Tag: M.W=150-200

Warr, Rebecca J. published the artcileInorganic asymmetric synthesis: asymmetric synthesis of a two-bladed propeller, octahedral metal complex, Related Products of pyridine-derivatives, the publication is Inorganic Chemistry (2006), 45(21), 8618-8627, database is CAplus and MEDLINE.

A C₂ hexadentate, in which two pyridine-2-aldehyde 2′-pyridylhydrazone (PAPHY) groups are linked to a chiral auxiliary derived from (R,R)-tartaric acid, (R,R)-I, reacts with Fe(II) benzenesulfonate to give the two-bladed propeller, octahedral complex (P_Fe)-[Fe{(R,R)-I}](PhSO₃)₂ with complete diastereoselectivity, as determined by ¹H NMR spectroscopy and x-ray crystallog. Saponification of the ester linkages and deprotonation of the hydrazone-NH groups in the configurationally pure diastereomer affords (P_Fe)-[Fe(5-HOCH₂PAPY)₂] with 85% retention of configuration at the Fe stereocenter, as determined by reprotonation of the neutral complex with enantiomerically pure (aR)-binaphthyl H₃PO₄ and anal. of the ¹H NMR spectrum of the mixture of diastereomeric salts produced. This is the 1st asym. synthesis of a two-bladed propeller, octahedral metal complex by the classical organic methodol. of chiral auxiliary-directed, asym. synthesis.

Inorganic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C5H5BO4S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hynes, John Jr. published the artcileDiscovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(14), 3101-3106, database is CAplus and MEDLINE.

A series of potent dual JAK1/3 inhibitors have been developed from a moderately selective JAK3 inhibitor. Substitution at the C6 position of the pyrrolopyridazine core with aryl groups provided exceptional biochem. potency against JAK1 and JAK3 while maintaining good selectivity against JAK2 and Tyk2. Translation to in vivo efficacy was observed in a murine model of chronic inflammation. X-ray co-crystal structure determination confirmed the presumed inhibitor binding orientation in JAK3. Efforts to reduce hERG channel inhibition will be described.

Bioorganic & Medicinal Chemistry Letters published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Luo, Zhongfeng published the artcileCesium Fluoride and Copper-Catalyzed One-Pot Synthesis of Benzoxazoles via a Site-Selective Amide C-N Bond Cleavage, Safety of 2-Bromopyridin-3-amine, the publication is Advanced Synthesis & Catalysis (2019), 361(17), 4117-4125, database is CAplus.

We report herein a two-step one-pot strategy for the synthesis of benzoxazoles from amides by using cesium fluoride/copper as catalysts. This approach involves the in situ generation of acyl fluorides from the corresponding amides, and the acyl fluorides undergo transamidation and cyclization to give benzoxazoles in good yields. In this work, the amide C-N bonds are activated by CsF to form the acyl fluoride intermediates, which further react with o-bromoanilines to efficiently yield benzoxazoles. Notably, this methodol. demonstrates a broad substrate scope, as primary/secondary benzamides are well tolerated, and this process might facilitate the development of one-pot transformations of amides.

Advanced Synthesis & Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yongda published the artcileAn Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3′-F₂-BINOL, Name: (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid, the publication is Journal of Organic Chemistry (2016), 81(6), 2665-2669, database is CAplus and MEDLINE.

An efficient asym. synthesis of 11-β-HSD inhibitor I has been accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chloro-1-phenylpropan-1-one. The key feature of the synthesis includes an asym. methallylation of 3-chloro-1-phenylpropan-1-one catalyzed by the highly effective organocatalyst (S)-3,3′-F₂-BINOL under solvent-free and metal-free conditions.

Journal of Organic Chemistry published new progress about 1351413-50-7. 1351413-50-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Pyridine,Boronic Acids,Boronic acid and ester, name is (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid, and the molecular formula is C11H8ClN3, Name: (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Xinyu published the artcileSelenium atoms induce organic doped systems to produce pure phosphorescence emission, Computed Properties of 91-02-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(8), 1179-1182, database is CAplus and MEDLINE.

A host-guest system is constructed using a guest containing two selenium atoms. The selenium atoms can increase the spin-orbit coupling constant and the conjugation degree, thereby increasing the emission wavelength, and making the materials show only phosphorescence emission.

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C10H15NO, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhou, Fei published the artcileNitroarenes as Nitrogen Source in Intermolecular Palladium-Catalyzed Aryl C-H Bond Aminocarbonylation Reactions, Name: 5-Methyl-2-(p-tolyl)pyridine, the publication is Angewandte Chemie, International Edition (2017), 56(16), 4530-4534, database is CAplus and MEDLINE.

A three-component palladium-catalyzed aminocarbonylation of aryl and heteroaryl sp² C-H bonds using nitroarenes as the nitrogen source was achieved using Mo(CO)₆ as the reductant and origin of the CO. This intermol. C-H bond functionalization does not requires any exogenous ligand to be added, and our mechanism experiments indicate that the palladacycle catalyst serves two roles in the aminocarbonylation reaction: reduce the nitroarene to a nitrosoarene and activate the sp² C-H bond.

Angewandte Chemie, International Edition published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C12H10O4S, Name: 5-Methyl-2-(p-tolyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xia, Hongyu published the artcileVisible Light Induced Aerobic Coupling of Arylboronic Acids Promoted by Hydrazone, Category: pyridine-derivatives, the publication is Advanced Synthesis & Catalysis (2022), 364(5), 922-929, database is CAplus.

A visible-light-induced oxidative coupling of arylboronic acids was developed for the synthesis of biaryls Ar¹Ar² [Ar¹ = Ar² = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar¹ = 4-BrC₆H₄, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar₂ = 4-H(O)CC₆H₄, 3-MeOC₆H₄, 4-AcC₆H₄, etc.]. The reaction that employed polydentate hydrazones as the bifunctional catalyst works smoothly under room temperature It was compatible with a wide range of functional group. The study of UV-Vis spectrum indicated that hydrazone and its complex with CuI show major absorptions upon visible-light, which secures the dual role of hydrazone as both ligand and photocatalyst in this reaction. Hence, the reaction was proposed to involve stepwise transmetallations, photo-induced oxidations, and reductive elimination.

Advanced Synthesis & Catalysis published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C9H9F5Si, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fang, Wei-Hui published the artcileTitanium-Oxo Cluster Based Precise Assembly for Multidimensional Materials, COA of Formula: C5H5NO3S, the publication is Chemistry of Materials (2017), 29(7), 2681-2684, database is CAplus.

Nanosized titanium-oxo clusters have been successfully organized into materials with various dimensions from 1D chain to 2D layer and finally 3D diamond framework. During the assembly, polymetallic dopants like {Cu2X2}, {Cu4X4} and {Cu4X4-DABCO-Cu4X4} (X = halide; DABCO = 1,4-diazabicyclo[2.2.2]octane) have been introduced to Ti-O structures for the first time, which brings versatile light absorption behaviors and bandgap properties. Based on the successes of the above mol. assembly, the developed methodol. has further been extended to the macroscopic scale assembly of a Cu-Ti layer to the surface of a Ti-O crystal. Therefore, this work provides an efficient approach for the assembly engineering of titanium-oxo clusters and the construction of core-shell materials with well-defined at. structures.

Chemistry of Materials published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, COA of Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guo, Peng published the artcileTwo three-dimensional pillar-layer Ag^I-frameworks with helical arrays containing hexamine, Category: pyridine-derivatives, the publication is Inorganic Chemistry Communications (2011), 14(1), 172-175, database is CAplus.

Two three-dimensional pillar-layer Ag^I-frameworks with helical arrays were synthesized at room temperature Compound 1, {[Ag₂(H₂O)(L2)₂L1]·H₂O}_n (L1 = hexamethylenetetramine, HL2 = 3-pyridinesulfonic acid), is constructed from two-dimensional (6,3) layers which are braced by helical arrays; compound 2, {[Ag₃(L1)₂(L3)]·6H₂O}_n (H₃L3 = citric acid), is created by two-dimensional layers which are made up of the mix-helical arrays and further pillared by L3 anions and Ag ions. Compounds 1 and 2 were characterized by single-crystal x-ray structure determination, powder X-ray diffraction, IR and TGA. Also, the water and methanol adsorption isotherms for compound 1 were studied.

Inorganic Chemistry Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Yaxin published the artcileHalogen-Bond-Promoted Photoactivation of Perfluoroalkyl Iodides: A Photochemical Protocol for Perfluoroalkylation Reactions, Safety of 2-Bromopyridin-3-amine, the publication is Organic Letters (2017), 19(6), 1442-1445, database is CAplus and MEDLINE.

A new protocol for photochem. perfluoroalkylation reactions using perfluoroalkyl iodide, amine additive, and THF solvent is reported. This protocol does not require a photoredox catalyst and proceeds at ambient temperature with irradiation from a compact fluorescent lamp, low-intensity UV lamp, or sunlight. This protocol can be applied to the synthesis of perfluoroalkyl-substituted phenanthridines and effect the iodo-perfluoroalkylation of alkenes/alkynes and the C-H perfluoroalkylation of electron-rich arenes and heteroarenes. This C-H perfluoroalkylation reaction offers a unique method for site-selective labeling of oligopeptides at the tryptophan residue.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C44H28ClFeN4, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem