Tag: M.W=150-200

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application In Synthesis of 766-11-0.

Collibee, Scott E.;Bergnes, Gustave;Chuang, Chihyuan;Ashcraft, Luke;Gardina, Jeffrey;Garard, Marc;Jamison, Chris R.;Lu, Kevin;Lu, Pu-Ping;Muci, Alexander;Romero, Antonio;Valkevich, Ellen;Wang, Wenyue;Warrington, Jeffrey;Yao, Bing;Durham, Nickie;Hartman, James;Marquez, Anna;Hinken, Aaron;Schaletzky, Julia;Xu, Donghong;Hwee, Darren T.;Morgans, David;Malik, Fady I.;Morgan, Bradley P. research published 《 Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function》, the research content is summarized as follows. Herein, the discovery of reldesemtiv I, a second-generation fast skeletal muscle troponin activator (FSTA) that increases force production at submaximal stimulation frequencies, is reported. Property-based optimization of high throughput screening hit, 4-(4-fluorobenzyl)-5-(phenethylamino)-1,2,4-thiadiazole, led to compounds with improved free exposure and in vivo muscle activation potency compared to the first-generation FSTA, tirasemtiv. The compound I demonstrated increased muscle force generation in a phase 1 clin. trial and is currently being evaluated in clin. trials for the treatment of amyotrophic lateral sclerosis.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Application In Synthesis of 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Formula: C6H6BrN.

Conn, Edward L.;Perry, Matthew A.;Shi, Kecheng;Wang, Guotao;Hoy, Susan;Sach, Neal W.;Qi, Wenying;Qu, Liqiang;Gao, Yu;Xu, Yan;Schmitt, Daniel C. research published 《 Identification of parallel medicinal chemistry protocols to expand branched amine design space》, the research content is summarized as follows. Methods for the synthesis of α-branched heteroaryl amines RCH(R¹)NH(R²) (R = tert-Bu, Ph, 1-methyl-1H-imidazol-4-yl, pyridin-2-yl, etc. R¹ = 1-methyl-1H-pyrazol-5-yl, pyridin-3-yl, 1-propyl-1H-pyrazol-4-yl, 4-bromo-2-hydroxyphenyl, etc.; R² = pyridin-2-yl, Ph, 4-phenylpyridin-2-yl, pyrazin-2-yl, etc.) via aldimine addition have been evaluated for compatibility with parallel synthesis. In situ activation of aliphatic carboxylic acids RC(O)OH as redox-active esters enables Zn-mediated decarboxylative radical imine R¹CH=NR² addition to access aliphatic-branched heterobenzylic amines. In situ activation of (hetero)aryl bromides RBr via Li-halogen exchange enables heteroaryl-lithium addition to imines to access (hetero)benzhydryl amines. Condensation of heteroaryl amines RNH₂ with heteroaryl aldehydes R¹CHO provides aldimines which may be intercepted with aryl Grignard reagents to provide modular access to (hetero)benzhydryl amines. These protocols minimize synthetic step count and maximize accessible design space, enhancing access to α-branched heteroaryl amines for medicinal chem.

Formula: C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Product Details of C6H6BrN.

Cook, Xinlan A. F.;Pantaine, Loic R. E.;Blakemore, David C.;Moses, Ian B.;Sach, Neal W.;Shavnya, Andre;Willis, Michael C. research published 《 Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions》, the research content is summarized as follows. Heteroaromatic sulfinates, e.g., I, are effective nucleophilic reagents in Pd(0)-catalyzed cross-coupling reactions with aryl halides e.g., 4-methoxy-bromobenzene. However, metal sulfinate salts can be challenging to purify and solubilize in reaction media, and are not tolerant to multi-step transformations. Here base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones were introduced. It was shown that, under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls, e.g., II. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.

Product Details of C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Name: 2-Bromo-6-methylpyridine.

Ceugniet, Fabien;Huaulme, Quentin;Sutter, Alexandra;Jacquemin, Denis;Leclerc, Nicolas;Ulrich, Gilles research published 《 Hetero-Substituted αβ-Fused BODIPY》, the research content is summarized as follows. Here, we report the synthesis and properties of heterosubtituted αβ-fused BODIPY fluorophores. The compounds were obtained in good yields by sequential and selective Stille cross-coupling reactions from 2,3,5,6-tetrahalo-BODIPY, allowing the introduction of different substituents at the 3,5 and 2,6 positions of the BODIPY ring. The final fused compounds were synthesized using oxidative cyclization with ferrous chloride. The fully fused compounds show a strong bathochromically shifted emission along with a hyperchromic shift of the absorption maxima. The fluorescence quantum yields remain relatively large for compounds emitting in this wavelength range. Computational studies have been carried out to fully understand the photophys. behavior of these dyes.

Name: 2-Bromo-6-methylpyridine, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Synthetic Route of 31181-90-5.

Chai, Chaoyang;Xu, Shengxian;Wang, Jinglan;Zhao, Feng;Xia, Hongying;Wang, Yibo research published 《 Synthesis, photophysical properties and DFT studies of the pyridine-imidazole (PyIm) Cu(I) complexes: Impact of the pyridine ring functionalized by different substituents》, the research content is summarized as follows. The pyridine-imidazole (PyIm) Cu(I) complexes [((Ph₂PC₆H₄)₂O)Cu(C₃H₃N₂C₅H₃N-R-5)]PF₆ with different substituents (bromide (P1), Me (P2) and Ph (P3)) attached on the pyridine ring were synthesized and characterized. All the complexes show the typical metal-to-ligand charge transfer (MLCT) absorption in the visible region. Complex P1 with an electron-withdrawing substituent on the pyridine ring, a Br group, shows a red shift of the emission wavelength compared to the unsubstituted complex. Conversely, an electron-donating substituent on the pyridine ring in complex P2, a Me group, shifts the emission to shorter wavelength. Complex P3 containing the extended π-conjugation system of the ligand also exhibits a red shift of the emission wavelength. All of the complexes exhibit efficient green-yellow emission in PMMA films at room temperature with emission wavelength of 547-569 nm and quantum yields of 24.8-53.0%. Meanwhile, DFT and TDDFT methods were employed to explain the photophys. properties.

Synthetic Route of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Category: pyridine-derivatives.

Chen, Fenglin;Chen, Ke;Zhang, Yao;He, Yuli;Wang, Yi-Ming;Zhu, Shaolin research published 《 Remote Migratory Cross-Electrophile Coupling and Olefin Hydroarylation Reactions Enabled by in Situ Generation of NiH》, the research content is summarized as follows. A highly efficient strategy for remote reductive cross-electrophile coupling has been developed through the ligand-controlled nickel migration/arylation. This general protocol allows the use of abundant and bench-stable alkyl bromides and aryl bromides for the synthesis of a wide range of structurally diverse 1,1-diarylalkanes in excellent yields and high regioselectivities under mild conditions. Authors also demonstrated that alkyl bromide could be replaced by the proposed olefin intermediate while using Pr bromide/Mn⁰ as a potential hydride source.

Category: pyridine-derivatives, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. HPLC of Formula: 766-11-0.

Chen, Fu-Min;Huang, Fei-Dong;Yao, Xue-Yi;Li, Tian;Liu, Feng-Shou research published 《 Direct C-H heteroarylation by an acenaphthyl-based α-diimine palladium complex: improvement of the reaction efficiency for bi(hetero)aryls under aerobic conditions》, the research content is summarized as follows. A bulky acenaphthyl skeleton-based α-diimine palladium complex with ortho-tert-Bu on N-aryl moieties was designed, synthesized and characterized. The developed palladium complex was applied for direct C-H arylation under aerobic reaction conditions. A range of heteroaryls, such as thiazoles, thiophenes, furans, imidazopyridines, indolizines, isoxazoles, imidazoles, triazoles, pyrazoles, indoles, pyrroles and pyrazolidinones, were used, while various coupling partners of heteroaryl bromides with wide functional groups were compatible. Upon using 0.05-0.1 mol% of a precatalyst, more than 90 examples of cross-coupling products were afforded in good to excellent yields, demonstrating that this phosphine-free catalytic system scaffold enables a general access to biheteroaryls.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , HPLC of Formula: 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Electric Literature of 16133-25-8.

Chen, Hao;Chen, Xiuhui;Sun, Ping;Wu, Dan;Yue, Hu;Pan, Jintao;Li, Xinxuan;Zhang, Cheng;Wu, Xinyi;Hua, Lei;Hu, Wenhui;Yang, Zhongjin research published 《 Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity》, the research content is summarized as follows. A series of novel 5-amide benzofuran derivatives I [ R = ethylsulfonyl, benzoyl, methoxysulfamoyl, cyclohexylcarbamoyl, etc.] were designed and synthesized as NLRP3-inflammasome inhibitors. Compound I [ R = 2-methylpropanoyl] showed slightly increased activity (IC₅₀ = 3.85μM) against IL-1β release. Notably, treatment with I [ R = 2-methylpropanoyl] was significantly inhibited NLRP3-mediated IL-1β release and ameliorate peritoneal inflammation in a mouse model of sepsis. Collectively, I [ R = 2-methylpropanoyl] was a promising lead compound for further chem. development as a NLRP3 inhibitor with anti-inflammation effects.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Electric Literature of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Application of C6H4BrNO.

Chen, Helen Y.;Plummer, Christopher W.;Xiao, Dong;Chobanian, Harry R.;DeMong, Duane;Miller, Michael;Trujillo, Maria E.;Kirkland, Melissa;Kosinski, Daniel;Mane, Joel;Pachanski, Michele;Cheewatrakoolpong, Boonlert;Di Salvo, Jerry;Thomas-Fowlkes, Brande;Souza, Sarah;Tatosian, Daniel A.;Chen, Qing;Hafey, Michael J.;Houle, Robert;Nolting, Andrew F.;Orr, Robert;Ehrhart, Juliann;Weinglass, Adam B.;Tschirret-Guth, Richard;Howard, Andrew D.;Colletti, Steven L. research published 《 Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs》, the research content is summarized as follows. A series of biaryl chromans exhibiting potent and selective agonism for the GPR40 receptor with pos. allosteric modulation of endogenous ligands (AgoPAM) were discovered as potential therapeutics for the treatment of type II diabetes. Optimization of physicochem. properties through modification of the pendant aryl rings resulted in the identification of compound I, which possesses an improved metabolic profile while demonstrating sustained glucose lowering.

Application of C6H4BrNO, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Reference of 31181-90-5.

Chen, Hongyun;Wang, Jinglan;Zhao, Feng;Wang, Yibo;He, Haifeng;Xia, Hongying research published 《 Synthesis, spectroscopic and DFT studies of copper(I) complexes inserting the electron-donating groups into pyridine-imidazole ligands vis an acetylide linker》, the research content is summarized as follows. The three Cu(I) complexes [Cu(POP)(NN̂)]PF₆, NN̂ = 2-(1H-imidazol-2-yl)-5-(p-tolylethynyl)pyridine (P1), 2-(1H-imidazol-2-yl)-5-((4-methoxyphenyl)ethynyl)pyridine (P2), 4-((6-(1H-imidazol-2-yl)pyridin-3-yl)ethynyl)-N,N-diphenylaniline (P3), were prepared and characterized. The different electron-donating groups such as methylphenyl, methoxyphenyl, and diphenylamine substituents were functionalized onto the pyridine ring part of the diimine ligands through an acetylide linker to enhance the light-absorption abilities, giving the larger light-absorption ability and red-shifted absorption bands for the investigated Cu(I) complexes. Yellow emissions in the range of 579-590 nm with quantum yields of 8.40-15.1% can be observed for all complexes at room temperature The photophys. properties were further explained by DFT and TDDFT methods.

Reference of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem