Tag: M.W=150-200

Recently I am researching about HORIUTI-POLANYI MECHANISM; STABILIZED PALLADIUM NANOPARTICLES; COPD BIOMARKER DESMOSINE; HETEROGENEOUS CATALYSIS; CARBOXYLIC-ACIDS; IONIC LIQUIDS; AMINES; WATER; HYDRODEHALOGENATION; TRANSFORMATION, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP17K01953, JP20K05734]. Name: Phenyl(pyridin-2-yl)methanone. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Tanaka, N; Usuki, T. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1-100 mol%) with H-2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 mol% Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept (R)).

Name: Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Tanaka, N; Usuki, T or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Quantum dots enable direct alkylation and arylation of allylic C(sp(3))-H bonds with hydrogen evolution by solar energy WOS:000652330400010 published article about SP(3) C-H; LIGHT PHOTOREDOX CATALYSIS; TRANSITION-METAL; FUNCTIONALIZATION; ALLYLATION; CARBONYL; PHOTOCATALYSIS; SELECTIVITY; ACTIVATION; ALDEHYDES in [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China; [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100190, Peoples R China; [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China in 2021, Cited 67. Category: pyridine-derivatives. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

Direct alkylation and arylation of allylic C(sp3)-H bonds are straight-forward approaches for accessing allylic C-C products. However, the engagement of allylic C-C bond- forming reaction without introducing extraneous functional groups and stoichiometric oxidant or reductant has proved difficult. Here, we report a general and mild strategy using semiconductor quantum dots (QDs) as photocatalysts for coupling a broad range of available allylic C(sp(3))-H bonds with alpha- amino C-H bonds or heteroarenes, respectively, under sunlight irradiation (> 85 examples). The protocol bypasses stoichiometric oxidant or reductant and pre-functionalization of both the coupling partners and produces hydrogen (H-2) as the byproduct. The outstanding efficiency and selectivity and step- and atom-economy represents the first direct alkylation and arylation of allylic C(sp(3))-H bonds with hydrogen evolution powered by solar energy.

Category: pyridine-derivatives. About Ethyl nicotinate, If you have any questions, you can contact Huang, C; Qiao, J; Ci, RN; Wang, XZ; Wang, Y; Wang, JH; Chen, B; Tung, CH; Wu, LZ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about PROTEIN; AGONISTS; LIGANDS; ANAPHYLATOXINS; REGULATORS; C5A, Saw an article supported by the National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [1145372, 1084018, 1028423]; Australian Research CouncilAustralian Research Council [DP130100629, DP180103244]; Australian Research Council Centre of Excellence in Advanced Molecular ImagingAustralian Research Council [CE140100011]; Queensland Government (CIF grant); University of QueenslandUniversity of Queensland; UQ Postdoctoral Research Fellowship; [1027369]; [1117017]. Product Details of 91-02-1. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Rowley, JA; Reid, RC; Poon, EKY; Wu, KC; Lim, JX; Lohman, RJ; Hamidon, JK; Yau, MK; Halili, MA; Durek, T; Iyer, A; Fairlie, DP. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound JR14a was among the most potent of the new antagonists in vitro, assessed by (a) inhibition of intracellular calcium release (IC50 10 nM) induced in human monocyte-derived macrophages by 100 nM C3a, (b) inhibition of beta-hexosaminidase secretion (IC50 8 nM) from human LAD2 mast cells degranulated by 100 nM C3a, and (c) selectivity for human C3aR over C5aR JR14a was metabolically stable in rat plasma and in rat liver microsomes and efficacious in rats when given orally to suppress rat paw inflammation, macrophage and mast cell activation, and histopathology induced by intraplantar paw administration of a C3aR agonist. Potent C3aR antagonists are now available for interrogating C3a receptor activation and suppressing C3aR-mediated inflammation in mammalian physiology and disease.

Product Details of 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Rowley, JA; Reid, RC; Poon, EKY; Wu, KC; Lim, JX; Lohman, RJ; Hamidon, JK; Yau, MK; Halili, MA; Durek, T; Iyer, A; Fairlie, DP or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Yu, T; Guo, MQ; Wen, SMM; Zhao, RR; Wang, JL; Sun, YL; Liu, QX; Zhou, HF in [Yu, Tao; Guo, Mingqing; Wen, Simiaomiao; Zhao, Rongrong; Wang, Jinlong; Sun, Yanli; Liu, Qixing; Zhou, Haifeng] China Three Gorges Univ, Res Ctr Green Pharmaceut Technol & Proc, Hubei Key Lab Nat Prod Res & Dev, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R China published Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen in 2021, Cited 51. Computed Properties of C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A simple, and practical oxidative scission of aromatic olefins to carbonyl compounds using O-2 as the sole oxidant with poly(ethylene glycol) dimethyl ether as a benign solvent has been developed. A wide range of monosubstituted, gem-disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.

Computed Properties of C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Yu, T; Guo, MQ; Wen, SMM; Zhao, RR; Wang, JL; Sun, YL; Liu, QX; Zhou, HF or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Structurally characterized mononuclear isostructural Ni(II), Cu(II) and Zn (II) complexes as a functional model for phenoxazinone synthase activity WOS:000499768700046 published article about COBALT(III) COMPLEX; CATECHOLASE; OXIDATION; DIOXYGEN; LIGAND; EXAMPLE in [Chatterjee, Arnab; Ghosh, Rajarshi] Univ Burdwan, Dept Chem, Burdwan 713104, W Bengal, India; [Khan, Sumitava] Burdwan Raj Coll, Dept Chem, Burdwan 713104, W Bengal, India in 2019.0, Cited 32.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Three new mononuclear complexes of the type [M(L)(2)](ClO4)(2), with Ni(II) (1), Cu(II) (2) and Zn(II) (3) ions, have been synthesized and structurally characterized, using the N,N,O donor Schiff base ligand 2-[(phenyl-pyridine-2-yl-methylene)-amino]-ethanol]. An X-ray diffraction study reveals identical crystallization patterns for each of the complexes, in the monoclinic crystal system with the C2/c space group. Interestingly, the synthesized complexes are isostructural in nature. The complexes showed biomimetic phenoxazinone synthase-like activity for the aerial oxidation of o-aminophenol to phenoxazine-2-one, separately in methanol (MeOH) and acetonitrile (ACN) solutions. For each of the complexes, the turnover numbers were found to be higher in MeOH than in ACN. The highest catalytic activity between among the three complexes was found to be for complex 2. (C) 2019 Elsevier Ltd. All rights reserved.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Chatterjee, A; Khan, S; Ghosh, R or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C12H9NO. Authors Kim, JH; Ofori, S; Parkin, S; Vekaria, H; Sullivan, PG; Awuah, SG in ROYAL SOC CHEMISTRY published article about in [Kim, Jong Hyun; Ofori, Samuel; Parkin, Sean; Awuah, Samuel G.] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA; [Awuah, Samuel G.] Univ Kentucky, Coll Pharm, Ctr Pharmaceut Res & Innovat, Lexington, KY 40536 USA; [Awuah, Samuel G.] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA; [Vekaria, Hemendra; Sullivan, Patrick G.] Univ Kentucky, Spinal Cord & Brain Injury Res Ctr, Lexington, KY USA; [Sullivan, Patrick G.] Univ Kentucky, Dept Neurosci, Lexington, KY USA; [Sullivan, Patrick G.] Lexington Vet Affairs Healthcare Syst, Lexington, KY USA in 2021.0, Cited 75.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Expanding the chemical diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chemistry of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiological stability. Biological evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of adenosine triphosphate (ATP). Mechanism-of-action efforts, RNA-Seq, quantitative proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple negative breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiology.

HPLC of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Kim, JH; Ofori, S; Parkin, S; Vekaria, H; Sullivan, PG; Awuah, SG or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Monticelli, S; Colella, M; Pillari, V; Tota, A; Langer, T; Holzer, W; Degennaro, L; Luisi, R; Pace, V in [Monticelli, Serena; Pillari, Veronica; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio] Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria; [Colella, Marco; Tota, Arianna; Degennaro, Leonardo; Luisi, Renzo] Univ Bari A Moro, Dept Pharm Drug Sci, Via E Orabona 4, I-70125 Bari, Italy published Modular and Chemoselective Strategy for the Direct Access to alpha-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds in 2019.0, Cited 62.0. SDS of cas: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

An expeditious, high-yielding synthesis of rare alpha-fluoroepoxides and alpha-fluoroaziridines through the addition of the unkown fluoroiodomethyllithium (LiCHIF)-formed via deprotonation the commercially available fluoroiodomethane with a lithium amide base-to carbonyl-like compounds is documented. The ring-closure reactions, leading to alpha-fluorinated three-membered heterocycles, rely on the diversely reactive C-I and C-F bonds. Excellent chemoselectivity was observed in the presence of highly sensitive functionalities-aldehyde, ketone, nitrile, alkene-which remained untouched during the homologation sequence.

SDS of cas: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Monticelli, S; Colella, M; Pillari, V; Tota, A; Langer, T; Holzer, W; Degennaro, L; Luisi, R; Pace, V or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Development of a Tunable Chiral Pyridine Ligand Unit for Enantioselective Iridium-Catalyzed C-H Borylation WOS:000664333800056 published article about C(SP(3))-H BORYLATION; BIPYRIDINE LIGAND; ARENES; ACTIVATION; COMPLEXES; CYCLOPROPANATION; C(SP(2))-H; FUNCTIONALIZATION; BONDS in [Song, Peidong; Yu, Tao; Li, Pengfei] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710054, Peoples R China; [Hu, Linlin; He, Yangqing] Xian Univ Technol, Dept Appl Chem, Xian 710048, Peoples R China; [Jiao, Jiao] Xi An Jiao Tong Univ, Sch Chem, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China; [Xu, Liang] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China; [Li, Pengfei] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2021.0, Cited 104.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Computed Properties of C12H9NO

Although pyridine derivatives are versatile supporting ligands in catalysis, the development of their chiral versions has been relatively limited. Herein, we report the design, synthesis, and proof-of-concept application of a structurally tunable chiral pyridine framework featuring an annulated compact ring system. Using an N,B-bidentate ligand skeleton containing the chiral pyridine moiety, we have developed an enantioselective iridium-catalyzed desymmetrizing C-H borylation reaction of diaryl(2-pyridyl)methane compounds with up to 96% ee and 93% yield. The resulting borylation products could be readily transformed into various chiral tri(hetero)arylmethane compounds. Density functional theory investigations revealed that the two chair conformations of the flexible ketal motif both favored the enantiomer that was consistent with experimental results. This work has thus introduced an effective and tunable chiral pyridine ligand framework that may be used in many catalytic asymmetric transformations.

Computed Properties of C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Song, PD; Hu, LL; Yu, T; Jiao, J; He, YQ; Xu, L; Li, PF or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 SYNTHESIS-STUTTGART published article about STEREOSELECTIVE ADDITION; DIMETHYLPHOSPHINE OXIDE; SYNERGISTIC EXTRACTION; CARBONYL-COMPOUNDS; PHOSPHORUS; ALKENES; CHALCOGENIDES; METHODOLOGY; ABSORPTION; COMPLEXES in [Gusarova, Nina K.; Ivanova, Nina I.; Khrapova, Kseniya O.; Volkov, Pavel A.; Telezhkin, Anton A.; Larina, Lyudmila I.; Afonin, Andrei V.; Pavlov, Dmitry V.; Trofimov, Boris A.] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, 1 Favorsky Str, Irkutsk 664033, Russia in 2020.0, Cited 69.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Quality Control of Phenyl(pyridin-2-yl)methanone

Tertiary alpha-hydroxyphosphine oxides have been synthesized via the catalyst- and solvent-free reaction between available secondary phosphine oxides and aliphatic, aromatic and heteroaromatic ketones at 20-62 degrees C in near to 96-98% yield. The developed method meets the requirements of green chemistry and the PASE (pot, atom, step economy) paradigm. According to quantum-chemical calculations at the B3LYP/6-311++G(d,p) level, the synthesized hydroxyphosphine oxides feature a weak (approximate to 3 kcal center dot mol(-1)) O-H center dot center dot center dot O=P intramolecular hydrogen bond.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gusarova, NK; Ivanova, NI; Khrapova, KO; Volkov, PA; Telezhkin, AA; Larina, LI; Afonin, AV; Pavlov, DV; Trofimov, BA or concate me.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones WOS:000518875700100 published article about N-HYDROXYPHTHALIMIDE; SELECTIVE OXIDATION; CATALYZED OXIDATION; MOLECULAR-OXYGEN; BENZYLPYRIDINES; C-SP(3)-H; NITRITE; SYSTEM; COPPER in [Qu, Jian-Ping] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China; [Wang, Hua; Liu, Jie; Kang, Yan-Biao] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China in 2020.0, Cited 32.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Computed Properties of C12H9NO

An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation. A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Wang, H; Liu, J; Qu, JP; Kang, YB or concate me.. Computed Properties of C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem