Tag: M.W=150-200

Fischer, E. published the artcileStereochemical studies of heterocyclic compounds. XII. Crystal and molecular structure of 1-(2-amino-1-cyano-2-thioethenyl)pyridinium ylides, Related Products of pyridine-derivatives, the publication is Journal fuer Praktische Chemie (Leipzig) (1983), 325(2), 261-8, database is CAplus.

E/Z Isomerization and hindered rotation of the pyridine ring were examined in I (R = Me, R¹ = Et). The former process had ΔG^* = 67 kJ/mol; the latter had ΔG^* = 46 kJ/mol. Crystallog. data, bond lengths, and bond angles were determined for I (R = H, R¹ = Ph); both E and Z isomers exists in the crystal. The C:C double bond is considerably longer than those in some olefins.

Journal fuer Praktische Chemie (Leipzig) published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Frischmuth, Annette published the artcilePreparation of Functionalized Indoles and Azaindoles by the Intramolecular Copper-Mediated Carbomagnesiation of Ynamides, SDS of cas: 39856-58-1, the publication is Angewandte Chemie, International Edition (2013), 52(38), 10084-10088, database is CAplus and MEDLINE.

The authors report a mild and general one-pot preparation of indoles and azaindoles using a 5-endo-dig copper-mediated intramol. carbometalation of magnesiated derivatives, which lead to cuprated intermediates that, after quenching with various electrophiles, afford functionalized N-heterocycles. Thus, 2-bromo-4-fluoroaniline reacted with PhSO₂Cl to give the N-phenylsulfonyl derivative, which was alkynylated with phenyl[(trimethylsilyl)ethynyl]iodonium triflate to give alkyne derivative I (R = F, CF₃, CN, CO₂CMe₃). I was then treated with iso-PrMgCl·LiCl to give the Mg reagents that were cyclized with electrophiles using a catalytic amount of CuCN·2LiCl to produce the corresponding indoles II [R¹ = CH₂C(CO₂Et):CH₂, COC₆H₄Cl-3, cyclopropylcarbonyl, 2-cyclohexenyl, COC₆H₄Me-4] in 62-93% yield.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, SDS of cas: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tanaka, Shunitz published the artcileMigration behavior of niacin derivatives in capillary electrophoresis, Related Products of pyridine-derivatives, the publication is Journal of Chromatography A (1995), 718(1), 233-7, database is CAplus.

The migration behavior of niacin derivatives was investigated by capillary zone electrophoresis (CZE) and micellar electrokinetic chromatog. (MEKC). When the pH of the buffer solution is lower than the pK_a of the pyridine ring in the niacin derivatives, they are pos. charged by protonation on the pyridine ring and migrate electrophoretically. The mobilities of niacin derivatives in CZE were controlled by the pH of the migrating buffer. Good separation of 13 niacin derivatives was achieved at pH 2.8. Further, to shorten the anal. time and to achieve a more complete separation, an investigation by MEKC using SDS micelles was performed. All 13 niacin derivatives were eluted within 30 min and a satisfactory separation was achieved.

Journal of Chromatography A published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C8H5F3N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Stambirskyi, Maksym V. published the artcilePhosphine Oxides (-POMe₂) for Medicinal Chemistry: Synthesis, Properties, and Applications, HPLC of Formula: 39856-58-1, the publication is Journal of Organic Chemistry (2021), 86(18), 12783-12801, database is CAplus and MEDLINE.

A general practical approach to hetero(aromatic) and aliphatic P(O)Me₂-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me₂. The P(O)Me₂ substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C13H18N2, HPLC of Formula: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Yiwen published the artcileConvenient synthesis of 2-aryl-1-haloindolizines from pyridinium salts and 2-aryl-1,1-dihaloalk-1-enes, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Synthesis (2011), 3447-3452, database is CAplus.

2-Aryl-1-haloindolizines were synthesized from pyridinium salts and 2-aryl-1,1-dihaloalk-1-enes using a DBU/THF system. 2-Aryl-1,1-dihaloalk-1-enes containing electron-withdrawing or -donating groups were efficiently converted into the corresponding 2-aryl-1-haloindolizines in moderate to excellent yields.

Synthesis published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C8H19NO2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Raghu, M. S. published the artcileSynthesis, characterization, antimicrobial and interaction studies of pteridines with human serum albumin: A combined multi-spectroscopic and computational study, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Molecular Structure (2022), 1250(Part_3), 131857, database is CAplus.

A novel series of pteridine derivatives I [R = H, F, Cl, F₃C, Br] was synthesized, and the structures of these mols. were established using elemental anal. and numerous spectroscopic methods. The disk diffusion technique was used to examine the antimicrobial potential of the newly synthesized mols. Among the compounds examined, I [R = F, F₃C] compounds had the highest impact against the examined bacterial and fungal strains. The compounds min. inhibitory concentration (MIC) was observed to be in the line of 0.41-6.83μM. UV-vis absorption, fluorescence quenching, FT-IR spectroscopy and CD (CD) along with mol. docking methods, were studies to assess the binding behavior of efficient pteridine derivatives I [R = F, F₃C] with human serum albumin (HSA). Formation of HSA-test compounds complex indicated the static quenching phenomena during fluorescence quenching of HSA by test compounds Synthesized I [R = F, F₃C] were further evaluated for three basic binding sites of HSA including subdomains IIA, IIIA, and IB, using mol. docking studies. Hydrophobic and interaction through hydrogen bonding influenced the binding pathway of HSA with test mols., according to the mol. docking data. Furthermore, the DFT technique was used to optimize the mol. geometry of potent I [R = F, F₃C] compounds using the B3LYP hybrid functional and the 6-311 + G(d, p) basis set. The optimized structure closely aligned with the test findings. The electrostatic potential framework was produced to visualize the mol.’s energy distribution and chem. reactive areas.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kim, Yong published the artcileCopper-Catalyzed, One-Pot, Three-Component Synthesis of Benzimidazoles by Condensation and C-N Bond Formation, Quality Control of 39856-58-1, the publication is Journal of Organic Chemistry (2011), 76(23), 9577-9583, database is CAplus and MEDLINE.

Benzimidazoles, e.g., I, were synthesized by the copper-catalyzed, one-pot, three-component reaction of 2-haloanilines, aldehydes, and NaN₃. The reaction was optimized when 2-iodo- or 2-bromoanilines (1.0 equiv), aldehydes (1.2 equiv), NaN₃ (2.0 equiv), 5 mol% of CuCl, and 5 mol % of TMEDA were reacted in DMSO at 120 °C for 12 h. Good yields were obtained and the reaction showed tolerance toward functional groups such as ester, nitro, and chloro. Aliphatic and heteroaromatic aldehydes also afforded the desired products in moderate to good yields.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Quality Control of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Perlovich, German L. published the artcileSolubility and Transfer Processes of Some Hydrazones in Biologically Relevant Solvents, Category: pyridine-derivatives, the publication is Journal of Chemical & Engineering Data (2013), 58(9), 2659-2667, database is CAplus.

Solubility values of 20 hydrazones in water, 1-octanol and hexane were determined by the isothermal saturation method. Thermophys. characteristics of fusion processes (m.ps. and fusion enthalpies) of the selected substances were measured by DSC method. The impact of structural modification of the mols. on solubility processes in the solvents was analyzed. Transfer processes from water to 1-octanol and from water to hexane were analyzed. Correlation equations connecting the transfer coefficients with physicochem. descriptors were obtained.

Journal of Chemical & Engineering Data published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guha, Somraj published the artcileIodine-promoted controlled and selective oxidation of (aryl)(heteroaryl)methanes, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2022), 87(8), 5424-5429, database is CAplus and MEDLINE.

Herein, an iodine-catalyzed controlled oxidation of (aryl)(heteroaryl)methanes to (aryl)(heteroaryl)methanols ArCH(O)Ar¹ [Ar = Ph, 2-MeC₆H₄, 4-ClC₆H₄, etc.; Ar¹ = pyridin-2-yl, benzothiazol-2-yl] was disclosed under metal-free reaction conditions. A catalytic system comprised of iodine/silyl chloride with HI as an additive in the presence of DMSO selectively oxidize the C(sp³)-H bonds without being over oxidized to corresponding ketones. Therapeutically important aryl heteroaryl methanol derivatives were obtained in good yields. The preliminary mechanistic investigation proved that the primary source of oxygen was DMSO.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oh, In-Chan published the artcileCharacterization of palladium electrodeposition in ammonia-free electrolyte with additives, Product Details of C5H5NO3S, the publication is Surface and Interface Analysis (2021), 53(12), 1035-1042, database is CAplus.

Electrodeposition of Pd provides excellent chem. and low-contact resistance with good elec. properties, such as different types of elec. contacts in the electronics industry. The conventional Pd plating process utilizes ammonia-based electrolytes. Ammonia was added continuously to maintain the optimum pH range in Pd electrolyte. In addition, the harmful and strong odor of the evaporating ammonia necessitates the use of a ventilator. A further disadvantage is that the brass substrate is corroded by ammonia vapor, and the corrosion products can contaminate the electrolytes, thereby changing the technol. properties of the deposited plating for the worse. Ethylenediamine has been proposed as an alternative to ammonia; however, Pd electrodeposition occurs as microcracks via hydrogen evolution. In this study, the effects of Pd electrolyte on ethylenediamine as a complexing agent and the properties of various additives are investigated to improve c.d. and internal stress in Pd electrodeposition that occurs on a brass substrate. Therefore, complexing agents such as 3-pyridine sulfonic acid, sodium nicotinate, butyne 1-4 diol, and sodium allylsulfonate are selected as additives, to serve as an alternative to ammonia in Pd electrolyte. In this study, the properties of electrodeposited Pd with various additives were examined The effect of additives on Pd electrolytes can be classified as dense surfaces without defects such as microcracks and pinholes, which improved surface roughness and corrosion resistance. Particularly, Pd electrolyte using sodium nicotinate has relatively improved surface roughness and properties. Pd electrolyte was optimized under ammonia-free conditions by the addition of sodium nicotinate.

Surface and Interface Analysis published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem