Tag: M.W=150-200

Tedder, Mariah L. published the artcileMicrowave-assisted C-H oxidation of methylpyridylheteroarenes via a Kornblum-Type reaction, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Tetrahedron (2022), 132805, database is CAplus.

Expansion of the operational capacity of soft-Lewis basic complexant scaffolds towards improved phys. properties for the chemoselective sequestration of minor actinides from the electronically similar lanthanides necessitates rapid access to synthons for efficient complexant construction for downstream employment in separations assays. Pursuant to the aforementioned, authors were interested in exploring the potential utility of advanced, unsym. heteroarene constructs for separations which required access to pyridyl carbaldehydes. Limited com. availability of synthetic precursors inspired effort to define a chemoselective, microwave assisted, Kornblum-type reaction via C-H functionalization. This efficient reaction sequence uses I₂ as a mild oxidant without acidic or basic additives, in concert with DMSO as the solvent and putative oxygen source to afford a diverse array of heteroaryl products devoid of competitive remote Me group oxidation, or degradation of the heteroaryl N atom. Method development, substrate scope, and a preliminary mechanistic hypothesis supported by D. Functional Theory are presented herein.

Tetrahedron published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C8H10BNO3, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Shuang published the artcileA Novel Ternary Ligand System for ^99mTc-Labeling of Hydrazino Nicotinamide-Modified Biologically Active Molecules Using Imine-N-Containing Heterocycles as Coligands, Application of Pyridine-3-sulfonic acid, the publication is Bioconjugate Chemistry (1998), 9(5), 583-595, database is CAplus and MEDLINE.

A hydrazinonicotinamide-functionalized cyclic platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonist [HYNICtide, cyclo(D-Val-NMeArg-Gly-Asp-Mamb(5-(6-(6-hydrazinonicotinamido)hexanamide)))] was labeled with ^99mTc using tricine and a series of imine-N-containing heterocycles as coligands. The imine-N-containing heterocycles include N-ω-Acetylhistamine (HIS-AC), N-(2-hydroxyethyl)isonicotinamide (ISONIC-HE), isonicotinic acid (ISONIC), isonicotinoyl-L-aspartic acid di-Me ester (ISONIC-L-Asp-OMe₂), 4-methyl-5-thiazoleethanol (MTE), nicotinic acid (NIC), 3-nitro-1,2,4-triazole (NTZ), 4-pyridylacetic acid (PA), 4-pyridineethanesulfonic acid (PES), and 3-pyridinesulfonic acid (PSA). The synthesis of these new ternary ligand [^99mTc]HYNICtide complexes can be performed in one or two steps in high yield and high specific activity (≥10 000 Ci/mmol HYNICtide). For example, the reaction of HYNICtide, [^99mTc]pertechnetate, nicotinic acid, stannous chloride, and tricine at pH ∼5 and 100° for 20 min results in the complex [^99mTc(HYNICtide)(tricine)(NIC)] in ≥90% yield as determined by radio-HPLC. It was found that ternary ligand technetium complexes, [^99mTc(HYNICtide)(tricine)(L)] (L = ISONIC, ISONIC-L-Asp-OMe₂, ISONIC-HE, MTE, PA, PES, and PSA) are formed as equal mixtures of two isomeric forms. Complex [^99mTc(HYNICtide)(tricine)(L)] (L = HIS-AC and NTZ) showed more than two well-resolved radiometric peaks at the retention times of interest, suggesting that they may have more than two forms in solution due to different bonding modalities of HIS-AC and NTZ. By a chirality experiment, it was found that the presence of two radiometric peaks is a result of the resolution of the two diastereomers which are formed by the combination of the chiral HYNICtide and the chiral technetium chelate. The formation of two diastereomers was also observed when a chiral imine-N-containing coligand was used for the radiolabeling of HYNIC-BA. The new ternary ligand [^99mTc]HYNICtide complexes were found to be stable for up to 6 h in the reaction mixture The high solution stability is attributed to their kinetic inertness. The composition of these complexes was determined to be 1:1:1:1 for Tc:HYNICtidepl:tricine (L = imine-N-containing heterocycles) through a series of mixed ligand experiments on the tracer (^99mTc) level. The lipophilicity of the ternary ligand [^99mTc]HYNICtide complexes can be systematically varied by the choice of polyaminocarboxylate and imine-N-containing coligands. Using the combination of tricine and an imine-N-containing coligand, HYNIC-derivatized peptides or other small mols. can be labeled with ^99mTc in high specific activity and high stability for potential use as radiopharmaceuticals.

Bioconjugate Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dunn, J. G. published the artcileBidentate nature of 2-pyridinecarboxaldehyde 2-pyridylhydrazone in its complexes with metal carbonyls, Formula: C11H10N4, the publication is Inorganic and Nuclear Chemistry Letters (1969), 5(7), 539-43, database is CAplus.

Substituted metal carbonyls in which the title compound (paphy) (I) is acting as a bidentate donor have been prepared The compounds prepared were Cr(CO)4(paphy), Mo(CO)4(paphy), and W(CO)4-(paphy). Mo(CO)6 (0.2 g.) was refluxed with 0.15 g. I in 5 ml. Me2C(OMe)2 (II) for 30 min. under N. The solution colored to a maroon-purple. After 30 min. the solution was filtered hot and the solid product washed with II. The product was stable under normal laboratory conditions. Similarity in the CO stretching frequencies between the I compounds and the bipyridine complex Mo(cO)4(bipy) is evidence of the bidentate nature of the I ligand. Further evidence is the fact that the complexes are diamagnetic and nonelectrolytes in EtCN and MeNO2. Mo-(CO)4(paphy) reacts with (C6H5)3P to produce cis-Mo(CO)3-(paphy)(PPh3); ir CO stretching frequencies are quite similar to the analogous bipyridine complex.

Inorganic and Nuclear Chemistry Letters published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Van der Does, L. published the artcileDidehydrohetarenes. XXV. Amination of alkyl substituted halopyridines with potassium amide in liquid ammonia, HPLC of Formula: 39919-70-5, the publication is Recueil des Travaux Chimiques des Pays-Bas (1972), 91(12), 1403-13, database is CAplus.

The action of KNH2 in liquid NH3 on Me substituted 3- and 4-bromo(or chloro)pyridines, of 5-bromo-2-tert-butylpyridine and of 3-bromo(or chloro) and 4-bromo(or chloro)-2,6-dimethylpyridine was studied. The results of the reactions indicate the occurrence of derivatives of 3,4-didehydropyridine as intermediates. An interpretation is given of the influence of the substituent and the hetero atom on the course of the aminations.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 39919-70-5. 39919-70-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 6-(tert-Butyl)pyridin-3-amine, and the molecular formula is C6H12N2O, HPLC of Formula: 39919-70-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhong, Shuai published the artcileVisible-light-induced 4CzIPN/LiBr system: a tireless electron shuttle to enable reductive deoxygenation of N-heteroaryl carbonyls, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Organic Chemistry Frontiers (2021), 8(16), 4419-4425, database is CAplus.

A visible-light-induced photoredox system that enabled efficient reductive deoxygenation of N-heteroaryl ketones and alcs. under mild conditions was reported. The combinational use of 4CzIPN as photocatalyst and LiBr as additive in acidic media constituted a tireless electron shuttle to transfer electrons from benzaldehyde to N-heteroaryl carbonyls. Mechanistically, the reduction course involved two-round sequential cascade of proton-coupled electron transfer, spin-center shift and single-electron-transfer processes. The presented reductive deoxygenation protocol provides a mild route to pharmaceutically valuable alkyl and benzyl N-containing heteroarenes.

Organic Chemistry Frontiers published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C3H3Br2ClO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Koovits, Paul J. published the artcileStructure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi, Name: 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(1), 126779, database is CAplus and MEDLINE.

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “Chagas box” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gueye, Mbosse Ndiaye published the artcileLanthanide(III) complexes with tridentate schiff base ligand, antioxidant activity and X-ray crystal structures of the Nd(III) and Sm(III) complexes, Application In Synthesis of 2215-33-0, the publication is South African Journal of Chemistry (2017), 70(1), 8-15, S1-S6, database is CAplus.

The tridentate N4-type Schiff base was synthesized from the condensation reaction of 2-hydrazinopyridine and pyridine-2-carbaldehyde. Neodymium and samarium complexes were isolated when the corresponding nitrate salt was added to the solution of the ligand. The isolated compounds were characterized by elemental analyses, IR study, room temperature magnetic measurements and single x-ray crystal diffraction of the two crystals. Both complexes crystallize in the monoclinic system with space group P21/c. The cell parameters of the Nd complex are a 11.0927(8), b 17.9926(13) Å, c 11.9395(9) Åand β 115.274(5)° while the Sm complex shows parameters cell of a 11.0477(8), b 17.9254(13), c 11.9149(8) Å and β 115.489(5)°. The x-ray study reveals isotopic Nd/Sm binuclear structures were each metal ion is nine-coordinated in the same fashion. Both metal centers have distorted tricapped trigonal prism geometry, with the Schiff base acting as tridentate ligand. The DPPH• radical scavenging effects of the Schiff base ligand and its Ln(III) complexes were screened. The Ln(III) complexes were significantly more efficient in quenching DPPH• than the free Schiff base ligand.

South African Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application In Synthesis of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gueye, Mbosse Ndiaye published the artcileSynthesis, physical studies and crystal structure determination of Y(III) and Er(III) complexes of 1-(pyridin-2-yl)-2-(pyridine-2-yl-methylene)hydrazine, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is European Journal of Chemistry (2017), 8(2), 137-143, database is CAplus.

Two isotype mononuclear yttrium(III) and erbium(III) complexes, {[Y(HL)(OAc)₂(H₂O)₂]. (H₂O)·(NO₃)} (1) and {[Er(HL)(OAc)₂(H₂O)₂].(H₂O)·(NO₃)} (2), where HL is the neutral Schiff base ligand 1-(pyridin-2-yl)-2-(pyridine-2-yl-methylene)hydrazine, and OAc is the acetate anion, were synthesized and characterized by physicochem. methods and single crystal x-ray determination Both complexes crystallize in the triclinic space group P-1 with unit cell dimensions for complex of Y(III) a 7.909(2), b 11.718(4), c 12.497(3) Å, α 78.907(3), β 73.840(3), γ 72.074(3)°, Z = 2, R₁ = 0.051 and wR₂ = 0.112 and for complex of Er(III) a 7.913(1), b 11.719(2), c 12.487(2) Å, α 78.832(1), α 73.674(1), γ 72.012(1)°, Z = 2, R₁ = 0.028, and wR₂ = 0.062. In both complexes, the coordination polyhedra around Ln(III) atoms are best described as a distorted tricapped trigonal prism. Antioxidant activities of the ligand and its Y(III) and Er(III) complexes were studied.

European Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bumagin, N. A. published the artcileEffecting heterogeneous catalysts on aluminum and silicon oxides, COA of Formula: C5H5BrN2, the publication is Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk (2015), 34-41, database is CAplus.

Convenient and technol. suitable methods for immobilization of palladium and 1,2-azole ligands on mesoporous aluminum and silicon oxides have been developed. The obtained palladium composites: Pd/Al2O3(60), Pd/Al2O3(90), Pd-L1/Al2O3(60), Pd-L2/SiO2(60) and L1PdCl2@SiO2 demonstrate high catalytic activity and recovery in the Suzuki reaction in aqueous media.

Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mdluli, Velabo published the artcileHigh-throughput Synthesis and Screening of Iridium(III) Photocatalysts for the Fast and Chemoselective Dehalogenation of Aryl Bromides, Computed Properties of 85237-71-4, the publication is ACS Catalysis (2020), 10(13), 6977-6987, database is CAplus.

A high-throughput optical screening method for the photocatalytic activity of a structurally diverse library of 1152 cationic iridium(III) complexes ([Ir(C^N)₂(N^N)]⁺), corresponding to all combinations of 48 cyclometalating (C^N) and 24 ancillary (N^N) ligands, was developed. This rapid assay utilizes the colorimetric changes of a high contrast indicator dye, coumarin 6, to monitor the photo-induced electron transfer from a sacrificial amine donor to the metal complex excited state. The resulting [Ir(C^N)₂(N^N)]⁰ can then reduce an aryl bromide to form the highly reactive aryl radical intermediate. The rate of this reaction is dictated by the mol. structure of both coordinating ligands. Relative reaction rate constants determined via this method correlated closely with ¹⁹F NMR measurements obtained using a fluorinated substrate. A simple model that expresses the rate constant as a product of a single ”strength” parameter assigned to each of the 72 ligands can well account for the 1152 measured rate constants The best performing complexes exhibit much higher reactivity than the benchmark photocatalysts commonly used in photoredox transformations. The catalysts were also successfully tested for their chemoselectivity. The developed screening methodol. can enable generation of the large data sets needed to use modern data science to extract structure-activity relationships.

ACS Catalysis published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Computed Properties of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem