Tag: M.W=150-200

Musci, Pantaleo published the artcileFlow technol. for telescoped generation, lithiation and electrophilic (C₃) functionalization of highly strained 1-azabicyclo[1.1.0]butanes, SDS of cas: 91-02-1, the publication is Angewandte Chemie, International Edition (2021), 60(12), 6395-6399, database is CAplus and MEDLINE.

Strained compounds are privileged moieties in modern synthesis. In this context, 1-azabicyclo[1.1.0]butanes are appealing structural motifs that can be employed as click reagents or precursors to azetidines. We herein report the first telescoped continuous flow protocol for the generation, lithiation, and electrophilic trapping of 1-azabicyclo[1.1.0]butanes. The flow method allows for exquisite control of the reaction parameters, and the process operates at higher temperatures and safer conditions with respect to batch mode. The efficiency of this intramol. cyclization/C3-lithiation/electrophilic quenching flow sequence is documented with more than 20 examples.

Angewandte Chemie, International Edition published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Barman, Milan K. published the artcileManganese-Catalyzed Direct Olefination of Methyl-Substituted Heteroarenes with Primary Alcohols, Formula: C11H10N4, the publication is Angewandte Chemie, International Edition (2018), 57(29), 9126-9130, database is CAplus and MEDLINE.

Herein, we present the first catalytic direct olefination of methyl-substituted heteroarenes with primary alcs. through an acceptorless dehydrogenative coupling. The reaction is catalyzed by a complex of the earth-abundant transition metal manganese that is stabilized by a bench-stable NNN pincer ligand derived from 2-hydrazinylpyridine. The reaction is environmentally benign, producing only hydrogen and water as byproducts. A large number of E-disubstituted olefins, e.g., I and II, were selectively obtained with high efficiency.

Angewandte Chemie, International Edition published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chonan, Tomomichi published the artcileDiscovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group, Recommanded Product: Ethyl 2-(2-chloropyridin-3-yl)acetate, the publication is Bioorganic & Medicinal Chemistry (2011), 19(5), 1580-1593, database is CAplus and MEDLINE.

Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring led to the identification of the fluorine substituted tert-butoxycarbonyl group. Advanced analog, 1,1,1-trifluoro-2-methylpropan-2-yl 4-{4-[(2-amino-6-methyl-1-benzothiophen-3-yl)carbonyl]piperazin-1-yl}piperidine-1-carboxylate (12c (I)) showed potent inhibitory activities in enzyme-assay and cell-based assays. Compound 12c also exhibited reduction of hepatic de novo fatty acid synthesis in rats after oral administration.

Bioorganic & Medicinal Chemistry published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H10ClNO2, Recommanded Product: Ethyl 2-(2-chloropyridin-3-yl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Arhancet, Graciela B. published the artcileDiscovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation, Recommanded Product: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(4), 1114-1119, database is CAplus and MEDLINE.

Inhibition of mPGES-1, the terminal enzyme in the arachidonic acid/COX pathway to regulate the production of pro-inflammatory prostaglandin PGE2, is considered an attractive new therapeutic target for safe and effective anti-inflammatory drugs. The discovery of a novel series of orally active, selective benzoxazole piperidinecarboxamides as mPGES-1 inhibitors is described. Structure-activity optimization of lead compound with cyclohexyl carbinols resulted in a compound, which showed excellent in vitro potency and selectivity against COX-2, and reasonable pharmacokinetic properties. Further SAR studies of the benzoxazole ring substituents lead to a novel series of highly potent compounds with improved PK profile, which were effective in a carrageenan-stimulated guinea pig air pouch model of inflammation. Based on its excellent in vitro and in vivo pharmacol., pharmacokinetic and safety profile and ease of synthesis, PF-4693627 (I) was advanced to clin. studies.

Bioorganic & Medicinal Chemistry Letters published new progress about 870459-90-8. 870459-90-8 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, and the molecular formula is C6H5BF3NO2, Recommanded Product: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shen, Zican published the artcileGeneral Light-Mediated, Highly Diastereoselective Piperidine Epimerization: From Most Accessible to Most Stable Stereoisomer, Computed Properties of 164464-60-2, the publication is Journal of the American Chemical Society (2021), 143(1), 126-131, database is CAplus and MEDLINE.

We report a combined photocatalytic and hydrogen atom transfer (HAT) approach for the light-mediated epimerization of readily accessible piperidines to provide the more stable diastereomer with high selectivity. The generality of the transformation was explored for a large variety of di- to tetrasubstituted piperidines with aryl, alkyl, and carboxylic acid derivatives at multiple different sites. Piperidines without substitution on nitrogen as well as N-alkyl and aryl derivatives were effective epimerization substrates. The observed diastereoselectivities correlate with the calculated relative stabilities of the isomers. Demonstration of reaction reversibility, luminescence quenching, deuterium labeling studies, and quantum yield measurements provide information about the mechanism.

Journal of the American Chemical Society published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C5H11NO2S, Computed Properties of 164464-60-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rao, Chepuri R. K. published the artcileTailoring the gold-polypyrrole nanostructures at water-toluene interphase, Application In Synthesis of 636-73-7, the publication is Synthetic Metals (2007), 157(10-12), 432-436, database is CAplus.

A method is described to obtain gold-polypyrrole nanostructures by reacting gold chloride with pyrrole at toluene-water interphase. By adjusting the concentration of the stabilizer, namely, pyridine-3-sulfonate, the shape of the nanostructures formed at the interphase can be tailored. This novel method facilitates the fabrication of Au-Ppy composite material that gives wider scope for biosensing applications.

Synthetic Metals published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bowers, Simeon published the artcileDesign and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration, Product Details of C5H5BrN2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5521-5527, database is CAplus and MEDLINE.

The SAR of a series of brain penetrant, trisubstituted thiophene based JNK inhibitors with improved pharmacokinetic properties is described. These compounds were designed based on information derived from metabolite identification studies which led to compounds such as 42 (I) with lower clearance, greater brain exposure and longer half life compared to earlier analogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Moshohoritou, R. published the artcileThe effect of some additives on the throwing power and stability of tin(II) solutions during A.C. Coloring of anodized aluminum. Part I: Heterocyclic organic compounds, Computed Properties of 636-73-7, the publication is Plating and Surface Finishing (1994), 81(1), 60-4, database is CAplus.

Nicotinic acid, piperidine-4-carboxylic acid, imidazole, 2-picolinic acid, 3-pyridinesulfonic acid, piperazine and piperidine were used as additives in electrolytic coloring of anodized aluminum from tin(II) solutions Their influence on the throwing power and their resistance to atm. oxidation were studied.

Plating and Surface Finishing published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yuasa, Makoto published the artcileSynergistic effect of organic additives and pulse-current plating in gold electrodeposition from a citric acid bath and corrosion resistance of the gold electroplate film. Relationship between structures of additives and corrosion resistance of the film, Computed Properties of 636-73-7, the publication is Hyomen Gijutsu (1995), 46(12), 1150-6, database is CAplus.

The synergistic effect of organic additives and pulse-current plating in gold electrodeposition from a citric acid bath was investigated. Then the corrosion resistance of the gold plated film was evaluated by physicochem. methods. By the synergistic effect, the bath containing 2,3-diaminopyridine (23 DAmPy) produced both lower film porosity and higher gold deposition efficiency. These properties are due to the moderate phys. adsorption of 23-DAmPy, whose structure is susceptible to cation, under pulse-current plating. In any event, the synergistic effect appears in pulse-current plating in the bath containing organic additive.

Hyomen Gijutsu published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H8N2O, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yuasa, Makoto published the artcileSynergistic effect of organic additives and pulse-current plating in a gold electrodeposition acid bath and gold plating film corrosion resistance, Product Details of C5H5NO3S, the publication is Hyomen Gijutsu (1994), 45(8), 842-3, database is CAplus.

Effects of addition of pyridine derivatives such as aminopyridines and pyridinesulfonic acids into a citric acid-base Au electrodeposition solution were discussed. Using both pyridine additives and pulse current effectively lowered porosity and increased deposition efficiency compared to using only d.c. or pulse current and both d.c. and pyridine additives.

Hyomen Gijutsu published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C15H20N2O2, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem