Tag: M.W=150-200

Yang, Bing published the artcileSelf-Assembled Amphiphilic Water Oxidation Catalysts: Control of O-O Bond Formation Pathways by Different Aggregation Patterns, Name: Pyridine-3-sulfonic acid, the publication is Angewandte Chemie, International Edition (2016), 55(21), 6229-6234, database is CAplus and MEDLINE.

The oxidation of water to mol. oxygen is the key step to realize water splitting from both biol. and chem. perspective. In an effort to understand how water oxidation occurs on a mol. level, a large number of mol. catalysts have been synthesized to find an easy access to higher oxidation states as well as their capacity to make O-O bond. However, most of them function in a mixture of organic solvent and water and the O-O bond formation pathway is still a subject of intense debate. Herein, we design the first amphiphilic Ru-bda (H₂bda=2,2′-bipyridine-6,6′-dicarboxylic acid) water oxidation catalysts (WOCs) of formula [Ru^II(bda)(4-OTEG-pyridine)₂] (1, OTEG=OCH₂CH₂OCH₂CH₂OCH₃) and [Ru^II(bda)(PySO₃Na)₂] (2, PySO₃^–=pyridine-3-sulfonate), which possess good solubility in water. Dynamic light scattering (DLS), scanning electron microscope (SEM), critical aggregation concentration (CAC) experiments and product anal. demonstrate that they enable to self-assemble in water and form the O-O bond through different routes even though they have the same bda^2- backbone. This work illustrates for the first time that the O-O bond formation pathway can be regulated by the interaction of ancillary ligands at supramol. level.

Angewandte Chemie, International Edition published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C8H11NO, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Asuero, Agustin G. published the artcileSpectrophotometric evaluation of acidity constants of two-step overlapping equilibria from the inflexion points of the absorbance versus pH graphs with application to the dipyridylglyoxal mono-(2-pyridyl)hydrazone system, Product Details of C11H10N4, the publication is Acta Pharmaceutica Technologica (1988), 34(3), 164-8, database is CAplus.

Some pyridylhydrazone type derivatives are being currently studied from a pharmacol. point of view. In this respect, the knowledge of acidity constants of a drug is of great worth in solving fundamental problems of pharmaceutical interest. Thus, an extension of the method of Irving, Rossotti and Harris (1955) for the evaluation of acidity constants of diprotic acids is presented. A simple method of developing the final equations given by those authors in a more usual anal. form is also presented, thus providing a rapid and convenient desk method of calculation The methods devised were applied to the evaluation of acidity constants of dipyridylglyoxal mono-(2-pyridyl)-hydrazone (DMPH). Results obtained agree well with those obtained by applying a three equation procedure.

Acta Pharmaceutica Technologica published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Product Details of C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gu, Lijun published the artcileSynthesis and antitumor activity of α-aminophosphonates containing thiazole[5,4-b]pyridine moiety, Related Products of pyridine-derivatives, the publication is Organic & Biomolecular Chemistry (2012), 10(35), 7098-7102, database is CAplus and MEDLINE.

A new procedure is developed for the synthesis of α-aminophosphonates containing thiazole[5,4-b]pyridine moiety from conveniently available starting materials. The target compounds were characterized by IR, ¹H NMR, ¹³C NMR, ³¹P NMR, mass spectrometry and elemental anal. The newly synthesized compounds were evaluated for their anticancer activities against PC-3, Bcap-37, H460 cells in vitro by the MTT method. Two compounds are highly effective against PC-3, Bcap-37 cells and good to H460 cells. Further study is necessary to find out the potential antitumor activities.

Organic & Biomolecular Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Niu, Nana published the artcileDesign and Synthesis of Tetrandrine Derivatives as Potential Anti-tumor Agents Against A549 Cell Lines, Category: pyridine-derivatives, the publication is ChemistrySelect (2019), 4(1), 196-201, database is CAplus.

Tetrandrine was converted to 5-bromotetrandrine using a mild oxidative system (DMSO/HBr). Suzuki-Miyaura and Sonogashira cross-coupling reactions were then employed to yield a set of 5-substituted tetrandrine derivatives I (R = 5-formylfuran-2-yl, pyrimidin-5-yl, 2-cyclopropylethynyl, etc.). Their antiproliferative activities against A549 cell lines in vitro were evaluated using the MTT assay. Most of the compounds were found to possess significant inhibitory activities and compound I (R = 2-methoxypyrimidin-5-yl) (A) had the highest (IC₅₀ = 3.04 μM). Further studies on the mechanism demonstrated by (A) showed that it promotes apoptosis of A549 cells in a dose-dependent manner and reduces the mitochondrial membrane potential. Western blot results showed that the compound up-regulated the levels of Bax protein and down-regulated the level of Bcl-2 protein. Compared to the control group, the expression of cleaved-caspase 3 and cleaved-PARP in cells was significantly increased.

ChemistrySelect published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nara, Susheel J. published the artcileDiscovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Journal of Medicinal Chemistry (2022), 65(13), 8948-8960, database is CAplus and MEDLINE.

While several farnesoid X receptor (FXR) agonists under clin. investigation for the treatment of nonalcoholic steatohepatitis (NASH) have shown beneficial effects, adverse effects such as pruritus and elevation of plasma lipids have limited their clin. efficacy and approvability. Herein, we report the discovery and preclin. evaluation of compound 32 (BMS-986339), a nonbile acid FXR agonist with a pharmacol. distinct profile relative to our previously reported agonist BMS-986318. Compound 32 exhibited potent in vitro and in vivo activation of FXR, albeit with a context-dependent profile that resulted in tissue-selective effects in vivo. To our knowledge, this is the first report that demonstrates differential induction of Fgf15 in the liver and ileum by FXR agonists in vivo. Compound 32 demonstrated robust antifibrotic efficacy despite reduced activation of certain genes in the liver, suggesting that the addnl. pharmacol. of BMS-986318 does not further benefit efficacy, possibly presenting an opportunity for reduced adverse effects. Further evaluation in humans is warranted to validate this hypothesis.

Journal of Medicinal Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Griswold, Jessica A. published the artcileStereoconvergent Conjugate Addition of Arylboronic Acids to α-Angelica Lactone Derivatives: Synthesis of Stereochemically Complex γ-Butyrolactones, Category: pyridine-derivatives, the publication is ACS Catalysis (2019), 9(12), 11614-11618, database is CAplus and MEDLINE.

Catalyzed stereoconvergent 1,4-additions to unsaturated carbonyls are rare but of high potential value. This letter details the development of enantioselective arylation reactions of boronic acids and β,γ-butenolides. These reactions are catalyzed by com. available hydroxy[(S)-BINAP]-rhodium(I) dimer to afford stereochem. complex γ-butyrolactone derivatives The reaction products provide functionality amenable to further manipulation and can lead to products with up to three contiguous stereocenters. The reaction proceeds under a dynamic kinetic resolution manifold by isomerizing the achiral starting material into an interconverting mixture of enantiomeric conjugate acceptors, followed by catalyst-controlled, enantiomer-selective 1,4-additionBase-promoted racemization of the intermediate α,β-butenolide is possible due to the high kinetic and thermodn. acidity of the γ-proton.

ACS Catalysis published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shah, Sonya C. published the artcileCovalent modification of cytochrome c with a hydrazone complex of platinum(II), COA of Formula: C11H10N4, the publication is Journal of the Serbian Chemical Society (1988), 53(3), 139-48, database is CAplus.

The complex Pt(sbpaphy)Cl^– (where sbpaphy is 2-(3-sulfobenzoyl)-pyridine-2-aldehyde 2′-pyridylhydrazone) modifies selectively the histidine (His) 33 residue in horse heart cytochrome c at pH 7.0. The reaction takes place under mild conditions and the Pt(sbpaphy)His label is stable at pH 7.0. The binding site is identified by UV-vis spectrophotometry and by studies of model complexes. The labeled protein is purified readily by cation-exchange chromatog. and the inorganic chromophore in it is quantitated easily owing to its strong UV absorption bands. Cyclic voltammetry, differential-pulse voltammetry, and UV-vis spectrophotometry show that labeling does not perturb the protein.

Journal of the Serbian Chemical Society published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C6H17NO3Si, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Butler, Richard N. published the artcileStereoisomerization in heterocyclic hydrazones derived from 2-acylpyridines and their oxidative cyclization with mercury(II) acetate and lead tetraacetate to fused 1,2,4-triazoles and 1,2,3-triazolium systems, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1984), 2109-16, database is CAplus.

Fourteen hydrazones I (R = H, Me, Ph; R¹ = 2-pyridyl, 4-O₂NC₆H₄, Ph, 4-BrC₆H₄, 4-MeOC₆H₄, 4-MeC₆H₄), prepared by coupling 2-formyl-, -benzoyl-, or -acetylpyridine with H₂NNHR¹ (R¹ as before), were isolated predominantly as E isomers, when the acyl substituent R was small (H = Me). When R = Ph, significant yield of Z isomers containing an intramol. H bond were also obtained. The structure of E-I (R = R¹ = Ph) was determined by x-ray crystallog. Oxidation reactions of I were not configuration dependent contrary to the report of R. Kuhn and W. Munzig (1952). A common metallo intermediate II, was obtained by oxidation of E– and Z–I (R = H, R¹ = 2-pyridyl) with Hg(OAc)₂. In Pb(OAc)₄ oxidation of the hydrazones, the product controlling factor was the nature of the methine substituent R. For the ketone derivatives I (R â‰?H), oxidation to fused 1,2,3-triazolium systems occurred via a 5-exo–tet cyclization with E- and Z-hydrazones, whereas for aldehyde systems, I (R = H), the oxidation involved dehydration to a nitrilimine and gave products by solvent addition or a 5-endo–dig cyclization to fused 1,2,4-triazolo systems. Thus, Pb(OAc)₄ oxidation of E– or Z–I (R = Ph, R¹ = 4-O₂NC₆H₄) gave 80% triazolopyridinium III, whereas similar oxidation of E– or Z–I (R = H, R¹ = 2-pyridyl) gave 73-86% triazolopyridine IV.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Butler, Richard N. published the artcileDetection of a metalo intermediate and geometrical isomerizations in an oxidative cyclization of a heterocyclic hydrazone with mercury(II) acetate, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Journal of the Chemical Society, Chemical Communications (1981), 376-7, database is CAplus.

Oxidative cyclization of the (E)-hydrazone I on treatment with Hg(OAc)₂ (AcOH, 70°, 16 h) gave 37% II, via the (Z)-intermediate III. The reaction mechanism, which involves a series of cis-trans isomerizations, is discussed.

Journal of the Chemical Society, Chemical Communications published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saku, Osamu published the artcileDiscovery of Novel 5,5-Diarylpentadienamides as Orally Available Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3436-3451, database is CAplus and MEDLINE.

We have developed a novel and potent chem. series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing issues related to pharmacokinetics. Our data suggest that substitution with alkoxy groups on the Ph ring at the 5-position increases their ability to penetrate the blood-brain barrier. This investigation culminated in the discovery of compound (R)-36b (I), which showed a good pharmacokinetic profile. In vivo, compound (R)-36b was found to be effective at reversing mech. allodynia in rats in a dose-dependent manner, and it reversed thermal hyperalgesia in a model of neuropathic pain induced by sciatic nerve injury.

Journal of Medicinal Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem