Tag: M.W=150-200

Recommanded Product: 614-18-6. Yu, HY; Xie, T; Qian, XH; Ai, LZ; Chen, C; Tian, HX in [Yu, Haiyan; Xie, Tong; Qian, Xinhua; Chen, Chen; Tian, Huaixiang] Shanghai Inst Technol, Dept Food Sci & Technol, Shanghai, Peoples R China; [Ai, Lianzhong] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai, Peoples R China published Characterization of the volatile profile of Chinese rice wine by comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry in 2019, Cited 35. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

BACKGROUND Chinese rice wine (CRW) is a kind of traditional fermentation wine in China. Aged CRW is more popular among consumers owing to its harmonious and pleasant flavor. The volatile profile of CRW has been extensively studied using gas chromatography/mass spectrometry (GC/MS). However, flavor components in CRW are far richer than those detected by GC/MS. To obtain more information about the volatile profile of fresh (5-year) and aged (10-year) CRW, a method based on comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry (GCxGC/qMS) was developed. The major volatile compounds contributing to the characteristic aroma of fresh and aged CRW were identified by surrogate odor activity value (OAV). RESULTS Ninety-eight volatile compounds were detected in the 5-year CRW samples and 107 in the 10-year samples by GCxGC/qMS. The numbers of compounds detected by GCxGC/qMS for the 5-year and 10-year samples were 71.4 and 65.4% higher than those detected by GC/MS. The aged wine had a more complex volatile profile than the fresh wine, with an increase in esters and aldehydes and a decrease in alcohols and organic acids. There were 22 volatile compounds with surrogate OAV > 1. Nine were the potent key aroma compounds in CRW: ethyl isovalerate (OAV 500-33 500), ethyl butyrate (OAV 84-334), ethyl isobutyrate (OAV 49-170), 2-nonenal (OAV 20-100), ethyl heptanoate (OAV 1-74), ethyl hexanoate (OAV 60-77), phenylethyl alcohol (OAV 2-18), benzaldehyde (OAV 28-30) and hexanal (OAV 4-11). CONCLUSION GCxGC/qMS showed better separation than GC/MS. The presented GCxGC/qMS method was suitable for characterization of the volatile profile of CRW. (c) 2019 Society of Chemical Industry

Recommanded Product: 614-18-6. Bye, fridends, I hope you can learn more about C8H9NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents WOS:000541253800008 published article about EPITHELIAL-MESENCHYMAL TRANSITION; PYRIDOXAL ISONICOTINOYL HYDRAZONE; POTENT IRON CHELATORS; ANTIPROLIFERATIVE ACTIVITY; BIOLOGICAL EVALUATION; CELL-DEATH; IN-VITRO; COMPLEXES; DERIVATIVES; CARCINOMA in [Zhang, Xin-Hui; Bo-Wang; Tao, Yuan-Yuan; Ma, Qin; Wang, Hao-Jie; He, Zhang-Xu; Wu, Hui-Pan; Li, Yi-Han; Zhao, Bing; Ma, Li-Ying; Liu, Hong-Min] Zhengzhou Univ, Collaborat Innovat Ctr New Drug Res & Safety Eval, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol,Minist Educ,Key, Zhengzhou 450001, Henan, Peoples R China in 2020.0, Cited 46.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Safety of Phenyl(pyridin-2-yl)methanone

In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound 5d displayed significant advantages in inhibition effect with an IC50 value of 0.031 mu M, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved respectively). Besides, compound 5d showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound 5d could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, 5d could evidently suppress the cell migration and invasion by blocking the EMT (epithelial-mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer. (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 91-02-1, If you have any questions, you can contact Zhang, XH; Wang, B; Tao, YY; Ma, Q; Wang, HJ; He, ZX; Wu, HP; Li, YH; Zhao, B; Ma, LY; Liu, HM or send Email.. Safety of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Authors Mangalam, NA; Kurup, MRP; Suresh, E; Kaya, S; Serdaro, G in ELSEVIER published article about in [Mangalam, Neema Ani; Kurup, M. R. Prathapachandra] Cochin Univ Sci & Technol, Dept Appl Chem, Kochi 682022, Kerala, India; [Mangalam, Neema Ani] Mar Thoma Coll, Dept Chem, Tiruvalla 689103, Kerala, India; [Kurup, M. R. Prathapachandra] Cent Univ Kerala, Sch Phys Sci, Dept Chem, Tejaswini Hills, Kasaragod 671320, Kerala, India; [Suresh, Eringathodi] Cent Salt & Marine Chem Res Inst, Analyt Sci Discipline, Bhavnagar 364002, Gujarat, India; [Kaya, Savas] Sivas Cumhuriyet Univ, Hlth Serv Vocat Sch, Dept Pharm, TR-58140 Sivas, Turkey; [Serdaro, Goncagul] Sivas Cumhuriyet Univ, Math & Sci Edu, TR-58140 Sivas, Turkey in 2021.0, Cited 53.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Five cobalt complexes synthesized from two aroylhydrazones were characterized by elemental analyses, thermogravimetric analysis, molar conductivity, magnetic susceptibility measurements, IR and electronic spectra. Single crystal X-ray structure of one of the complex is also reported and it got crystallized in triclinic space group P (1) over bar and the crystal structure shows a distorted octahedral geometry around the metal center. Spectral data reveal that both the aroylhydrazones are tridentate and coordinate through the azomethine nitrogen, hydrazonic oxygen, and pyridyl nitrogen. Magnetic susceptibility measurements confirm the paramagnetic nature of the Co(II) complexes and one of the complex was found to be diamagnetic in nature. Additionally, HF/6-311G(d,p)/LANL2DZ calculations were performed to predict the possible intramolecular interactions contributing to the lowering of the stabilization energy. Accordingly, pi -> pi* transitions were found to be responsible for the stabilization energy for the ligands and their cobalt complexes. To describe and discuss the chemical reactivity and stability of synthesized complexes, quantum chemical parameters like frontier orbital energies, hardness, softness, energy gap, electronegativity, chemical potential, electrophilicity, polarizability and dipole moment were calculated. Also, the main electronic structure principles such as maximum hardness, minimum polarizability, and minimum electrophilicity principles were considered to evaluate the stability of the complexes. (C) 2021 Elsevier B.V. All rights reserved.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Ethyl nicotinate. I found the field of Chemistry very interesting. Saw the article Isoenthalpy Catalytic Effects of Pyridines in Reactions of Phenyloxyrane with N-Aroylbenzenesulfonamides published in 2019, Reprint Addresses Shpanko, IV (corresponding author), V Stus Donetsk Natl Univ, UA-21021 Vinnitsa, Ukraine.. The CAS is 614-18-6. Through research, I have a further understanding and discovery of Ethyl nicotinate.

Additive nature of the combined effect of the structure (X, Y substituents) and temperature on the rate and free activation energy has been established for the reactions of phenyloxirane with Y-substituted N-aroylbenzenesulfonamides catalyzed by X-substituted pyridines. The cross reaction series is isoenthalpic with respect to the structural effects. The mechanism of the catalytic process has been discussed.

Welcome to talk about 614-18-6, If you have any questions, you can contact Shpanko, IV; Sadovaya, IV or send Email.. Quality Control of Ethyl nicotinate

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 91-02-1. In 2021.0 CHEM PAP published article about ACTIVE ALPHA-PHENYLPYRIDYLMETHANOLS; ALCOHOL-DEHYDROGENASE; CARBONYL REDUCTASE; ARYL HETEROARYL; HYDROGENATION; LIGANDS; HYDROSILYLATION; BIOCATALYST; DERIVATIVES; COMPLEXES in [Baydas, Yasemin] Bayburt Univ, Dept Food Engn, Fac Engn, TR-6900 Bayburt, Turkey; [Kalay, Erbay] Kafkas Univ, Kars Vocat Sch, TR-36100 Kars, Turkey; [Sahin, Engin] Bayburt Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-69000 Bayburt, Turkey in 2021.0, Cited 67.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Chiral heterocyclic secondary alcohols have received much attention due to their widespread use in pharmaceutical intermediates. In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asymmetric reduction of prochiral ketones to chiral secondary alcohols. Secondary chiral carbinols were obtained by asymmetric bioreduction of different prochiral substrates with results up to>99% enantiomeric excess (ee). (R)-1-(benzofuran-2-yl)ethanol 5a, which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective beta-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of (R)-5a in enantiomerically pure form was obtained in 96% yield. Also, production of (R)-5a in terms of yield and gram scale through catalytic asymmetric reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcohols compared to chemical processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis.

Welcome to talk about 91-02-1, If you have any questions, you can contact Baydas, Y; Kalay, E; Sahin, E or send Email.. Product Details of 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Wu, K; Yang, ZJ; Meng, XG; Chen, R; Huang, JK; Shao, L in [Wu, Kai; Yang, Zhijun; Meng, Xiangguo; Chen, Rong; Huang, Jiankun] Shanghai Univ Med & Hlth Sci, Sch Pharm, 279 Zhouzhu Highway,Pudong New Area, Shanghai 201318, Peoples R China; [Wu, Kai; Yang, Zhijun; Meng, Xiangguo; Shao, Lei] Shanghai Univ Med & Hlth Sci, Microbial Pharmacol Lab, 279 Zhouzhu Highway,Pudong New Area, Shanghai 201318, Peoples R China; [Shao, Lei] Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, 285 Gebaini Rd, Shanghai 200040, Peoples R China published Engineering an alcohol dehydrogenase with enhanced activity and stereoselectivity toward diaryl ketones: reduction of steric hindrance and change of the stereocontrol element in 2020.0, Cited 44.0. Application In Synthesis of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Steric hindrance in the binding pocket of an alcohol dehydrogenase (ADH) has a great impact on its activity and stereoselectivity simultaneously. Due to the subtle structural difference between two bulky phenyl substituents, the asymmetric synthesis of diaryl alcohols by bioreduction of diaryl ketones is often hindered by the low activity and stereoselectivity of ADHs. To engineer an ADH with practical properties and to investigate the molecular mechanism behind the asymmetric biocatalysis of diaryl ketones, we engineered an ADH from Lactobacillus kefiri (LkADH) to asymmetrically catalyse the reduction of 4-chlorodiphenylketones (CPPK), which are not catalysed by the wild type (WT) enzyme. Mutants seq1-seq5 with gradually increased activity and stereoselectivity were obtained through iterative shrinking mutagenesis. The final mutant seq5 (Y190P/I144V/L199V/E145C/M206F) demonstrated the highest activity and excellent stereoselectivity of >99% ee. Molecular simulation analyses revealed that mutations may enhance the activity by eliminating steric hindrance, inducing a more open binding loop and constructing more noncovalent interactions. The pro-R pose of CPPK with a halogen bond formed a pre-reaction conformation more easily than the pro-S pose, resulting in the high ee of (R)-CPPO in seq5. Moreover, different halogen bonds formed due to the different positions of chlorine substituents, resulting in opposite substrate binding orientation and stereoselectivity. Therefore, the stereoselectivity of seq5 was inverted toward ortho- rather than para-chlorine substituted ketones. These results indicate that the stereocontrol element of LkADH was changed to recognise diaryl ketones after steric hindrance was eliminated. This study provides novel insights into the role of steric hindrance and noncovalent bonds in the determination of the activity and stereoselectivity of enzymes, and presents an approach producing key intermediates of chiral drugs with practical potential.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Wu, K; Yang, ZJ; Meng, XG; Chen, R; Huang, JK; Shao, L or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article External modulation of Rotimer exudate secretion in monogonant rotifers WOS:000670078900003 published article about IONS; ALGINATE in [Evelin, Balazs; Galik-Olah, Zita; Datki, Zsolt] Univ Szeged, Fac Med, Dept Psychiat, Vasas Szent Peter U 1-3, H-6724 Szeged, Hungary; [Galik, Bence] Univ Pecs, Szentagothai Res Ctr, Bioinformat & Sequencing Core Facil, Bioinformat Res Grp, Ifjusag U 20, H-7624 Pecs, Hungary; [Galik, Bence] Med Univ Bialystok, Dept Clin Mol Biol, Ul Jana Kilinskiego 1, PL-15089 Bialystok, Poland; [Somogyvari, Ferenc] Univ Szeged, Fac Med, Dept Med Microbiol & Immunobiol, Dom Sq 10, H-6720 Szeged, Hungary in 2021, Cited 34. Recommanded Product: 614-18-6. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

The Rotimer, a rotifer-specific biopolymer, is an exogenic bioactive exudate secreted by different monogonant species (e.g. Euchlanis dilatata or Lecane bulla). The production of this viscoelastic biomolecule is induced by different micro-particles, thereby forming a special Rotimer-Inductor Conglomerate (RIC) in a web format. In this case, the water insoluble Carmine crystals, filtered to size (max. diameter was 50 mu m), functioned as an inductor. The RIC production is an adequate empirical indicator to follow up this filamentous biopolymer secretion experientially; moreover, this procedure is very sensitive to the environmental factors (temperature, pH, metals and possible natural pollutant agents). The above mentioned species show completely different reactions to these factors, except to the presence of calcium and to the modulating effects of different drugs. One of the novelties of this work is that the Rotimer secretion and consequently, the RIC-formation is a mutually obligatory and evolutionary calcium-dependent process in the concerned monogonants. This in vivo procedure needs calcium, both for the physiology of animals and for fiber formation, particularly in the latter case. The conglomerate covered area (%) and the detection of the longest filament (mm) of the given RIC were the generally and simultaneously applied methods in the current modulating experiments. Exploring the regulatory (e.g. calciumdependency) and stimulating (e.g. Lucidril effect) possibilities of biopolymer secretion are the basis for optimizing the RIC-production capacities of these micro-metazoans.

Recommanded Product: 614-18-6. Welcome to talk about 614-18-6, If you have any questions, you can contact Evelin, B; Galik-Olah, Z; Galik, B; Somogyvari, F; Kalman, J; Datki, Z or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C12H9NO. Weng, WZ; Guo, JS; Liu, KX; Shao, TQ; Song, LQ; Zhu, YP; Sun, YY; Meng, QG in [Weng, Wei-Zhao; Guo, Jiang-Shan; Liu, Kai-Xuan; Shao, Tian-Qi; Song, Li-Qun; Zhu, Yan-Ping; Sun, Yuan-Yuan; Meng, Qing-Guo] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Shandong, Peoples R China published Metal-free oxidative C(sp(3))-H functionalization: a facile route to quinoline formaldehydes from methyl-azaheteroarenes in 2020.0, Cited 67.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A facile protocol for the synthesis of quinoline formaldehydes via direct oxidative C-H bonds functionalization of methyl-azaheteroarenes in the presence of I-2-DMSO has been described. This method is metal-free and easy to operate. This reaction provided a convenient route for the preparation of a range of important quinoline formaldehydes.

Computed Properties of C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Diastereoselection and induced chirality at-metal in distorted-tetrahedralbis[(RorS)-1-(p-R-1-C6H4)-N-(phenyl(pyridin-2-yl)methylene)ethanamino-kappa N-2,N]-Delta/?-copper(PF6)(2) WOS:000551325700001 published article about TETRAHEDRAL ZINC(II) COMPLEXES; SCHIFF-BASE LIGANDS; CIRCULAR-DICHROISM; CRYSTAL-STRUCTURE; X-RAY; ELECTRONIC-PROPERTIES; COPPER(II) COMPLEXES; CYCLIC VOLTAMMETRY; HELICITY INVERSION; THERMAL ANALYSES in [Enamullah, Mohammed; Hossain, Mohammad Anwar; Bindu, Mortuza Mamun; Islam, Mohammad Khairul; Zaman, Mohammad Al-Moktadir] Jahangirnagar Univ, Dept Chem, Dhaka, Bangladesh in 2020.0, Cited 41.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Computed Properties of C12H9NO

The enantiopure Schiff bases (RorS)-1-(p-R-1-C6H4)-N-(phenyl(pyridin-2-yl)methylene)ethanamine (R-1= H and OCH3) are synthesized from reaction between the 2-benzoyl-pyridine andchiral-amine (RorS)-1-(p-R-1-C6H4)ethylamine, respectively. These Schiff bases react with the copper(II) acetate to give distorted-tetrahedralbis[(RorS)-1-(p-R-1-C6H4)-N-(phenyl(pyridin-2-yl)methylene)ethanamino-kappa N-2,N]-Delta/?-Cu(PF6)(2)in the presence of NH4PF6. A conformational change fromcis- totrans-isomer occurs in solution and thereby, the copper(II) coordinates to the solelytrans-form to provide the complexes. Cyclic voltammograms demonstrate two quasi-reversible one electron charge transfer processes for the Cu2+/Cu(+)and Cu+/Cu(0)couples in acetonitrile. ECD spectra reveal expected mirror-image relationships and indicate enantiopurity or enantiomeric excess of theRorS-ligands and their associated complexes in solution. Comparisons of experimental and simulated ECD spectra suggest induced chirality at-metal center, which diastereoselectively provides the Delta-Cu-Ror ?-Cu-Sdiastereomer as major product in solution. DFT/TDDFT optimized structures and excited state properties correspond well to the experimental results.

Computed Properties of C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Visible-light-driven photochemical activity of ternary Ag/AgBr/TiO(2)nanotubes for oxidation C(sp(3))-H and C(sp(2))-H bonds WOS:000579576200011 published article about AG-AT-AGCL; HIGHLY EFFICIENT; SELECTIVE OXIDATION; PHOTOCATALYTIC ACTIVITY; BENZYL ALCOHOL; AEROBIC OXIDATION; ESCHERICHIA-COLI; STYRENE; EPOXIDATION; DEGRADATION in [Hosseini-Sarvari, Mona; Dehghani, Abdulhamid] Shiraz Univ, Dept Chem, Shiraz 7194684795, Iran in 2020.0, Cited 79.0. SDS of cas: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

The Ag/AgBr/TiO2 ternary component nanotube as a heterogeneous photocatalyst was used for the solvent-free oxidation of the benzylic C(sp(3))-H bond to the corresponding carbonyl compound or the solvent-controlled selective oxidative cleavage of the CQC double bond of styrene to benzaldehyde under visible light at room temperature. A wide variety of carbonyl compounds were successfully synthesized through the developed photocatalytic process. Several advantages such as solvent-free conditions, sans additional oxidant, simple reaction, short reaction time, and easy separation of the product promote the reaction to be green. Moreover, the Ag/AgBr/TiO2 nanotubes could be used several times without reduction in their photocatalytic activity.

SDS of cas: 91-02-1. Welcome to talk about 91-02-1, If you have any questions, you can contact Hosseini-Sarvari, M; Dehghani, A or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem