Tag: M.W=150-200

Pyridine is colorless, but older or impure samples can appear yellow. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Quality Control of 16133-25-8.

Brulet, Jeffrey W.;Borne, Adam L.;Yuan, Kun;Libby, Adam H.;Hsu, Ku-Lung research published 《 Liganding Functional Tyrosine Sites on Proteins Using Sulfur-Triazole Exchange Chemistry》, the research content is summarized as follows. Tuning reactivity of sulfur electrophiles is key for advancing click chem. and chem. probe discovery. To date, activation of the sulfur electrophile for protein modification has been ascribed principally to stabilization of a fluoride leaving group (LG) in covalent reactions of sulfonyl fluorides and arylfluorosulfates. We recently introduced sulfur-triazole exchange (SuTEx) chem. to demonstrate the triazole as an effective LG for activating nucleophilic substitution reactions on tyrosine sites of proteins. Here, we probed tunability of SuTEx for fragment-based ligand discovery by modifying the adduct group (AG) and LG with functional groups of differing electron-donating and -withdrawing properties. We discovered the sulfur electrophile is highly sensitive to the position of modification (AG vs. LG), which enabled both coarse and fine adjustments in solution and proteome activity. We applied these reactivity principles to identify a large fraction of tyrosine sites (~30%) on proteins (~44%) that can be liganded across >1500 probe-modified sites quantified by chem. proteomics. Our proteomic studies identified noncatalytic tyrosine and phosphotyrosine sites that can be liganded by SuTEx fragments with site specificity in lysates and live cells to disrupt protein function. Collectively, we describe SuTEx as a versatile covalent chem. with broad applications for chem. proteomics and protein ligand discovery.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Quality Control of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Name: 5-Bromo-2-fluoropyridine.

Buragohain, Pori;Surineni, Naresh;Barua, Nabin C.;Bhuyan, Purnajyoti D.;Boruah, Paran;Borah, Jagat C.;Laisharm, Surbala;Moirangthem, Dinesh Singh research published 《 Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent》, the research content is summarized as follows. A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. Antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Name: 5-Bromo-2-fluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. COA of Formula: C5H3BrFN.

Campbell, Mark W.;Yuan, Mingbin;Polites, Viktor C.;Gutierrez, Osvaldo;Molander, Gary A. research published 《 Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization》, the research content is summarized as follows. Herein, the implementation of efficient, sustainable, diaryl ketone hydrogen-atom transfer (HAT) catalysis to activate native C-H bonds for multicomponent dicarbofunctionalization of alkenes was reported. The ability to forge new carbon-carbon bonds between reagents typically viewed as commodity solvents provided a new, more atom-economic outlook for organic synthesis. Through detailed exptl. and computational investigation, the critical effect of hydrogen bonding on the reactivity of this transformation was uncovered.

COA of Formula: C5H3BrFN, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Quality Control of 31181-90-5.

Capocasa, Giorgio;Di Berto Mancini, Marika;Frateloreto, Federico;Lanzalunga, Osvaldo;Olivo, Giorgio;Di Stefano, Stefano research published 《 Easy Synthesis of a Self-Assembled Imine-Based Iron(II) Complex Endowed with Crown-Ether Receptors》, the research content is summarized as follows. Herein authors report that an imine-based iron complex decorated with crown-ether moieties self-assembles in CH₃CN solution from three building blocks (namely Fe(CH₃CN)₂(OTf)₂, 2-picolylamine and aldehyde 6a) added in the proper molar ratio (1:2:2, resp.). Aldehyde 6a, endowed with a benzocrown-ether receptor, can be prepared in two steps from com. materials with high yields (79%) and no need of chromatog. separations The self-assembled complex is highly stable in CH₃CN solution The complex has been tested as catalyst for the oxidation of aromatic compounds endowed with primary ammonium anchoring group with H₂O₂. An unexpected yet moderate selectivity for remote meta over ortho hydroxylation was obtained, which is mainly due to the steric hindrance of the catalyst.

Quality Control of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Product Details of C5H4ClNO2S.

Cellnik, Torsten;Healy, Alan R. research published 《 Sulfonyl Chlorides as Thiol Surrogates for Carbon-Sulfur Bond Formation: One-Pot Synthesis of Thioethers and Thioesters》, the research content is summarized as follows. A method to synthesize thioethers and thioesters directly from readily available sulfonyl chlorides was reported. A transient intermediate formed during phosphine-mediated deoxygenation of sulfonyl chlorides was trapped in situ by activated alcs. or carboxylic acids to effect carbon-sulfur bond formation. The method is operationally simple and tolerates a broad range of functional groups. Special attention was focused on the late-stage diversification of densely functionalized natural products and pharmaceuticals.

Product Details of C5H4ClNO2S, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Recommanded Product: Pyridine-3-sulfonyl chloride.

Kan, Chun;Song, Fan;Shao, Xiaotao;Wu, Linyun;Zhu, Jing research published 《 Fe(III) induced fluorescent probe based on triamine and rhodamine derivatives and its applications in biological imaging》, the research content is summarized as follows. It is important to design a sensitive and efficient probe for detecting Fe³⁺ in environment and organisms. In this work, a rhodamine-based probe (RBTN) was designed by acylation reaction at high temperature RBTN has a good specific fluorescence sensing for Fe³⁺ in the EtOH/H₂O (1:1, volume/volume, HEPES, 0.5 mM, pH = 7.3) solution The reversibility between RBTN and Fe³⁺ was confirmed by adding Na₄P₂O₇. At the same time, RBTN has a lower detection limit, as low as 0.148 μM. In addition, RBTN can be used to detect Fe³⁺ in environmental water samples, and the recovery rate of Fe³⁺ is higher. Finally, biol. experiments confirmed that RBTN could be used to detect Fe³⁺ in cells, vivo and plant tissues.

Recommanded Product: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Recommanded Product: 5-Bromopicolinaldehyde.

Lv, Jie;Li, Qianqian;Wang, Jinglan;Xu, Shengxian;Zhao, Feng;He, Haifeng;Wang, Yibo research published 《 Orange-red emissive Cu(I) complexes bearing Schiff base ligands: Synthesis, structures, and photophysical properties》, the research content is summarized as follows. Herein, the three novel copper(I) complexes bearing Schiff base ligands of the types [Cu(Phen-PyMethylene-Adam-Amine)(POP)]PF₆ (P1), [Cu(Methoxyl-Phen-PyMethylene-Adam-Amine)(POP)]PF₆ (P2), and [Cu(TriflMethyl-Phen-PyMethylene-Adam-Amine)(POP)]PF₆ (P3) (Phen-PyMethylene-Adam-Amine = ((5-phenylpyridin-2-yl)methylene)adamantan-1-amie, Methoxyl-Phen-PyMethylene-Adam-Amine = ((5-(4-methoxyphenyl)pyridin-2-yl)methylene)adamantan-1-amine, TriflMethyl-Phen-PyMethylene-Adam-Amine = ((5-(4-(trifluoromethyl)phenyl)pyridin-2-yl)methylene)adamantan-1-amine,POP = bis[2-diphenylphosphino]phenyl-ether) have been prepared and studied. Incorporation of the bulky adamantyl group into the complexes can enhance the stability of the complexes. The different electron-donating/withdrawing groups such as -H, -OCH₃, and -CF₃ substituents were functionalized onto the pyridine ring part of Schiff base ligands to tune the emission behavior of the resulting Schiff base Cu(I) complexes. All complexes exhibit the lowest energy metal-to-ligand charge transfer (MLCT) characters in 400-450 nm region showing a slight blue-shift of the absorption wavelengths in the order P3 > P1 > P2. Organe-red emissions at 611-619 nm with photoluminescence quantum yields (PLQY) of 1.0-1.3% can be observed in the solid state. Addnl., the photophys. properties were also studied theor. using d. functional theory (DFT) and time dependent DFT.

Recommanded Product: 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Recommanded Product: 2-Bromo-6-methylpyridine.

Wan, Lin-Xi;Zhen, Yong-Qi;He, Zhen-Xiang;Zhang, Yang;Zhang, Lan;Li, Xiaohuan;Gao, Feng;Zhou, Xian-Li research published 《 Late-Stage Modification of Medicine: Pd-Catalyzed Direct Synthesis and Biological Evaluation of N-Aryltacrine Derivatives》, the research content is summarized as follows. A new series of N-aryltacrine derivatives was designed and synthesized as cholinesterase inhibitors by the late-stage modification of tacrine, using the palladium-catalyzed Buchwald-Hartwig cross-coupling reaction. In vitro inhibition assay against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) demonstrated that most of the synthesized compounds had potent AChE inhibitory activity with neg. inhibition of BuChE. Among them, N-(4-(trifluoromethyl)phenyl)-tacrine (I) and N-(4-methoxypyridin-2-yl)-tacrine (II) showed the most potent activity against AChE (IC₅₀ values of 1.77 and 1.48μM, resp.). The anti-AChE activity of I and II was 3.5 times more than that of tacrine (IC₅₀ value of 5.16μM). Compound II also displayed anti-BuChE activity with an IC₅₀ value of 19.00μM. Cell-based assays against HepG2 and SH-SY5Y cell lines revealed that II had significantly lower hepatotoxicity compared to tacrine, with addnl. neuroprotective activity against H₂O₂-induced damage in SH-SY5Y cells. The advantages including synthetic accessibility, high potency, low toxicity, and adjunctive neuroprotective activity make compound II a new promising multifunctional candidate for the treatment of Alzheimer’s disease.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Recommanded Product: 2-Bromo-6-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Electric Literature of 16133-25-8.

Kan, Chun;Shao, Xiaotao;Wu, Linyun;Zhang, Yao;Bao, Xiaofeng;Zhu, Jing research published 《 A novel “OFF-ON-OFF” fluorescence chemosensor for hypersensitive detection and bioimaging of Al(III) in living organisms and natural water environment》, the research content is summarized as follows. High-selectivity detection of trace Al³⁺ ions in water and biol. systems by a fluorescence imaging method is not yet mature. Herein, we synthesized a novel reversible Al³⁺-specific fluorescent probe named RBLF by linking Rhodamine B and pyridine-3-sulfonyl chloride through o-phenylenediamine in several reactions. RBLF exhibited an ultra-high sensitive and excellent selective response towards Al³⁺ by fluorescence and UV-vis spectra in aqueous solutions What is more worth mentioning is that its response is fast, dual changes in color and fluorescence of the probe solution that can occur instantaneously after adding with Al³⁺. Its detection limit for Al³⁺ ions in aqueous system solutions is 14.23 nM, which is far below the maximum allowable amount of Al³⁺ in drinking water. Moreover, the probe provided an effective method for detecting low concentrations of Al³⁺ in natural water, living cells, zebrafish and plant tissues.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Electric Literature of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem