Tag: M.W=150-200

Salameh, Nihad published the artcileWaste-Minimized Continuous-Flow Synthesis of Oxindoles Exploiting a Polymer-Supported N Heterocyclic Palladium Carbene Complex in a CPME/Water Azeotrope, Computed Properties of 39856-58-1, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(11), 3766-3776, database is CAplus.

The development of an effective synthetic protocol for the synthesis of oxindoles in flow based on a C(sp³)-H activation process promoted by a supported N-heterocyclic carbene palladium heterogeneous catalytic system using cyclopentyl Me ether (CPME) as the reaction medium was reported. The design of the catalyst, the selection of the solvent medium, and the definition of a tailored continuous flow reactor have been all designed to establish an efficient waste-minimized process for the intramol. cyclization of N-methyl-2-halo-acetanilides. The use of CPME in its aqueous azeotropic mixture has allowed to reach high yields of products with a simplified precipitation workup that includes the downstream process separation and recycling of the solvent. An assessment of the environmental and safety hazard features has also been made in order to better clarify the implications in terms of sustainability of the newly developed process.

ACS Sustainable Chemistry & Engineering published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Computed Properties of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Carballo, Rosa published the artcileSupramolecular networks through second-sphere coordination based on 1D metal-4,4′-dipyridyldisulfide coordination polymers and hydrogenfumarate or sulfonate anions, Computed Properties of 636-73-7, the publication is Polyhedron (2012), 31(1), 118-127, database is CAplus.

Four H-bonded assemblies [M(dpds)₂(OH₂)₂]A₂·nH₂O (A = anion) are described. These assemblies result from the 2nd-sphere coordination interactions between the 1-dimensional coordination polymers [M(dpds)₂(OH₂)₂]²⁺, M = Zn(II), and Cu(II), dpds = 4,4′-dipyridyldisulfide, and the pyridine-3-sulfonate (3pySO₃^–) or hydrogenfumarate (Hfum^–) anions. Significantly, supramol. structural variations are observed depending on the presence of H₂O lattice mols., which formed discrete aggregates when the Hfum^– anion was used. The effects of geometrical variations in the building blocks are also evident on using Jahn-Teller-distorted divalent Cu(II) ions or regular octahedral species based on Zn(II) ions. The 2nd-sphere effects on the stabilization of the compounds are illustrated by TGA experiments

Polyhedron published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sokolova, Ekaterina A. published the artcileHighly Fluorescent Pyrido[2,3-b]indolizine-10-Carbonitriles through Pseudo Three-Component Reactions of N-(Cyanomethyl)pyridinium Salts, Related Products of pyridine-derivatives, the publication is European Journal of Organic Chemistry (2019), 2019(40), 6770-6775, database is CAplus.

An interaction of N-(cyanomethyl)pyridinium salts with vinamidinium perchlorates or enaminones proceeds as a pseudo-three component process and results in the formation of 3- or 2-substituted pyrido[2,3-b]indolizine-10-carbonitriles, resp. Optical properties of these compounds have been evaluated, revealing effective green light emission with fluorescence quantum yields of up to 0.81.

European Journal of Organic Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C6H6N2O, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Storozhenko, Olga A. published the artcileMn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Beilstein Journal of Organic Chemistry (2018), 3078-3087, database is CAplus and MEDLINE.

The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)₃·2H₂O or KMnO₄ as stoichiometric oxidants allowed the use of a wide range of nucleophiles, such as nitromethane, (aza)indoles, pyrroles, phenols, pyrazole, indazole and di-Et malonate. The formation of the target compounds presumably proceeds through a domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction sequence.

Beilstein Journal of Organic Chemistry published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C26H41N5O7S, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Recio, Javier published the artcileStudies on the preparation of aminobipyridines and bipyridine sultams via an intramolecular free radical pathway, Safety of 2-Bromopyridin-3-amine, the publication is RSC Advances (2020), 10(18), 10447-10451, database is CAplus and MEDLINE.

A variety of aminated bipyridines and bipyridine sultams are prepared by intramol. radical [1,5]-ipso and [1,6]-ortho substitutions, using a sulfonamide as a linker to connect the pyridyl radical to the pyridine under attack. For the cases studied, different regiochemistries were observed depending on the initial position of the sulfonamide linker.

RSC Advances published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Solov’ev, M. Yu. published the artcileSynthesis, structure, and properties of a number of 3-sulfanilamidic derivatives of pyridine, Application of Pyridine-3-sulfonic acid, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (2004), 47(2), 28-36, database is CAplus.

3-Pyridinesulfochloride was synthesized by the dehydroxochloration of 3-pyridinesulfonic acid and used for the synthesis of a number of primary and secondary sulfonylamides and also (3-pyridinesulfonyl)-pyperidinecarboxylic acids and their amides NMR ¹H-spectra of the synthesized compounds are described and interpreted. The rating of their potential suitability for biol. tests is carried out according to Lipinski rules and “lead-like”-conception. Also, the rating of ability of the received compounds to penetrate through the hemato-encephalic barrier was made using the special neuron-net model. The conclusion about the expediency of testing of the synthesized compounds is made for the area of development of CNS acting drugs.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C6H16OSi, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Al-Sanea, Mohammad M. published the artcileSynthesis and in Vitro Screening of Phenylbipyridinylpyrazole Derivatives as Potential Antiproliferative Agents, Application of (6-Ethoxypyridin-3-yl)boronic acid, the publication is Molecules (2015), 20(1), 1031-1045, 15 pp., database is CAplus and MEDLINE.

A series of phenyl(bipyridinyl)pyrazoles I (R = F, MeS, morpholin-4-yl, etc.) were synthesized and screened at 10 μM against over 60 tumor cell lines at the U.S. National Cancer Institute (NCI). Compounds I [R = pyrrolidin-1-yl, 4-benzylpiperazin-1-yl (II)] showed a broad spectrum of activity against NCI cell lines with mean growth of 53% and 58%, resp. Compound I [R = 4-methylpiperazin-1-yl (III)] behaved differently as it showed a high degree of selectivity and potency by inhibiting 96% of growth of leukemia SR cell line at 10 μM. Standard COMPARE anal. was performed at the GI₅₀ level and the results exhibited a high correlation in the form of pairwise correlation coefficient (PCC) of more than 0.6 between three of the current compounds and three standard known anticancer agents. Compound III demonstrated a high correlation level with merbarone (NSC S336628) with a PCC value of 0.631. Compound II showed a considerably high PCC value of 0.626 with dichloroallyl lawsone, while compound I (R = benzyloxy), showed PCC values of 0.601 and 0.604 with both dichloroallyl lawsone and N,N-dibenzyldaunomycin (NSC S268242), resp. These three standard agents have anticancer activity via two major mechanism of actions, inhibition of topoisomerase II and inhibition of biosynthesis of pyrimidine nucleotides, therefore, compounds I are promising therapeutic agents for targeting different human malignancies. Prediction of drug-likeness and toxicity of the synthesized derivatives I were also considered.

Molecules published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Application of (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Al-Janabi, Ahmed S. M. published the artcileSynthesis, anti-bacterial evaluation, DFT study and molecular docking as a potential 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 inhibitors of a novel Schiff bases, Formula: C12H9NO, the publication is Journal of Molecular Structure (2021), 129454, database is CAplus and MEDLINE.

New Schiff bases (L¹H) I (I), (L²H) II (II), (L³H) III (III) were synthesized by reaction of 2-benzoylpyridine with different amines (2-amino-6-chlorobenzothiazole, isonicotinohydrazide and N¹-(naphthalen-1-yl)ethane-1,2-diamine) and characterized by ¹H-NMR, ¹³C-NMR, IR mass spectroscopy and elemental anal. The compounds (I), (II) and (III) were assayed by the disk diffusion method for anti-bacterial against five pathogenic bacteria species (Staphylococcus aureus, Micrococcus luteus, Staphylococcus pyogenes, Bacillus subtilis, and E. coli). All prepared Schiff bases (I), (II) and (III) showed good activity compared to pos. control (streptomycin). Moreover the L³H showed the highest activity against S. aureus, and M. luteus than the other compounds and streptomycin. In addnl. mol. docking studies with 3-chymotrypsin-like protease (3CLpro), the essential enzyme for SARS-CoV-2 proliferation. The rest of compounds have shown promising results as 3CLpro inhibitors interacting with the active sites of the enzymes. Finally, DFT’s estimated electrostatic mol. potential results were used to illustrate the mol. docking findings. The DFT calculations showed that L³H has the highest dipole moment and electrophilicity index. Interestingly, L²H of the largest energy gap ΔE = 2.49 eV, there are several hydrophilic interactions that could facilitate the binding with the receptors. All of these parameters could be shared to significantly affect the protein sites of binding affinity with different extent.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Grases, F. published the artcileA kinetic fluorimetric method for determination of microamounts of platinum(IV) with 2,2′-dipyridyl ketone hydrazone, SDS of cas: 2215-33-0, the publication is Analytical Letters (1980), 13(A3), 181-9, database is CAplus.

A kinetic method for determination of traces of Pt(IV) is based on the autoxidation of the hydrazone of 2,2′-dipyridyl ketone, in which a fluorescent product (λ_ex 359 nm, λ_em = 435 nm) is formed. The reaction is followed by the measurement of the rate of appearance of the fluorescence. The proposed method suffers very few interferences.

Analytical Letters published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, SDS of cas: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Alo, Babajide I. published the artcileDirected metalation of pyridinesulfonamides. Synthesis of pyridine-fused isothiazoles and 1,2-oxathioles, Application of Pyridine-3-sulfonic acid, the publication is Journal of Heterocyclic Chemistry (1992), 29(1), 61-4, database is CAplus.

4-Lithio-N–tert-butylpyridine-3-sulfonamide reacted with Ph₂CO or CO₂ to give the corresponding intermediates, which on appropriate treatment gave the addition product I (from Ph₂CO reaction product) or isothiazolo[5,4-c]pyridin-3-one 1,1-dioxides II (R = H, Me₃C) (from CO₂ reaction product). Metalation of 2- and 4-[N,N-(dialkylamino)sulfonyl]pyridines with LiN(CHMe₂)₂ gave anions which reacted with Ph₂CO to give carbinols, which cyclized thermally to 1,2-oxathiolo[3,4-b]- III and -[4,3-c]pyridine dioxide IV, resp.

Journal of Heterocyclic Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem