Tag: M.W=150-200

Palav, Amey published the artcileRapid, chemoselective and mild oxidation protocol for alcohols and ethers with recyclable N-chloro-N-(phenylsulfonyl)benzenesulfonamide, Synthetic Route of 91-02-1, the publication is Tetrahedron Letters (2021), 153094, database is CAplus.

A sulfonimide reagent, N-chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) was identified as a mild and selective oxidant. Without activation, the reagent was proved to oxidize primary and secondary alcs. as well as their sym. and mixed ethers to corresponding aldehydes and ketones. With recoverable PS-TEMPO catalyst, selective oxidation over chlorination of primary and secondary alcs. and their ethers with electron-donating substituents was achieved. The reagent precursor of NCBSI was recovered quant. and can be reused for synthesizing NCBSI.

Tetrahedron Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hidalgo, M. published the artcileSurface-enhanced resonance Raman spectroscopy of 2-pyridylhydrazone and 1,10-phenanthroline chelate complexes with metal ions on colloidal silver, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1996), 318(2), 229-37, database is CAplus.

Surface-enhanced resonance Raman spectra (SERRS) of the complexes PAPH-Co(II), PAPH-Ni(II), PAPH-Fe(II), and PHEN-Fe(II) (PAPH = 2-pyridine carboxyaldehyde 2-pyridylhydrazone and PHEN = 1,10-phenanthroline) adsorbed on silver colloid have been studied. Differences among SERS spectra of ligands and SERRS spectra of complexes have been investigated. Ultra-sensitive methods for metal determination with limits of detection at the ng mL^-1 level are presented.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Laserna, J. J. published the artcileKinetic determination of cobalt by complexation with pyridine-2-aldehyde 2-pyridylhydrazone and ligand oxidation with bromate, Category: pyridine-derivatives, the publication is Mikrochimica Acta (1985), 2(5-6), 457-67, database is CAplus.

Optimum conditions are outlined for the kinetic determination of Co. The rate of disappearance of pyridine-2-aldehyde 2-pyridylhydrazone (PAPH) in acidic medium is monitored spectrophotometrically at 372 nm. The method is based on the modification of the oxidation rate by complexation of PAPH with Co ions. The detection limit was 0.25 μg/mL. Beer’s law was obeyed for 0.40-1.50 μg/mL.

Mikrochimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ohmura, Toshimichi published the artcileOrganocatalytic Diboration Involving “Reductive Addition” of a Boron-Boron σ-Bond to 4,4′-Bipyridine, Related Products of pyridine-derivatives, the publication is Journal of the American Chemical Society (2015), 137(8), 2852-2855, database is CAplus and MEDLINE.

A 4,4′-bipyridine-based catalyst system for diboration of pyrazine derivatives was established. The catalyst cycle consists of the following two steps: (1) reductive addition of the boron-boron bond of bis(pinacolato)diboron to 4,4′-bipyridine to form N,N’-diboryl-4,4′-bipyridinylidene and (2) oxidative boryl transfer from the intermediate to pyrazine to give N,N’-diboryl-1,4-dihydropyrazine with regeneration of 4,4′-bipyridine.

Journal of the American Chemical Society published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tolmachova, Kateryna A. published the artcile(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library, Recommanded Product: 2-Bromopyridin-3-amine, the publication is ACS Combinatorial Science (2018), 20(11), 672-680, database is CAplus and MEDLINE.

Multigram synthesis of (chlorosulfonyl)benzenesulfonyl fluorides is described. Selective modification of these building blocks at the sulfonyl chloride function under parallel synthesis conditions is achieved. It is shown that the reaction scope includes the use of (hetero)aromatic and electron-poor aliphatic amines (e.g., amino nitriles). Utility of the method is demonstrated by preparation of the sulfonyl fluoride library for potential use as covalent fragments, which is demonstrated by a combination of in silico and in vitro screening against trypsin as a model enzyme. As a result, several inhibitors were identified with activity on par with that of the known inhibitor.

ACS Combinatorial Science published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C19H14N2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schlesinger, Arthur H. published the artcilePreliminary evaluation of some quaternary ammonium salts as phytoxic agents, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Journal of Agricultural and Food Chemistry (1959), 33-4, database is CAplus.

cf. C.A. 46, 491f. Some 60 quaternary ammonium salts RR₁R₂R₃NX were prepared by standard chem. methods. Many of these salts exhibited considerable phytotoxicity in seed-germination tests. In a series of 1-substituted pyridinium bromides, maximum phytotoxicity was noticed when R was C₁₂ to C₁₄. Other active types of similar compounds are also mentioned. Lack of selectivity towards mono- or dicotyledeuous species is evident from these examples.

Journal of Agricultural and Food Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lessing, Timo published the artcileActivation-free one-pot alkynylation-cyclization synthesis of 2-substituted 4-azaindoles and indoles, Application In Synthesis of 39856-58-1, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2018), 54(3), 334-338, database is CAplus.

2-Substituted 4-azaindoles and indoles were rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation-cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Frankish, Neil H. published the artcileThe indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis, Computed Properties of 2215-33-0, the publication is Journal of Pharmacy and Pharmacology (2018), 70(1), 101-110, database is CAplus and MEDLINE.

Objectives : Compounds PH2 and PH5 are distereoisomers of novel indane compounds, synthesized as analogs of secondary metabolites of the fern, Onychium. In this study, we compare their effects on a variety of inflammatory models. Methods : In an effort to extend our knowledge of their anti-inflammatory profile, we have investigated their activity in two models of delayed-type hypersensitivity (DTH); the methylated bovine serum albumin model (mBSA) and the oxazolone contact hypersensitivity (CHS) model, on IL2 release from Jurkat cells and in the dextran sulfate sodium (DSS) murine model of inflammatory bowel disease. Key findings : Both diastereoisomers are equipotent in reducing paw swelling in the mBSA model and in inhibiting interleukin (IL) 2 release from Jurkat cells. They are equally ineffective in the oxazolone contact hypersensitivity model (CHS). Only the diastereoisomer, PH5, protects against DSS-induced colitis and of its two enantiomers, only the S,S-enantiomer, PH22, possesses this activity. PH2 is ineffective in the DSS model. Conclusions : The results suggest that the beneficial effect of PH5, and its enantiomer PH22, in the DSS model is a consequence of an action on a target specific to the colitis model. The implications of such data suggest an unknown target in this disease model that may be exploited to therapeutic advantage.

Journal of Pharmacy and Pharmacology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Georgiou, Charis published the artcilePushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders, Formula: C5H5BrN2, the publication is Journal of Molecular Biology (2017), 429(16), 2556-2570, database is CAplus and MEDLINE.

Fragment-based drug discovery is an increasingly popular method to identify novel small-mol. drug candidates. One of the limitations of the approach is the difficulty of accurately characterizing weak binding events. This work reports a combination of X-ray diffraction, surface plasmon resonance experiments and mol. dynamics simulations for the characterization of binders to different isoforms of the cyclophilin (Cyp) protein family. Although several Cyp inhibitors have been reported in the literature, it has proven challenging to achieve high binding selectivity for different isoforms of this protein family. The present studies have led to the identification of several structurally novel fragments that bind to diverse Cyp isoforms in distinct pockets with low millimolar dissociation constants A detailed comparison of the merits and drawbacks of the exptl. and computational techniques is presented, and emerging strategies for designing ligands with enhanced isoform specificity are described.

Journal of Molecular Biology published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Radunsky, Christian published the artcileA Family of Hydrazone-Based Nucleosides for Use in Metal-Mediated Base Pairs, COA of Formula: C11H10N4, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2013), 639(8-9), 1621-1627, database is CAplus.

A new family of hydrazone-based nucleosides for use in metal-mediated base pairs was devised. The artificial nucleobases are derivatives of the papy ligand (papy = pyridinecarboxaldehyde-2′-pyridylhydrazone). By replacing the pendant pyridine moiety in papy by furan and thiophene, resp., tridentate nucleosides with N, N, N-, N, N, O- and N, N, S-donor sites were obtained. As only a few transition metal complexes with pendant furan ligands are reported, a model nucleobase (furancarboxaldehyde-2′-pyridylhydrazone) for the N,N,O-donor nucleoside was synthesized. The mol. structures of its Cu²⁺, Ni²⁺, and Co²⁺ complexes are reported. In all complexes, only weak M-O(furan) bonding is observed The Co²⁺ complex displays a pentagonal bipyramidal coordination arrangement. In general, the structures of the metal complexes suggest that the resp. nucleosides can be applied in metal-mediated base pairs.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem