Tag: M.W=150-200

Zhu, Yinggui published the artcileElectrogenerated chemiluminescence behavior of Tb complex and its application in sensitive sensing Cd²⁺, Safety of Pyridine-3-sulfonic acid, the publication is Electrochimica Acta (2017), 1-8, database is CAplus.

The authors report a novel rare earth metal complex with the weak ligand of aromatic sulfonic acid (pyridine-3-sulfonic acid, 3-pSO₃H), and characterized by FTIR, UV-visible, energy-dispersive x-ray spectroscopy (EDX), electrochemiluminescence spectra, etc. Then an excellent electrochemiluminescence (ECL) signal was observed with K₂S₂O₈ as the coreactant in NaAc-HAc buffer solution For another thing, the electrochem. properties of the compound were thoroughly studied in MeCN solution, the possible ECL reaction mechanism is proposed as well. Also, a simple and straightforward ECL platform is reported for sensitive and selective detection of Cd²⁺ due to the effective quenching after addition of Cd²⁺. Other heavy/transition metal ions do not interfere with the sensing. The limit of detection is determined as 0.13 nM, the results suggested that as-prepared complex could be a promising material for developing ECL sensors to detect the Cd²⁺ rapidly indwell in environmental and practical samples.

Electrochimica Acta published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C38H74Cl2N2O4, Safety of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yong published the artcileDiscovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents, HPLC of Formula: 39856-58-1, the publication is ACS Medicinal Chemistry Letters (2018), 9(11), 1117-1122, database is CAplus and MEDLINE.

The multi-functional cytokine TGFβ plays a central role in regulating antitumor immunity. It has been postulated that inhibition of TGFβ signaling in concert with checkpoint blockade will provide improved and durable immune response against tumors. Herein, we describe a novel series of 4-azaindole TGFβ receptor kinase inhibitors with excellent selectivity for TGFβ receptor 1 kinase. The combination of compound 3f and an antimouse-PD-1 antibody demonstrated significantly improved antitumor efficacy compared to either treatment alone in a murine tumor model.

ACS Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C39H35N5O8, HPLC of Formula: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Yan published the artcilePotassium tert-butoxide promoted regioselective deuteration of pyridines, Formula: C13H13N, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(21), 3497-3500, database is CAplus and MEDLINE.

A regioselective deuteration at the β- and γ-position of pyridines was reported. Efficient deuteration occurred with a combination of KO^tBu and DMSO-d₆, replenishing the prevailing α-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Formula: C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Obdyakov, V. F. published the artcileStabilization of palladium in homogeneous chlorideless catalysts of oxidation of olefins C₂-C₄ by oxygen into carbonyl compounds, HPLC of Formula: 636-73-7, the publication is Kataliz v Promyshlennosti (2007), 19-25, database is CAplus.

The first step of homogeneous oxidation of olefins C₂-C₄ by oxygen in the presence of catalyst Pd + GPK-x, were GPK-x is phosphovanadomolybdic heteropoly acid H_3+xPV^V_x Mo_12-xO₄₀, consist in reduction of GPK-x with olefin in the presence Pd-complexes at 30-60° into H_mGPK-x where m=[V^IV]_∑/[GKP-x] – is excellent reduction catalyst. In this case the redox-system Pd¹₂/Pd⁰₂ works and with increasing of temperature in converts into system Pd²⁺/Pd_MET with higher redox-potential. During this transformation interval of values m is diminished where the catalyst remained as homogeneous and from reduced solution metallic Pd begins to precipitate To prevent the Pd precipitation it needs to introduce in catalyst the stabilizers stable from oxidation As stabilizers can be used 3-pyridinesulfonic acid of more cheaper 2,6-pyridinecarboxylic (dipicolinic) acid (I). In the presence of the stabilizers the activity of catalyst is diminished but the area of its homogeneity will extend. Complexes of Pd with I are stable at temperatures of regeneration of catalyst (150-160°). Therefore I is considered as rather perspective stabilizer of Pd in catalysts Pd + GPK-x and can be used in industrial homogeneous processes of oxidation of olefins C₂-C₄ with oxygen.

Kataliz v Promyshlennosti published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liang, Ren-Xiao published the artcileEnantioselective Arylation of Tetrasubstituted Enamines: Access to Enantioenriched Indolenine and 1H-Indole Derivatives, Application of 2-Bromopyridin-3-amine, the publication is ACS Catalysis (2021), 11(3), 1827-1832, database is CAplus.

Palladium-catalyzed intramol. enantioselective β-arylation of tetrasubstituted endocyclic and exocyclic enamines was developed. A range of optically active medium-ring fused indolenines or 3,3′-spiroindolenines were achieved in enantiomeric ratios up to 98:2 with Cs₂CO₃ or K₃PO₄ as the base in the presence of chiral PHOX ligands. The use of Ag₃PO₄ as a base led to enantioenriched 1H-indoles in good enantiomeric ratios (up to 89:11) with (S)-DIFLUORPHOS as a chiral ligand, which proceeded via a possible domino enamine-isomerization/β-arylation sequence.

ACS Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zheng, Wei-Xiang published the artcileSynthesis of Aryl Ketones from Carboxylic Acids and Arylboronic Acids Using 2-Chloroimidazolium Chloride as a Coupling Reagent, Synthetic Route of 91-02-1, the publication is Synthesis, database is CAplus.

Carboxylic acids are an abundant and structurally diverse class of com. available materials, which are commonly used as stable reagents in organic synthesis. The Suzuki-Miyaura coupling reaction directly using carboxylic acid as a substrate has been rarely reported. Here, authors report an efficient coupling reaction of carboxylic acids with arylboronic acids in toluene in the presence of IPrCl-Cl, Pd(OAc)₂, PPh₃, and K₃PO₄·7H₂O at 90 °C to give the corresponding aryl ketones.

Synthesis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H10F2Si, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Anwei published the artcileMn(III) active site in hydrotalcite efficiently catalyzes the oxidation of alkylarenes with molecular oxygen, Computed Properties of 91-02-1, the publication is Molecular Catalysis (2021), 111276, database is CAplus.

Developing efficient heterogeneous catalytic systems based on easily available materials and mol. oxygen for the selective oxidation of alkylarenes is highly desirable. In the present research, NiMn hydrotalcite (Ni₂Mn-LDH) was found as an efficient catalyst in the oxidation of alkylarenes using mol. oxygen as the sole oxidant without any additive. Impressive catalytic performance, excellent stability and recyclability, broad applicable scope and practical potential for the catalytic system were observed Mn³⁺ species is proposed to be the efficient active site, and Ni²⁺ played an important role in stabilizing the Mn³⁺ species in the hydrotalcite structure. The kinetic study showed that the aerobic oxidation of diphenylmethane is a first-order reaction over Ni₂Mn-LDH with the activation energy (E_a) and pre-exponential factor (A₀) being 85.7 kJ mol^-1 and 1.8 x 10⁹ min^-1, resp. The Gibbs free energy (ΔG^≠) is -10.4 kJ mol^-1 K^-1 for the oxidation based on Eyring-Polanyi equation, indicating the reaction is exergonic. The mechanism study indicated that the reaction proceeded through both radical and carbocation intermediates. The two species were then trapped by mol. oxygen and H₂O or hydroxyl species, resp., to yield the corresponding products. The present research might provide information for constructing highly efficient and stable active site for the catalytic aerobic oxidation based on available and economic material.

Molecular Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H17NO2, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Lantao published the artcileAsymmetric Synthesis of Planar Chiral Ferrocenes by Enantioselective Intramolecular C-H Arylation of N-(2-Haloaryl)ferrocenecarboxamides, Application of 2-Bromopyridin-3-amine, the publication is Organic Letters (2014), 16(20), 5336-5338, database is CAplus and MEDLINE.

The palladium-catalyzed intramol. C-H arylation reaction of N-(2-bromoaryl)ferrocenecarboxamides furnishes planar chiral ferrocene derivatives TADDOL-derived phosphoramide ligands induce enantioselectivities ranging from 91:9 to 98:2 er.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Panteleev, Jane published the artcileDomino Rhodium-Catalyzed Alkyne Arylation/Palladium-Catalyzed N Arylation: A Mechanistic Investigation, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Angewandte Chemie, International Edition (2011), 50(39), 9089-9092, S9089/1-S9089/32, database is CAplus and MEDLINE.

We report an example in which two different metals with two different phosphine ligands promote two out of three possible reactions and do so in a time-resolved way, thus leading to an efficient preparation of dihydroquinolines. Importantly, we show that one of the two phosphine ligands is selective in binding to only one of the metals, and the other ligand is nondiscriminating in its binding properties; yet one of the two metal-phosphine complexes is far more reactive and selectivity is observed This study raised the more general question of matching ligands and metals in order to efficiently promote only the desired reaction rather than competing processes. Thus, complex sequences of reactions that contain multiple catalytically active species can ultimately be created in a single reaction vessel.

Angewandte Chemie, International Edition published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jia, Jing-jing published the artcileSynthesis, structure and magnetic analysis of the cobalt polymer based on N-[(3-pyridine)-sulfonyl]aspartate, Product Details of C5H5NO3S, the publication is Chinese Journal of Structural Chemistry (2017), 36(2), 266-272, database is CAplus.

One new cobalt polymer [Co(L)·3H₂O]_n (1, H₂L = N-[(3-pyridine)-sulfonyl]aspartate) has been synthesized and characterized by single-crystal x-ray diffraction and elemental anal. Polymer 1 belongs to the monoclinic system, space group P21/n with a = 11.479(2), b = 7.3180(15), c = 16.424(3) Å, β = 109.56(3) °, V = 1300.1(5) ų, M_r = 385.22, Z = 12, F(000) = 790, S = 1.054, R = 0.0670, wR = 0.1147,(Δρ)_max = 1.158 and (Δρ)_min = -0.754 e/ų. TGA showed that the polymer first lost one coordinated water mol. and then another two coordinated water mols. The values of the Curie and Curie-Weiss constants of polymer 1 are Cm = 2.67 cm³ mol^-1 K and θ = -21.66 K.

Chinese Journal of Structural Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem