Tag: M.W=150-200

Abinaya, R. published the artcileVisible light mediated selective oxidation of alcohols and oxidative dehydrogenation of N-heterocycles using scalable and reusable La-doped NiWO₄ nanoparticles, Computed Properties of 91-02-1, the publication is Green Chemistry (2021), 23(16), 5990-6007, database is CAplus.

Visible light-mediated selective and efficient oxidation of various primary benzyl alcs. RCH₂OH (R = Ph, 2-bromophenyl, pyridin-2-yl, etc.)/secondary benzyl alcs. such as 1-(phenyl)-ethanol, diphenylmethanol, 1-phenylethane-1,2-diol, etc. to aldehydes RCHO/ketones such as acetophenone, benzophenone, chalcone, etc. and oxidative dehydrogenation (ODH) of partially saturated heterocycles using a scalable and reusable heterogeneous photoredox catalyst in aqueous medium are described. A systematic study led to a selective synthesis of aldehydes under an argon atm. while the ODH of partially saturated heterocycles under an oxygen atm. resulted in very good to excellent yields. The methodol. is atom economical and exhibits excellent tolerance towards various functional groups, and broad substrate scope. Furthermore, a one-pot procedure was developed for the sequential oxidation of benzyl alcs. and heteroaryl carbinols I (R¹ = H, C(O)OMe) followed by the Pictet-Spengler cyclization and then aromatization to obtain the β-carbolines II in high isolated yields. This methodol. was found to be suitable for scale up and reusability. To the best of our knowledge, this is the first report on the oxidation of structurally diverse aryl carbinols and ODH of partially saturated N-heterocycles e.g., III using a recyclable and heterogeneous photoredox catalyst under environmentally friendly conditions.

Green Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hou, Zhong-Wei published the artcileElectrochemical Synthesis of Polycyclic N-Heteroaromatics through Cascade Radical Cyclization of Diynes, Recommanded Product: 2-Bromopyridin-3-amine, the publication is ACS Catalysis (2017), 7(9), 5810-5813, database is CAplus.

An electrochem. cyclization reaction of easily available urea-tethered diynes was developed for the synthesis of N-doped polycyclic aromatic hydrocarbons (PAHs). The employment of ferrocene as a mild and selective redox catalyst allows access to a variety of electron-rich PAHs including helicene-like structures without overoxidn. The electrosynthetic method involves an unprecedented amidyl radical cascade cyclization process to form three rings in a single operation.

ACS Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileReactions between technetium(VII) and some hydrazones and the spectrofluorometric determination of technetium(VII) with 2,2′-dipyridyl ketone hydrazone, Product Details of C11H10N4, the publication is Analytica Chimica Acta (1984), 71-8, database is CAplus.

The reactions between pertechnetate and 5 hydrazones are described. Of these, the Tc(VII)/2,2′-dipyridyl ketone hydrazone system was found to be most sensitive, and was studied in detail. Spectrofluorometric procedures for the determination of Tc(VII) over the range 0.01-12 mg L^-1 are reported. The reaction proceeds most favorably under acidic conditions (1.4M HCl). For 1 mg L^-1 Tc(VII), 100 mg L^-1 levels of U(VI), Re(VII), Mo(VI), or W(VI) do not interfere when the reaction proceeds at room temperature Sensitivity improves at higher temperatures

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileFluorometric reaction-rate method for determination of mercury with 2,2′-dipyridyl ketone hydrazone, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Microchemical Journal (1985), 32(3), 367-72, database is CAplus.

A simple and sensitive fluorometric reaction-rate method for determination of Hg(II) (0.03-0.3 ppm), based on its catalytic effect on the autoxidation of 2,2′-dipyridyl ketone hydrazone, was developed. The reaction is followed by the measurement of the rate of appearance of the blue fluorescence (λ_ex = 359, λ_em = 430 nm). The exptl. variables and interferences in the determination are also reported.

Microchemical Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileDetermination of cobalt(II) by use of a very simple monitored thermometric technique based on the action of this cation on the aerial oxidation of 2,2′-dipyridyl ketone hydrazone, Quality Control of 2215-33-0, the publication is Journal of Thermal Analysis (1984), 29(6), 1397-402, database is CAplus.

Co(II) 0.1-0.9 ppm was determined by catalysis of autoxidation of 1.0mM di(2-pyridyl) ketone hydrazone at pH 12 (Clark-Lubs buffer), monitored by thermometry. The relative standard deviation was 2.1%. The selectivity was good.

Journal of Thermal Analysis published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Decristoforo, Clemens published the artcile99M-technetium-labelled peptide-HYNIC conjugates: Effects of lipophilicity and stability on biodistribution, Computed Properties of 636-73-7, the publication is Nuclear Medicine and Biology (1999), 26(4), 389-396, database is CAplus and MEDLINE.

The aim of this study was to explore the effects of lipophilicity and stability on the biodistribution of ^99mTc labeled peptides through the use of different co-ligands. 6-Hydrazinopyridine-3-carboxylic acid (HYNIC) was coupled to the somatostatin analog RC160 and radiolabeled using a range of ethylenediaminediacetic acid (EDDA) and EDTA derivatives as well as tricine and pyridine/tricine as co-ligands. After labeling with technetium-99m, chromatog., stability, protein-binding, and rat biodistribution studies were performed. For most co-ligands, biodistribution correlated well with in vitro properties. Lipophilic substitution on EDDA resulted in higher protein binding, increased liver uptake, and intestinal excretion. Stabilization of tricine with pyridines reduced blood levels and lowered liver uptake. EDTA derivatives showed high instability in vitro and in vivo.

Nuclear Medicine and Biology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Deng, Tianning published the artcileOxidation of Non-Activated Anilines to Generate N-Aryl Nitrenoids, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Journal of the American Chemical Society (2020), 142(9), 4456-4463, database is CAplus and MEDLINE.

A low temperature, protecting group-free oxidation of 2-substituted anilines was developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to constructed functionalized N-heterocycles. Exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol % of Sc(OTf)₃ triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrated the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones.

Journal of the American Chemical Society published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Hong-hong published the artcileSynthesis and catalytic esterification of a novel solid acid catalyst 3-pyridine sulfonic acid-phosphomolybdic acid, Category: pyridine-derivatives, the publication is Huaxue Shiji (2016), 38(6), 506-510, database is CAplus.

A novel solid acid was synthesized by the reaction of 12-molybdophosphoric acid (HPM) with 3-pyridine sulfonic acid (PSA) and confirmed by X-ray powder diffraction, FT-IR, TG and potentiometric titration Then the solid acid was employed for esterification to evaluate its acid-catalytic activity. Various reaction parameters, including methanol/oleic acid molar ratio, catalyst dosage, reaction temperature and time were systematically examined These results indicated that the prepared catalyst maintained the Keggin structure of the raw HPM, and exhibited good thermal stability and higher acidity. The catalyst exhibited excellent catalytic activity in esterification and good reusability. 96.5% Conversion of oleic acid was obtained under the following conditions: mole ratio of alc. to acid 7:1, the reaction temperature 80°C, catalyst amount 10 wt% of the weight of oleic acid and the reaction time 5 h. After the fourth recycling, there was no obvious change in phase and Keggin structure for the catalysts.

Huaxue Shiji published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C9H22OSi, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pu, Chunlan published the artcileDesign, synthesis and biological evaluation of indole derivatives as Vif inhibitors, Application of 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(17), 4150-4155, database is CAplus and MEDLINE.

In this article, design, synthesis and biol. evaluation of indole derivatives as viral infectivity factor (Vif) inhibitors is reported. Fragment-based virtual screening (FBVS) was conducted and a series of fragments was obtained, among which, 5-(pyridin-2-yl)-1H-indole can form H-bonds with Tyr148 and Ile155 and based on this fragment other indole derivatives were synthesized. Through the immune-fluorescence staining and Western blot assays, 3-(1H-indol-5-yl)pyridin-6-amine (I) shows potent activity in inhibiting Vif-mediated A3G degradation Further docking experiment shows that compound I form H-bond interactions with residues His139, Tyr148 and Ile155. Therefore, I is a promising lead compound against Vif that can be used to treat AIDS.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Feng published the artcileHydrogen bonding effects on topological structures of two supramolecular transition metal coordination complexes based on organosulphonate ligands, Formula: C5H5NO3S, the publication is Inorganic Chemistry Communications (2010), 13(5), 656-658, database is CAplus.

The syntheses, x-ray crystal structures and topol. analyses of two supramol. coordination complexes, [Co(H₂O)₄(ps)₂] 1 and [Cu(H₂O)₂(ps)₂] 2 (ps^– = pyridine-3-sulfonic anion), are reported. Although the basic coordination environments and patterns around the metal centers of 1 and 2 are similar, the overall topologies of the two complexes are very different due to the formation of distinct hydrogen bonding interactions resulting from organosulfonate ligands.

Inorganic Chemistry Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem