Tag: M.W=150-200

Ju, Zhao-Yang published the artcileSelective Aerobic Oxidation of C_sp³-H Bonds Catalyzed by Yeast-Derived Nitrogen, Phosphorus, and Oxygen Codoped Carbon Materials, COA of Formula: C12H9NO, the publication is Journal of Organic Chemistry (2022), 87(6), 3978-3988, database is CAplus and MEDLINE.

Nitrogen, phosphorus and oxygen codoped carbon catalysts were successfully synthesized using dried yeast powder as pyrolysis precursor. The yeast-derived heteroatom-doped carbon (yeast@C) catalysts exhibited outstanding performance in the oxidation of C_sp3-H bonds to ketones and esters giving excellent products yields (up to 98% yield) without organic solvents at low O₂ pressure (0.1 MPa). The catalytic oxidation protocol exhibited broad range of substrates (38 examples) with good functional group tolerance, excellent regioselectivity and synthetic utility. The yeast-derived heteroatom-doped carbon catalysts showed good reusability and stability after recycle six times without any significant loss of activity. Exptl. results and DFT calculations proved the important role of N-oxide (N⁺-O^–) on the surface of yeast@C and a reasonable carbon radical mechanism.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jun published the artcileSelective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate, Application In Synthesis of 39856-58-1, the publication is Organic Letters (2021), 23(21), 8396-8401, database is CAplus and MEDLINE.

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C8H11NO, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jun published the artcileConstruction and regulation of imidazo[1,5-a]pyridines with AIE characteristics via iodine mediated Csp²-H or Csp-H amination, Related Products of pyridine-derivatives, the publication is Chinese Chemical Letters (2021), 32(10), 3083-3086, database is CAplus.

The widespread applications of aggregation-induced emission luminogens (AIEgens) inspire the creation of AIEgens with novel structures and functionalities. In this work, we focused on the direct and efficient synthesis of a new type of AIEgens, imidazo[1,5-a]pyridine derivatives, via iodine mediated cascade oxidative Csp²-H or Csp-H amination route from phenylacetylene or styrenes under mild conditions. The resulted compounds showed excellent AIE characteristics with tunable maximum emissions, attractive bioimaging performance, and potential anti-inflammatory activity, which exert broad application prospects in material, biol., medicine, and other relevant areas.

Chinese Chemical Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C10H10O6, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hajjami, Maryam published the artcileSynthesis and Characterization of Magnetic Functionalized Ni and Cu Nano Catalysts and Their Application in Oxidation, Oxidative Coupling and Various Multi-Component Reactions, Quality Control of 91-02-1, the publication is Catalysis Letters (2021), 151(8), 2420-2435, database is CAplus.

Two magnetic nano catalysts of nickel and copper, Fe₃O₄@SiO₂@DOP-BenPyr-M(II), (M=Ni and Cu) have been synthesized. These catalysts were applied as recoverable, efficient and new heterogeneous catalysts for the high yielding and room temperature one-pot procedure of selective oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides. In addition, the catalytic activity of Fe₃O₄@SiO₂@DOP-BenPyr-Ni(II) was investigated as heterogeneous nanocatalyst for synthesis of 2,3-dihydroquinazolin-4(1H)-ones, 5-substituted 1H-tetrazoles and polyhydroquinolines. The synthesized catalysts were characterized by FT-IR, TGA, XRD, VSM, EDX, ICP and SEM techniques. These catalysts were recovered by an external magnet and reused several times without significant loss of catalytic efficiency.

Catalysis Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gong, Xinchi published the artcileHeterogeneous copper-catalyzed synthesis of diaryl sulfones, Category: pyridine-derivatives, the publication is Organic & Biomolecular Chemistry (2021), 19(48), 10662-10668, database is CAplus and MEDLINE.

A carbon-supported copper nanoparticle with high catalytic activity for the synthesis of diaryl sulfones is reported. For the first time, this Cu-NP is proved to be able to effectively promote the reaction of arylboronic acids and arylsulfonyl hydrazides to generate diaryl sulfones at room temperature The reaction shows excellent substrate universality, and substrates with different substituents can undergo the reaction smoothly, leading to the desired products in good yields. The Cu-NP is found to be made of low valence Cu based on XRD. Hence, the reaction catalyzed by the Cu-NP is believed to involve a Cu-mediated organometallic cycle.

Organic & Biomolecular Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Deng, Tianning published the artcileI(III)-Catalyzed Oxidative Cyclization-Migration Tandem Reactions of Unactivated Anilines, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Organic Letters (2020), 22(22), 9102-9106, database is CAplus and MEDLINE.

An I(III)-catalyzed oxidative cyclization-migration tandem reaction using Selectfluor as the oxidant was developed that converts unactivated anilines into 3H-indoles is reported herein. The reaction requires as little as 1 mol % of the iodocatalyst and is mild, tolerating pyridine and thiophene functional groups, and the dependence of the diastereoselectivity of the process on the identity of the iodoarene or iodoalkane precatalyst suggests that the catalyst is present for the stereochem. determining C-N bond forming step.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Feng V. published the artcileParallel synthesis of N-biaryl quinolone carboxylic acids as selective M₁ positive allosteric modulators, Product Details of C6H9BN2O2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(2), 531-536, database is CAplus and MEDLINE.

An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M₁ pos. allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

Bioorganic & Medicinal Chemistry Letters published new progress about 774170-15-9. 774170-15-9 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amine,Boronic Acids, name is (6-(Methylamino)pyridin-3-yl)boronic acid, and the molecular formula is C38H24F4O4P2, Product Details of C6H9BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tominaga, Yoshinori published the artcileSynthesis of 2-methylthioindolizine-3-carbonitriles using nitroketene dithioacetal, Product Details of C7H7ClN2, the publication is Journal of Heterocyclic Chemistry (1988), 25(6), 1745-9, database is CAplus.

The reaction of 1-cyanomethylpyridinium chloride or bromide, with 1,1-bis(methylthio)-2-nitroethylene in the presence of Et₃N in ethanol gave the corresponding 2-methylthioindolizine-3-carbonitrile I (R = H, Ph; R¹ = H, Me, Et; R² = H, Et, Ph, CH₂Ph; R³ = H, Me, Et) and 2-methylthio-1-nitroindolizine-3-carbonitrile in good yields, resp. Compounds I (R-R³ = H; R = R² = H, R¹ = R³ = Me) were key intermediates for the synthesis of cycl[3,2,2]azine derivatives

Journal of Heterocyclic Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C11H16BNO3, Product Details of C7H7ClN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ouyang, Yifan published the artcileDiscovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor, Application In Synthesis of 612845-44-0, the publication is Journal of Medicinal Chemistry (2022), 65(11), 7833-7842, database is CAplus and MEDLINE.

RIOK2 is an atypical kinase implicated in multiple human cancers. Although recent studies establish the role of RIOK2 in ribosome maturation and cell cycle progression, its biol. functions remain poorly elucidated, hindering the potential to explore RIOK2 as a therapeutic target. Here, we report the discovery of CQ211 (I), the most potent and selective RIOK2 inhibitor reported so far. CQ211 displays a high binding affinity (K_d = 6.1 nM) and shows excellent selectivity to RIOK2 in both enzymic and cellular studies. It also exhibits potent proliferation inhibition activity against multiple cancer cell lines and demonstrates promising in vivo efficacy in mouse xenograft models. The crystal structure of RIOK2-CQ211 sheds light on the mol. mechanism of inhibition and informs the subsequent optimization. The study provides a cell-active chem. probe for verifying RIOK2 functions, which may also serve as a leading mol. in the development of therapeutic RIOK2 inhibitors.

Journal of Medicinal Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Application In Synthesis of 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oebbeke, Matthias published the artcileFragment Binding to Kinase Hinge: If Charge Distribution and Local pK_a Shifts Mislead Popular Bioisosterism Concepts, Related Products of pyridine-derivatives, the publication is Angewandte Chemie, International Edition (2021), 60(1), 252-258, database is CAplus and MEDLINE.

Medicinal-chem. optimization follows strategies replacing functional groups and attaching larger substituents at a promising lead scaffold. Well-established bioisosterism rules are considered, however, it is difficult to estimate whether the introduced modifications really match the required properties at a binding site. The electron d. distribution and pK_a values are modulated influencing protonation states and bioavailability. Considering the adjacent H-bond donor/acceptor pattern of the hinge binding motif in a kinase, the authors studied by crystallog. a set of fragments to map the required interaction pattern. Unexpectedly, benzoic acid and benzamidine, decorated with the correct substituents, are totally bioisosteric just as carboxamide and phenolic OH. A mono-dentate pyridine nitrogen out-performs bi-dentate functionalities. The importance of correctly designing pK_a values of attached functional groups by addnl. substituents at the parent scaffold is rendered prominent.

Angewandte Chemie, International Edition published new progress about 90778-25-9. 90778-25-9 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Amine,Alcohol, name is 3-Amino-5-(trifluoromethyl)pyridin-2-ol, and the molecular formula is C6H5F3N2O, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem