Tag: M.W=150-200

Hong, Seunghee published the artcileDiscovery of New Benzothiazole-Based Inhibitors of Breakpoint Cluster Region-Abelson Kinase Including the T315I Mutant, COA of Formula: C6H8BNO3, the publication is Journal of Medicinal Chemistry (2013), 56(9), 3531-3545, database is CAplus and MEDLINE.

The existence of drug resistance caused by mutations in the break-point cluster region-Abelson tyrosine kinase (Bcr-Abl) kinase domain remains a clin. challenge due to limited effective treatment options for chronic myeloid leukemia. Herein the authors report a novel series of benzothiazole-based inhibitors that are effective against wild-type and T315I mutant Bcr-Abl kinases. The original hit compound, nocodazole, was extensively modified through a structure-based drug design strategy, especially by varying the groups at the C2 and C6 positions of the scaffold. In addition, the introduction of water-solubilizing groups at the terminal Et group resulted in enhanced physicochem. properties and potency in cellular inhibition. Several compounds inhibited the kinase activity of both wild-type Bcr-Abl and the T315I mutant with IC₅₀ values in the picomolar range and exhibited good antiproliferative effects on Ba/F3 cell lines transformed with either wild-type or T315I mutant Bcr-Abl.

Journal of Medicinal Chemistry published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, COA of Formula: C6H8BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dau, Phuong V. published the artcileSingle-Atom Ligand Changes Affect Breathing in an Extended Metal-Organic Framework, Product Details of C13H13N, the publication is Inorganic Chemistry (2012), 51(10), 5671-5676, database is CAplus and MEDLINE.

2-Phenylpyridine-5,4′-dicarboxylic acid (1, dcppy), a derivative of 4,4′-biphenyldicarboxylic (2, bpdc) was used as the organic linking component for several metal-organic frameworks (MOFs). The pyridine component of 1 does not interfere with the solvothermal synthetic procedure, and hence both 1 and 2 form similar isoreticular MOFs. Zr⁴⁺-based UiO-67-dcppy, Al³⁺-based DUT-5-dcppy, Zn²⁺-based DMOF-1-dcppy, and interpenetrated Zn²⁺-based BMOF-1-dcppy were readily synthesized from 1. Similarly, isostructural frameworks from 2 were prepared (UiO-67, DUT-5, DMOF-1-bpdc, and interpenetrated BMOF-1-bpdc). The structures and phys. properties of these frameworks were characterized by powder x-ray diffraction (PXRD), single XRD, TGA, and gas sorption anal. Generally, frameworks prepared from 1 or 2 displayed similar properties; however, gas sorption data showed that BMOF-1-dcppy displayed a very large hysteresis with N₂ and CO₂ suggestive of possible framework flexibility. In contrast, the analogous framework prepared from 2 (BMOF-1-bpdc) showed low uptake of N₂ and CO₂. The substantial difference in the gas sorption behavior of these MOFs is attributed to the pyridine nature of 1 that results in weakened π-π interactions between the interpenetrated nets.

Inorganic Chemistry published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Product Details of C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Baydas, Yasemin published the artcileAsymmetric reduction of aromatic heterocyclic ketones with bio-based catalyst Lactobacillus kefiri P2, Related Products of pyridine-derivatives, the publication is Chemical Papers (2021), 75(3), 1147-1155, database is CAplus.

In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asym. reduction of prochiral ketones RC(O)R¹ (R = pyridin-2-yl, 2H-1,3-benzodioxol-5-yl, furan-2-yl, etc.; R¹ = Me, Ph, pyridin-2-yl) to chiral secondary alcs R/S-RCH(R¹)OH. Secondary chiral carbinols were obtained by asym. bioreduction of different prochiral substrates with results up to > 99% enantiomeric excess (ee). The compound R/S-RCH(R¹)OH (R = pyridin-2-yl, R¹ = Me (I)) which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective β-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of I in enantiomerically pure form was obtained in 96% yield. Also, production of I in terms of yield and gram scale through catalytic asym. reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcs. compared to chem. processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis.

Chemical Papers published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gupta, Ankur published the artcileSynthesis of biologically potent novel 5-(2-bromopyridin-3-yl-amino)-2-alkyl/aryl-isoindoline-1,3-dione analogs via Buchwald-Hartwig C-N coupling reaction, COA of Formula: C5H5BrN2, the publication is Letters in Organic Chemistry (2013), 10(2), 139-146, database is CAplus.

A novel series of N-alkyl/aryl substituted phthalimide analogs containing 2-bromopyridyl functionality were synthesized applying optimized Buchwald-Hartwig amination conditions using palladium acetate, cesium carbonate, and ±BINAP in toluene at 110°C under argon atm. The target heteroaryl phthalimide derivatives were obtained in moderate yield ranging from 40% to 51%. In the extra precision (XP) docking studies, at the ATP site of human topoisomerase IIα (hTopoIIα) (PDB id 1ZXM), we identified that compound I (R = Me) demonstrated remarkable H-bond interactions with catalytic MG²⁺, ASN 91, SER 148, SER 149, ALA 167 and compound I (R = 3-pyridyl) with ARG 162, ASN 163, GLY 164, LSY 168, ASN 95 indicating their significance as a plausible hTopoIIα inhibitors. In the in vitro evaluation of A549 cell line, compounds I (R = Me, 3-pyridyl) were observed to have only moderate cytotoxicity (IC₅₀ 180μg/mL and 210μg/mL resp.). The developed process could be widely employed for the synthesis of novel heterocyclic compounds with one of the components as N-alkyl/aryl substituted phthalimide derivatives and has the potential to be developed as a major route for the identification of active drug candidates.

Letters in Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Galenko, E. E. published the artcileSynthesis of Water-Soluble α-Aminopyrroles, 1-(2-Amino-1H-pyrrol-3-yl)pyridinium Chlorides, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Russian Journal of General Chemistry (2021), 91(7), 1424-1428, database is CAplus.

A method for the synthesis of water-soluble α-aminopyrroles, 1-(2-amino-1H-pyrrol-3-yl)pyridinium chlorides, by the reaction 1-(cyanomethyl)pyridinium chloride with alkyl 3-aryl-2H-azirine-2-carboxylates was developed.

Russian Journal of General Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yasui, Kosuke published the artcileThe Effect of the Leaving Group in N-Heterocyclic Carbene-Catalyzed Nucleophilic Aromatic Substitution Reactions, Product Details of C5H5BrN2, the publication is Bulletin of the Chemical Society of Japan (2020), 93(12), 1424-1429, database is CAplus.

The reactivity order of the leaving group was F > Cl â‰?Br > I in N-heterocyclic carbene-catalyzed CS_NAr reactions of aryl halides bearing an α,β-unsaturated amide was discussed. Based on a qual. Marcus anal., the nature of the transition state in this catalytic CS_NAr was primarily determined by the potential energy of the Meisenheimer complex, even though it was not involved as a discrete intermediate in the reaction pathway.

Bulletin of the Chemical Society of Japan published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C14H26O2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jung, Sungouk published the artcileEffect of substitution of methyl groups on the luminescence performance of Ir^III complexes: Preparation, structures, electrochemistry, photophysical properties and their applications in organic light-emitting diodes (OLEDs), Application of 5-Methyl-2-(p-tolyl)pyridine, the publication is European Journal of Inorganic Chemistry (2004), 3415-3423, database is CAplus.

A series of dimethyl-substituted tris(pyridylphenyl)iridium(III) derivatives [(n-MePy-n’-MePh)₃Ir] [n = 3, n’ = 4 (1); n = 4, n’ = 4 (2); n = 4, n’ = 5 (3); n = 5, n’ = 4 (4); n = 5, n’ = 5 (5)] have been synthesized and characterized to investigate the effect of the substitution of Me groups on the solid-state structure and photo- and electroluminescence. The absorption, emission, cyclic voltammetry and electroluminescent performance of 1–5 have also been systematically evaluated. The structures of 2 and 4 have been determined by a single-crystal x-ray diffraction anal. Under reflux (> 200°) in glycerol solution, fac-type complexes with a distorted octahedral geometry are predominantly formed as the major components in all cases. Electrochem. studies showed much smaller oxidation potentials relative to Ir(ppy)₃ (Hppy = 2-phenylpyridine). All complexes exhibit intense green photoluminescence (PL), which has been attributed to metal-to-ligand charge transfer (MLCT) triplet emission. The maximum emission wavelengths of thin films of 1, 3, 4 and 5 at room temperature are in the range 529-536 nm, while 2 displays a blue-shifted emission band (λ_max = 512 nm) with a higher PL quantum efficiency (Φ_PL = 0.52) than those of complexes 1 and 3–5; this is attributed to a decrease of the intermol. interactions. Multilayered organic light-emitting diodes (OLEDs) were fabricated by using three (2, 3 and 4) of these Ir^III derivatives as dopant materials. The electroluminescence (EL) spectra of the devices, which have the maximum peaks at 509-522 nm, with shoulder peaks near 552 nm, are consistent with the PL spectra in solution at 298 K. The devices show operating voltages at 1 mA/cm² of 4.9, 5.6, 5.1, and 4.6 V for Ir(ppy)₃, 2, 3, and 4, resp. In particular, the device with 2 shows a higher external quantum efficiency (η_ext = 11% at 1 mA/cm²) and brightness (4543 cd/m² at 20 mA/cm²) than Ir(ppy)₃ (η_ext = 6.0% at 1 mA/cm²; 3156 cd/m² at 20 mA/cm²) and other Ir(dmppy)₃ derivatives, (dmppy = dimethyl-substituted ppy), under the same conditions. The Me groups at the meta (Ph) and para (Py) positions to the Ir metal atom have a great influence on absorption, emission, redox potentials and electroluminescence.

European Journal of Inorganic Chemistry published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Application of 5-Methyl-2-(p-tolyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sato, Masayuki published the artcileReaction of 2,2,6-trimethyl-1,3-dioxin-4-one with isoquinolinium and pyridinium ylides, Name: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Chemical & Pharmaceutical Bulletin (1982), 30(12), 4359-64, database is CAplus.

The reactions of diketene-acetone adduct [2,2,6-trimethyl-1,3-dioxin-4-one (I)] with heterocyclic ylides were studied. Heating I with isoquinolinium bis(ethoxycarbonyl)methylide gave pyrroloisoquinoline II (R = CO₂Et). Similarly, isoquinolinium cyano(ethoxycarbonyl)methylide and phenacylide gave pyrroloisoquinolinecarbonitrile III and II (R = Bz), resp. Isoquinolinium dicyanomethylide reacted with I to give bis(methyloxooxazinyl)methylide IV. Pyridinium ylides similarly reacted with I to give indolizines and oxazinylmethylides.

Chemical & Pharmaceutical Bulletin published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Name: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chatterjee, Arnab published the artcilepH dependent catecholase activity of Fe(II) complexes of type [Fe(L)]X₂ [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO^–₄ (1), PF^–₆ (2)]: Role of counter anion on turnover number, SDS of cas: 91-02-1, the publication is Inorganica Chimica Acta (2020), 119933, database is CAplus.

Two mononuclear Fe(II) complexes having same ligand framework, coordination geometry but different counter anions [Fe(L)]X₂ [L = N-(phenyl-pyridin-2-yl-methylene)-ethane-1,2-diamine; X = ClO^–₄ (1), PF^–₆ (2)] have been synthesized and crystallog. characterized. Both the complexes catalyzed catechol-quinone oxidation pH dependently. In the pH range 8.3-8.5 the suitable activity of both the complexes were found. Counter anions in the complexes played a significant role in controlling the turn over numbers of the catalytic reactions. In acetonitrile (MeCN), the turn over number for 1 was 4.99 h^-1 and for 2, it was 42.75 h^-1.

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vantomme, Ghislaine published the artcileAdaptation in Constitutional Dynamic Libraries and Networks, Switching between Orthogonal Metalloselection and Photoselection Processes, Formula: C11H10N4, the publication is Journal of the American Chemical Society (2014), 136(26), 9509-9518, database is CAplus and MEDLINE.

Constitutional dynamic libraries of hydrazones ^aA^bB and acylhydrazones ^aA^cC undergo reorganization and adaptation in response to a chem. effector (metal cations) or a phys. stimulus (light). The set of hydrazones [¹A¹B, ¹A²B, ²A¹B, ²A²B] undergoes metalloselection on addition of zinc cations which drive the amplification of Zn(¹A²B)₂ by selection of the fittest component ¹A²B. The set of acylhydrazones [E-¹A¹C, ¹A²C, ²A¹C, ²A²C] undergoes photoselection by irradiation of the system, which causes photoisomerization of E-¹A¹C into Z-¹A¹C with amplification of the latter. The set of acyl hydrazones [E-¹A¹C, ¹A³C, ²A¹C, ²A³C] undergoes a dual adaptation via component exchange and selection in response to two orthogonal external agents: a chem. effector, metal cations, and a phys. stimulus, light irradiation Metalloselection takes place on addition of zinc cations which drive the amplification of Zn(¹A³C)₂ by selection of the fittest constituent ¹A³C. Photoselection is obtained on irradiation of the acylhydrazones that leads to photoisomerization from E-¹A¹C to Z-¹A¹C configuration with amplification of the latter. These changes may be represented by square constitutional dynamic networks that display up-regulation of the pairs of agonists (¹A²B, ²A¹B), (Z-¹A¹C, ²A²C), (¹A³C, ²A¹C), (Z-¹A¹C, ²A³C) and the simultaneous down-regulation of the pairs of antagonists (¹A¹B, ²A²B), (¹A²C, ²A¹C), (E-¹A¹C,²A³C), (¹A³C, ²A¹C). The orthogonal dual adaptation undergone by the set of acylhydrazones amounts to a network switching process.

Journal of the American Chemical Society published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C15H21BO3, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem