Tag: M.W=150-200

Zhang, Lei published the artcileMetal-ligand binding interactions in rhodium/palladium-catalyzed synthesis of dihydroquinolines, HPLC of Formula: 612845-44-0, the publication is Journal of Organic Chemistry (2014), 79(24), 12159-12176, database is CAplus and MEDLINE.

A domino Rh- and Pd-catalyzed synthesis of dihydroquinolines is disclosed. Two metals and two ligands are placed in one reaction vessel along with the two reactive reagents to afford selective sequential coupling despite the potential for side reactions. In this report, we describe mechanistic investigations attempting to discern the catalyst-ligand interactions occurring in this domino reaction. Through these studies, the reactivity and relative catalyst ligand loadings were successfully tuned to efficiently access the heterocyclic products.

Journal of Organic Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C15H20O6, HPLC of Formula: 612845-44-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xue, Yuan published the artcilePalladium-Catalyzed β-C(sp³)-H Nitrooxylation of Ketones and Amides Using Practical Oxidants, Safety of Pyridine-3-sulfonic acid, the publication is ACS Catalysis (2021), 11(22), 14188-14193, database is CAplus.

Herein, a Pd(II)-catalyzed β-C(sp³)-H nitrooxylation of ketones and native amides was reported. The fine-tuned removable aminooxyamide auxiliary enabled β-C(sp³)-H functionalization of various aliphatic ketones. Practical iron(III) nitrate nonahydrate was used as the nitrate source and a single-electron oxidant for Pd(II)/Pd(III)/Pd(IV) catalysis. For amide substrates, N-iodosuccinimide (NIS) was applied as a bystanding two-electron oxidant in combination with silver nitrate for β-C(sp³)-H nitrooxylation. Palladacycle intermediates were isolated and characterized to elucidate the reaction mechanism for the C(sp³)-H activation of ketones with the L,X-type imino-amide directing group.

ACS Catalysis published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C9H10O3S, Safety of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Y. published the artcileNon-covalent interactions governing the supramolecular assembly of copper(II) complexes with hydrazone-type ligand: Experimental and quantum chemical study, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Polyhedron (2021), 115142, database is CAplus.

Two new mono- and one binuclear μ-nitrato bridged Cu(II) complexes [Cu(L)(HL)]ClO₄ (1), [Cu(HL)(NO₃)(H₂O)]2NO₃•H₂O (2) and [Cu₂(L₂)(μ-NO₃)₂] (3), with an unsym. NNO donor Schiff base (HL) were synthesized and characterized by elemental anal., FTIR, CV, UV-visible and EPR spectroscopy. Their mol. structures were also determined by single crystal x-ray crystallog. In the binuclear complex 3, the Cu··· Cu distance is 3.494 Å. In 1, 2 and 3, the Cu(II) centers have distorted square pyramidal geometry (τ₅ = 0.05-0.17). Evidence of weak π···π stacking intermol. interactions along with other noncovalent interactions (H bonding) was observed by analyzing the resp. crystal structures of the complexes. Thus, these H bonds, π···π stacking interactions and other weak intermol. interactions establish as supramol. architectures a crystalline network environment. The noncovalent interactions were also studied by employing Hirshfeld Anal. The room temperature magnetic moments of the mononuclear complexes are less than the spin only values which are indicative of small interactions. Also, significant magnetic interactions were not exhibited by binuclear Cu(II) complex 3 in the variable temperature magnetic measurements. The X-band EPR spectra of all three complexes exhibit Cu(II) hyperfine structures as well as zero-field splitting which are appropriate for the triplet states of dimers. In 1 and 2, the presence of pseudo dipolar interactions is proposed. Quantum chem. calculations (DFT) were carried out on complexes 1–3 to explore the electronic and spectral properties of these newly synthesized complexes. These complexes show significant antiproliferative and SOD activity. The SOD activity measured in terms of k_McCF is in the range 4.94-12.31 (mol L)^-1s^-1 x 10⁴.

Polyhedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C9H10O3S, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Singh, Yogendra Pratap published the artcileMolecular structures, spectral, electrochemical, DFT and antioxidant activities of copper(II) complexes with NNO donor Schiff base ligand, Application In Synthesis of 91-02-1, the publication is Journal of Molecular Structure (2021), 129457, database is CAplus.

The synthesis and solid state structural, spectral and electrochem. solution characterization of [Cu(L)(acpy)]ClO₄ 1 and [Cu(L)(NO₃)] 2 [where L = N’-[(E)-phenyl(pyridin-2-yl)methylidene]thiophene-2-carbohydrazide and acpy = 2,6-Diacetylpyridine] were done by elemental anal., UV-visible, FTIR, electrochem. techniques (CV and DPV) and EPR spectroscopy. The single crystal structures were solved by the x-ray diffraction technique. In complex 1, copper ion is in a distorted octahedral environment. The geometry of copper(II) in complex 2 is distorted square pyramidal (τ = 0.201). The mono deprotonated, HL ligand act as a tridentate to a copper(II) ion. On the basis of d. functional theory (DFT) calculation, the electronic excitations involve transitions mainly from metal ligand bonding mostly the α-LUMO within the dominant Cu d_xy character and to α-LUMO+1. EPR spectra for polycrystalline samples showed the copper(II) hyperfine features as well as half-field signal which are appropriate for ΔM_s = ±2 of dimers. Presence of half-field signal in 1 is due to solid-solid interaction (intra-mol.) where as in 2 the nature of interaction is intra-mol. The antioxidant superoxide measurements show that the both complexes 1 and 2 behave as superoxide mimic in alk. nitro blue tetrazolium chloride assay.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ishii, Hajime published the artcileEquilibria and kinetics of the extraction of nickel with 2-pyridinecarbaldehyde 2-(5-substituted)pyridylhydrazones, Formula: C11H10N4, the publication is Analytical Sciences (1988), 4(1), 73-6, database is CAplus.

The equilibrium and kinetics of the extraction of Ni with benzene solutions of 2-pyridinecarbaldehyde 2-(5-substituted)pyridylhydrazones were studied at 25 ± 0.1° and an ionic strength of 0.2. The extracted species was found too be NiL₂ for each hydrazone, where L denotes the undissociable part of the hydrazone. Partition constants of the hydrazones and extraction constants of their Ni complexes between an aqueous and a benzene phase were determined The rate of extraction was best described by a two-term expression, both terms being 1st order in Ni ion and HL concentrations The first term has zero dependence on H⁺ concentration, whereas the 2nd is inversely first order with respect to H⁺ concentration These results support the hypothesis that the rate-determining steps involve 2 concurrent reactions of Ni with neutral and anionic forms of the hydrazones. Kinetic data and activation parameters for the first reaction were determined, but those for the second one involving the anion could not be obtained.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Jong Hyun published the artcileAnticancer gold(III)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition, Application In Synthesis of 91-02-1, the publication is Chemical Science (2021), 12(21), 7467-7479, database is CAplus and MEDLINE.

Expanding the chem. diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chem. of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiol. stability. Biol. evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of ATP (ATP). Mechanism-of-action efforts, RNA-Seq, quant. proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple neg. breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiol.

Chemical Science published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileExtraction equilibria of nickel(II) with several heterocyclic substituted hydrazones, Quality Control of 2215-33-0, the publication is Analytical Sciences (1993), 9(6), 835-41, database is CAplus.

The extraction of nickel(II) with seven N,N,N-tridentate heterocyclic hydrazones, a neutral form of which is abbreviated as HL, using chloroform or benzene as an extraction solvent has been studied, the extraction equilibrium being analyzed on the basis of the data for the proton dissociation of H₃L²⁺, the formation of Ni(HL)²⁺ and Ni(HL)₂²⁺ complexes and the proton dissociation of Ni(HL)₂²⁺ complexes in aqueous solution Nickel(II) is extracted as NiL₂ although it forms such complexing ions an Ni(HL)²⁺ or Ni(HL)₂²⁺ in the aqueous phase. The distribution constants of HL and NiL₂ (the abbreviations of which are K_d and K_dm, resp.) have been determined under the same condition as in aqueous solution The logarithmic plots of Kdm vs. K_d displayed two straight lines with slopes of 1.9; one is for hydrazones bearing one pyridyl or one quinolyl ring in the aldehyde moiety and the other for hydrazones bearing another pyridyl ring introduced to the aldehyde moiety. This is attributed to an intramol. hydrogen bond between the imino hydrogen and the nitrogen of pyridine of the latter hydrazones.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C13H16BFO4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Taya, Toshiki published the artcileKinetic study of solvent extraction of nickel(II) from aqueous solution by some heterocyclic substituted-hydrazones, Application In Synthesis of 2215-33-0, the publication is Analytical Sciences (1991), 7(Suppl.), 21-4, database is CAplus.

Solvent extraction of nickel(II) complexes with five heterocyclic hydrazones (containing pyridine- or/ and quinoline-nitrogen atoms as the coordinating sites) into chloroform or benzene was studied kinetically at 25°C and μ = 0.1 by means of a spectrophotometric method. The kinetics of extraction of nickel(II) ion is first order in each of the aqueous nickel(II) concentration and the hydrazone concentration in the organic phase. The observed second-order rate constant, k_obs, -pH profiles suggest three rate-determining steps to be considered in the aqueous phase: Ni²⁺ + H₂L⁺ â†? Ni²⁺ + HL â†?and Ni(OH)⁺ + HL â†? The rate constant for the formation of 1:1 complexes with 2-pyridylmethanone 2-pyridylhydrazone (PAPH) was consistent with those for bipyridine and terpyridine. Replacement of pyridyl group by quinolyl group affects the distribution constant (K_d) of the ligand between the two phases rather than the rate constants The influence of the structure of ligands on the rate constants is also discussed.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C18H34N4O5S, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Lei published the artcileChiral Bifunctional Phosphine-Carboxylate Ligands for Palladium(0)-Catalyzed Enantioselective C-H Arylation, Product Details of C5H5BrN2, the publication is Angewandte Chemie, International Edition (2018), 57(5), 1394-1398, database is CAplus and MEDLINE.

Previous enantioselective Pd⁰-catalyzed C-H activation reactions proceeding via the concerted metalation-deprotonation mechanism employed either a chiral ancillary ligand, a chiral base, or a bimol. mixture thereof. This study describes the development of new chiral bifunctional ligands based on a binaphthyl scaffold which incorporates both a phosphine and a carboxylic acid moiety. The optimal ligand provided high yields and enantioselectivities for a desymmetrizing C(sp²)-H arylation leading to 5,6-dihydrophenanthridines, whereas the corresponding monofunctional ligands showed low enantioselectivities. The bifunctional system proved applicable to a range of substituted dihydrophenanthridines, and allowed the parallel kinetic resolution of racemic substrates.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C14H10O4S2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bryson, D. J. published the artcileFar infrared spectra of five-coordinate complexes, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Inorganic and Nuclear Chemistry Letters (1969), 5(5), 347-8, database is CAplus.

Examination of the spectra of complexes formed by the ligand 2-pyridine-carboxaldehyde 2′-pyridylhydrazone (paphy) in the region 400-150 cm.-1 indicates that a distinction may probably be made between 4, 5, and 6 coordination because of differences in frequencies of the peaks assignable to metal-halogen vibrations. The metal-halogen frequencies are presented for the 5-coordinate complexes: M(paphy)X2,M = β-Co, Mn, Zn, X = Cl, Br; the octahedral complexes: α-Co(paphy)Cl2, Ni(paphy)Cl2, and Ni-(paphy)Br2; and the tetrahedral pyridine complexes: M(py)2X2, X = Co, Zn, X = Cl, Br.

Inorganic and Nuclear Chemistry Letters published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem