Tag: M.W=150-200

I found the field of Chemistry very interesting. Saw the article Iridium-Catalyzed Enantioselective Transfer Hydrogenation of Ketones Controlled by Alcohol Hydrogen-Bonding and sp(3)-C-H Noncovalent Interactions published in 2020.0. Safety of Phenyl(pyridin-2-yl)methanone, Reprint Addresses Sawamura, M (corresponding author), Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 0600810, Japan.; Sawamura, M (corresponding author), Hokkaido Univ, Inst Chem React Design & Discovery WPI ICReDD, Sapporo, Hokkaido 0010021, Japan.; Mori, S (corresponding author), Ibaraki Univ, Inst Quantum Beam Sci, Mito, Ibaraki 3108512, Japan.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Iridium-catalyzed enantioselective transfer hydrogenation of ketones with formic acid was developed using a prolinol-phosphine chiral ligand. Cooperative action of the iridium atom and the ligand through alcohol-alkoxide interconversion is crucial to facilitate the transfer hydrogenation. Various ketones including alkyl aryl ketones, ketoesters, and an aryl heteroaryl ketone were competent substrates. An attractive feature of this catalysis is efficient discrimination between the alkyl and aryl substituents of the ketones, promoting hydrogenation with the identical sense of enantioselection regardless of steric demand of the alkyl substituent and thus resulting in a rare case of highly enantioselective transfer hydrogenation of tert-alkyl aryl ketones. Quantum chemical calculations revealed that the sp(3)-C-H/pi interaction between an sp(3)-C-H bond of the prolinol-phosphine ligand and the aryl substituent of the ketone is crucial for the enantioselection in combination with O-H center dot center dot center dot O/sp(3)-C-H center dot center dot center dot O two-point hydrogen-bonding between the chiral ligand and carbonyl group.

Safety of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Ethyl nicotinate. Authors Du, JY; Li, YM; Xu, JC; Huang, MQ; Wang, J; Chao, JF; Wu, JH; Sun, HB; Ding, HM; Ye, H in ELSEVIER SCI LTD published article about in [Du, Jingyi; Huang, Mingquan; Wang, Juan; Wu, Jihong; Ye, Hong] Beijing Technol & Business Univ BTBU, China Light Ind, Key Lab Brewing Mol Engn, Beijing 100048, Peoples R China; [Li, Yueming; Xu, Jianchun; Chao, Jinfu; Sun, Huibin; Ding, Haimei] Qingdao Langyatai Grp Ltd, Qingdao 266500, Peoples R China in 2021, Cited 44. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

A study was carried out to determine systematically the key aroma-active compounds of Langyatai Baijiu with Jian flavour (LBJF) using sensory omics analysis (SOA). A total of 56 odorants were screened out using gas chromatography-olfactometry-mass spectrometry (GC-O-MS)/Osme analysis. Among them, 15 aroma-active components were first identified. After quantitation, 30 odorants had odour activity values (OAVs) > 1.0 in LBJF. Recombinant and omission experiments proved that the esters, alcohols, acids, especially ethyl hexanoate, gamma psi psi-nonalactone, and dimethyl trisulfide, were critical to the flavour of LBJF. The basic and commercial liquors had obvious differences in the skeleton compositions of esters and acids. This study uncovers the characteristics of Jian flavour Baijiu (JFB) and provides a scientific basis for the quality control of JFB, which is helpful for the development of Chinese Baijiu flavour styles.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 91-02-1. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Discovery of thiosemicarbazone-containing compounds with potent anti- proliferation activity against drug-resistant K562/A02 cells published in 2020.0, Reprint Addresses Gu, XK; Qiu, JY (corresponding author), Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Welcome to talk about 91-02-1, If you have any questions, you can contact Gu, XK; Li, X; Guan, MY; Jiang, CY; Song, QH; Sun, N; Zou, YT; Zhou, QQ; Chen, J; Qiu, JY or send Email.. SDS of cas: 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. I found the field of Chemistry very interesting. Saw the article Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O published in 2020.0, Reprint Addresses Bao, HL (corresponding author), Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem,Key Lab Coal Ethylene G, Fuzhou 350002, Peoples R China.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

alpha-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords alpha-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.

Welcome to talk about 91-02-1, If you have any questions, you can contact Zhu, NB; Su, M; Wan, WM; Li, YJ; Bao, HL or send Email.. COA of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY, Saw an article supported by the Ministry of Higher Education (MOHE), Malaysia via Fundamental Research Grant Scheme (FRGS) [FRGS/1/2014/ST01/MUSM/03/1]; School of Science, Monash University Malaysia. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Choo, KB; Lee, SM; Lee, WL; Cheow, YL. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Quality Control of Phenyl(pyridin-2-yl)methanone

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

Quality Control of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: Ethyl nicotinate. In 2021 NAT CHEM published article about SELECTIVE DEHYDROGENATIVE SILYLATION; HYDROSILYLATION REACTIONS; ATOM-TRANSFER; REACTIVITY; CONVERSION; COMPLEXES; MECHANISM; OLEFINS; BONDS; SCOPE in [Dong, Jie; Yan, Zhongfei; Ma, Junyang; Zhu, Chengjian; Xie, Jin] Nanjing Univ, Jiangsu Key Lab Adv Organ Mat Chem & Biomed, State Key Lab Coordinat Chem, Innovat Ctr ChemBIC,Sch Chem & Chem Engn, Nanjing, Peoples R China; [Yuan, Xiang-Ai; Mu, Liying] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu, Shandong, Peoples R China; [Yan, Zhongfei] Anyang Normal Univ, Coll Chem & Chem Engn, Anyang, Peoples R China; [Zhu, Chengjian] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou, Peoples R China in 2021, Cited 55. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

Transition-metal-catalysed, redox-neutral dehydrosilylation of alkenes is a long-standing challenge in organic synthesis, with current methods suffering from low selectivity and narrow scope. In this study, we report a general and simple method for the manganese-catalysed dehydrosilylation and hydrosilylation of alkenes, with Mn-2(CO)(10) as a catalyst precursor, by using a ligand-tuned metalloradical reactivity strategy. This enables versatility and controllable selectivity with a 1:1 ratio of alkenes and silanes, and the synthetic robustness and practicality of this method are demonstrated using complex alkenes and light olefins. The selectivity of the reaction has been studied using density functional theory calculations, showing the use of an (PrPNP)-Pr-i ligand to favour dehydrosilylation, while a JackiePhos ligand favours hydrosilylation. The reaction is redox-neutral and atom-economical, exhibits a broad substrate scope and excellent functional group tolerance, and is suitable for various synthetic applications on a gram scale.

Welcome to talk about 614-18-6, If you have any questions, you can contact Dong, J; Yuan, XA; Yan, ZF; Mu, LY; Ma, JY; Zhu, CJ; Xie, J or send Email.. Recommanded Product: Ethyl nicotinate

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Metal-free photocatalysts for the oxidation of non-activated alcohols and the oxygenation of tertiary amines performed in air or oxygen WOS:000513109400004 published article about SELECTIVE OXIDATION; ALPHA-OXYGENATION; FREE CATALYST; AMIDES in [Zhang, Yu; Schilling, Waldemar; Riemer, Daniel; Das, Shoubhik] Georg August Univ Gottingen, Inst Organ & Biomol Chem, Gottingen, Germany in 2020, Cited 25. Product Details of 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

This protocol describes the use of 9-fluorenone as a cheap and non-toxic photocatalyst for the oxidation of non-activated alcohols performed under the irradiation of a blue light-emitting diode. It also describes the use of the similarly cheap and non-toxic photocatalyst rose bengal for the selective alpha-oxygenation of tertiary amines to produce the corresponding amides in a selective way using the same light source. We have provided detailed instructions on how to assemble the light-emitting diode equipment and set up the photocatalytic reaction, where an oxygen atmosphere is created with an O-2-filled balloon. Further details are provided using four example reactions that illustrate how this system works: alcohol oxidation to prepare terephthlalaldehyde and androstanedione, and amine oxidation to make 2-phenyl-3,4-dihydroisoquinolin-1(2H)-one and (4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)m-tolyl)methanone. The times needed to perform these photocatalytic reactions are 18, 76, 22 and 54 h, respectively. We believe that this protocol represents a robust methodology for the late-stage modification of amines and the selective oxidation of steroids. Cheap and non-toxic photocatalysts 9-fluorenone or rose bengal are used to oxidize non-activated alcohols or oxygenate tertiary amines, respectively, under irradiation from a blue light-emitting diode.

Product Details of 91-02-1. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Liang, L; Li, WQ; Zheng, JR; Li, RX; Chen, HY; Yuan, ZW in ROYAL SOC CHEMISTRY published article about SULFANE SULFURS; SULFIDE; H2S; MITOCHONDRIA; METABOLISM; EMISSION in [Liang, Li; Li, Weiqing; Zheng, Jinrong; Li, Ruixi; Chen, Haiyan; Yuan, Zhenwei] China Pharmaceut Univ, Sch Engn, Dept Biomed Engn, 24 Tongjia Lane, Nanjing 210009, Peoples R China in 2020.0, Cited 36.0. HPLC of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Hydrogen polysulfides (H2Sn, n > 1) belong to sulfane sulfur in the reactive sulfur species (RSS) family and play significant roles in maintaining biological homeostasis in organisms. The detection of H2Sn in living systems is essential, but further understanding of its intact function in living cells has been limited, owing to the lack of appropriate analytical tools. In this work, a new fluorescent probe PP-PS was designed for the detection of endogenous H2Sn. The probe has a large Stokes shift (178 nm), low detection limit (1 nM), and short response time (1 minute). Besides, PP-PS was successfully applied in the imaging of endogenous H2Sn in lysosomes of living cancer cells, xenograft mouse tumor tissues, and LPS-induced mouse inflammation tissues. These results revealed that the probe PP-PS could act as a new fluorescence imaging tool to study the function of intracellular hydropolysulfides.

HPLC of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation WOS:000510109900013 published article about RUTHENIUM(II) ARENE COMPLEXES; VITRO ANTICANCER ACTIVITY; IN-VITRO; RIBONUCLEOTIDE REDUCTASE; ZN(II) COMPLEXES; DNA CLEAVAGE; PHASE-II; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; SPECTRAL CHARACTERIZATION; CYTOTOXIC ACTIVITIES in [Saswati; Mohanty, Monalisa; Banerjee, Atanu; Biswal, Sonaleen; Dinda, Rupam] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India; [Horn, Adolfo, Jr.] Univ Estadual Norte Fluminense, Lab Ciencias Quim, Campos Dos Goytacaces, RJ, Brazil; [Schenk, Gerhard] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia; [Brzezinski, Krzysztof] Univ Bialystok, Inst Chem, Ciolkowskiego 1K, PL-15245 Bialystok, Poland; [Sinn, Ekkehard] Western Michigan Univ, Dept Chem, Kalamazoo, MI 49008 USA; [Reuter, Hans] Univ Osnabruck, Inst Chem New Mat, Barbarastr 6, D-49069 Osnabrucks, Germany in 2020.0, Cited 98.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Two new dimeric Zn(II) ([{ZnL1(DMSO2)}(2)]center dot DMSO (1), [{(ZnLCl)-Cl-2}(2)] (2)) and a novel tetrameric Zn(II) complex ([(Zn2L3)(2)(mu-OAc)(2)(mu(3)-O)(2)] (3)), where H2L1 = 4-(p-methoxyphenyl) thiosemicarbazone of o-hydroxynapthaldehyde, HL2 = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H2L3 = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal X-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10(12)M(-1)), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, circular dichroism and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10(3) to 10(4) M-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Saswati; Mohanty, M; Banerjee, A; Biswal, S; Horn, A; Schenk, G; Brzezinski, K; Sinn, E; Reuter, H; Dinda, R or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Solvent-free microwave-assisted synthesis of imidazo[1,5-a]pyridine and -quinoline derivatives WOS:000481164400001 published article about RATIOMETRIC FLUORESCENT-PROBE; COMPLEXES; EFFICIENT; LIGHT; TRANSANNULATION; ALDEHYDES; EMISSION; LIGANDS; IMIDAZO; SHIFT in [Herr, Jasmin Martha; Roessiger, Carina; Goettlich, Richard] Justus Liebig Univ Giessen, Inst Organ Chem, Heinrich Buff Ring 17, D-35392 Giessen, Germany; [Herr, Jasmin Martha; Roessiger, Carina; Albrecht, Georg; Goettlich, Richard] Justus Liebig Univ Giessen, Ctr Mat Res LaMa, Giessen, Germany; [Albrecht, Georg] Justus Liebig Univ Giessen, Inst Appl Phys, Giessen, Germany; [Yanagi, Hisao] NAIST, Dept Mat Sci, Nara, Japan in 2019.0, Cited 39.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A quick and highly efficient microwave-assisted preparation of imidazopyridines and -quinolines is described, starting from the corresponding ketones and amines. The method requires no solvent and uses activated MnO2 as an oxidant. A mechanism for the cyclization is proposed and discussed.

Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem