Tag: M.W=150-200

Schmuelling, M. published the artcileSteric and electronic tuning of the lability of square planar d⁸ metal complexes: platinum(II) â‰?palladium(II), Computed Properties of 636-73-7, the publication is Journal of the Chemical Society, Chemical Communications (1992), 1609-11, database is CAplus.

Electronic tuning of Pt^II complexes via cyclometalation, i.e. the introduction of a Pt-C bond trans to the leaving ligand, can increase their lability to that of related Pd^II complexes.

Journal of the Chemical Society, Chemical Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schmuelling, Michael published the artcileTo what extent can the Pt-C bond of a metallacycle labilize the trans position? A temperature- and pressure-dependent mechanistic study, Product Details of C5H5NO3S, the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) (1994), 1257-63, database is CAplus.

The orthoplatinated complexes [Pt{C₆H₃X(CH₂NMe₂)}(NC₅H₄SO₃-3)(H₂O)] (X = H 1a or 3-MeO 1b) were designed for mechanistic studies in H₂O. The aqua ligand is located trans to the Pt-C bond of the Ph group which lies in the Pt(II) coordination plane. The rates of substitution of the aqua ligand by nucleophiles (Nu) (Cl^–, Br^–, I^–, N₃^–, SCN^–, thiourea, N,N’-dimethylthiourea or N,N,N’,N’-tetramethylthiourea) were studied as a function of concentration, pH, temperature, and pressure by using a stopped-flow technique. The pK_a value of the aqua ligand in 1a is 9.75 ± 0.505 and the observed pseudo-first-order rate constants for the substitution reaction are given by k_obs = k₁[Nu] + k_-1. The k_-1 term arises from the reverse solvolysis reaction and is insignificant for stronger, S-donor nucleophiles. The values of k₁ are âˆ? orders of magnitude higher than the corresponding rate constants for anation reactions of [Pt(dien)(H₂O)]²⁺ (dien = diethylenetriamine) and close to the rate constants for anation of [Pd(dien)(H₂O)]²⁺. The effect is largely due to a strong decrease in ΔH^{â§?/sup>, ΔSâ§?/sup> and ΔVâ§?/sup>, clearly shows that the substantial rate increase is not associated with a changeover in mechanism and that the substitution process is still associative.}

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999) published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pedroni, J. published the artcileEnantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system, Category: pyridine-derivatives, the publication is Chemical Science (2015), 6(9), 5164-5171, database is CAplus and MEDLINE.

Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C-H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range of synthetically attractive cyclopropyl containing dihydroquinolones and dihydroisoquinolones as well as allows for an efficient enantioselective construction of the 7-membered ring of the cyclopropyl indolobenzazepine core of BMS-791325.

Chemical Science published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sarkar, Nabin published the artcileAluminum-catalyzed selective hydroboration of carbonyls and dehydrocoupling of alcohols, phenols, amines, thiol, selenol, silanols with HBpin, Name: Phenyl(pyridin-2-yl)methanone, the publication is Polyhedron (2022), 115902, database is CAplus.

A popular N,N’-chelated NacNac analog, i.e., conjugated bis-guanidinate (CBG) stabilized aluminum dihydride LAlH₂ [1; L = ArNC(ArNH):NC:(NHAr)NAr, where Ar = 2,6-Et₂-C₆H₃], demonstrates excellent catalytic hydroboration of a wide array of carbonyls with pinacolborane (HBpin) under neat conditions with good tolerance of reducible functional groups such as alkyl, alkene, halide, nitrile, nitro, ester, amide, and heteroaryl. In addition, we investigated complex 1 catalyzed cross-dehydrocoupling (CDC) of alcs., phenols, amines, thiol, selenol, and silanols with HBpin under mild reaction conditions. Furthermore, several control experiments have been performed to understand the mechanisms in hydroboration and CDC reactions. All corresponding catalytic intermediates have been identified and characterized by ¹H and ¹³C{¹H} NMR spectroscopic methods. In contrast to several reports on metal-catalyzed hydroboration of carbonyls, this is the second report for the mol. aluminum catalyzed CDC of organic substrates with HBpin.

Polyhedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Munshi, Sadeka J. published the artcileMetal(II) chloride complexes containing a tridentate N-donor Schiff base ligand: syntheses, structures and antimicrobial activity, Synthetic Route of 91-02-1, the publication is Journal of Coordination Chemistry (2021), 74(12), 2004-2016, database is CAplus.

One new tridentate N-coordinate ligand, N’-phenyl-N”-(phenyl(pyridin-2-yl)methylene)ethane-1,2-diamine (L), were synthesized and characterized. The tridentate N₃-coordinate ligand L were used in the synthesis of a series of three mononuclear complexes [M(L)Cl₂] [M = Cu(II), Co(II), and Zn(II)] and one polynuclear Cd(II) complex [Cd(L)Cl₂]_n and these complexes were characterized by spectroscopic techniques. The structure of all the complexes has been solved by single-crystal X-ray diffraction studies and the data reveal that all mononuclear complexes have distorted square pyramidal geometry and the polynuclear Cd(II) complex has distorted octahedral geometry. The antimicrobial activity of all complexes was investigated against Gram-pos. (Bacillus subtilis, Staphylococcus aureus) and Gram-neg. (Escherichia coli, Proteus vulgaris) bacteria by disk diffusion method. The compounds demonstrated significant antimicrobial activity while [Cu(L)Cl₂] exhibited the best antibacterial activity among all the synthesized complexes.

Journal of Coordination Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Makida, Yusuke published the artcileAsymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes, COA of Formula: C5H5BrN2, the publication is Angewandte Chemie, International Edition (2016), 55(39), 11859-11862, database is CAplus and MEDLINE.

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η³-methallyl)₂(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Joseph, Jayan T. published the artcileAryl/heteroaryl pentafluorobenzenesulfonates (ArOPFBs): new electrophilic coupling partners for room temperature Suzuki-Miyaura cross-coupling reactions, HPLC of Formula: 1008506-24-8, the publication is Tetrahedron Letters (2015), 56(36), 5106-5111, database is CAplus.

The first Suzuki-Miyaura cross-coupling reaction between aryl pentafluorobenzenesulfonates e.g., I, and aryl boronic acids under mild conditions was described. High chemoselectivity of these bench stable aryl pentafluorobenzenesulfonates over tosylates, triflates, mesylates, and chlorides for the successful synthesis of highly ortho substituted biaryls was also discussed. Addnl., the generality of this protocol was further extended to other boron containing nucleophiles (boronates, trifluoroborates) and alkyl boronic acids. This process had several advantages which include use of mild catalyst, rapid reaction conditions, wide substrate scope, facile synthesis and high chemoselectivity with good yields.

Tetrahedron Letters published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, HPLC of Formula: 1008506-24-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Odashima, Tsugikatsu published the artcileSynthesis and properties of 3-, 4-, and 5-nitro-2-pyridinecarboxaldehyde 2-pyridylhydrazones and characterization of their metal complexes, Synthetic Route of 2215-33-0, the publication is Bulletin of the Chemical Society of Japan (1993), 66(3), 797-803, database is CAplus.

Three title hydrazones (I, R = 3-, 4-, and 5-NO₂), were synthesized. Their properties and reactivities with metal ions and the extraction and characteristics of the resultant complexes were investigated and compared with one another. As a result, useful information on the mol. design of highly sensitive hydrazone reagents was obtained.

Bulletin of the Chemical Society of Japan published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Synthetic Route of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileComplexation behavior of heterocyclic hydrazones. I. Structure and acid-base equilibria for heterocyclic hydrazones, Application In Synthesis of 2215-33-0, the publication is Bulletin of the Chemical Society of Japan (1993), 66(12), 3652-61, database is CAplus.

The acid-base equilibrium of twenty-one hydrazones substituted by Ph, pyridyl and/or quinolyl groups have been investigated in aqueous solutions over the region of H_– to H₀ acidity function by a spectrophotometric method at 25 °C. For 2-pyridinecarbaldehyde 2-(5-substituted)pyridylhydrazones, although the proton dissociation of the neutral species (HL) satisfied a Hammett correlation, those of H₂L⁺ and H₃L²⁺ did not. The thermodn. parameters for the proton dissociations of H₂L⁺ of seven representative ligands were determined by a temperature-coefficient method at 25 °C and an ionic strength of 0.1 (KCl). The enthalpy and entropy changes for the proton dissociations of H₃L²⁺ and H₂L⁺ were influenced by the steric effects of the Me group and/or the introduced quinolyl ring. An anal. of the pH dependence of the ¹H NMR signals for three hydrazones in an acetone-d₆-D₂O solution gave more profitable information concerning the fine structures of HL, H₂L⁺, and H₃L²⁺. Each ¹H and ¹³C NMR chem. shift of some ring-substituted Me derivatives (HL form) in a dioxane-D₂O solution has been briefly assigned. On the other hand, a single-crystal X-ray anal., ¹H NMR data in chloroform-d and thermodn. data for di-2-pyridyl ketone 2-pyridylhydrazone (DPPH) suggested that the intramol. hydrogen bond in the DPPH mol. is broken by the addition of a proton on the H₂L⁺ species in an aqueous solution

Bulletin of the Chemical Society of Japan published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C10H10O2, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Heinrich, Timo published the artcileDiscovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology, Application of 2-Bromopyridin-3-amine, the publication is Journal of Medicinal Chemistry (2021), 64(16), 11904-11933, database is CAplus and MEDLINE.

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol.

Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem