Tag: M.W=150-200

Gunaga, Prashantha published the artcileSelective I_Kur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide, HPLC of Formula: 636-73-7, the publication is Journal of Medicinal Chemistry (2017), 60(9), 3795-3803, database is CAplus and MEDLINE.

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (I) as a potent I_Kur current blocker with selectivity vs. hERG, Na and Ca channels and an acceptable preclin. PK profile. On further characterization in vivo, Compound I demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2′ position for a series of close analogs by employing hydrogen bond donors. As a result, 5-(5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide (II) was identified as the lead compound in this series. Compound II showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clin. candidate. Further optimization of II to mitigate pH dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile.

Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Qiu, Zhi-Hui published the artcilecatena-Poly[[diaquamanganese(II)]-di-μ-pyridine-3-sulfonato-κ²N:O;κ²O:N], Quality Control of 636-73-7, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(6), m765, m765/1-m765/7, database is CAplus and MEDLINE.

In the title polymeric complex, [Mn(C₅H₄NO₃S)₂(H₂O)₂]_n, the Mn atom is located on a center of inversion and is coordinated by two O atoms and two N atoms derived from four different pyridine-3-sulfonate (pySO₃) ligands, and two O atoms derived from two H₂O mols. in a distorted trans-N₂O₄ octahedral geometry. The metal atoms are bridged by the pySO₃ ligands to form a 1-dimensional chain. The chains are further connected into a three-dimensional architecture via H bonds. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Bingyang published the artcilePorous organic polymer-supported manganese catalysts with tunable wettability for efficient oxidation of secondary alcohols, Application of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Catalysis (2022), 87-95, database is CAplus.

Porous organic polymers (POPs) feature high surface areas, tunable components, and designable hierarchical pores, thus showing versatile applications including catalysis, separation, gas storage and so on. However, the inherently hydrophobic property may be unfavorable for the catalytic reaction that involves hydrophilic reactants. By using the hydrophilic principle of the amide bond, R-NH-CO-R can be constructed in the porous frameworks to regulate the wettability. Herein, we report the construction of an amphiphilic and hierarchical porous Mn-N4 catalyst via the solvothermal copolymerization, in which N,N-methylenebisacrylamide is used as a hydrophilic monomer. This POP-based manganese catalyst can effectively promote the oxidation of secondary alc. to produce the ketone using aqueous hydrogen peroxide as the oxidant under mild conditions. Note that this amphiphilic catalyst displays high catalytic activity as its homogeneous counterpart in the selective oxidation of alcs. The present work has provided a successful approach for improving the catalytic activity by tuning the wettability of POP-based heterogeneous catalysts.

Journal of Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H15ClO3, Application of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Lixian published the artcileManganese-catalyzed asymmetric transfer hydrogenation of hydrazones, COA of Formula: C12H9NO, the publication is Journal of Catalysis (2022), 487-497, database is CAplus.

The enantioselective reduction of C=N bonds constitutes an effective strategy for the production of chiral amines. Herein, manganese-catalyzed asym. transfer hydrogenation of hydrazones by employing a readily available chiral aminobenzimidazole manganese(I) complex under mild conditions was reported. The present protocol allows for the enantioselective transfer hydrogenation of a wide range of arylalkyl, dialkyl and diaryl hydrazones, providing the desired chiral hydrazines in excellent yields and enantioselectivities (65 examples, up to 99.9% ee). Of note, the current method is compatible with the challenging diaryl hydrazones without the requirement of an ortho-substitution on the Ph ring. A preliminary study of the mechanism suggests that a manganese-hydride pathway is involved, and the high enantiocontrol of the reaction is attributed to a π-π stacking interaction between substrate and catalyst.

Journal of Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C26H41N5O7S, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ayesa, Susana published the artcileSolid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Bioorganic & Medicinal Chemistry (2009), 17(3), 1307-1324, database is CAplus and MEDLINE.

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relation of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the series show sub-nanomolar inhibition of the target enzyme as well as an excellent selectivity profile and good cellular potency. Mol. modeling of the most interesting inhibitors describes interactions in the extended S3 pocket and explains the observed selectivity towards cathepsin K.

Bioorganic & Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ai, Jing-Jing published the artcileFe-S Catalyst Generated In Situ from Fe(III)- and S₃^·--Promoted Aerobic Oxidation of Terminal Alkenes, Application In Synthesis of 91-02-1, the publication is Organic Letters (2021), 23(12), 4705-4709, database is CAplus and MEDLINE.

An iron-sulfur complex formed by the simple mixture of FeCl₃ with S₃^·- generated in situ from K₂S is developed and applied to selective aerobic oxidation of terminal alkenes. The reaction was carried out under an atm. of O₂ (balloon) and could proceed on a gram scale, expanding the application of S₃^·- in organic synthesis. This study also encourages to explore the application of an Fe-S catalyst in organic reactions.

Organic Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Application In Synthesis of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xu, Lei published the artcileThe amine-catalysed Suzuki-Miyaura-type coupling of aryl halides and arylboronic acids, Application of 2-Bromopyridin-3-amine, the publication is Nature Catalysis (2021), 4(1), 71-78, database is CAplus.

A robust and chemoselective organocatalytic Suzuki-Miyaura-type coupling of aryl halides viz. Me 2-(4-bromophenyl)propanoate, Me 2-(4-chlorophenyl)propanoate, 5-bromopyrimidine, etc. with arylboronic acids viz. phenylboronic acid, naphthalen-2-ylboronic acid, furan-3-ylboronic acid, etc. catalyzed by amines, e.g. 2-methyl-N1,N3-di-o-tolylbenzene-1,3-diamine was reported. The utility and scope of this reaction were demonstrated by the synthesis of several com. relevant small mols. viz. Me 2-([1,1′-biphenyl]-4-yl)propanoate, Me 2-(4-(naphthalen-2-yl) phenyl)propanoate, 5-(furan-3-yl)pyrimidine, etc. and a selection of derivatives of pharmaceutical drugs e.g., Boscalid.

Nature Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C7H9BO3S, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kopf, Sara published the artcileBase-Mediated Remote Deuteration of N-Heteroarenes – Broad Scope and Mechanism, Application In Synthesis of 39856-58-1, the publication is European Journal of Organic Chemistry (2022), 2022(19), e202200204, database is CAplus.

Using KOtBu as base and DMSO-d₆ as deuterium source, a general and applicable method was presented for the selective deuteration of a set of nitrogen-containing heterocycles (pyridines, azines and bioactive mols.). Exptl. and DFT mechanistic studies indicated that this reaction proceeded via deprotonation of the substrates by the dimsyl anion. The relative thermodn. stability of the heterocycle anions determines the distribution and degree of deuteration.

European Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Constable, Edwin C. published the artcileThe preparation and coordination chemistry of 2,2′:6′,2″-terpyridine macrocycles – 1, Product Details of C7H7ClN2, the publication is Polyhedron (1982), 1(3), 303-6, database is CAplus.

Derivatives of 2,2′:6′,2”-terpyridine were prepared with the intention of forming macrocycles incorporating the 2,2′:6′,2”-terpyridyl moiety. Bis(methylhydrazino)phenylterpyridine I (R = MeNNH₂) and a number of metal complexes of this novel pentadentate ligand were prepared Thus, Ortoleva-King reaction of 2-acetyl-6-bromopyridine with iodine and pyridine gave pyridinium iodide II. Cyclocondensation of II and 2-bromo-6-cinnamoylpyridine in refluxing HOAc containing NH₄OAc gave I (R = Br). Reaction of the latter with MeNHNH₂ gave I (R = MeNNH₂) which formed colored complexes with Cr, Mn, Fe, Co, and Ni.

Polyhedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Product Details of C7H7ClN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhao, Chongjian published the artcileSyntheses, structures and photoluminescence of Cd(II) coordination polymers based on in situ synthesized bifunctional ligands, Name: Pyridine-3-sulfonic acid, the publication is Inorganic Chemistry Communications (2014), 30-35, database is CAplus.

By employing Cd(II) salt, NaN₃, and CN-(CH₂)_n-NC (n = 1, 2) and with the absence or presence of secondary ligands, four new cadmium coordination frameworks, named, {[Cd₄(btm)₄(H₂O)₂]·3H₂O}_n (1); [Cd₂(btm)₂(H₂O)]_n (2); [Cd₂(bte)(PMA)_0.5(H₂O)]_n (3); and [Cd(tzp)(2,2′-bipy)]_n (4) (H₂btm = bis(tetrazole) methane: H₂bte = 1,2-bis(tetrazole-5-yl)ethane; H₂tzp = 1H-tetrazolate-5-propionic acid; bipy = bipyridine; PMA = 1,2,4,5-benzenetetracarboxylic acid) were synthesized via in situ hydrothermal reaction. Single crystal x-ray diffraction reveals that compounds 1–3 are all three-dimensional (3D) frameworks. Compound 1 is constructed by Cd1- and Cd3-btm^2- layers and large bridging metalloligands. Compound 2 exhibits a 3D framework with two-dimensional (2D) Cd-btm^2- (adopting μ₆:κN1, N1′: κN2: κN3: κN4: κN3′: κN4’coordination mode) layers pillared by μ₃:κN1, N1′: κN2: κN4′ btm^2-. Compound 3 is built up by the Cd-bte^2- layers and the linker PMA, with left- and right-handed helical chains arranged alternately. It is notable that btm^2- takes on six different coordination modes in 1 and 2. Compound 4 represents a 2D layered framework, which can be simplified into a Shubnikov plane net (4.82̂) topol. network with 3-connected T shape linker tzp^2- ligands. In addition, the research results show that compounds 1–4 exhibit different fluorescent behaviors and thermal stabilities.

Inorganic Chemistry Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C18H12FN, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem