Tag: M.W=150-200

Mochizuki, Yuki; Imai, Hiroaki; Oaki, Yuya published the artcile< A Layered Polydiacetylene Containing Hydrogen-Bonding 4,4'-Bipyridyl Guests: Reversible Color Changes with a Wide-Range Temperature Response>, Application of C10H8N2, the main research area is polydiacetylene bipyridyl host guest intercalation hydrogen bonding; host-guest systems; hydrogen bonding; layered compounds; polydiacetylenes; thermoresponsive materials.

Layered organic polymers have intercalation capabilities and dynamic properties. In classical intercalation chem., the interlayer guests are intercalated in the host layers via electrostatic interaction. The present work shows the organic layered materials with the host-guest interlayer interaction via hydrogen bond. Polydiacetylene (PDA) exhibits color changes from blue to red with the application of external stimuli, such as thermal and mech. stresses. Here we report on a layered PDA containing 4,4′-bipyridyl in the interlayer space as a hydrogen-bonding guest. Whereas the layered PDA without interlayer guest shows the color transition at 65°C, gradual color changes with two-stage reversibility are observed in the temperature range of -20-240°C by the introduction of the hydrogen-bonding guest. The weaker interlayer interaction via the hydrogen bond promotes the dynamic motion directing the thermoresponsive color changes in a wide temperature range.

ChemPlusChem published new progress about Color. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Karges, Johannes; Jakubaszek, Marta; Mari, Cristina; Zarschler, Kristof; Goud, Bruno; Stephan, Holger; Gasser, Gilles published the artcile< Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl-Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy>, Synthetic Route of 366-18-7, the main research area is EGFR RuII polypyridyl nanobody conjugate photosensitizer photodynamic therapy; bioinorganic chemistry; medicinal inorganic chemistry; metal-based drugs; metals in medicine; photodynamic therapy.

There is a current surge of interest in the development of novel photosensitizers (PSs) for photodynamic therapy (PDT), as those currently approved are not completely ideal. Among the tested compounds, we have previously investigated the use of RuII polypyridyl complexes with a [Ru(bipy)2(dppz)]2+ and [Ru(phen)2(dppz)]2+ scaffold (bipy=2,2′-bipyridine; dppz=dipyrido[3,2-a:2′,3′-c]phenazine; phen=1,10-phenanthroline). These complexes selectively target DNA. However, because DNA is ubiquitous, it would be of great interest to increase the selectivity of our PDT PSs by linking them to a targeting vector in view of targeted PDT. Herein, we present the synthesis, characterization, and in-depth photophys. evaluation of a nanobody-containing RuII polypyridyl conjugate selective for the epidermal growth factor receptor (EGFR) in view of targeted PDT. Using ICP-MS and confocal microscopy, we could demonstrate that our conjugate has high selectivity for the EGFR receptor, which is a crucial oncol. target because it is overexpressed and/or deregulated in a variety of solid tumors. However, in contrast to expectations, this conjugate was found to not produce reactive oxygen species (ROS) in cancer cells and is therefore not phototoxic.

ChemBioChem published new progress about Cytotoxicity. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Zhijie; Qiao, Yuanyuan; Li, Miaomiao; Ma, Pengtao; Niu, Jingyang; Wang, Jingping published the artcile< Two synthetic routes generate two isopolyoxoniobates based on {Nb16} and {Nb20}>, Safety of 2,2′-Bipyridine, the main research area is copper bipyridine isopolyoxoniobate preparation thermal stability; crystal structure copper bipyridine isopolyoxoniobate.

Self-assembly reactions of the Lindqvist-ion salt K7HNb6O19·13H2O, SeO2, and [Cu(2,2′-bipy)]2+ give, depending on different routes, two isopolyoxoniobates based on {Nb16} and {Nb20}, resp., which, as new members of the very limited isopolyoxoniobate family, are observed for the 1st time. Also, the solution behavior was studied to determine the stability of the {Nb16} cluster in water.

Dalton Transactions published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kress, Thomas J.; Moore, Larry L.; Costantino, Silvio M. published the artcile< Selective chlorinations in sulfuric acid. Synthesis of some 2-amino-5-chloro-, 2-amino-3-chloro-, and 2-amino-3,5-dichloropyridines>, Application In Synthesis of 22280-62-2, the main research area is pyridine amino chlorination; chlorination aminopyridine sulfuric acid.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. 2-Aminopyridine and a number of Me substituted 2-aminopyridines underwent selective chlorination. The chlorination of 2-aminopyridine at various H2SO4 concentrations and the distribution of chlorinated products was studied in detail. With increasing acidity dichlorination decreases, and in 72% H2SO4 only traces of dichlorination occur. The selectivity of the chlorination reaction is ascribed to differences in the rate of chlorination of protonated vs nonprotonated substrates.

Journal of Organic Chemistry published new progress about Chlorination. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application In Synthesis of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oelschlegel, Manuel; Hua, Shao-An; Schmid, Lucius; Marquetand, Philipp; Baeck, Anna; Borter, Jan-Hendrik; Luecken, Jana; Dechert, Sebastian; Wenger, Oliver S.; Siewert, Inke; Schwarzer, Dirk; Gonzalez, Leticia; Meyer, Franc published the artcile< Luminescent Iridium Complexes with a Sulfurated Bipyridine Ligand: PCET Thermochemistry of the Disulfide Unit and Photophysical Properties>, SDS of cas: 366-18-7, the main research area is crystallog luminescent iridium complex sulfurated bipyridine ligand; PCET thermochem disulfide unit photophys property.

Mol. systems combining light harvesting and charge storage are receiving great attention in the context of, for example, artificial photosynthesis and solar fuel generation. As part of ongoing efforts to develop new concepts for photoinduced proton-coupled electron transfer (PCET) reactivities, we report a cyclometallated iridium(III) complex [1]+ equipped with our previously developed sulfurated bipyridine ligand S-Sbpy. A new one-step synthetic protocol for S-Sbpy is developed, starting from com. available 2,2′-bipyridine, which significantly facilitates the use of this ligand. The iridium complex [Ir(ppy)2(S-Sbpy)](PF6) ([1]PF6) features a two-electron reduction with potential inversion (|E1| > |E2|) at moderate potentials (E1 = -1.17, E2 = -1.08 V vs. Fc+/0 at 253 K), leading to a dithiolate species [1]-. Protonation with weak acids allows for determination of pKa = 23.5 in MeCN for the S-H···S- unit of [1]H. The driving forces for both the H atom and the hydride transfer are calculated to be ∼ 60 kcal mol-1 and verified exptl. by reaction with a suitable H atom and a hydride acceptor, demonstrating the ability of [1]+ to serve as a versatile PCET reagent, albeit with limited thermal stability. In the MeCN solution, an orange emission for [1]PF6 from a triplet-excited state was found. D. functional calculations and ultrafast absorption spectroscopy are used to give insight into the excited-state dynamics of the complex and suggest a significantly stretched S-S bond for the lowest triplet-state T1. The structural responsiveness of the disulfide unit is proposed to open an effective relaxation channel toward the ground state, explaining the unexpectedly short lifetime of [1]+. These insights as well as the quant. ground-state thermochem. data provide valuable information for the use of S-Sbpy-functionalized complexes and their disulfide-/dithiol-directed PCET reactivity.

Inorganic Chemistry published new progress about Attenuated-total-reflectance IR spectroscopy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Smil, David; Wong, Jong Fu; Williams, Eleanor P.; Adamson, Roslin J.; Howarth, Alison; McLeod, David A.; Mamai, Ahmed; Kim, Soyoung; Wilson, Brian J.; Kiyota, Taira; Aman, Ahmed; Owen, Julie; Poda, Gennady; Horiuchi, Kurumi Y.; Kuznetsova, Ekaterina; Ma, Haiching; Hamblin, J. Nicole; Cramp, Sue; Roberts, Owen G.; Edwards, Aled M.; Uehling, David; Al-awar, Rima; Bullock, Alex N.; O’Meara, Jeff A.; Isaac, Methvin B. published the artcile< Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma>, Reference of 916791-62-3, the main research area is preparation ALK2 inhibitor diffuse intrinsic pontine glioma.

There are currently no effective chemotherapeutic drugs approved for the treatment of diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric cancer resident in the pons region of the brainstem. Radiation therapy is beneficial but not curative, with the condition being uniformly fatal. Anal. of the genomic landscape surrounding DIPG has revealed that activin receptor-like kinase-2 (ALK2) constitutes a potential target for therapeutic intervention given its dysregulation in the disease. An open science approach has been adopted to develop a series of potent, selective, orally bioavailable, and brain-penetrant ALK2 inhibitors based on the lead compound LDN-214117. Modest structural changes to the C-3, C-4, and C-5 position substituents of the core pyridine ring afforded compounds M4K2009, M4K2117, and M4K2163, each with a superior potency, selectivity, and/or blood-brain barrier (BBB) penetration profile. Robust in vivo pharmacokinetic (PK) properties and tolerability mark these inhibitors as advanced preclin. compounds suitable for further development and evaluation in orthotopic models of DIPG.

Journal of Medicinal Chemistry published new progress about Activin receptor ACVRLK2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 916791-62-3 belongs to class pyridine-derivatives, and the molecular formula is C5H2Cl2FN, Reference of 916791-62-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jin-Biao; Wu, Chun; Chen, Feng; Leung, Chung-Hang; Ma, Dik-Lung published the artcile< A simple iridium(III) dimer as a switch-on luminescent chemosensor for carbon disulfide detection in water samples>, Application of C10H8N2, the main research area is iridium dimer luminescent chemosensor carbon disulfide water; Carbon disulfide; Chemosensor; Iridium(III) dimer; Luminescence.

A series of iridium(III) dimers were synthesized and their ability to interact with diethyldithiocarbamate for CS2 sensing was evaluated. Upon the addition of CS2, diethylamine can capture CS2 to form diethyldithiocarbamate, which could chelate with the iridium(III) dimer to form a diethyldithiocarbamate iridium(III) complex, resulting in a yellow luminescence. Dimer 8 exhibited a maximum 18-fold of luminescence enhancement upon the addition of CS2. The luminescence signal of the detection system could be readily distinguished from the highly fluorescent media using time-resolved emission spectroscopy (TRES). The capability of the system to determine CS2 level in water samples was also demonstrated.

Analytica Chimica Acta published new progress about Environmental analysis. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yao, Kun; Yuan, Qianjia; Qu, Xingxin; Liu, Yangang; Liu, Delong; Zhang, Wanbin published the artcile< Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles>, Related Products of 581-47-5, the main research area is chiral piperidinyl amino acid enantioselective preparation.

Chiral piperidine-containing amino acid derivatives, e.g., I, were synthesized via Pd-catalyzed asym. allylic substitution cascade reaction of cinnamyl carbonates, chloroacetamides and substituted pyridines. In situ generated α-(pyridin-1-yl)-acetamides were used as nucleophiles in this cascade reaction. The products could be easily converted into potential bioactive compounds, unnatural chiral amino acids and dipeptides. Pd-catalyzed asym. allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles.

Chemical Science published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ohmori, Junya; Kubota, Hirokazu; Shimizu-Sasamata, Masao; Okada, Masamichi; Sakamoto, Shuichi published the artcile< Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonists: Synthesis and Structure-Activity Relationships of 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and Related Compounds>, Name: 2-Amino-3-nitro-6-picoline, the main research area is azaquinoxalinedione AMPA receptor antagonist structure activity; imidazolyl pyridopyrazinedione preparation AMPA receptor antagonist.

The authors have synthesized and evaluated azaquinoxalinediones for their activity in inhibiting [3H]AMPA binding from rat whole brain. It was found that the azaquinoxalinedione nucleus functions as a bioisostere for quinoxalinedione in AMPA receptor binding. The detailed structure-activity relationships of 6- and/or 7-substituted 2,3(1H,4H)-pyrido[2,3-b]pyrazinedione derivatives showed some differences in comparison with those of the corresponding substituted quinoxalinediones, including 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (I) (YM90K). X-ray study showed that conformation of the 7-nitro group of I·HCl was nearly coplanar with the quinoxaline ring, whereas the 6-imidazol-1-yl group was rotated with respect to the aromatic ring. Binding studies indicated that the bulkiness of the 6-substituent on the pyridopyrazinediones may be responsible for the selectivity against the glycine site on the NMDA receptor. Among the azaquinoxalinediones tested, 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione (II) exhibited a combination of the best affinity to the AMPA receptor with a Ki value of 0.14 μM and selectivity against the glycine site (no affinity at 10 μM). In vivo, II also protected against sound-induced seizures in DBA/2 mice (min. ED, 10 mg/kg i.p.).

Journal of Medicinal Chemistry published new progress about Anticonvulsants. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pegu, David; Singh, Ngangbam Bedamani published the artcile< Quantum chemical calculations of molecular structure, electronic, thermodynamic and non-linear optical properties of 2-amino-3-nitro-6-methyl pyridine>, Name: 2-Amino-3-nitro-6-picoline, the main research area is amino nitro methyl pyridine mol structure hyperpolarizability.

In the present study, we report a theor. study on mol. structure, electronic and thermodynamical properties of 2-amino-3-nitro-6-Me pyridine (2A3N6MP) by using ab initio Hartree Fock (HF) and d. functional theory (DFT) methods employing B3LYP exchange correlation with 6-311++G(d,p) basis set. The ground state mol. geometrical parameters, have been calculated and compared with available reported values. The calculated HOMO and LUMO energy shows that charge transfer takes place within the mol. and the mol. is chem. soft mol. The dipole moment, linear polarizability and first hyperpolarizability values were also computed. Finally the temperature dependence thermodn. properties were also determined and interpreted.

International Journal of Advanced Research published new progress about Dipole moment. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem