Tag: M.W=150-200

Raydan, Daniel published the artcileManganese-Catalyzed Synthesis of Imines from Primary Alcohols and (Hetero)Aromatic Amines, COA of Formula: C5H5BrN2, the publication is Synlett (2022), 33(13), 1290-1294, database is CAplus.

Herein, the synthesis of a wide variety of imines through oxidative coupling of alcs. and aromatic amines catalyzed by Mn complexes bearing NN triazole ligands was described. A wide variety of imines in excellent yields (up to 99%) was prepared Mn-based catalysts proved to be highly efficient and versatile, allowing for the first time the preparation of several imines containing N-based heterocycles.

Synlett published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kanchanadevi, Sivaswamy published the artcileRuthenium(III) hydrazone complexes with triphenylphosphine/triphenylarsine co-ligands: Synthesis, DNA/BSA binding, antioxidative and cytotoxic activity, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Inorganica Chimica Acta (2021), 120532, database is CAplus.

New ruthenium(III) complexes with (E)-3-methoxy-N’-(phenyl(pyridin-2-yl)methylene)benzohydrazide (HL) were synthesized and characterized by various physicochem. and spectroscopic methods. The ligand acted as a tridentate, monobasic chelating ligand with NNO donor sites in all the complexes. The x-ray crystal structure of one of the complexes, [Ru^III(L)(PPh₃)Cl₂] (1) demonstrated a distorted octahedral coordination geometry around the metal center. Interactions of these complexes with calf thymus-DNA (CT-DNA) assessed by absorption and emission spectroscopy revealed intercalative mode of binding. Bovine serum albumin (BSA) binding of the ligand and complexes studied by absorption spectroscopy, fluorescence and synchronous spectroscopic methods revealed that the compounds bind to BSA via static binding. Antioxidant study of the ligand and complexes showed significant antioxidant activity against DPPH radical. In addition, the in vitro cytotoxicity of the ligand and complexes against human breast cancer cell line (MCF-7) and human lung cancer cells (A-549) was assayed. The results showed higher cytotoxic activity with lower IC₅₀ values indicating their efficiency in killing the cancer cells even at low concentrations

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kanchanadevi, Sivaswamy published the artcileInvestigation of DNA/BSA binding and cytotoxic properties of new Co(II), Ni(II) and Cu(II) hydrazone complexes, Formula: C12H9NO, the publication is Inorganica Chimica Acta (2021), 120536, database is CAplus.

Two mononuclear complexes of Co(II) (1) and Ni(II) (2) and a chloro bridged binuclear copper(II) complex (3) of 2-benzoylpyridine-4-methoxybenzoylhydrazone have been synthesized in order to explore their biol. activities, such as DNA binding, protein-binding, antioxidant activity and anticancer activity. Anal. and spectroscopic techniques have been used to characterize the complexes. The mol. structures of 2 and 3 have been obtained by single crystal XRD. Interaction of the ligand and the complexes with calf thymus DNA (CT-DNA) has been explored by absorption and emission titrations, which revealed that the compounds interacted with CT-DNA through intercalation. Absorption titration and biol. studies revealed that the complexes interact with BSA through different binding modes to different extents. The radical scavenging ability of the ligand and the complexes was studied against DPPH radicals. The ligand and its metal complexes were tested for potential cytotoxicity towards human breast cancer (MCF-7) and lung cancer (A-549) cell lines.

Inorganica Chimica Acta published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sgaragli, Gianpietro published the artcileRole of taurine in thermoregulation and motor control: behavioral and cellular studies, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Advances in Experimental Medicine and Biology (1996), 527-535, database is CAplus.

Taurine may have a role in the striatonigral system of the rat. Considering that, whether a neurotransmitter or a neuromodulator, taurine must be recognized before initiating its action, in the present contribution a structure-activity relationship study is presented which gives some information on the nature of a possible recognition site in the rabbit brain, helping to explain the role of endogenous taurine in the central mechanisms of thermoregulation.

Advances in Experimental Medicine and Biology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C15H21BO3, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Bing published the artcileAsymmetric Stepwise Reductive Amination of Aryl N-Heteroaryl Ketones with Benzyl Amines via Iridium Catalysis, SDS of cas: 91-02-1, the publication is Asian Journal of Organic Chemistry (2021), 10(11), 2950-2953, database is CAplus.

An asym. reductive amination of aryl N-heteroaryl ketones RC(O)R¹ (R = 2-methylphenyl, naphthalen-1-yl, 3,5-dimethoxyphenyl; R¹ = Me, pyridin-2-yl, quinolin-2-yl, etc.) with Benzyl Amines ArCH₂NH₂ (Ar = Ph, 2,6-dimethylphenyl) has been realized via one-pot two-step process, using p-toluenesulfonic acid and chiral iridium complexes as catalysts, a mixture of formic acid/triethylamine as a reductant. Twenty-three examples of chiral aryl N-heteroaryl methylamines (S)-RCH(R¹)NHCH₂Ar were obtained with good yields and up to 99% ee.

Asian Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C3H6O2, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Kun published the artcileTetraphosphine/palladium-catalyzed Suzuki-Miyaura coupling of heteroaryl halides with 3-pyridine- and 3-thiopheneboronic acid. An efficient catalyst for the formation of biheteroaryls, Safety of 2-Bromopyridin-3-amine, the publication is Applied Organometallic Chemistry (2013), 27(4), 232-238, database is CAplus.

An easily prepared tetraphosphine N,N,N’,N’-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine associated with [Pd(η³-C₃H₅)Cl]₂ affords an efficient catalyst for Suzuki-Miyaura coupling of 3-pyridineboronic acid with heteroaryl bromides. Reaction could be performed with as little as 0.02 mol% catalyst and a high turnover number of 2500 is obtained. A wide range of substrates is investigated with satisfactory yields, and good compatibility with aminogroup-substituted pyridines and unprotected indole is exhibited. This protocol can also be applied successfully to the reaction of heteroaryl bromides with 3-thiopheneboronic acid. This Pd-tetraphosphine catalyst efficiently restrains the poisoning effect from heteroaryls, and shows good stability and longevity.

Applied Organometallic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C12H21NO7, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tominaga, Yoshinori published the artcileSynthesis and reaction of 3,4-diaminothiophenes, Synthetic Route of 17281-59-3, the publication is Yakugaku Zasshi (1979), 99(11), 1081-90, database is CAplus.

Addition of pyridinium chloride I and CS₂ gave Ia, which was alkylated by XCH₂Y (X = Cl, Br; Y = CN, CO₂Et, Bz, CONH₂), cyclized, and iodomethylated to give II (R¹ = CN, CO₂Et, Bz, CONH₂; R² = pyridinio iodide). Cleavage of II iodide by addition of MeNH₂ followed by cyclization, acid hydrolysis, and neutralization gave II (R¹ = CN, CO₂Et, Bz, CONH₂; R² = NH₂). Also prepared were thieno[3,2-d]pyrimidinones III (R³ = Me, Ph; R⁴ = NH₂, NHBz, pyridinio chloride) and the thieno[3′,4′:4,5]imidazo[1,2-a]pyridine IV.

Yakugaku Zasshi published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C12H9N3O4, Synthetic Route of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tominaga, Yoshinori published the artcileA new synthesis of 3,4-diaminothiophenes, Category: pyridine-derivatives, the publication is Heterocycles (1977), 6(11), 1871-6, database is CAplus.

Thiophenediamines I (R = CN, CONH₂, CO₂Et, Bz) were prepared by treating R¹CH₂CNCl^– (R¹ = pyridinio) with CS₂-NaOH, treating R¹C(CN):C(SNa)S^– with R²CH₂R (R² = Cl, Br), cyclizing R¹C(CN):C(S^–)SCH₂R with NEt₃, methylating ylides II (R³ = S^–), treating II (R³ = SMe) with MeNH₂-HCl and neutralizing. I condensed with R⁴COCOR⁴ (R⁴ = H, Me, Ph) to give the thienopyrazines III.

Heterocycles published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C10H15NO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bornholdt, Jan published the artcileRing Opening of Pymisyl-Protected Aziridines with Organocuprates, Application In Synthesis of 636-73-7, the publication is Chemistry – A European Journal (2010), 16(41), 12474-12480, S12474/1-S12474/100, database is CAplus and MEDLINE.

The pyrimidine-2-sulfonyl (pymisyl) group is introduced as a new protecting group that can be used to activate aziridines towards ring opening. It is readily introduced and removed under mild conditions. Regioselective ring opening of pymisyl-protected 2-methylaziridine with organocuprates gives the corresponding sulfonamides in high yields, and the pymisyl group can subsequently be removed upon treatment with a thiolate. The versatility of this new nitrogen protecting group is illustrated with a new synthesis of Selegiline, a monoamine oxidase-B inhibitor marketed for the treatment of Parkinson’s disease.

Chemistry – A European Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Barlaam, Bernard published the artcileNew heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors, COA of Formula: C6H7ClN2O, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(24), 5446-5449, database is CAplus and MEDLINE.

A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthesized and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and phys. properties suitable for oral dosing were achieved within this series: I [X = CH, N] were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.

Bioorganic & Medicinal Chemistry Letters published new progress about 742070-73-1. 742070-73-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Amine,Ether, name is 2-Amino-3-chloro-6-methoxypyridine, and the molecular formula is C6H7ClN2O, COA of Formula: C6H7ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem