Tag: M.W=150-200

Avci, Davut; Alturk, Sumeyye; Sonmez, Fatih; Tamer, Omer; Basoglu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Dege, Necmi published the artcile< A novel series of mixed-ligand M(II) complexes containing 2,2′-bipyridyl as potent α-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking>, Application of C10H8N2, the main research area is 2,2′-Bipyridyl and 6-methylpyridine-2-carboxylic acid; DFT/HSE06; Docking; XRD, FT-IR and UV–Vis; α-Glucosidase.

Diabetes mellitus (DM) is a common degenerative disease and characterized by high blood glucose levels. Since the effective antidiabetic treatments attempt to decrease blood glucose levels, keeping glucose under control is very important. Recent studies have demonstrated that α-glucosidase inhibitor improves postprandial hyperglycemia and then reduces the risk of developing type 2 diabetes in patients. Therefore, the design and synthesis of high affinity glucosidase inhibitors are of great importance. In this regard, novel series of mixed-ligand M(II) complexes containing 2,2′-bipyridyl {[Hg(6-mpa)2(bpy)(OAc)]·2H2O, (1), [Co(6-mpa)2(bpy)2], (2), [Cu(6-mpa)(bpy)(NO3)]·3H2O, (3), [Mn(6-mpa)(bpy)(H2O)2], (4), [Ni(6-mpa)(bpy)(H2O)2]·H2O, (5), [Fe(6-mpa)(bpy)(H2O)2]·2H2O, (6), [Fe(3-mpa)(bpy)(H2O)2]·H2O, (7)} were synthesized as potential α-glucosidase inhibitors. Their effects on α-glucosidase activity were evaluated. All synthesized complexes displayed α-glucosidase inhibitory activity with IC50 values ranging from 0.184 ± 0.015 to > 600 μM. The exptl. spectral analyses were carried out using FT-IR and UV-Vis spectroscopic techniques for these complexes characterized by XRD and LC-MS/MS. Moreover, the calculations at d. functional theory approximation were used to obtain optimal mol. geometries, vibrational wavenumbers, electronic spectral behaviors, and major contributions to the electronic transitions for the complexes 1-7. Finally, to display interactions between the synthesized complexes and target protein (the template structure Saccharomyces cerevisiae isomaltase), the mol. docking study was carried out.

JBIC, Journal of Biological Inorganic Chemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bubnov, Michael P.; Teplova, Irina A.; Cherkasova, Anna V.; Baranov, Evgenii V.; Fukin, Georgy K.; Romanenko, Galina V.; Bogomyakov, Artem S.; Starikov, Andrey G.; Cherkasov, Vladimir K.; Abakumov, Gleb A. published the artcile< Metal-ligand ferromagnetic exchange interactions in heteroligand bis-o-semiquinonato nickel complexes with 2,2'-dipyridine and 1,10-phenanthroline>, COA of Formula: C10H8N2, the main research area is nickel semiquinonate complex preparation ferromagnetic exchange; optimized mol structure nickel semiquinonate complex; crystal structure nickel semiquinonate complex.

Novel bis-o-semiquinonato nickel complexes (2,2′-bpy)Ni(3,6-DBSQ)2 (1) and (1,10-phen)Ni(3,6-DBSQ)2 (2) was synthesized (2,2′-bpy is 2,2′-dipyridine; 1,10-phen is 1,10-phenanthroline; 3,6-DBSQ is anion-radical of 3,6-tert-butyl-o-benzoquinone). Single crystal x-ray diffraction study indicated distorted octahedral environment of nickel atom in both complexes. Variable temperature magnetic susceptibility measurement detected predomination of ferromagnetic exchange interactions between high spin nickel ion and anion-radicals of o-semiquinones. DFT calculations are in a good agreement with exptl. structural and magnetic results.

Polyhedron published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yakhontov, L. N.; Portnov, M. A.; Azimov, V. A.; Lapan, E. I. published the artcile< Derivatives of azaindoles. XXXII. Comparative study of azaindole ionization constants by applying correlation methods>, Application In Synthesis of 23612-36-4, the main research area is azaindoles ionization; ionization azaindoles; pyrrolopyridines; pyridines pyrrolo.

The pKa values were determined exptl. of the following 1-(R-substituted)-3-(R1-substituted)-4-azaindoles (I), 1-(R-substituted)-3-(R1-substituted)-5-azaindoles (II), and 1-(R-substituted)-4-(R1-substituted)-6-(R2-substituted)-5-azaindolines (III) (compound, and R, R1, or R, R1, and R2 given): I, H, H; I, H, Br; I, H, Cl; I, H, NO2; I, H, CH2CO2Et; I, H, CH2CONH2; I, Ac, H; I, Ac, Br; I, Ac, NHAc; I, H, CH2NMe2; I, H, (4-azaindol-3-yl)-methyl; II, H, H; II, Ph, H; II, H, Br; II, H, NO2; III, H, H, H; III, Ph, H, H; III, Ph, OH, H; III, Ph, Cl, H; III, H, Cl, H; III, H, Cl, Cl; III, PhCH2, OH, H; III, PhCH2, Cl, H. Correlations were obtained between pKa and Taft ionization constants

Zhurnal Organicheskoi Khimii published new progress about Ionization. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Application In Synthesis of 23612-36-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sultan, Madiha; Kanavarioti, Anastassia published the artcile< Nanopore device-based fingerprinting of RNA oligos and microRNAs enhanced with an Osmium tag>, Name: 2,2′-Bipyridine, the main research area is RNA miRNA osmium nanopore device based fingerprinting.

Protein and solid-state nanopores are used for DNA/RNA sequencing as well as for single mol. anal. We proposed that selective labeling/tagging may improve base-to-base resolution of nucleic acids via nanopores. We have explored one specific tag, the Osmium tetroxide 2,2′-bipyridine (OsBp), which conjugates to pyrimidines and leaves purines intact. Earlier reports using OsBp-tagged oligodeoxyribonucleotides demonstrated proof-of-principle during unassisted voltage-driven translocation via either alpha-Hemolysin or a solid-state nanopore. Here we extend this work to RNA oligos and a third nanopore by employing the MinION, a com. available device from ONT. Conductance measurements demonstrate that the MinION visibly discriminates oligoriboadenylates with sequence A15PyA15, where Py is an OsBp-tagged pyrimidine. Such resolution rivals traditional chromatog., suggesting that nanopore devices could be exploited for the characterization of RNA oligos and microRNAs enhanced by selective labeling. This observation leads to the conjecture that the MinION/OsBp platform senses a 2-nucleotide sequence, in contrast to the reported 5-nucleotide sequence with native nucleic acids. Such improvement in sensing, enabled by the presence of OsBp, may enhance base-calling accuracy in enzyme-assisted DNA/RNA sequencing.

Scientific Reports published new progress about Fingerprint sensors. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Horan, Alexandra M.; Duong, Vincent K.; McGarrigle, Eoghan M. published the artcile< Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts>, Related Products of 581-47-5, the main research area is bis heteroaryl preparation; halopyridine pyridylsulfonium salt coupling reaction.

Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E.

Organic Letters published new progress about Coupling reaction. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stapleton, David; Gao, Guang; Michell, Belinda J.; Widmer, Jane; Mitchelhill, Ken; Teh, Trazel; House, Colin M.; Witters, Lee A.; Kemp, Bruce E. published the artcile< Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase>, Name: 3-Bromo-1H-pyrrolo[3,2-c]pyridine, the main research area is AMP activated protein kinase subunit sequence; rat AMP activated protein kinase subunit; pig AMP activated protein kinase subunit; Snf1 kinase interacting protein homolog mammal; yeast CAT3 Snf4p homolog rat pig; Sip1p GAL38 yeast homolog rat pig.

The 5′-AMP-activated protein kinase is responsible for the regulation of fatty acid synthesis by phosphorylation and inactivation of acetyl-CoA carboxylase. The porcine liver 5′-AMP-activated protein kinase 63-kDa catalytic subunit co-purifies 14,000-fold with a 38- and 40-kDa protein (Mitchelhill, K. I. et al. (1994) J. Biol. Chem. 269, 2361-2364). The 63-kDa subunit is homologous to the Saccharomyces cerevisiae Snf1 protein kinase, which regulates gene expression during glucose derepression. Peptide amino acid and polymerase chain reaction-derived partial cDNA sequences of both the pig and rat liver enzymes show that the 38-kDa protein is homologous to Snf4p (CAT3) and that the 40-kDa protein is homologous to the Sip1p/Spm/GAL83 family of Snf1p interacting proteins. Sucrose d. gradient and crosslinking experiments with purified 5′-AMP-activated protein kinase suggest that both the 38- and 40- kDa proteins associate tightly with the 63-kDa catalytic polypeptide in either a heterotrimeric complex or in dimeric complexes. The 40-kDa subunit is autophosphorylated within the 63-kDa subunit complex. The sequence relationships between the mammalian 5′-AMP-activated protein kinase and yeast Snf1p extend to the subunit proteins consistent with conservation of the functional roles of these polypeptides in cellular regulation by this family of metabolite-sensing protein kinases.

Journal of Biological Chemistry published new progress about Phosphorylation, autophosphorylation. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Name: 3-Bromo-1H-pyrrolo[3,2-c]pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Related Products of 5315-25-3.

Hylland, Knut T.;Schmidtke, Inga L.;Wragg, David S.;Nova, Ainara;Tilset, Mats research published 《 Synthesis of substituted (N,C) and (N,C,C) Au(III) complexes: the influence of sterics and electronics on cyclometalation reactions》, the research content is summarized as follows. Cyclometalated Au(III) complexes are of interest due to their catalytic, medicinal, and photophys. properties. Herein, we describe the synthesis of derivatives of the type [(N-C)Au(O₂CCF₃)₂] and [(N-C-C)Au(O₂CCF₃)] by a cyclometalation route (N-C, N-C-C = chelating 2-arylpyridine ligands). The scope of the synthesis is explored by substituting the 2-arylpyridine core with electron donor or acceptor substituents at one or both rings. Notably, a variety of functionalized Au(III) complexes can be obtained in one step from the corresponding ligand and Au(OAc)₃, eliminating the need for organomercury intermediates, which is commonly reported for similar syntheses. The influence of substituents in the ligand backbone on the resulting complexes was assessed using DFT calculations, ¹⁵N NMR spectroscopy and single-crystal X-ray diffraction anal. A correlation between the electronic properties of the (N-C) ligands and their ability to undergo cyclometalation was found from exptl. studies combined with natural charge anal., suggesting the cyclometalation at Au(III) to take place via an electrophilic aromatic substitution-type mechanism. The formation of Au(III) pincer complexes from tridentate (N-C-C) ligands was investigated by synthesis and DFT calculations, in order to assess the feasibility of C(sp³)-H bond activation as a synthetic pathway to (N-C-C) cyclometalated Au(III) complexes. It was found that C(sp³)-H bond activation is feasible for ligands containing different alkyl groups (iso-Pr and ethyl), although the C-H activation is less energetically favored compared to a ligand containing tert-Bu groups.

Related Products of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. COA of Formula: C6H6BrN.

Hyun, Sung-Min;Reid, Kaleb A.;Vali, Shaik Waseem;Lindahl, Paul A.;Powers, David C. research published 《 Cis-divacant octahedral Fe(II) in a dimensionally reduced family of 2-(Pyridin-2-yl)pyrrolide complexes》, the research content is summarized as follows. Four-coordinate transition-metal complexes can adopt a diverse array of coordination geometries, with square planar and tetrahedral coordination being the most prevalent. Previously, we reported the synthesis of a trinuclear Fe(II) complex, Fe₃TPM₂, supported by a 3-fold-sym. 2-pyridylpyrrolide ligand [i.e., tris(5-(pyridin-2-yl)-1H-pyrrol-2-yl)methane] that featured a rare cis-divacant octahedral (CDO) geometry at each Fe(II) center. Here, a series of truncated 2-pyridylpyrrolide ligands are described that support mono- and binuclear Fe(II) complexes that also exhibit CDO geometries. Metalation of the tetradentate ligand bis[5-(pyridin-2-yl)-1H-pyrrol-2-yl]methane (H₂BPM) in THF (THF) results in the binuclear complex Fe₂(BPM)₂(THF)₂ in which both Fe(II) ions are octahedrally coordinated. The coordinated THF solvent ligands are labile: THF dissociation leads to Fe₂(BPM)₂, which features five-coordinate Fe(II) ions. The Fe-Fe distance in these binuclear complexes can be elongated by ligand methylation. Metalation of bis[5-(6-methylpyridin-2-yl)-1H-pyrrol-2-yl]methane (H₂BPM^Me) in THF leads to the formation of four-coordinate, CDO Fe(II) centers in Fe(BPM^Me)₂. Further ligand truncation affords bidentate ligands 2-(1H-pyrrol-2-yl)pyridine (PyrPyrrH) and 2-methyl-6-(1H-pyrrol-2-yl)pyridine (Pyr^MePyrrH). Metalation of these ligands in THF affords six-coordinate complexes Fe(PyrPyrr)₂(THF)₂ and Fe(Pyr^MePyrr)₂(THF)₂. Dissociation of labile solvent ligands provides access to four-coordinate Fe(II) complexes. Ligand disproportionation at Fe(PyrPyrr)₂ results in the formation of Fe(PyrPyrr)₃ and Fe(0). Ligand methylation suppresses this disproportionation and enables isolation of Fe(Pyr^MePyrr)₂, which is rigorously CDO. Complete ligand truncation, by separating the 2-pyridylpyrrolide ligands into the constituent monodentate pyridyl and pyrrolide donors, affords Fe(Pyr)₂(Pyrr)₂ in which Fe(II) is tetrahedrally coordinated. Computational anal. indicates that the potential energy surface that dictates the coordination geometry in this family of four-coordinate complexes is fairly flat in the vicinity of CDO coordination. These synthetic studies provide the structural basis to explore the implications of CDO geometry on Fe-catalyzed reactions. Four-coordinate transition metal complexes can adopt a diverse array of coordination geometries, with square planar and tetrahedral coordination being the most prevalent. Previously, the authors reported the synthesis of a trinuclear Fe(II) complex, Fe3TPM2, supported by a three-fold sym. 2-pyridylpyrrolide ligand (i.e., tris(5-(pyridin-2-yl)-1H-pyrrol-2-yl)methane), that featured a rare cis-divacant octahedral (CDO) geometry at each Fe(II) center. Here, a series of truncated 2-pyridylpyrrolide ligands is described that support mono- and binuclear Fe(II) complexes that also exhibit CDO geometries. Metalation of tetradentate ligand bis(5-(pyridin-2-yl)-1H-pyrrol-2-yl)methane (H₂BPM) in THF results in a binuclear complex Fe₂(BPM)₂(THF)₂ in which both Fe(II) ions are octahedrally coordinated. The coordinated THF solvent ligands are labile: THF dissociation leads to Fe₂(BPM)₂, which features five-coordinate Fe(II) ions. The Fe-Fe distance in these binuclear complexes can be elongated by ligand methylation. Metalation of bis(5-(6-methylpyridin-2-yl)-1H-pyrrol-2-yl)methane (H₂BPMMe) in THF leads to the formation of four-coordinate, CDO Fe(II) centers in Fe(BPMMe)₂. Further ligand truncation affords bidentate ligands 2-(1H-pyrrol-2-yl)pyridine (PyrPyrrH) and 2-methyl-6-(1H-pyrrol-2-yl)pyridine (PyrMePyrrH). Metalation of these ligands in THF affords six-coordinate complexes Fe(PyrPyrr)₂(THF)₂ and Fe(PyrMePyrr)₂(THF)₂. Dissociation of labile solvent ligands provides access to four-coordinate Fe(II) complexes. Ligand disproportionation at Fe(PyrPyrr)₂ results in the formation of Fe(PyrPyrr)₃ and Fe(0). Ligand methylation suppresses this disproportionation and enables isolation of Fe(PyrMePyrr)₂, which is rigorously CDO. Complete ligand truncation, by separating the 2-pyridylpyrrolide ligands into the constituent monodentate pyridyl and pyrrolide donors, affords Fe(Pyr)₂(Pyrr)₂ in which the Fe(II) is tetrahedrally coordinated. Computational anal. indicates that the potential energy surface that dictates the coordination geometry in this family of four-coordinate complexes is fairly flat in the vicinity of CDO coordination. These synthetic studies provide the structural basis to explore the implications of CDO geometry on Fe-catalyzed reactions.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Recommanded Product: 2-Bromo-6-methylpyridine.

Jain, Nimisha;Mary, Angelina;Manjunath, Vishesh;Sakla, Rahul;Devan, Rupesh S.;Jose, D. Amilan;Naziruddin, Abbas Raja research published 《 Ruthenium complexes bearing N-heterocyclic carbene based CNC and CN^Ĉ^H2C’ pincer ligands: Photophysics, electrochemistry, and solar energy conversion》, the research content is summarized as follows. Ruthenium terpyridine-supported diimidazolylpyridine NHC complexes were prepared and examined for redox and photophys. properties. A combination of N-heterocyclic carbene (NHC) based C-N-C, or C-N-CH₂C’ pincer ligands and carboxy-Ph terpyridine donors is used to prepare ruthenium complexes. The unsym. coordination of C-N-CH₂C’ pincer ligand via the CN donor atoms gave a rigid five-membered ring, and binding through N-CH₂C donor side rendered a six-membered chelate ring in [Ru(C-N-CH₂C’)(4′-tpy-4-HO₂CC₆H₄)](PF₆)₂. The latter binding gives the ruthenium center a near-ideal octahedral configuration with a more potent ligand field that could destabilize the thermally accessible-d-d states. The ambient condition excited-state lifetimes became consequently more prolonged than in the small-bite angle [Ru(C-N-C)(4′-tpy-4-HO₂CC₆H₄)](PF₆)₂ congener. Enhancement of lifetimes could be essential for better electron injection into the TiO₂ conduction band. Photophys. attributes of these complexes are studied to evaluate their potential use in dye-sensitized solar cells (DSSCs). The electrochem. and computational study also suggests a favorable regeneration of [Ru(C-N-CH₂C’)(4′-tpy-4-HO₂CC₆H₄)](PF₆)₂ bearing I^–₃/I^–electrolyte in a DSSC set-up. We herein report the syntheses, photo-functional attributes, redox behavior, and the preliminary device characteristics. Computed geometries of complexes in different electronic states and the bonding attributes of NHC ligands in different pincer-motifs of C-N-C vs. C-N-CH₂C’ are also reported.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Recommanded Product: 2-Bromo-6-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. SDS of cas: 766-11-0.

Jevtic, Ivana I.;Lai, Thu Hang;Penjisevic, Jelena Z.;Dukic-Stefanovic, Sladjana;Andric, Deana B.;Brust, Peter;Kostic-Rajacic, Sladjana V.;Teodoro, Rodrigo research published 《 Newly synthesized fluorinated cinnamylpiperazines possessing low in vitro MAO-B binding》, the research content is summarized as follows. Herein, the synthesis and pharmacol. evaluation of ten novel fluorinated cinnamylpiperazines I (R = 2-fluorophenyl, phenyl; R¹ = (4-fluorophenyl)carbonyl, 2-fluoropyridin-3-yl, 6-fluoropyridin-2-yl, etc.)as potential monoamine oxidase B (MAO-B) ligands were reported. The designed derivatives I consist of either cinnamyl or 2-fluorocinnamyl moieties connected to 2-fluoropyridylpiperazines. The three-step synthesis starting from com. available tert-Bu piperazine-1-carboxylate afforded the final products I in overall yields between 9% and 29%. An in vitro competitive binding assay using l-[³H]Deprenyl as radioligand was developed and the MAO-B binding affinities of the synthesized derivatives I were assessed. Docking studies revealed that the compounds I were stabilized in both MAO-B entrance and substrate cavities, thus resembling the binding pose of l-Deprenyl. Although the results revealed that the novel fluorinated cinnamylpiperazines I do not possess sufficient MAO-B binding affinity to be eligible as positron emission tomog. (PET) agents, the herein developed binding assay and the insights gained within our docking studies will certainly pave the way for further development of MAO-B ligands.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , SDS of cas: 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem