionalization of pyridines have been disclosed, in which bromodifluoro-N-arylacetamide was sliced into five fragments and three or four of them were transferred to pyridine partners. Through this reaction, novel N-difluoromethyl-2-imine dihydropyridine derivatives can be conveniently accessed from com. available 4-amino substituted pyridines. This strategy demonstrates a novel fluorination method featuring high atom economy, environmental friendliness, an easily available catalyst, and simple operation.

Organic Letters published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Computed Properties of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ze; Li, Wenwei; Lu, Maolin; Bess, Julian Jr; Chao, Cara W.; Gorman, Jason; Terry, Daniel S.; Zhang, Baoshan; Zhou, Tongqing; Blanchard, Scott C.; Kwong, Peter D.; Lifson, Jeffrey D.; Mothes, Walther; Liu, Jun published the artcile< Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles>, Formula: C10H8N2, the main research area is .

Abstract: The HIV-1 envelope glycoprotein (Env) trimer, composed of gp120 and gp41 subunits, mediates viral entry into cells. Recombinant Env trimers have been studied structurally, but characterization of Env embedded in intact virus membranes has been limited to low resolution Here, we deploy cryo-electron tomog. and subtomogram averaging to determine the structures of Env trimers on aldrithiol-2 (AT-2)-inactivated virions in ligand-free, antibody-bound and CD4-bound forms at subnanometer resolution Tomog. reconstructions document mol. features consistent with high-resolution structures of engineered soluble and detergent-solubilized Env trimers. One of three conformational states previously predicted by smFRET was not observed by cryo-ET, potentially owing to AT-2 inactivation. We did observe Env trimers to open in situ in response to CD4 binding, with an outward movement of gp120-variable loops and an extension of a critical gp41 helix. Overall features of Env trimer embedded in AT-2-treated virions appear well-represented by current engineered trimers.

Nature Structural & Molecular Biology published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Karges, Johannes; Heinemann, Franz; Jakubaszek, Marta; Maschietto, Federica; Subecz, Chloe; Dotou, Mazzarine; Vinck, Robin; Blacque, Olivier; Tharaud, Mickael; Goud, Bruno; Vinuelas Zahinos, Emilio; Spingler, Bernhard; Ciofini, Ilaria; Gasser, Gilles published the artcile< Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy>, HPLC of Formula: 366-18-7, the main research area is ruthenium polypyridyl complex preparation cancer PDT photosensitizer.

The utilization of photodynamic therapy (PDT) for the treatment of various types of cancer has gained increasing attention over the last decades. Despite the clin. success of approved photosensitizers (PSs), their application is sometimes limited due to poor water solubility, aggregation, photodegradation, and slow clearance from the body. To overcome these drawbacks, research efforts are devoted toward the development of metal complexes and especially Ru(II) polypyridine complexes based on their attractive photophys. and biol. properties. Despite the recent research developments, the vast majority of complexes utilize blue or UV-A light to obtain a PDT effect, limiting the penetration depth inside tissues and, therefore, the possibility to treat deep-seated or large tumors. To circumvent these drawbacks, we present the first example of a DFT guided search for efficient PDT PSs with a substantial spectral red shift toward the biol. spectral window. Thanks to this design, we have unveiled a Ru(II) polypyridine complex that causes phototoxicity in the very low micromolar to nanomolar range at clin. relevant 595 nm, in monolayer cells as well as in 3D multicellular tumor spheroids.

Journal of the American Chemical Society published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wandas, M.; Lorenc, J.; Kucharska, E.; Maczka, M.; Hanuza, J. published the artcile< Molecular structure and vibrational spectra of 3 (or 4 or 6)-methyl-5-nitro-2-pyridinethiones: FT-IR, FT-Raman and DFT quantum chemical calculations>, Synthetic Route of 22280-62-2, the main research area is structure vibrational spectra methylnitropyridinethione FT IR Raman DFT quantum.

IR and Raman spectra (RS) of polycrystalline 3-(or 4 or 6)-methyl-5-nitro-2-pyridinethione were measured and analyzed by d. functional theory (DFT) quantum chem. calculations The B3LYP/6-311G(2d,2p) approach was applied for both the thiol and thione tautomers due to the possibility of the formation of these two thiole forms. Mol. structures of these compounds were optimized starting from different mol. geometries of the thiol group and thione group. Two conformations of the 2-mercaptopyridine, trans and cis, were taken into account. The studied compounds appear in the solid state in the thione form. The effect of the hydrogen-bond formation in the studied compounds was considered.

Journal of Raman Spectroscopy published new progress about Conformation. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Neranon, Kitjanit; Alberch, Laura; Ramstroem, Olof published the artcile< Design, Synthesis and Self-Assembly of Functional Amphiphilic Metallodendrimers>, HPLC of Formula: 366-18-7, the main research area is self assembly functional amphiphilic metallodendrimers decomplexation; amphiphiles; coordination; metallodendrimers; nanomaterials; self-assembly; supramolecular systems.

A new family of alkynylated, amphiphilic dendrimers consisting of amidoamine linkers connected to 5,5′-functionalized 2,2′-bipyridine cores has been developed and evaluated in the formation of metallodendrimers of different generations and in self-assembly protocols. A convergent synthetic strategy was applied to provide dumbbell-shaped amphiphilic dendrimers, where the 2,2′-bipyridine cores could be coordinated to FeII centers to afford corresponding metallodendrimers. The ability of the metallic- and non-metallic dendritic structures to self-assemble into functional supramol. aggregates were furthermore evaluated in aqueous solution Spherical aggregates with sizes of a few hundred nanometers were generally produced, where controlled disassembly of the metallodendrimers through decomplexation could be achieved.

ChemistryOpen published new progress about Alkynylation. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kucharska, E.; Hanuza, J.; Lorenc, J. published the artcile< Conformation of azo-bridge in 3,3'-dinitro-2,2'-azobipyridine and its 4,4'(or 5,5' or 6,6')-dimethyl-derivatives: Vibrational studies and DFT quantum chemical calculations>, Product Details of C6H5FN2O2, the main research area is conformation azo bridge dinitroazobipyridine dimethylderivative vibrational DFT quantum; Azopyridines; IR and Raman spectra; Methyl and nitro groups; Quantum chemical calculations; Vibrational characteristics of the azo-bond.

Syntheses of 3,3′-dinitro-2,2′-azobipyridine and 4,4′ (or 5,5′ or 6,6′)-dimethyl-3,3′-dinitro-2,2′-azobipyridine were described. Mol. structures of these compounds were determined and compared, to the basic compound, azobipyridine, reported by us earlier. The conformation of the azo-bond and other structural data are discussed in terms of substitution place of Me chromophore. FTIR and Raman spectra of these compounds were measured and analyzed. The 6-311G (2d,2p) basis set with the B3LYP functional were used to discuss the space conformation and dynamics of the studied compounds

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Chromophores. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Product Details of C6H5FN2O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Goldberg, Frederick W.; Finlay, M. Raymond V.; Ting, Attilla K. T.; Beattie, David; Lamont, Gillian M.; Fallan, Charlene; Wrigley, Gail L.; Schimpl, Marianne; Howard, Martin R.; Williamson, Beth; Vazquez-Chantada, Mercedes; Barratt, Derek G.; Davies, Barry R.; Cadogan, Elaine B.; Ramos-Montoya, Antonio; Dean, Emma published the artcile< The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor>, Recommanded Product: 6-Amino-3-nitro-2-picoline, the main research area is AZD7648 preparation DNA protein kinase inhibitor cancer.

DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been challenging to identify inhibitors of the DNA-PK catalytic subunit (DNA-PKcs) with good selectivity vs. the structurally related PI3 (lipid) and PI3K-related protein kinases. We screened our corporate collection for DNA-PKcs inhibitors with good PI3 kinase selectivity, identifying compound 1. Optimization focused on further improving selectivity while improving phys. and pharmacokinetic properties, notably co-optimization of permeability and metabolic stability, to identify compound 16 (AZD7648). Compound 16 had no significant off-target activity in the protein kinome and only weak activity vs. PI3Kα/γ lipid kinases. Monotherapy activity in murine xenograft models was observed, and regressions were observed when combined with inducers of DSBs (doxorubicin or irradiation) or PARP inhibition (olaparib). These data support progression into clin. studies (NCT03907969).

Journal of Medicinal Chemistry published new progress about Antitumor agents (potential as). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ritter, Helmut; Kaiser, M. published the artcile< Proton NMR spectra of nitrated aminopyridines>, Related Products of 21901-29-1, the main research area is NMR nitrated aminopyridine hydrogen bond; pyridine aminonitro NMR; steric hindrance hydrogen bond aminonitropyridine.

The 1H NMR spectra of 26 nitrated aminopyridines were measured and interpreted. Chem. shift assignments were based on existing chem. shift rules for substituted pyridines and spectral comparison with compounds of similar structure. Some o-aminonitropyridines were found to give a splitting of the amino signals due to intermol. hydrogen bonding; steric hindrance is shown to influence this bonding.

Magnetic Resonance in Chemistry published new progress about Intramolecular hydrogen bond. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Related Products of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharyya, Manjit K.; Gogoi, Anshuman; Chetry, Sanjib; Dutta, Debajit; Verma, Akalesh K.; Sarma, Bipul; Franconetti, Antonio; Frontera, Antonio published the artcile< Antiproliferative evaluation and supramolecular association in Mn(II) and Zn(II) bipyridine complexes: Combined experimental and theoretical studies>, SDS of cas: 366-18-7, the main research area is manganese methylbenzoate bipyridine complex preparation crystal mol structure antiproliferative; zinc pyridinedicarboxylate bipyridine complex preparation crystal mol structure antiproliferative; Apoptosis; Cooperativity; Cytotoxicity; Docking; T-cell lymphoma; π–π stacking.

Two new coordination complexes viz. [Mn2(μ-O,O’-4-Mebz)2(bpy)2(μ2-H2O)(4-Mebz)2] (1) and [Zn(bpy)(pdc)(H2O)]·3.5H2O (2) (where bpy = 2,2′-bipyridine, 4-Mebz = 4-Me benzoate and pdc = 2,6-pyridine dicarboxylate) were synthesized and structurally characterized by single crystal x-ray diffraction, FT-IR, electronic spectroscopy, Thermogravimetric Anal. (TGA) and Powder x-ray diffraction (PXRD) techniques. Complex 1 consists of a dinuclear Mn(II) unit bridged by a solvent water mol. while 2 is a mononuclear complex. The supramol. assemblies found in the solid state of both complexes have been described. In 2, several π-stacking interactions modes have been further studied using D. Functional Theory (DFT) calculations Furthermore, the activity of the complexes against a few pathogenic bacteria has been studied and confirmed. Finally, the antiproliferative activities of both complexes have been studied in T-cell lymphoma cell line by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, apoptosis assay and mol. docking simulation. Both the complexes exhibit gratifying cytotoxicity through apoptotic cell death with negligible cytotoxicity (∼5-10%) in normal cells. It is worth mentioning that Mn(II) and Zn(II) complexes exhibit interaction modes with highly expressed cancer target proteins under study with higher binding affinity and the results are comparable with reference inhibitors.

Journal of Inorganic Biochemistry published new progress about Antibacterial agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem