Tag: M.W=150-200

Liu, Tao published the artcileStraightforward installation of carbon-halogen, carbon-oxygen and carbon-carbon bonds within metal-organic frameworks (MOF) via palladium-catalyzed direct C-H functionalization, Application In Synthesis of 85237-71-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(87), 13261-13264, database is CAplus and MEDLINE.

The straightforward C-H functionalization of UiO-67-dcppy materials, was realized by a Pd-catalyzed PSM. This novel protocol provides an efficient method for the synthesis of various functionalized MOFs, which showed promising adsorbent ability in removing phenolic contaminates from water.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Application In Synthesis of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Peng published the artcileLigand-Promoted meta-C-H Amination and Alkynylation, Application of 3-Amino-5-(trifluoromethyl)pyridin-2-ol, the publication is Journal of the American Chemical Society (2016), 138(42), 14092-14099, database is CAplus and MEDLINE.

Using a modified norbornene (Me bicyclo[2.2.1]hept-2-ene-2-carboxylate) as a transient mediator, meta-C-H amination and meta-C-H alkynylation of aniline and phenol substrates have been developed for the first time. Both the identification of a monoprotected 3-amino-2-hydroxypyridine/pyridone-type ligand and the use of a modified norbornene as a mediator are crucial for the realization of these two unprecedented meta-C-H transformations. A variety of substrates are compatible with both meta-C-H amination and meta-C-H alkynylation. Amination and alkynylation of heterocyclic substrates including indole, indoline, and indazole afford the desired products in moderate to high yields.

Journal of the American Chemical Society published new progress about 90778-25-9. 90778-25-9 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Amine,Alcohol, name is 3-Amino-5-(trifluoromethyl)pyridin-2-ol, and the molecular formula is C6H8O4, Application of 3-Amino-5-(trifluoromethyl)pyridin-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guan, Aiying published the artcileN-Phenyl heteroarylamine analogues of fluazinam using the intermediate derivatization methods approach, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Journal of Chemical Sciences (Bangalore, India) (2014), 126(4), 1107-1114, database is CAplus.

Twenty-one N-Ph heteroarylamine analogs of fluazinam were prepared via nucleophilic substitution reaction of 2,6-dichloro-3,5-dinitrotoluene with heteroarylamines using the intermediate derivatization method. 2,6-Dichloro-3,5-dinitrotoluene, the key intermediate, was synthesized by nitration of 2,6-dichlorotoluene. Preliminary bioassays indicated that most of the compounds showed good fungicidal activity against rice blast. The activity of I was equal to that of fluazinam. The relationship between mol. structure and biol. activity suggested that introduction of electron-withdrawing groups in the pyridine ring was important for optimizing fungicidal activity against rice blast.

Journal of Chemical Sciences (Bangalore, India) published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jiang, Min published the artcileA Facile Copper-Catalyzed One-Pot Domino Synthesis of 5,12-Dihydroindolo[2,1-b]quinazolines, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Organic Letters (2012), 14(6), 1420-1423, database is CAplus and MEDLINE.

A domino synthesis of 5,12-dihydroindolo[2,1-b]quinazoline derivatives via copper-catalyzed Ullmann-type intermol. C-C and intramol. C-N couplings is reported. Good yields of various 5,12-dihydroindolo[2,1-b]quinazoline derivatives were obtained. Reaction scopes, limitations, and the reaction mechanism are discussed.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sun, Maolin published the artcilePractical and rapid construction of 2-pyridyl ketone library in continuous flow, Synthetic Route of 91-02-1, the publication is Journal of Flow Chemistry (2021), 11(2), 91-98, database is CAplus.

Herein, a practical method for the rapid synthesis of 2-pyridyl ketone ArC(O)R [Ar = 2-pyridyl; R = Me, Ph, Bn, etc.] library in continuous flow was reported, in which the 2-lithiopyridine formed by Br/Li exchange reacts with com. available esters to obtain 2-pyridyl ketones ArC(O)R in a good yield at short reaction time. This protocol functions broadly on a variety of esters and had been applied to the synthesis of TGF-β type 1 receptor inhibitor LY580276 intermediate ArC(O)R [Ar = 6-methyl-2-pyridyl; R = (4-fluorophenyl)methyl] in an environmentally friendly method. It was rapid, reliable, and cost-efficient to afford diverse kinds of 2-pyridyl ketones ArC(O)R in the compound library.

Journal of Flow Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C19H36BNO2Si, Synthetic Route of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gu, Xiaoke published the artcileDiscovery of thiosemicarbazone-containing compounds with potent anti-proliferation activity against drug-resistant K562/A02 cells, COA of Formula: C12H9NO, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(24), 127638, database is CAplus and MEDLINE.

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. A series of thiosemicarbazone-containing compounds were synthesized. Biol. evaluation showed that the most active compound (E)-6-(2-(1-(4-bromophenyl)ethylidene)hydrazine-1-carbothioamido)-N-hydroxyhexanamide displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC₅₀ value of 0.44μM. Notably, compound (E)-6-(2-(1-(4-bromophenyl)ethylidene)hydrazine-1-carbothioamido)-N-hydroxyhexanamide exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound (E)-6-(2-(1-(4-bromophenyl)ethylidene)hydrazine-1-carbothioamido)-N-hydroxyhexanamide could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, resp. Overall, (E)-6-(2-(1-(4-bromophenyl)ethylidene)hydrazine-1-carbothioamido)-N-hydroxyhexanamide may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Bioorganic & Medicinal Chemistry Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chesnokova, Alexandra N. published the artcileSynthesis and properties of composite membranes for polymer electrolyte membrane fuel cells, Application In Synthesis of 636-73-7, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2014), 251-256, database is CAplus.

The paper is devoted to the sol-gel synthesis of proton conductive organic-silicon composite membranes based on tetra-Et orthosilicate (TEOS) and copolymers of 2-methyl-5-vinylpyridine and vinyl chloride (MVP-VC), 2-methyl-5-vinylpyridine and vinyl acetate (MVP-VA), copolymers of ethylene glycol vinyl glycidyl ether and styrene (KS-1 and KS-2), and nitrogen-containing heteroaromatic derivatives of sulfonic acids: 2-phenyl-5-benzimidazolsulfonic acid (PBISA) and pyridine-3-sulfonic acid (PSA). Properties of synthesized membranes, such as proton conductivity, activation energy, ion exchange capacity, dimensional stability have been investigated.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Im, Yirang published the artcileEffect of nitrogen position of carboline on the device performances of blue phosphorescent organic light-emitting diodes, Synthetic Route of 39856-58-1, the publication is Synthetic Metals (2015), 24-28, database is CAplus.

A δ-carboline derived compound, 5-(3′-(9-carbazolyl)[1,1′-biphenyl]-3-yl)pyrido[3,2-b]indole, was synthesized as a high triplet energy bipolar host material for blue phosphorescent organic light-emitting diodes and it was compared with α-carboline derived host material with the same backbone structure. The δ-carboline derived host material showed better electron transport properties than the host with α-carboline due to better electron accepting properties. Therefore, the new host material reduced driving voltage and increased the power efficiency of blue phosphorescent organic light-emitting diodes compared to a standard host with α-carboline moiety. A high external quantum efficiency of 25.3% and a high power efficiency of 36.4 lm/W were achieved in the blue phosphorescent organic light-emitting diodes.

Synthetic Metals published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Synthetic Route of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Seet, Ai-Mee published the artcileSpectrophotometric determination of palladium(II) using 1,3-bis(2′-pyridyl)-1,2-diazaprop-2-ene, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Mikrochimica Acta (1974), 235-43, database is CAplus.

Pd was determined spectrophotometrically at 573 nm (molar absorptivity was 1.8 × 104) after complexation in 0.05N HCl with 1,3-bis-(2-pyridyl)-1,2-diaza-2-propene (I) and extraction of the complex into C6H6. Beer’s law was obeyed for â‰?00 μg Pd when the complex is extracted into 10 ml. C6H6. Complexes with 1:1 and 2:1 Pd-I mole ratios were formed. For determinations of 10-80 μg Pd, relative standard deviations were 1.99-4.64%.

Mikrochimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C9H5ClO4S, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Seet, Ai-Mee published the artcileDetermination and properties of erythrocyte lipoyl dehydrogenase, SDS of cas: 2215-33-0, the publication is Mikrochimica Acta (1975), 2(4-5), 407-12, database is CAplus.

Erythrocyte lipoyl dehydrogenase activity was determined colorimetrically with Pd(II)-1,3-bis(2′-pyridyl)-1,2-diazaprop-2-ene. The properties of red cell enzyme were described and normal values for erythrocyte lipoyl dehydrogenase were given. The possible role of this enzyme in the erythrocytes was discussed.

Mikrochimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C9H5ClO4S, SDS of cas: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem