Tag: M.W=150-200

Zeng, Kui published the artcileDirect nitrogen interception from chitin/chitosan for imidazo[1,5-a]pyridines, Name: Phenyl(pyridin-2-yl)methanone, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(41), 6068-6071, database is CAplus and MEDLINE.

A catalyst-free one-pot methodol. that enable direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed. This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands. In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines were unprecedentedly synthesized by this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C15H24S, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Makinen, Silja K. published the artcileHighly selective guest uptake in a silver sulfonate network imparted by a tetragonal to triclinic shift in the solid state, Formula: C5H5NO3S, the publication is Chemistry – A European Journal (2001), 7(23), 5176-5182, database is CAplus and MEDLINE.

The Ag sulfonate network presented herein, Ag 3-pyridinesulfonate, reversibly and selectively absorbs MeCN while undergoing a major structural rearrangement. The origin of this structural flexibility is a coupling of the weak coordinating ability of the SO₃ group with the geometrically pliant Ag(I) center. Single crystal and powder x-ray structures of both the desolvated and solvated forms are presented in addition to the mechanism of their reversible interconversion. A heterogeneous gas chromatog. study showing selective extraction of the MeCN is also presented. Extended solid frameworks which reorder to any extent are not common but the structure presented herein transforms from a tetragonal to a triclinic crystal system. The results indicate that cooperative interactions in systems based on supposedly weaker interactions can yield softer yet functional networks with behavior unlike that observed in more rigid inorganic frameworks.

Chemistry – A European Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Lei published the artcilePalladium(0)-catalyzed asymmetric C(sp³)-H arylation using a chiral binol-derived phosphate and an achiral ligand, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Chemical Science (2017), 8(2), 1344-1349, database is CAplus and MEDLINE.

The first efficient palladium(0)-catalyzed enantioselective C(sp³)-H activation reaction using a catalytic chiral base and an achiral phosphine ligand was reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.

Chemical Science published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C16H20N2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hoepping, Alexander published the artcileAn alternative synthesis of sodium cyanodithioformate and the disodium salt of cis-1,2-dicyanoethylene-1,2-dithiol, Category: pyridine-derivatives, the publication is Journal fuer Praktische Chemie/Chemiker-Zeitung (1998), 340(3), 269-270, database is CAplus.

A new synthesis of Na cyanodithioformate and the disodium salt of cis-1,2-dicyanoethylene-1,2-dithiol is reported. The key step involves a nucleophilic thiolation with elemental S starting from a substituted acetonitrile. This method may serve as a cyanide- and CS₂-free alternative in the preparation of the title compounds

Journal fuer Praktische Chemie/Chemiker-Zeitung published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Galli, Ubaldina published the artcileIdentification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2, Application of Pyridine-3-sulfonic acid, the publication is European Journal of Medicinal Chemistry (2012), 58-66, database is CAplus and MEDLINE.

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogs of nicotinamide. Biol. data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

European Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nevskaya, Alisa A. published the artcileSynthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines, Product Details of C12H9NO, the publication is Tetrahedron Letters (2021), 153552, database is CAplus.

An efficient approach to the synthesis of indolizines and pyrrolo[2,1-a]isoquinolines based on a domino reaction was described. The reactivity of the derivatives and the structure-activity anal. are carried out in a number of the obtained compounds A hit was found showing high cytotoxicity on tumor cells whose cytotoxic effect was comparable to that of the known topoisomerase I inhibitor camptothecin.

Tetrahedron Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kowol, Christian R. published the artcileImpact of Stepwise NH₂-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention, Safety of 2-Bromopyridin-3-amine, the publication is Journal of Medicinal Chemistry (2016), 59(14), 6739-6752, database is CAplus and MEDLINE.

One of the most promising classes of iron chelators are α-N-heterocyclic thiosemicarbazones with Triapine as the most prominent representative. In several clin. trials Triapine showed anticancer activity against hematol. diseases, however, studies on solid tumors failed due to widely unknown reasons. Some years ago, it was recognized that “terminal dimethylation” of thiosemicarbazones can lead to a more than 100-fold increased activity, probably due to interactions with cellular copper depots. To better understand the structural requirements for the switch to nanomolar cytotoxicity, we systematically synthesized all eight possible N-methylated derivatives of Triapine and investigated their potential against Triapine-sensitive as well as -resistant cell lines. While only the “completely” methylated compound exerted nanomolar activity, the data revealed that all compounds with at least one N-dimethylation were not affected by acquired Triapine resistance. In addition, these compounds were highly synergistic with copper treatment accompanied by induction of reactive oxygen species and massive necrotic cell death.

Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Neudeck, Sven published the artcileNew Powerful and Oxidatively Rugged Dinuclear Ru Water Oxidation Catalyst: Control of Mechanistic Pathways by Tailored Ligand Design, Name: Pyridine-3-sulfonic acid, the publication is Journal of the American Chemical Society (2014), 136(1), 24-27, database is CAplus and MEDLINE.

A new powerful and oxidatively rugged pyrazolate-based water oxidation catalyst of formula {[Ru^II(py-SO₃)₂(H₂O)]₂(μ-Mebbp)}^–, 1(H₂O)₂^–, has been prepared and thoroughly characterized spectroscopically and electrochem. This new catalyst has been conceived based on a specific ligand tailoring design, so that its performance has been systematically improved. It was also demonstrated how subtle ligand modifications cause a change in the O-O bond formation mechanism, thus revealing the close activation energy barriers associated with each pathway.

Journal of the American Chemical Society published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chowdhury, Santanu published the artcileA new luminescent sulfate bridged dimeric copper(II) complex with DNA binding and SO₂ fixation ability: Synthesis and structure, Computed Properties of 2215-33-0, the publication is Polyhedron (2009), 28(17), 3863-3871, database is CAplus.

New luminescent mononuclear and dinuclear Cu(II) (S = 1/2) complexes [Cu(HL)(H₂O)₂](ClO₄)₂ (1a) and [Cu₂(HL)₂(μ-SO₄)₂]·2H₂O (1b) were synthesized with the acyclic tridentate pyridine-2-carboxaldehyde-2-pyridylhydrazone ligand, HL (1). The mononuclear complex 1a can be converted into the disulfate bridged dimeric Cu(II) complex 1b by passing freshly prepared SO₂ through the basic medium. On excitation at 290 nm, the ligand fluoresces at 364 nm due to an intraligand ¹(π-π^_*) transition. Upon complexation with Cu(II), the emission peak is slightly blue shifted (356 nm, F/F ₀ 0.76 for 1a and 354 nm, F/F ₀ 0.89 for 1b) with a little quenching in the emission intensity. The association constants (K_ass (5.06 ± 0.004) × 10⁴ for 1a and K_ass (5.46 ± 0.006) × 10⁴ for 1b at 298 K) and the thermodn. parameters were determined by UV-visible spectroscopy. The mol. structure of the complex 1b (Cu···Cu 4.456 Å) was determined by single crystal x-ray diffraction studies. The complex 1b exhibits a strong interaction towards DNA as revealed from the K_b (intrinsic binding constant) 6.3 × 10⁴ M^-1 and K_sv (Stern-Volmer quenching constant) 2.93 values.

Polyhedron published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fathi, Ahlam M. published the artcileCharacteristics of multidentate Schiff base ligand and its complexes using cyclic voltammetry, fluorescence, antimicrobial behavior and DFT-calculations, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Journal of Molecular Structure (2021), 129263, database is CAplus.

The electrochem. behavior of a series of the metal complexes [Fe(III), Ni(II), Ru(III),Pd(II) and Hf(IV)] derived from the Schiff base ligand (E)-5-((phenyl(-pyridin-2-yl)methylene)amino)pyrimidine-2,4(1H,3H)-dione (H₂L) which was previously prepared from condensation of 5-aminouracil and 2-benzoylpyridine was studied by using cyclic voltammetric technique. The Schiff base ligand H₂L and its metal complexes exhibited quasi-reversible oxidation-reduction with three electron transfer and it was suggested that their reactions on the platinum surface electrode are not purely diffusion controlled but also under adsorption control. The redox reactive sites of the H₂L and its complexes were located via the geometry optimization and frequency calculations using d. functional theory (DFT) at the B3LYP/LanL2DZ level of theory. In addition, the Schiff base ligand and its metal complexes exhibit fluorescent properties. The antimicrobial activity of the Schiff base ligand H₂L and its metal complexes was tested against Gram-pos. bacteria (Staphylococcus aureus and Bacillus cereus), Gram-neg. bacteria (E. coli and Pseudomonas aeruginosa) and fungal strain (Aspergillus niger) by using agar well-diffusion method. The microbial testes of the ligand (H₂L) and its metal complexes exhibited good inhibition efficiency to prevent growth of bacteria.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem