Tag: M.W=150-200

Pires, Marina J. D. published the artcileSynthesis of Substituted 4-, 5-, 6-, and 7-Azaindoles from Aminopyridines via a Cascade C-N Cross-Coupling/Heck Reaction, Name: 2-Bromopyridin-3-amine, the publication is Organic Letters (2016), 18(13), 3250-3253, database is CAplus and MEDLINE.

A practical palladium-catalyzed cascade C-N cross-coupling/Heck reaction of alkenyl bromides with amino-o-bromopyridines is described for a straightforward synthesis of substituted 4-, 5-, 6-, and 7-azaindoles using a Pd₂(dba)₃/XPhos/t-BuONa system. This procedure consists of the first cascade C-N cross-coupling/Heck approach toward all four azaindole isomers from available aminopyridines. The scope of the reaction was investigated and several alkenyl bromides were used, allowing access to different substituted azaindoles. This protocol was further explored for N-substituted amino-o-bromopyridines.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chang, Yu-Che published the artcileRe^I-Catalyzed highly regio- and stereoselective C-H addition to terminal and internal alkynes, Name: 5-Methyl-2-(p-tolyl)pyridine, the publication is Organic Chemistry Frontiers (2019), 6(4), 432-436, database is CAplus.

An effective ortho C-H functionalization of arylpyridines e.g., I and detachable N-pyrimidyl indoles II (R = H, CH₃, C(O)CH₃) by terminal and internal alkynes R¹CCR² (R¹ = H, C₆H₅, CH₃(CH₂)₂, C₆H₅CC; R² = 4-CH₃C₆H₄, (CH₂)₅OH, cyclohexyl, etc.) using a Re(I) catalyst providing an efficient access to various E-selective alkenylation products e.g., III were developed. The catalytic reaction is compatible with various aliphatic alkynes, aromatic terminal alkynes and internal alkynes, and structurally different nitrogen heterocycles. Deuterium-labeling experiments indicate that significant deuterium scrambling occurs with the directing groups and acetylenic sp C-H bonds before the migratory insertion.

Organic Chemistry Frontiers published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Name: 5-Methyl-2-(p-tolyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Muralirajan, Krishnamoorthy published the artcileCobalt-Catalyzed Mild Ring-Opening Addition of Arenes C-H Bond to 7-Oxabicyclic Alkenes, Quality Control of 85237-71-4, the publication is Advanced Synthesis & Catalysis (2017), 359(3), 513-518, database is CAplus.

A mild approach for a Cp*Co(III)-catalyzed C-H naphthylation of arenes by 7-oxabicyclic alkenes has been developed. In some cases, intermediate products with a 1,2-dihydronaphthalen-1-ol group have been isolated at room temperature in good yield. The catalytic reaction proceeds via C-H activation, insertion, β-oxygen elimination, protonation, and dehydration, resp. These simple protocols, featuring mild conditions and tolerance of functional groups, exhibit great potential for a variety of synthetic applications.

Advanced Synthesis & Catalysis published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Quality Control of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Anmol published the artcileComparative study of palladium(II) complexes bearing tridentate ONS and NNS Schiff base ligands: Synthesis, characterization, DFT calculation, DNA binding, bioactivities, catalytic activity, and molecular docking, Application In Synthesis of 91-02-1, the publication is Polyhedron (2022), 115895, database is CAplus.

Two palladium (II) Schiff base complexes were prepared by using equivalent molar of Schiff base ligand [L¹ = (E)-2-(((2-(benzylthio)phenyl)imino)methyl)naphthalen-1-ol and L² = (E)-N-(2-(benzylthio)phenyl)-1-phenyl-1-(pyridin-2-yl)methanimine] and sodium tetrachloropalladate. The structure of ligands and complexes were characterized by physicochem. and spectroscopic analyses. The results suggested that the Pd(II) complexes have a distorted square planar geometry when coordinated to the tridentate ONS from L¹ and the NNS donor ligand from L². Electronic absorption and spectrofluorometric measurements were employed to investigate the DNA binding of ligands and their associated complexes with CT-DNA. DFT calculations were used to optimize the geometric structures and calculate the electronic and structural properties of the synthesized compounds NBO anal. was also performed in combination with the TD-DFT method. Moreover, to study the reactivity and bioactivity, the synthesized compounds were tested for in-vitro antioxidant activity by utilizing the DPPH method, in-vitro anti-inflammatory activity using protein denaturation method, and in-vitro anti-diabetic activity employing α-glucosidase and α-amylase enzymes. The results reflect that PdL¹ is more biol. potent than PdL² or other related palladium complexes, as discussed in the literature. The binding mechanism of the synthesized compounds with CT-DNA, α-glucosidase, and α-amylase, was investigated using mol. docking experiments In addition to these, the catalytic activity of palladium metal complexes (PdL¹ and PdL²) was evaluated for the Suzuki-Miyaura reaction for comparisons.

Polyhedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C13H16BF3O2S, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Costa, Marta published the artcileSelective synthesis of some imidazopyridine-fused chromones, Related Products of pyridine-derivatives, the publication is Tetrahedron (2011), 67(45), 8622-8627, database is CAplus.

A fused heterocyclic scaffold combining the imidazo[1,2-a]pyridine with a substituted chromone was synthesized in a one-pot procedure. The reaction proceeds by intramol. cyclization of 1-(2-imino-2H-chromen-3-yl)pyridinium chloride in ethanol and in the presence of DABCO. A detailed study of the exptl. conditions allowed a clear understanding of the reaction pathway.

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lombardini, J. B. published the artcileAnalogs of taurine as inhibitors of the phosphorylation of an �0 K molecular weight protein present in a mitochondrial fraction of the rat retina, SDS of cas: 636-73-7, the publication is Amino Acids (1997), 13(2), 115-130, database is CAplus.

It was previously demonstrated that taurine inhibits the phosphorylation of a â‰?0 K apparent mol. weight protein present in the mitochondrial fraction of the rat retina. Analogs of taurine were tested for their inhibitory activity on the phosphorylation of this 20 K protein. The most potent analogs were (±)trans-2-aminocyclopentanesulfonic acid (TAPS) and 1,2,3,4-tetrahydroquinoline-8-sulfonic acid (THQS), which were 21 and 7 times more potent than the parent compound, taurine, resp. Median-effect plots were used to calculate the inhibitory median effect and combination index values for the combined effects of taurine and taurine analogs. It was determined that the inhibitory taurine analogs were antagonistic to taurine when used in combination with taurine to inhibit the phosphorylation of the 20 K apparent mol. weight protein. It was concluded that the distance between the N and S atoms in the taurine structure was important for inhibitory activity. If the N atom was either within or attached to an unsaturated ring structure, the inhibitory potency was decreased. If both the S and N atoms were present within the ring structure, the analog has no activity.

Amino Acids published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lombardini, John B. published the artcileEffects of kinase inhibitors and taurine analogs on the phosphorylation of specific proteins in mitochondrial fractions of rat heart and retina, SDS of cas: 636-73-7, the publication is Advances in Experimental Medicine and Biology (1996), 343-350, database is CAplus.

Quant. effects of various kinase inhibitors, specifically chelerythrine chloride, staurosporine, and W-7, and various taurine analogs (singly and in combination with taurine) on the phosphorylation of both the cardiac 44 kDa and retinal 20 kDa proteins are reported. Effects of the analogs on phosphorylation of both proteins suggest that the structural requirements for being either an inhibitor or stimulator are rather restricted.

Advances in Experimental Medicine and Biology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jiang, Nan published the artcileDirect dissolution and NMR analysis of the plant cell walls via perdeuterated pyridinium-based ionic liquid, HPLC of Formula: 17281-59-3, the publication is Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry (2010), 55(1), 235-236, database is CAplus.

This article presents the perdeuterated pyridinium ionic liquid system for direct dissolution and NMR anal. of the Wiley milled and ball-milled plant cell walls to reveal the detailed structure of the plant cell walls. The unique properties and easy preparation of pyridinium-based ionic liquid [Hpyr]Cl-d₆ offer significant benefits over imidazolium-based ionic liquids for NMR characterization of the non-ball-milled plant cell walls. Further applications of this novel ionic liquid-based solvent system include the determination of lignin content, H:S:G ratios and inter-unit lignin bonding arrangements, without the need for lengthy lignin isolation procedures.

Preprints of Symposia – American Chemical Society, Division of Fuel Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jiang, Nan published the artcilePerdeuterated pyridinium molten salt (ionic liquid) for direct dissolution and NMR analysis of plant cell walls, Category: pyridine-derivatives, the publication is Green Chemistry (2009), 11(11), 1762-1766, database is CAplus.

A bi-solvent system consisting of perdeuterated pyridinium molten salt and DMSO-d₆ has been developed for direct dissolution and NMR anal. of plant cell walls, which will shed a new light on efficient detailed structure of the plant cell walls and benefit lignin engineering for biofuel and biomaterial research.

Green Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xu, Pengcheng published the artcilePalladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones, Computed Properties of 91-02-1, the publication is Organic & Biomolecular Chemistry (2021), 19(6), 1274-1277, database is CAplus and MEDLINE.

An approach for the synthesis of quinolizinone I (R = H, 6-Me, 7-F, etc.; R¹ = H, Me, Ph; R² = H, Me, pentyl; R³ = H, Me; X = N, CH) with potential bioactivity has been developed via palladium-catalytic dearomative cyclocarbonylation of allyl alc. R⁴C(R¹)=C(R²)CH(R³)OH (R⁴ = pyridin-2-yl, 5-fluoropyridin-2-yl, pyrazin-2-yl, etc.). Diverse quinolizinone compounds I could be attained with good efficiencies. A feasible reaction pathway could be a successive procedure of allylation, dearomatization, CO insertion and the Heck reaction.

Organic & Biomolecular Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C10H10O2, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem