Tag: M.W=150-200

Azizollahi, Hamid published the artcileSynthesis of [3.4]-Spirooxindoles through Cascade Carbopalladation of Skipped Dienes, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Advanced Synthesis & Catalysis (2020), 362(9), 1899-1904, database is CAplus.

A synthetic route to [3.4]-spirooxindoles based on cascade carbopalladation reactions of 1,4-dienes was described. While carbopalladation of alkenes have been used to access mainly [4.4]- or [4.5]-spirocycles, 4-exo-trig carbopalladation was not been yet applied to the synthesis of relevant [3.4]-spirooxindole scaffolds bearing a cyclobutyl ring. In addition, the cascade reaction generates an exocyclic double bond that can serve as a platform to further diversify the substitution pattern of the spirooxindole nuclei.

Advanced Synthesis & Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Berger, Olivier published the artcilePhosphorus-Carbon Bond Formation: Palladium-Catalyzed Cross-Coupling of H-Phosphinates and Other P(O)H-Containing Compounds, Computed Properties of 39856-58-1, the publication is Advanced Synthesis & Catalysis (2013), 355(7), 1361-1373, database is CAplus.

Two generally applicable systems were developed for the cross-coupling of P(O)H compounds with C_sp2-X and related partners. Pd catalysis using a ligand/additive combination, typically either xantphos/ethylene glycol or 1,1′-bis(diphenylphosphino)ferrocene/1,2-dimethoxyethane, with diisopropylethylamine as the base, proved to be generally useful for the synthesis of numerous P-C containing compounds E.g., reaction of RP(O)(OEt)H (R = octyl) with 2-bromopyridine in the presence of 2 mol% Pd(OAc)₂/xantphos, toluene and ethylene glycol and (ⁱPr)₂NEt at 115° to give 93% yield of (Oct)P(O)(OEt)(2-pyridyl). Routinely, 2 mol% of catalyst are employed (less than half the amount typically employed in most other literature reports). In most cases, excellent results were obtained with a variety of electrophiles (RX, where R = alkenyl, allyl, alkynyl, etc.). The full account of the studies is disclosed, including tandem hydrophosphinylation/coupling and coupling/coupling for doubly catalytic P-C bond formation. The methodol. compares favorably with any existing literature report. The use of an additive appears to be a generally useful strategy to control the reactivity of phosphinylidene compounds

Advanced Synthesis & Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Computed Properties of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dumitru, Florina published the artcileHomo- and heteroduplex complexes containing terpyridine-type ligands and Zn²⁺, Synthetic Route of 2215-33-0, the publication is European Journal of Inorganic Chemistry (2005), 4255-4262, database is CAplus.

We describe a study of the equilibrium binding of Zn²⁺ to binary mixtures of tridentate ligands terpyridine (1), 2,5-(CHNC₆H₅)₂pyridine (2) and (2-pyridyl)NHNCH(2-pyridyl) (3) which leads to the formation of a dynamic mixture of homo ([Zn(1)₂](CF₃SO₃)₂ 4, [Zn(2)₂](CF₃SO₃)₂ 5, [Zn(3)₂](CF₃SO₃)₂ 6) and hetero ([Zn(1)(3)](CF₃SO₃)₂ 7, [Zn(1)(2)](CF₃SO₃)₂ 8, [Zn(2)(3)](CF₃SO₃)₂ 9) coordination compounds We report the crystal structures of five such complexes (4, 5, 7–9) which assemble into complementary duplex compounds that further self-organize into double helical- or lamellar-type architectures in the solid state. The ligand exchange between homo-duplex complexes in solution leads to the preferential formation of the heteroduplex complexes. As might be expected these processes display a statistical distribution of homo-duplex:heteroduplex:homo-duplex complexes of 1:2:1 for the mixtures resulting from 4:6 and 5:6 ligands. However, complex 8 is preferred in a 4:5 mixture which presents a composition of 1:4:1 (amplification factor of about 33%). The X-ray structural determinations of selected single crystals resulting from the stoichiometric mixtures of homo-duplex complexes show unique heteroduplex superstructures 7–9 in the solid state. The present results present the solid-state structures of homo- and hetero-complexes resulting from terpyridine-type ligands 1–3 and Zn²⁺ metal ions. The heteroduplex Zn²⁺ complexes 7–9 are quant. crystallized in the solid state by statistical (7, 9) and structural (8) driven selection in solution from a binary mixture of the terpyridine-type complexes and then trapped by crystallization in the solid state.

European Journal of Inorganic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Synthetic Route of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Beier, Markus published the artcileNucleotides. Part 62. Pyridinium salts. An effective class of catalysts for oligonucleotide synthesis, Related Products of pyridine-derivatives, the publication is Helvetica Chimica Acta (1999), 82(6), 879-887, database is CAplus.

Various pyridinium salts were tested as catalysts for the condensation step in the phosphoramidite approach of oligonucleotide synthesis. Pyridinium chloride turned out to be the most effective activator, speeding up the condensation tremendously. Pyridinium bromide and tosylate can also he regarded as powerful substitutes for the commonly used 1H-tetrazole. The acidic pK_a of the pyridinium cation provides an optimal range for phosphoramidite activation, which is followed by a nucleophilic attack of the pyridine ring to give a P-pyridinio intermediate as the most likely precursor of phosphite ester formation. ³¹P-NMR studies indirectly support this proposal.

Helvetica Chimica Acta published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Purificacao, Sara I. published the artcileOne-Pot Synthesis of 1,2-Disubstituted 4-, 5-, 6-, and 7-Azaindoles from Amino-o-halopyridines via N-Arylation/Sonogashira/Cyclization Reaction, SDS of cas: 39856-58-1, the publication is Organic Letters (2017), 19(19), 5118-5121, database is CAplus and MEDLINE.

A direct synthesis of several 1,2-disubstituted 4-, 5-, 6-, and 7-azaindoles from available amino-o-halopyridines is described. This procedure involves a palladium-catalyzed N-arylation followed by a Sonogashira reaction and subsequent cyclization in a one-pot manner, exhibiting a wide scope and compatibility with electron-withdrawing and electron-donating groups. The strategy represents an advancement in azaindole chem. with a straightforward approach toward 1,2-disubstituted azaindoles, while avoiding complex N-arylations of hindered 2-substituted azaindoles and difficult purification steps of intermediates.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, SDS of cas: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nguyen, Phuhai published the artcileEvaluation of the antiprion activity of 6-aminophenanthridines and related heterocycles, COA of Formula: C5H5BrN2, the publication is European Journal of Medicinal Chemistry (2014), 363-371, database is CAplus and MEDLINE.

Several 6-(amino)phenanthridine derivatives and related heterocyclic compounds such as benzonaphtyridine derivatives were prepared A reduction of one of the three aromatic rings was also performed. The compounds were first tested for their antiprion activity in a previously described yeast-based colorimetric prion assay. The most potent derivatives were then assayed ex-vivo against the mammalian prion PrP^Sc in a cell-based assay. Several of the new compounds were found more potent than the parent lead 6-aminophenanthridine. The most promising compounds against yeast and mammalian prions were 8-azido-6-aminophenanthridine and 7,10-dihydrophenanthridin-6-amine. In the mammalian cell-based assay, the IC₅₀ of these two compounds were around 5 μM and 1.8 μM, resp. The synthesis of the target compounds was achieved by a coupling reaction of boronic acid esters, such as 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile with suitable aryl bromides or aryl chlorides. The tilte compounds thus formed included 6-phenanthridinamine derivatives and analogs, such as benzo[c][2,6]naphthyridin-5-amine, benzo[h][1,6]naphthyridin-5-amine, benzo[c][1,8]naphthyridin-6-amine, benzo[c][1,6]naphthyridine, benzo[c]-1,5-naphthyridine.

European Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Xiaoqing published the artcileInfluence of Guest/Host Morphology on Room Temperature Phosphorescence Properties of Pure Organic Doped Systems, Name: Phenyl(pyridin-2-yl)methanone, the publication is Journal of Physical Chemistry Letters (2021), 12(30), 7357-7364, database is CAplus and MEDLINE.

Guest/host phosphorescence materials have attracted much attention; traditionally, researchers have focused on the influence of the electronic properties and energy levels of the mols. on the phosphorescence activities. The effects of the morphol. on the phosphorescence are ignored. Three isoquinoline guests with different aliphatic rings and 3 hosts are selected to construct guest/host materials. The guests are dispersed in the host as clusters. The morphols. of the guest/host directly affect the phosphorescence. In these systems, the guests have strong intermol. interactions, which are beneficial to stabilize the triplet excitons; meanwhile, the hosts should have weak intermol. interactions with easily changed morphol. to accept the guest clusters, which synergistically ensure that the doped materials have excellent RTP properties. This is the 1st work focusing on the effect of mol. morphol. on the phosphorescence of guest/host systems.

Journal of Physical Chemistry Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhao, Bin published the artcileElectrochemical fluorosulfonylation of alkenes to access vicinal fluorinated sulfones derivatives, Quality Control of 91-02-1, the publication is Tetrahedron (2022), 132651, database is CAplus.

Herein, a practical and efficient fluorosulfonylation of the various alkenes with sulfonyl radical sources and Et₃N·3HF as cost-effective fluorination reagents under mild conditions is reported. Remarkably, this protocol features very green and sustainable conditions obviating the need of chem. oxidants and transition metal catalyst. A variety of substituents on both sulfonyl hydrazides and alkenes are tolerated to give vicinal fluorinated sulfones in moderate to excellent yields. Also, the synthetic utility of this transformation is further demonstrated by a gram-scale reaction and the late-stage functionalization of complex mols.

Tetrahedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C20H17FO4S, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Varghese, Hema Tresa published the artcileVibrational spectroscopic studies and ab initio calculations of pyridine-3-sulfonic acid, Synthetic Route of 636-73-7, the publication is Asian Journal of Chemistry (2007), 19(4), 2627-2632, database is CAplus.

FT-Raman and FT-IR spectra of pyridine-3-sulfonic acid were recorded and analyzed. The mol. geometry and vibrational wave numbers of pyridine-3-sulfonic acid have been calculated using the Hartree-Fock method with different basis sets. Comparison of the observed fundamental vibrational wavenumbers of pyridine-3-sulfonic acid with calculated results by Hartree-Fock method is found in agreement with the exptl. data.

Asian Journal of Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C10H15NO, Synthetic Route of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Krommyda, Kalliopi published the artcileA Remarkable Effect of Aluminum on the Novel and Efficient Aqueous-Phase Hydrogenation of Levulinic Acid into γ-Valerolactone Using Water-Soluble Platinum Catalysts Modified with Nitrogen-Containing Ligands, SDS of cas: 636-73-7, the publication is Catalysis Letters (2019), 149(5), 1250-1265, database is CAplus.

The catalytic performance of novel water-soluble platinum catalysts modified with various nitrogen-containing and phosphine ligands in the hydrogenation reaction of levulinic acid (LA) into γ-valerolactone (GVL) has been studied in environmentally attractive, green, aqueous monophasic systems. The presence of the Lewis acid aluminum enormously increases the catalytic activity of water-soluble platinum catalysts modified with nitrogen-containing ligands in the LA hydrogenation reaction and high catalytic activities up to 3540 TOF’s per h with a quant. selectivity towards GVL have been achieved using Na₂PtCl₆·6H₂O precursors modified with the bidentate bathophenanthrolinedisulfonic acid disodium salt (BPhDS) ligand and low amounts of AlCl₃·6H₂O promotors (molar ratio of AlCl₃·6H₂O/Pt = 0.17) in aqueous media. This unprecedented increase in catalytic activity with aluminum promotors for water-soluble transition metal catalytic systems in aqueous-phase hydrogenation reactions has not been described until now in the literature. The apparent activation energy of platinum catalyst modified with the monodentate nitrilotriacetic acid trisodium salt ligand in aqueous medium was calculated and amounts to a relative low value of 73.04 kJ mol^-1 when one considers that in the LA hydrogenation reaction this catalyst reduces a less reactive keto group into alc. functionality. A recycling experiment of the Pt/BPhDS/Al catalyst from the aqueous monophasic LA hydrogenation reaction mixture followed by biphasic recovery of the catalyst in active form from organic reaction products by extraction and simple phase separation of an aqueous/organic two-phase system formed after addition of di-Et ether has shown that the Pt/BPhDS/Al catalyst is stable without loss of activity and selectivity in a consecutive run.

Catalysis Letters published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem