Tag: M.W=150-200

Blanchard, Stephanie published the artcileDihydrodipyridopyrazines: synthesis and functionalization, Safety of 2-Bromopyridin-3-amine, the publication is Studii si Cercetari Stiintifice: Chimie si Inginerie Chimica, Biotehnologii, Industrie Alimentara (Universitatea Bacau) (2010), 11(1), 45-65, database is CAplus.

This paper is a combination of the authors’ prior published work with new exptl. material. Different conceptual synthetic approaches to the elaboration of a new family of planar polynuclear nitrogen containing aromatic heterocycles – the dihydrodipyridopyrazines – are reviewed: the arynic reaction, the sequence palladium coupling reaction – substitution – reduction – cyclization – substitution or via Smiles rearrangement. Further functionalization of these compounds by substitution reaction, metalation sequence and palladium-catalyzed coupling reaction are also discussed.

Studii si Cercetari Stiintifice: Chimie si Inginerie Chimica, Biotehnologii, Industrie Alimentara (Universitatea Bacau) published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lopez-Fontal, Elkin published the artcileShip in a bottle: confinement-promoted self-assembly, HPLC of Formula: 636-73-7, the publication is Chemical Science (2018), 9(7), 1760-1768, database is CAplus and MEDLINE.

Understanding self-assembly in confined spaces is essential to fully understand mol. processes in confined cell compartments and will offer clues on the behavior of simple confined systems, such as protocells and lipid-vesicle based devices. Using a model system composed of lipid vesicles, a membrane impermeable receptor and a membrane-permeable ligand, we have studied in detail how compartmentalization modulates the interaction between the confined receptor and its ligand. We demonstrate that confinement of one of the building blocks stabilizes complex self-assembled structures to the extent that dilution leads, counterintuitively, to the formation of long range assemblies. The behavior of the system can be explained by considering a confinement factor that is analogus, although not identical, to the effective molarity for intramol. binding events. The confinement effect renders complex self-assembled species robust and persistent under conditions where they do not form in bulk solution Moreover, we show that the formation of stable complex assemblies in systems compartmentalized by semi-permeable membranes does not require the prior confinement of all components, but only that of key membrane impermeable building blocks. To use a macroscopic analogy, lipid vesicles are like ship-in-a bottle constructs that are capable of directing the assembly of the confined ship following the confinement of a few key wooden planks. Therefore, we believe that the confinement effect described here would have played an important role in shaping the increase of chem. complexity within protocells during the first stages of abiogenesis. Addnl., we argue that this effect can be exploited to design increasingly efficient functional devices based on comparatively simple vesicles for applications in biosensing, nanoreactors and drug delivery vehicles.

Chemical Science published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shukla, Satyendra Nath published the artcileNovel NNO pincer type Schiff base ligand and its complexes of Fe(IIl), Co(II) and Ni(II): Synthesis, spectroscopic characterization, DFT, antibacterial and anticorrosion study, Product Details of C12H9NO, the publication is Journal of Molecular Structure (2021), 130582, database is CAplus.

A novel NNO pincer type ligand (E)-N’-(phenyl(pyridin-2-yl)methylene)isonicotinohydrazide, PPMINH, was synthesized by condensation of 2-benzoyl pyridine and isonicotinylhydrazide. The ligand PPMINH on reaction with metal ions Fe(III), Co(II) and Ni(II) yielded six metal derivatives Different anal. tools like; Elemental analyses, ESI-MS, FTIR, molar conductivity, UV-spectra, magnetic susceptibility, NMR and EPR measurement were used. Theor. FTIR, ¹H NMR and ¹³C NMR of ligand and complex 6 exhibits quite a good correlation coefficient EPR spectrum of complex 6 at LNT suggests octahedral geometry around Ni(II). The ligand and complexes were screened for antibacterial activity. DFT was carried out to optimize the geometry of the ligand and complexes. The properties most relevant to their potential action as corrosion inhibitors was calculated all parameters of DFT from the inhibitor mol. to the metal atom. The corrosion inhibition effect of compounds on mild steel in an acidic medium was studied for 24, 48, 72 h using weight loss measurement.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C18H17NO8, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhao published the artcilePd-Catalyzed Suzuki coupling reactions of aryl halides containing basic nitrogen centers with arylboronic acids in water in the absence of added base, Category: pyridine-derivatives, the publication is New Journal of Chemistry (2017), 41(24), 15420-15432, database is CAplus.

The Pd-catalyzed Suzuki coupling reactions of a series of aryl chlorides and aryl bromides containing basic nitrogen centers with arylboronic acids in water in the absence of added base were reported. The reactions proceeded either partially or entirely under acidic conditions. After surveying twenty-two phosphorus ligands, high yields of products were obtained with aryl chlorides only when a bulky ligand, 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole (cataCXiumPtB) was used. In contrast, aryl bromides produced high yields of products in the absence of both added base and added ligand. In order to explore the Suzuki coupling process entirely under acidic conditions, a series of reactions were conducted in buffered acidic media using several model substrates. 4-Chlorobenzylamine, in the presence of cataCXiumPtB, produced high yields of product at buffered pH 6.0; the yields dropped off precipitously at buffered pH 5.0 and lower. The fall-off in yield was attributed to the decomposition of the Pd-ligand complex due to the protonation of the ligand in the more acidic aqueous media. In contrast, in the absence of an added ligand, 4-amino-2-chloropyridine produced quant. yields at buffered pH 3.5 and 4.5 while 4-amino-2-bromopyridine produced quant. yields in a series of buffered media ranging from pH 4.5 to 1.5. These substrates were only partially protonated in acidic media and could behave as active Pd ligands in the Suzuki catalytic cycle.

New Journal of Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhao published the artcileAqueous Suzuki Coupling Reactions of Basic Nitrogen-Containing Substrates in the Absence of Added Base and Ligand: Observation of High Yields under Acidic Conditions, Product Details of C5H5BrN2, the publication is Journal of Organic Chemistry (2016), 81(18), 8520-8529, database is CAplus and MEDLINE.

A series of aqueous heterogeneous Suzuki coupling reactions of substrates containing basic nitrogen centers with phenylboronic acid in the absence of added base and ligand is presented. High yields of products were obtained by employing aryl bromides containing aliphatic 1°, 2°, and 3° amine substituents, and good to high yields were obtained by employing a variety of substituted bromopyridines. In the former series, the pH of the aqueous phase changed from basic to acidic during the course of the reaction, while in the latter series the aqueous phase was on the acidic side of the pH scale throughout the entire course of reaction. A mechanistic interpretation for these observations, which generally preserves the oxo palladium catalytic cycle widely accepted in the literature, is presented.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileIndirect spectrofluorometric kinetic determination of palladium and nickel based on the oxidation of 2,2′-dipyridylketone hydrazone and dipyridylglyoxal hydrazone, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1984), 359-64, database is CAplus.

Kinetic methods for Pd (0.1-0.8 mg L^-1) and Ni (0.1-0.7 mg L^-1) are based, resp., on the uncatalyzed bromate oxidation of 2,2′-dipyridylketone hydrazone (DPKH) in acidic media and of dipyridylglyoxal hydrazone (DPDKH) in basic media, to yield fluorescent products. Complexation of DPKH and DPDKH by Pd(II) and Ni(II), resp., causes a decrease in ligand concentration and thus in reaction rate, which can be related to the concentration of metal. The method for Pd is relatively free from interferences.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileEffect of surfactants on the fluorescence intensity of organic reagents, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Microchemical Journal (1985), 31(1), 44-9, database is CAplus.

The effect of 45 surfactants on the fluorescence intensity of 12 organic reagents was studied and is discussed. There is a marked enhancement in the fluorescence intensity of organic reagents with nonrigid structures and with Ph groups closely located.

Microchemical Journal published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zapf, Christoph W. published the artcileCovalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with Nanomolar Potency in a Whole-Blood Assay, HPLC of Formula: 774170-15-9, the publication is Journal of Medicinal Chemistry (2012), 55(22), 10047-10063, database is CAplus and MEDLINE.

We wish to report a strategy that targets interleukin-2 inducible T cell kinase (Itk) with covalent inhibitors. Thus far, covalent inhibition of Itk has not been disclosed in the literature. Structure-based drug design was utilized to achieve low nanomolar potency of the disclosed series even at high ATP concentrations Kinetic measurements confirmed an irreversible binding mode with off-rate half-lives exceeding 24 h and moderate on-rates. The analogs are highly potent in a cellular IP1 assay as well as in a human whole-blood (hWB) assay. Despite a half-life of approx. 2 h in resting primary T cells, the covalent inhibition of Itk resulted in functional silencing of the TCR pathway for more than 24 h. This prolonged effect indicates that covalent inhibition is a viable strategy to target the inactivation of Itk.

Journal of Medicinal Chemistry published new progress about 774170-15-9. 774170-15-9 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amine,Boronic Acids, name is (6-(Methylamino)pyridin-3-yl)boronic acid, and the molecular formula is C15H21BO2, HPLC of Formula: 774170-15-9.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Moise, Iuliana-Monica published the artcileSwitching the reactivity of cyanomethylpyridinium salts in the 1,3-cycloaddition conditions with alkyl propiolates to cyanoindolizines or cyanoazaindolizinyl-indolizines, Related Products of pyridine-derivatives, the publication is Tetrahedron (2020), 76(41), 131502, database is CAplus.

A particular reactivity of 1-cyanomethylpyridinium salts was revealed in the [3 + 2] cycloaddition conditions with alkyl propiolates. Cyanoindolizines I [R = H, 7-Me, 7-OMe, etc.] were obtained in reactions carried out at room temperature while refluxing in CH₃CN provided unexpected Et or Me 3-(3-cyanoimidazo[1,2-a]pyridin-2-yl)indolizine-1-carboxylates II. The structure of the new 2:1 azaindolizine-indolizine adducts was secured by X-ray anal. Methodol. efforts had enabled the adjustment of the reactivity towards the formation of 3-cyanoindolizines I or cyanoazaindolizine-indolizines II. A mechanism for the formation of azaindolizine-indolizines was proposed.

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cameron, Alan J. published the artcileColorimetric determination of palladium with pyridine-2-carboxaldehyde 2′-pyridylhydrazone, Related Products of pyridine-derivatives, the publication is Analytica Chimica Acta (1968), 40(3), 413-19, database is CAplus.

Pd can be determined colorimetrically by extraction of the 1:1:1 Pd(II)-chlorine-pyridine-2-carboxaldehyde 2′-pyridylhydrazone complex from an acidic aqueous solution into σ-dichlorobenzene and measurement of the absorbance of the extract solution The method is suitable for the determination of 10-110 μg. of Pd. Tolerance amounts for many metals have been determined and compare very favorably with those of other methods.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem