Tag: M.W=150-200

Kos, Martin published the artcileEnantioenriched Ruthenium-Tris-Bipyridine Complexes Bearing One Helical Bipyridine Ligand: Access to Fused Multihelicenic Systems and Chiroptical Redox Switches, Application of Phenyl(pyridin-2-yl)methanone, the publication is Inorganic Chemistry (2021), 60(16), 11838-11851, database is CAplus and MEDLINE.

The synthesis and photophys. and chiroptical properties of novel aza[n]helicenes (6a–d, 10a,b, n = 4-7) substituted with one or two 2-pyridyl groups are described. The preparation was performed via an adapted Mallory reaction using aromatic imines as precursors. The obtained novel class of helical 2,2′-bipyridine ligands was then coordinated to Ru(bipy)₂²⁺ units, thus affording the first diastereomerically and enantiomerically pure [RuL(bipy)₂]²⁺ (11a,c, L = 6a,c) or [Ru₂L'(bipy)₄]⁴⁺ (12, L’ = 10b) complexes. The topol. and stereochem. of these novel metal-based helical architectures were studied in detail, notably using X-ray crystallog. Interestingly, the coordination to ruthenium(II) enabled the preparation of fused multihelical systems incorporating aza- and ruthena-helicenes within the same scaffold. The photophys., chiroptical, and redox properties of these complexes were examined in detail, and efficient redox-triggered chiroptical switching activity was evidenced.

Inorganic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Application of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Crichton, Robert R. published the artcileIron mobilization from ferritin by chelating agents, HPLC of Formula: 2215-33-0, the publication is Journal of Inorganic Biochemistry (1980), 13(4), 305-16, database is CAplus and MEDLINE.

The release of Fe from horse spleen ferritin (I) by the chelating agents, deferrioxamine B (II), rhodotorulic acid (III), 2,3-dihydroxybenzoate (IV), 2,2′-bipyridyl (V), and pyridine-2-aldehyde 2-pyridylhydrazone (VI), was studied in vitro. I prepared by classical procedures involving thermal denaturation released its Fe less effectively than I isolated by a modified procedure that avoided this step. II and III were the most effective in releasing Fe from both preparations of I. When FMN was added, Fe release by II, III, and IV was effectively blocked, whereas both V and VI showed a marked simulation. A substantial increase in Fe release was also observed for V and VI with ascorbate; a less important increase was noted for III. EDTA exerted a marked inhibition of Fe release from I with III, IV, V, and VI. The effects of citrate and oxalate on Fe release by the chelators was small. The effect of the concentration of flavin on Fe release from I by II and V was studied. II was unable to mobilize Fe(II) from I following reduction by reduced FMN, whereas V could rapidly complex Fe(II). The results are discussed in the context of current concepts of storage Fe mobilization in the treatment of Fe overload.

Journal of Inorganic Biochemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, HPLC of Formula: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Crichton, Robert R. published the artcileFerritin iron mobilization by chelating agents, Quality Control of 2215-33-0, the publication is FEBS Letters (1980), 110(2), 271-4, database is CAplus and MEDLINE.

The release of ferritin Fe in vitro by 5 Fe chelators was examined Deferrioxamine B (I) and rhodotorulic acid (II) released the greatest amounts of Fe from ferritin; over 24 h incubation at 37°, I and II released 225 and 250 g-atoms Fe/ferritin mol., resp. Of the other chelators, only pyridine-2-aldehyde-2-pyridylhydrazone (III) gave a reasonable release of 85 g-atoms Fe/ferritin mol. in 24 h. The effects of ascorbate, EDTA, and FMN on Fe release were also studied. FMN (1 mM) almost completely inhibited Fe release by I and II, 2 Fe-chelators currently employed in the treatment of Fe overload; the possible in vivo inhibition of these compounds by endogenous flavins was discussed. In contrast, Fe mobilization by III and bipyridyl was substantially enhanced by FMN.

FEBS Letters published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Jing published the artcileBiarylsulfonamide CCR9 inhibitors for inflammatory bowel disease, Application of 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(17), 3661-3664, database is CAplus and MEDLINE.

Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, affects millions of people worldwide. CCR9 has been shown to be a key chemokine receptor mediating the local inflammatory responses in the GI tract. The CCR9 inhibitor Vercirnon advanced to phase 3 clin. trials, but carries several liabilities which we sought to improve.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C17H37NO3, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bell, Colin Frank published the artcileNephelometric determination of silver and mercury with bis(I,3-di-(2′-pyridyl)-I,2-diaza-2-propenato) cobalt(III) perchlorate, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1970), 52(2), 313-21, database is CAplus.

Procedures are described for the nephelometric determination of Ag and Hg, based on adduct-formation with the Co(III) complex of 1,3-di(2-pyridyl)-1,2-diaza-2-propene (PAPHY). The procedures are rapid, sensitive, and reproducible and compare favorably with other nephelometric methods for these metals. The nature of the adducts is discussed.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Alvarez-Builla, Julio published the artcileUse of dipolar species under phase-transfer catalysis. Part 1. 1,3-Dipolar cycloaddition in a two-phase system, Application In Synthesis of 17281-59-3, the publication is Journal of Chemical Research, Synopses (1984), 202-3, database is CAplus.

Eleven indolizines were prepared in 18-82% yield by 1,3-dipolar cycloaddition of pyridinium ylides with RCCCO₂Me (R = MeO₂C, Ph) in a 2-phase system. Addition of MeO₂CCCCO₂Me to N-(methoxycarbonylmethyl)pyridinium chloride and KOH, supported on alumina (1:1) suspended in MeCN, at room temperature for >18 h, followed by dehydrogenation with 5% Pd-C at reflux for 4 h gave 44% indolizine I. Phase-transfer catalysts did not significantly improve the yields.

Journal of Chemical Research, Synopses published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Application In Synthesis of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kale, Manoj G. published the artcileThiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B, Category: pyridine-derivatives, the publication is Journal of Medicinal Chemistry (2013), 56(21), 8834-8848, database is CAplus and MEDLINE.

A pharmacophore-based search led to the identification of thiazolopyridine ureas, e.g., I, as a novel scaffold with antitubercular activity acting through inhibition of DNA Gyrase B (GyrB) ATPase. Evaluation of the binding mode of thiazolopyridines in a Mycobacterium tuberculosis (Mtb) GyrB homol. model prompted exploration of the side chains at the thiazolopyridine ring C-5 position to access the ribose/solvent pocket. Potent compounds with GyrB IC₅₀ â‰?1 nM and Mtb MIC â‰?0.1 μM were obtained with certain combinations of side chains at the C-5 position and heterocycles at the C-6 position of the thiazolopyridine core. Substitutions at C-5 also enabled optimization of the physicochem. properties. Representative compounds were cocrystd. with Streptococcus pneumoniae (Spn) ParE; these confirmed the binding modes predicted by the homol. model. The target link to GyrB was confirmed by genetic mapping of the mutations conferring resistance to thiazolopyridine ureas. The compounds are bactericidal in vitro and efficacious in vivo in an acute murine model of tuberculosis.

Journal of Medicinal Chemistry published new progress about 1351413-50-7. 1351413-50-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Pyridine,Boronic Acids,Boronic acid and ester, name is (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid, and the molecular formula is C6H8BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sindhuja, Elangovan published the artcilePalladium(II) thiocarboxamide complexes: synthesis, characterisation and application to catalytic Suzuki coupling reactions, Product Details of C13H13N, the publication is Dalton Transactions (2012), 41(17), 5351-5361, database is CAplus and MEDLINE.

A simple route to synthesize palladium(II) complexes from the reaction of N-substituted pyridine-2-thiocarboxamide ligands and PdCl₂(PPh₃)₂ has been developed. The new complexes are very soluble in common solvents and have been fully characterized (elemental anal., FTIR, ¹H, ³¹P, ¹³C-NMR), including an x-ray diffraction anal. The mol. structures of all the complexes were determined and reveal square planar geometry around Pd with little distortion. The complexes were tested in the Suzuki coupling of electronically deactivated aryl and heteroaryl bromides and have much greater activity, without using any promoting additives or phase transfer agent under aerobic conditions. Higher reaction rates were obtained by varying R substituents on the aromatic ring of pyridine-2-thiocarboxamide. The effect of other variables on the cross-coupling reaction, such as temperature, solvent and base, is also reported.

Dalton Transactions published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C17H20ClN3, Product Details of C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fischer, Eberhard published the artcilePreparation and reactions of pyridinium betaines, HPLC of Formula: 17281-59-3, the publication is Zeitschrift fuer Chemie (1978), 18(4), 137-8, database is CAplus.

Reaction of the pyridinium compounds I (R = H, Me) with R¹NCS (R¹ = Et, Ph, 4-ClC₆H₄) gave the betaines II, which reacted with R²COCl (R² = Ph, 2-, 3-O₂NC₆H₄, 3,4-Cl₂C₆H₃, CH₂Cl, OMe, COCl) to give the pyridinum chlorides III.

Zeitschrift fuer Chemie published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Panchaud, Philippe published the artcile3-Pyridinesulfonyl azide: A useful reagent for radical azidation, Name: Pyridine-3-sulfonic acid, the publication is Advanced Synthesis & Catalysis (2004), 346(8), 925-928, database is CAplus.

Radical azidations and carboazidations have been achieved using 3-pyridinesulfonyl azide as azidating agent. Due to its base properties and its polarity, the excess of reagent is readily removed at the end of the reaction by filtration through silica gel or by extraction with either aqueous 1M HCl or 1M CuSO₄. The use of this reagent greatly facilitates the tedious purifications of the final azides frequently encountered when reactions are run according to the original procedure involving benzenesulfonyl azide. Thus, reaction of Et 2-iodoacetate with 1-octene in presence of Bu₆Sn₂/di-tert-Bu hyponitrite/3-pyridinesulfonyl azide in C₆H₆ gave 80% Et 4-azidodecanoate.

Advanced Synthesis & Catalysis published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem