Tag: M.W=150-200

Zhao, Huaxin; Ma, Guobin; Xie, Xiaojuan; Wang, Yong; Hao, Jian; Wan, Wen published the artcile< Pd(II)-Catalyzed decarboxylative meta-C-H difluoromethylation>, Name: 2,4-Bipyridine, the main research area is difluoroacetic acid arylpyridine decarboxylative meta selective difluoromethylation palladium catalyst.

A palladium(II)-catalyzed decarboxylative meta-selective C-H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a migratory insertion is involved in this meta-C-H functionalization.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluoromethylation (decarboxylative). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,4-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wandas, M.; Lorenc, J.; Kucharska, E.; Maczka, M.; Hanuza, J. published the artcile< Molecular structure and vibrational spectra of 3 (or 4 or 6)-methyl-5-nitro-2-pyridinethiones: FT-IR, FT-Raman and DFT quantum chemical calculations>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is structure vibrational spectra methylnitropyridinethione FT IR Raman DFT quantum.

IR and Raman spectra (RS) of polycrystalline 3-(or 4 or 6)-methyl-5-nitro-2-pyridinethione were measured and analyzed by d. functional theory (DFT) quantum chem. calculations The B3LYP/6-311G(2d,2p) approach was applied for both the thiol and thione tautomers due to the possibility of the formation of these two thiole forms. Mol. structures of these compounds were optimized starting from different mol. geometries of the thiol group and thione group. Two conformations of the 2-mercaptopyridine, trans and cis, were taken into account. The studied compounds appear in the solid state in the thione form. The effect of the hydrogen-bond formation in the studied compounds was considered.

Journal of Raman Spectroscopy published new progress about Conformation. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Choi, Hyukjae; Lee, Wonhwa; Kim, Eonmi; Ku, Sae-Kwang; Bae, Jong-Sup published the artcile< Inhibitory effects of collismycin C and pyrisulfoxin A on particulate matter-induced pulmonary injury>, Name: 2,2′-Bipyridine, the main research area is pulmonary injury collismycin C pyrisulfoxin A particulate matter; Akt; Collismycin C; Particulate matter; Pyrisulfoxin A; Vascular permeability.

Inhalation of fine particulate matter (PM2.5) is associated with elevated pulmonary injury caused by the loss of vascular barrier integrity. Marine microbial natural products isolated from microbial culture broths were screened for pulmonary protective effects against PM2.5. Two 2,2′-bipyridine compounds isolated from a red alga-associated Streptomyces sp. MC025-collismycin C (2) and pyrisulfoxin A (5)-were found to inhibit PM2.5-mediated vascular barrier disruption. To confirm the inhibitory effects of collismycin C and pyrisulfoxin A on PM2.5-induced pulmonary injury. In this study, we investigated the beneficial effects of collismycin C and pyrisulfoxin A on PM-induced lung endothelial cell (EC) barrier disruption and pulmonary inflammation. Permeability, leukocyte migration, proinflammatory protein activation, reactive oxygen species (ROS) generation, and histol. were evaluated in PM2.5-treated ECs and mice. Collismycin C and pyrisulfoxin A significantly scavenged PM2.5-induced ROS and inhibited the ROS-induced activation of p38 mitogen-activated protein kinase as well as activated Akt, which helped in maintaining endothelial integrity, in purified pulmonary endothelial cells. Furthermore, collismycin C and pyrisulfoxin A reduced vascular protein leakage, leukocyte infiltration, and proinflammatory cytokine release in the bronchoalveolar lavage fluid of PM-treated mice. These data suggested that collismycin C and pyrisulfoxin A might exert protective effects on PM-induced inflammatory lung injury and vascular hyperpermeability.

Phytomedicine published new progress about Bronchoalveolar lavage fluid. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kulkarni, Santosh S.; Newman, Amy Hauck published the artcile< Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists>, Name: 6-Amino-3-nitro-2-picoline, the main research area is quinoline benzothiazole preparation glutamate receptor antagonist SAR; pyridothiazole imidazopyridine preparation glutamate receptor antagonist SAR.

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5. Compound I showed antagonist activity (IC50 = 0.26 μM) in the functional assay measuring hydrolysis of phosphoinositide and may provide a new lead for further SAR investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about Metabotropic glutamate receptors, group I, mGluR5 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kucharska, E.; Michalski, J.; Sasiadek, W.; Talik, Z.; Bryndal, I.; Hanuza, J. published the artcile< Vibrational spectra, crystal structure, DFT quantum chemical calculations and conformation of the hydrazo - bond in 6-methyl-3-nitro-2-(2-phenylhydrazinyl)pyridine>, Computed Properties of 19346-45-3, the main research area is crystal structure methylnitro phenylhydrazinyl pyridine; vibrational spectra ethylnitro phenylhydrazinyl pyridine; DFT ethylnitro phenylhydrazinyl pyridine.

The crystal and mol. structures of 6-methyl-3-nitro-2-(2-phenylhydrazinyl)pyridine (6-methyl-3-nitro-2-phenylhydrazopyridine) have been determined by X-ray diffraction and quantum chem. DFT anal. The crystal is monoclinic, space group C2/c, with Z = 8 formula units in the elementary unit cell of dimensions a = 16.791(4), b = 6.635(2), c = 21.704(7) Å, β = 100.54(3)°. The mol. consists of two nearly planar pyridine subunits. A conformation of the linking hydrazo-bridge CNHNHC is bend and the dihedral angle between the planes of the Ph and pyridine rings is 88.2(5)°. The hydrogen bonding of the type NH···N and possibly also CH···O favors a dimer formation in the crystal structure. The dimers are further linked by a NH···O hydrogen bond, so forming a layer parallel to the ab plane. The mol. structure of the studied compound has been determined using the DFT B3LYP/6-311G(2d,2p) approach and compared to that derived from X-ray studies. The IR and Raman wavenumbers have been calculated for the optimized geometry of a possible monomer structural model but the possibility of the dimer formation through the NH···N hydrogen bond has also been considered. The structural and vibrational properties of the intra-mol. NH···O interaction are described.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Crystal structure. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Computed Properties of 19346-45-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

He, Yuan-Chun; Xiao, Li-Yuan; Yuan, Zi-Han; Zhang, Jie; Wang, Yan; Xu, Na published the artcile< Two coordination polymers constructed by 5-[(4-carboxyphenoxy)methyl]benzene-1,3-dicarboxylic acid and 2,2′-bipyridine: syntheses, structures and luminescence properties>, Electric Literature of 366-18-7, the main research area is carboxyphenoxy methyl benzene dicarboxylic acid bipyridine luminescence; 2,2′-bipyridine; cadmium; coordination polymer; crystal structure; manganese; tricarboxylic acid.

Coordination polymers (CPs) have attracted increasing interest in recent years. In this work, two new CPs, namely poly[[aquabis(2,2′-bipyridine-κ2N,N′){μ3-5-[(4-carboxylatophenoxy)methyl]benzene-1,3-dicarboxylato-κ4O1,O1′:O3:O5}(μ-formato-κ3O:O,O′)dicadmium(II)] monohydrate], {[Cd2(C16H9O7)(HCO2)(C10H8N2)2(H2O)]·H2O}n (1), and poly[[(2,2′-bipyridine-κ2N,N′){μ3-5-[(4-carboxylphenoxy)methyl]benzene-1,3-dicarboxylato-κ4O1,O1′:O3:O5}manganese(II)] sesquihydrate], {[Mn(C16H10O7)(C10H8N2)]·1.5H2O}n (2), have been prepared using the tricarboxylic acid 5-[(4-carboxyphenoxy)methyl]benzene-1,3-dicarboxylic acid and 2,2′-bipyridine under hydrothermal conditions. CP 1 displays a two-dimensional layer structure which is further extended into a three-dimensional (3D) supramol. structure via intermol. π-π interactions, while CP 2 shows a different 3D supramol. structure extended from one-dimensional ladder chains by intermol. π-π interactions. In addition, the solid-state luminescence spectra of 1 and 2 were studied at room temperature

Acta Crystallographica, Section C: Structural Chemistry published new progress about Crystallography. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mantlo, Nathan B.; Chakravarty, Prasun K.; Ondeyka, Debra L.; Siegl, Peter K. S.; Chang, Raymond S.; Lotti, Victor J.; Faust, Kristie A.; Schorn, Terry W.; Chen, Tsing Bau published the artcile< Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists>, Name: 2-Amino-3-nitro-6-picoline, the main research area is Angiotensin II antagonist tetrazolylbiphenylylimidazopyridine; imidazopyridine tetrazolylbiphenylyl Angiotensin II antagonist; structure activity antihypertensive tetrazolylbiphenylylimidazopyridine.

Several title Angiotensin II (AII) antagonists I (R = Et, Pr, Bu, R1 = R2 = H, Me; R1 = Me, R2 = H; R1 = H, R2 = Me) were prepared Substituents at the 2, 5, and 7-positions of the imidazopyridine have a profound effect on the in vitro binding affinity to AII receptors (rabbit aorta membrane preparation) and on the inhibition of the AII-induced pressor responses in conscious rats. The most active compound, I (R = Et, R1 = R2 = Me) is extremely potent in vitro (IC50 = 0.3 nM, rabbit aorta), and in vivo (ED50 = 0.048 mg/Kg i.v. and 0.026 mg/Kg p.o., conscious rat). This compound is a specific AT1 antagonist, and substantially lowers the blood pressure of high renin hypertensive rats upon oral dosing (0.1 and 0.3 mg/Kg) with a duration of action exceeding 24 h.

Journal of Medicinal Chemistry published new progress about Antihypertensives. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aramesh-Boroujeni, Zahra; Jahani, Shohreh; Khorasani-Motlagh, Mozhgan; Kerman, Kagan; Noroozifar, Meissam published the artcile< Evaluation of DNA, BSA binding, DNA cleavage and antimicrobial activity of ytterbium(III) complex containing 2,2′-bipyridine ligand>, Product Details of C10H8N2, the main research area is albumin DNA ytterbium antimicrobial activity; Antibacterial activity; binding interaction; bovine serum albumin; fish salmon-DNA; molecular docking; ytterbium(III) complex.

In order to estimate the biol. potential of a synthesized complex [Yb(bpy)2Cl3.OH2] where bpy is 2,2′-bipyridine, its binding behavior with fish salmon-DNA and bovine serum albumin were studied by different kinds of spectroscopy and mol. modeling methods. This complex was selected for its antibacterial and antifungal activities as well as the DNA cleavage activities were examined by agarose gel electrophoresis. The analyses of fluorescence data at four temperatures were done in order to evaluate the binding and thermodn. parameters of the interaction of Yb(III) complex with DNA and BSA. The exptl. results indicated that the major binding modes were based on groove binding with DNA and BSA. In addition, iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, CD, and viscosity studies reflected the binding of Yb(III) complex explicitly with the FS-DNA mainly in a groove binding mode. Moreover, mol. docking studies indicated that this complex was bound to the minor groove of DNA and to polar and apolar residues located in the subdomain IB of BSA (site 3). Also, the results of competitive experiments assessed site 3 of BSA as the most probable binding site for this complex. The mol. docking results were in good agreement with our exptl. results. From both exptl. and docking results, the binding constant values displayed the remarkably high affinity of Yb(III) complex to DNA as well as BSA.Communicated by Ramaswamy H. Sarma

Journal of Biomolecular Structure and Dynamics published new progress about Acinetobacter baumannii. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xia; Yang, Qiu-Xia; Long, Cheng-Yu; Tan, Yan; Qu, Yi-Xin; Su, Min-Hui; Huang, Si-Jie; Tan, Weihong; Wang, Xue-Qiang published the artcile< Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines>, Electric Literature of 22961-45-1, the main research area is heteroaryl alkyl ether amine nucleophilic amination; amine heteroaryl preparation anticancer activity green chem.

A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C-O bond cleavage, offering a new amination strategy to access several anticancer-active compounds This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.

Organic Letters published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Electric Literature of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E. published the artcile< Substituent effects on the isomer ratios in the rearrangement of some 2- and 4-nitraminopyridines>, SDS of cas: 21901-29-1, the main research area is substituent effect rearrangement nitraminopyridine.

The preparation and rearrangement in 92% H2SO4 of I-III (R = H, Me, MeO, Br, Cl, CO2H) were investigated. The product isomer ratios can be explained by differential electronic stabilization of the appropriate σ complexes for aromatic nitration and steric effects seem relatively unimportant. Deuteration [3-D in I, R = Me] had no effect on the product distribution.

Australian Journal of Chemistry published new progress about Rearrangement. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem