Tag: M.W=150-200

Reams, Steve G. published the artcileEffect of chelating agents and respiratory inhibitors on regulation of the cadA gene in Escherichia coli, Related Products of pyridine-derivatives, the publication is Archives of Microbiology (1997), 167(4), 209-216, database is CAplus and MEDLINE.

The cadA gene that encodes Lys decarboxylase in E. coli is induced by low pH and during anaerobic growth by Lys. Operon fusions of cadA to lacZ was used to investigate the effects of aeration on cadA regulation. When an insertion mutation in osmZ (= hns) was introduced, a cadA-lacZ fusion was derepressed in the presence of air to approx. the same level as seen during anaerobic growth. The pH-dependent regulation of cadA was not affected by osmZ. Introduction of mutations in rpoS, fur, or fnr had no effect on cadA expression. Defects in arcB or arcA largely abolished expression of cadA during anaerobic growth. Nonetheless, strains defective in both arcB and osmZ showed the same high cadA-lac expression in air as seen in the single osmZ derivatives Blocking the respiratory chain with mutations or chem. inhibitors also caused derepression of a cadA-lacZ fusion in air, while agents affecting the proton gradient had no effect. Derepression of cadA in air was also mediated by several chelating agents, in particular by methoxyindole carboxylic acid. Addition of Fe²⁺ overcame this effect. Chelating agents also abolished the expression during aerobic growth of several genes known to be under arcAB control and which are normally repressed during anaerobic growth but induced in the presence of air. This implies that the effect of chelating agents on cadA expression is mediated via the arcAB regulatory system.

Archives of Microbiology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gomez Fernandez, Mario Andres published the artcileStudies on The Application of The Paterno-Buechi Reaction to The Synthesis of Novel Fluorinated Scaffolds, Quality Control of 91-02-1, the publication is Chemistry – A European Journal (2021), 27(63), 15722-15729, database is CAplus and MEDLINE.

In the context of new scaffolds obtained by photochem. reactions, Paterno-Buechi reactions between heteroaromatic, trifluoromethylphenyl ketone and electron rich alkenes to give oxetanes are described. A comprehensive study has been carried out on the reaction of aromatic ketones with fluorinated alkenes. Depending on the substitution pattern at the oxetane ring, a metathesis reaction is described as a minor side process to give mono-fluorinated alkenes. Overall, this last reaction corresponds to a photo-Wittig reaction and yields amide isosteres. In order to explain the uncommon regioselectivity of the Paterno-Buechi reaction with these alkenes, electrostatic-potential-derived charges (ESP) have been determined In a second computational study, the relative stabilities of the typical 1,4-diradical intermediates of the Paterno-Buechi reaction have been determined The results explain the regioselectivity. Further transformations of the oxetanes or previous functionalization of the fluoroalkenes open perspectives for oxetanes as core structures for biol. active compounds

Chemistry – A European Journal published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Quality Control of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hu, Essa published the artcileDiscovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors, HPLC of Formula: 1366482-32-7, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(6), 2262-2265, database is CAplus and MEDLINE.

Aminopyridinyl-substituted dimethoxycinnolines such as piperidinylpyridinyl dimethoxycinnolines I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) were prepared as selective inhibitors of phosphodiesterase 10A (PDE10A) for potential use in the treatment of schizophrenia. Bromodimethoxycinnoline II was prepared in two steps from 2-amino-4,5-dimethoxyacetophenone; Suzuki coupling of II with fluoropyridinyl boronic acids followed by aryl substitution reactions with amines and nitrogen heterocycles yielded aminopyridinyl-substituted dimethoxycinnolines. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) inhibited PDE10A with IC₅₀ values of 1.3-13.2 nM and were selective for PDE10A over phosphodiesterases 1-9 and 11 (particularly PDE3) by greater than 350-fold. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl), in which the piperidinyl moiety was hydroxy- or hydroxyalkyl-substituted, showed reduced clearance in rats [0.15-2.15 L/(h × kg)] relative to methoxyethyl- and methoxyazetidinyl-substituted pyridinyl cinnolines. I (R = Me; R¹ = HO; R² = 2-pyridinyl) suppressed the conditioned avoidance response in rats (a model of schizophrenia) at a dosage of 5.6 mg/kg. The structure of I (R = Me; R¹ = HOCMe₂; R² = H) bound to the catalytic domain of human PDE10A was determined by X-ray crystallog.

Bioorganic & Medicinal Chemistry Letters published new progress about 1366482-32-7. 1366482-32-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Chloride,Boronic acid and ester,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (5-Chloro-6-fluoropyridin-3-yl)boronic acid, and the molecular formula is C5H4BClFNO2, HPLC of Formula: 1366482-32-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hu, Essa published the artcileDiscovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors, Application In Synthesis of 1366482-40-7, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(6), 2262-2265, database is CAplus and MEDLINE.

Aminopyridinyl-substituted dimethoxycinnolines such as piperidinylpyridinyl dimethoxycinnolines I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) were prepared as selective inhibitors of phosphodiesterase 10A (PDE10A) for potential use in the treatment of schizophrenia. Bromodimethoxycinnoline II was prepared in two steps from 2-amino-4,5-dimethoxyacetophenone; Suzuki coupling of II with fluoropyridinyl boronic acids followed by aryl substitution reactions with amines and nitrogen heterocycles yielded aminopyridinyl-substituted dimethoxycinnolines. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl) inhibited PDE10A with IC₅₀ values of 1.3-13.2 nM and were selective for PDE10A over phosphodiesterases 1-9 and 11 (particularly PDE3) by greater than 350-fold. I (R = H, Me, Cl, F₂CH, cyclopropyl; R¹ = HO, HOCMe₂; R² = H, Me, cyclopropyl, 2-pyridinyl), in which the piperidinyl moiety was hydroxy- or hydroxyalkyl-substituted, showed reduced clearance in rats [0.15-2.15 L/(h × kg)] relative to methoxyethyl- and methoxyazetidinyl-substituted pyridinyl cinnolines. I (R = Me; R¹ = HO; R² = 2-pyridinyl) suppressed the conditioned avoidance response in rats (a model of schizophrenia) at a dosage of 5.6 mg/kg. The structure of I (R = Me; R¹ = HOCMe₂; R² = H) bound to the catalytic domain of human PDE10A was determined by X-ray crystallog.

Bioorganic & Medicinal Chemistry Letters published new progress about 1366482-40-7. 1366482-40-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (5,6-Difluoropyridin-3-yl)boronic acid, and the molecular formula is C5H4BF2NO2, Application In Synthesis of 1366482-40-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wilson, Jonathan E. published the artcileDiscovery and development of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists for the treatment of diabetes, SDS of cas: 1008506-24-8, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(12), 2947-2951, database is CAplus and MEDLINE.

A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides that were identified from a high-throughput screen of the Merck compound collection for GPR142 agonists. This work led to the discovery of 3-phenoxy-benzo-[1,2,4]-triazolo-[1,4]-oxazepine I, a potent GPR142 agonist with an off-target and PK profile suitable for in vivo studies. This compound and a related analog II were shown to be active in mouse oral glucose tolerance tests (OGTTs). Furthermore, a GPR142 knock-out mouse OGTT study with compound II provides evidence that its glucose-lowering effect is mediated by GPR142.

Bioorganic & Medicinal Chemistry Letters published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C9H13NO2, SDS of cas: 1008506-24-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mangalam, Neema Ani published the artcileDiversities in the chelation of aroylhydrazones towards cobalt(II) salts: Synthesis, spectral characterization, crystal structure and some theoretical studies, COA of Formula: C12H9NO, the publication is Journal of Molecular Structure (2021), 129978, database is CAplus.

Five Co complexes synthesized from two aroylhydrazones were characterized by elemental analyses, TGA, molar conductivity, magnetic susceptibility measurements, IR and electronic spectra. Single crystal x-ray structure of one of the complex is also reported and it got crystallized in triclinic space group P1̅ and the crystal structure shows a distorted octahedral geometry around the metal center. Spectral data reveal that both the aroylhydrazones are tridentate and coordinate through the azomethine N, hydrazonic O, and pyridyl N. Magnetic susceptibility measurements confirm the paramagnetic nature of the Co(II) complexes and one of the complex is diamagnetic in nature. Addnl., HF/6-311G(d,p)/LANL2DZ calculations were performed to predict the possible intramol. interactions contributing to the lowering of the stabilization energy. Accordingly, πâ†?π^* transitions are responsible for the stabilization energy for the ligands and their Co complexes. To describe and discuss the chem. reactivity and stability of synthesized complexes, quantum chem. parameters like frontier orbital energies, hardness, softness, energy gap, electronegativity, chem. potential, electrophilicity, polarizability and dipole moment were calculated Also, the main electronic structure principles such as maximum hardness, min. polarizability, and min. electrophilicity principles were considered to evaluate the stability of the complexes.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cabalin, L. M. published the artcileSample illumination configurations for spatially resolved Raman spectrometry using a charge-coupled device detector, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1995), 42(10), 1379-83, database is CAplus and MEDLINE.

Two simple configurations for sample illumination using a CCD detectors are shown. The choice of an appropriate sample illumination can be crucial to obtain spatial and spectral information of complex samples. Simultaneous Raman spectra of a heterogeneous sample of 3 compounds can be obtained using a vertical sample illumination. Spatially resolved resonant Raman and surface-enhanced resonant Raman spectra of Ni 2-pyridinecarboxaldehyde 2-pyridylhydrazone complex were observed with a low integration time. Dividing the CCD in 2 regions and with horizontal multiline sample illumination (Ar-ion laser at 488 nm and He-Ne laser at 632.8 nm) spatially resolved fluorescence of a homogeneous mixture of dyes were obtained. The total image was acquired in only 1 s.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Montes, R. published the artcileSpectrophotometric reaction-rate method for the determination of nitrite in waters with pyridine-2-aldehyde 2-pyridylhydrazone, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1987), 34(12), 1021-6, database is CAplus and MEDLINE.

A method for the kinetic determination of submicrogram amounts of NO₂^– was developed, based on the bromate oxidation of pyridine-2-aldehyde 2-pyridylhydrazone in an acidic medium by NO₂^–. The reaction is monitored spectrophotometrically at 372 nm. A comparative study with HCl and HClO₄ media shows that the anal. parameters are affected by the type of acid used. Within-day precision, based on 10 replicate determinations, was >0.011 μg/mL, which corresponds to 2.2-1.5% relative standard deviation at the concentrations examined Application of this method in the determination of NO₂^– in water is discussed. The recovery of NO₂^– from drinking waters was 90-117%, and the average relative standard deviation for NO₂^– determination is polluted river water was 3.2%. Large amounts of NO₂^– and NH₄⁺ do not interfere. However, there is interference by Cu²⁺, Pd²⁺, and electroactive substances. Major advantages for the method are simplicity, absence of a reagent blank, and the wide determination range.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Montes, R. published the artcileKinetic determination of nitrite in drinking water by fluorometry, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytical Sciences (1991), 7(3), 467-71, database is CAplus.

A method for the kinetic determination of nanogram amounts of NO₂^– is based on its acceleration of the rate of bromination of pyridine-2-aldehyde 2-pyridylhydrazone in acidic medium. The reaction is followed by fluorometry while monitoring the formation of a fluorescent product using an excitation wavelength of 291 nm and an emission wavelength of 432 nm. The method was applied to drinking water anal., with a detection limit of 4.6 ng/mL and recoveries 92-105%. The relative standard deviation of the method is 2.4%. The major advantages of this method are simplicity, absence of a reagent blank, selectivity, and sensitivity.

Analytical Sciences published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Montes, Rafael published the artcileCoupling of redox and complex formation processes for the kinetic determination of palladium, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analyst (Cambridge, United Kingdom) (1985), 110(11), 1339-41, database is CAplus.

A kinetic-spectrophotometric procedure for the determination of μg amounts of Pd(II) with pyridine-2-aldehyde 2-pyridylhydrazone (I) is described. The bromate oxidation of the dye is followed at 372 nm. The method is based on the decrease in the reaction rate produced by Pd complexation of I. A relative standard deviation of 2.5% was obtained in the range 0.5-3.2 μg/mL of Pd. Factors influencing the sensitivity and interferences from model solutions are discussed.

Analyst (Cambridge, United Kingdom) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem