Tag: M.W=150-200

Qin, Mingze published the artcileDiscovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents, Recommanded Product: Methyl 4-chloropicolinate, the main research area is urea triazole antitumor neoplasm; Antitumor activity; Diaryl ureas; Organic synthesis; Structure-activity relationship.

Herein, the authors report a novel series of diaryl urea derivatives bearing a triazole moiety, from which potent antitumor agents have been identified. With a modified triazole, most compounds showed high level activity in both cellular and enzymic assays, accompanied with a suitable ClogD7.4 value. The most active compound, I, effectively suppressed proliferation of HT-29, H460 and MDA-MB-231 cancer cells, with IC50 values of 0.90, 0.85 and 1.54 μM, resp. Compound I also exhibited significant inhibition of tyrosine kinases including c-Kit, RET and FLT3. Furthermore, compound I could obviously induce apoptosis of HT-29 cells in a concentration-dependent manner. The study of structure-activity relationships also revealed that a hydrophilic tail at the 4-position of the triazole was crucial for high activity of the compound

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Recommanded Product: Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ren, Hang published the artcileVersatile synthesis and biological evaluation of novel 3′-fluorinated purine nucleosides, Category: pyridine-derivatives, the main research area is Suzuki Stille coupling nucleoside fluororibose human aminopurine preparation antitumor; 3’-fluororibonucleoside; 6-substituted purine; anticancer; purine nucleoside; synthesis.

A unified synthetic strategy accessing novel 3′-fluorinated purine nucleoside derivatives and their biol. evaluation were achieved. Novel 3′-fluorinated analogs were constructed from a common 3′-deoxy-3′-fluororibofuranose intermediate. Employing Suzuki and Stille cross-coupling reactions, fifteen 3′-fluororibose purine nucleosides, e.g. I, and eight 3′-fluororibose 2-chloro/2-aminopurine nucleosidese, e.g. II, with various substituents at position 6 of the purine ring were efficiently synthesized. Furthermore, 3′-fluorine analogs of natural products nebularine and 6-methylpurine riboside were constructed via our convergent synthetic strategy. Synthesized nucleosides were tested against HT116 (colon cancer) and 143B (osteosarcoma cancer) tumor cell lines. We have demonstrated 3′-fluorine purine nucleoside analogs display potent tumor cell growth inhibition activity at sub- or low micromolar concentration

Beilstein Journal of Organic Chemistry published new progress about Antitumor agents. 917471-30-8 belongs to class pyridine-derivatives, name is (5-(Prop-1-yn-1-yl)pyridin-3-yl)boronic acid, and the molecular formula is C8H8BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhong, Lili published the artcileSynthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities, Application In Synthesis of 24484-93-3, the main research area is sorafenib deuterium anticancer agent cervical carcinoma; Antitumor activities; Deuterium substitution; Pharmacokinetics; Sorafenib.

Deuterium substitution has been widely known that can improve the pharmacokinetic profiles due to isotope effect. Herein, a series of deuterated sorafenib derivatives have been synthesized and characterized by 1H NMR, 13C NMR and MS. Their antitumor activities were evaluated in vitro against human hepatoma cell line HepG2 and human cervical carcinoma cell line HeLa. The LogP values were detected by high-performance liquid chromatog. Subsequently, the metabolic stability and pharmacokinetics study were assessed in vitro and in vivo.

Molecular Diversity published new progress about Antitumor agents. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Application In Synthesis of 24484-93-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

El-Damasy, Ashraf Kareem published the artcileDesign and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities, Name: Methyl 4-chloropicolinate, the main research area is benzothiazole amide preparation Raf kinase inhibitory anticancer activity; urea benzothiazole preparation Raf kinase inhibitory anticancer activity; Amide; Anticancer activity; B-Raf(V600E); Benzothiazole; C-Raf; Pyridylamide; Urea.

A new series of benzothiazole amide and urea derivatives tethered with the privileged pyridylamide moiety by ether linkage at the 6-position of benzothiazole (22 final compounds) has been designed and synthesized as potent anticancer sorafenib analogs. A selected group of twelve derivatives was appraised for its antiproliferative activity over a panel of 60 human cancer cell lines at a single dose concentration of 10 μM at National Cancer Institute (NCI, USA). Some compounds exhibited promising growth inhibitions and thus were further tested in advanced 5-dose testing assay to determine their GI50 values. The cellular based assay results revealed that 3,5-bis-trifluoromethylphenyl urea derivative I is the best derivative with superior potency and efficacy compared to sorafenib as well as notable extended spectrum activity covering 57 human cancer cell lines. Kinase screening of compound I showed its kinase inhibitory effect against both B-RafV600E and C-Raf. Moreover, the most potent derivatives in cells were investigated for their RAF inhibitory activities, and the results were rationalized with the mol. docking study. Profiling of CYP450 and hERG channel inhibitory effects for the active compounds revealed their low possibilities to exhibit undesirable drug-drug interactions and cardiac side effects.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Name: Methyl 4-chloropicolinate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Mingze published the artcileDesign and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents, SDS of cas: 24484-93-3, the main research area is triazolylpyridine dimethylaminoethyl preparation antitumor agent; 4-(2-(Dimethylamino)ethyl)-4H-1,2,4-triazole; Antitumor activity; Synthesis.

New 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridine derivatives were synthesized and evaluated for their in vitro cytotoxicity against five cancer cell lines namely MKN-45, H460, HT-29, A549, and U87MG, as well as the normal cell line WI-38. Nearly all the compounds exhibited superior potency to sorafenib with a better selectivity towards the MKN-45, H460, and HT-29 cell lines. In addition, the enzymic screening result demonstrated that the optimized compounds possessed potent Raf kinase inhibition as well as favorable enzyme selectivity. The most promising compound, I, showed high levels of cytotoxicity against MKN-45, H460, and HT-29 cells with IC50 values of 51, 72, and 130 nM, resp., which are 45.5, 30.4, and 27.8 folds higher than the corresponding IC50 values for sorafenib against these cell lines. Structure-activity relationships revealed that the dimethylaminoethyl group was crucial for high activity.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, SDS of cas: 24484-93-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beaulieu, Pierre L. published the artcileStructure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype, HPLC of Formula: 81565-19-7, the main research area is crystal structure quinazolinone preparation hepatitis virus polymerase inhibitor antiviral.

The authors describe the structure-based design of a novel lead chemotype that binds to thumb pocket 2 of HCV NS5B polymerase and inhibits cell-based gt1 subgenomic reporter replicons at sub-micromolar concentrations (EC50 <200 nM). This new class of potent thumb pocket 2 inhibitors features a 1H-quinazolin-4-one scaffold derived from hybridization of a previously reported, low affinity thiazolone chemotype with the recently described anthranilic acid series. Guided by x-ray structural information, a key NS5B-ligand interaction involving the carboxylate group of anthranilic acid based inhibitors was replaced by a neutral two-point hydrogen bonding interaction between the quinazolinone scaffold and the protein backbone. The in vitro ADME and in vivo rat PK profile of representative analogs are also presented and provide areas for future optimization of this new class of HCV polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 81565-19-7 belongs to class pyridine-derivatives, name is 3-Chloro-4-(trifluoromethyl)pyridine, and the molecular formula is C6H3ClF3N, HPLC of Formula: 81565-19-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gardner, Evan J. published the artcileTris(pyrazolyl)borate Copper Hydroxide Complexes Featuring Tunable Intramolecular H-Bonding, Application In Synthesis of 24484-93-3, the main research area is crystal structure copper pyrazolylborate pendant heterocycle arm; copper pyridyl pyrimidyl pyrazolylborate preparation intramol hydrogen bonding.

A modular synthesis provides access to new tris(pyrazolyl)borate ligands XpyMeTpK that possess a single functionalized pendant pyridyl (py) or pyrimidyl (pyd) arm designed to engage in tunable intramol. H-bonding to metal-bound functionalities. To illustrate such H-bonding interactions, [XpyMeTpCu]2(μ-OH)2 (6a-6e) complexes were synthesized from the corresponding XpyMeTpCu-OAc (5a-5e) complexes. Single crystal x-ray structures of three new dinuclear [XpyMeTpCu]2(μ-OH)2 complexes reveal H-bonding between the pendant heterocycle and bridging hydroxide ligands while the donor arm engages the Cu center in an unusual monomeric DMAPMeTpCu-OH complex. Vibrational studies (IR) of each bridging hydroxide complex reveal reduced νOH frequencies that tracks with the H-bond accepting ability of the pendant arm. Reversible protonation studies that interconvert [XpyMeTpCu]2(μ-OH)2 and [XpyMeTpCu(OH2)]OTf species indicate that the acidity of the corresponding aquo ligand decreases with increasing H-bond accepting ability of the pendant arm.

Inorganic Chemistry published new progress about Crystal structure. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Application In Synthesis of 24484-93-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Armaghan, Mahsa published the artcileIsolation of first row transition metal-carboxylate zwitterions, Synthetic Route of 24484-93-3, the main research area is first row transition metal carboxylate zwitterion hydroxymethylpyridylbenzoate preparation; crystal structure first row transition metal carboxylate zwitterion hydroxymethylpyridylbenzoate.

Zwitterionic 3d metal carboxylates of Zn(II), Cu(II), Ni(II) and Co(II) were isolated and structurally authenticated by x-ray crystallog. 2-Hydroxymethylpyridine-carboxylate ligands with different sizes and shapes demonstrate variable coordination modes with first row transition metals under different conditions, yielding a class of 17 complexes, predominantly zwitterions. The nature of the ligands permits the carboxylates to be uncoordinated, anionic and conjugated, thereby balancing the pos. charges on the metal centers.

RSC Advances published new progress about Crystal structure. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, Synthetic Route of 24484-93-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yuan, Yu-Chang published the artcileMetal-Free Catalyzed Synthesis of Fluorescent Indolizine Derivatives, Computed Properties of 91-02-1, the publication is Journal of Organic Chemistry (2021), 86(18), 12737-12744, database is CAplus and MEDLINE.

A mild and high efficient method to prepare indolizines such as I [R = H, Me; R¹ = Me, Ph, CH₂CH₂CO₂Et; R² = H, Me, OEt; R³ = Me, Ph, 4-ClC₆H₄; R¹R² = (CH₂)₃] by two-component reaction with the acid as the catalyst was developed. In this reaction, a new ring efficiently formed in one-step reaction. A wide range of substrates could be applied and the desired products were obtained in 8-95% yields under metal-free conditions. Different indolizine derivatives I were synthesized by general conditions and microwave irradiation conditions, and compound I [R = H, R¹ = Me, R² = H, R³ = Ph] gave the best results with an isolated yield of 95% and 82%, resp. The structures of synthesized compounds I were characterized by spectral anal., and compound I [R = H, R¹R² = (CH₂)₃, R³ = 4-ClC₆H₄] was confirmed by single crystal X-ray anal. UV-vis absorption and fluorescence properties of these compounds I were correlated with substituent groups on indolizine rings.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C8H14O2, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhu, Shan-Shan published the artcilePolymerization-Enhanced Photocatalysis for the Functionalization of C(sp³)-H Bonds, Safety of Phenyl(pyridin-2-yl)methanone, the publication is ACS Catalysis (2022), 12(1), 126-134, database is CAplus.

A series of conjugated polymeric photocatalysts (CPPs) based on 1,2,3,5-tetrakis(carbazol-9-yl)4,6-dicyanobenzene (4CzIPN) were synthesized via nucleophilic substitution reaction and Sonogashira-Hagihara coupling. Among the as-prepared CPPs (CPP1-CPP6), CPP3 [the copolymer of a tetrakis(dibromocarbazolyl)isophthalonitrile with 1,3,5-triethynylbenzene] was selected as the optimized heterogeneous photocatalyst for visible-light-driven functionalization of C(sp³)-H bonds to synthesize 87 final products with yields up to 99%. The heterogeneous photocatalyst CPP3 is easily recovered from the reaction with excellent retention of photocatalytic activity, which can be reused at least for five times. Time-dependent d. functional theory (TD-DFT) calculations demonstrate that the photocatalysis performance of CPP3 is superior to the corresponding monomer 4CzIPN because of the enhanced intersystem crossing (ISC) process. Spin-orbit coupling calculations prove that the rate constant of ISC outcompetes that of reverse intersystem crossing (RISC). The rapidly generated and long-lived triplet state T₁ is considered to be a more accessible excited state than the singlet-state S₁ generated from either direct excitation or RISC. The successful application of this polymerization-enhanced photocatalysis strategy should guide a metal-free approach to the rational design of CPP-type heterogeneous photocatalysts to address the dilemma of homogeneous photocatalysts in sustainability, stability, and recyclability.

ACS Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C19H34ClN, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem