Tag: M.W=150-200

Chen, Dongsheng published the artcileOne-Pot Synthesis of Indole-3-acetic Acid Derivatives through the Cascade Tsuji-Trost Reaction and Heck Coupling, COA of Formula: C5H5BrN2, the publication is Journal of Organic Chemistry (2018), 83(12), 6805-6814, database is CAplus and MEDLINE.

A practical palladium-mediated cascade Tsuji-Trost reaction/Heck coupling of N-Ts o-bromoanilines with 4-acetoxy-2-butenoic acid derivatives using a Pd(OAc)2/P(o-tol)3/DIPEA system is described for a straightforward synthesis of indole-3-acetic acid derivs, e.g. I. This methodol. was successfully applied to synthesize various substituted indole/azaindole-3-acetic acid derivatives and Almotriptan, which is a drug for the acute treatment of migraine. Moreover, a plausible cyclization mechanism has been proposed.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zheng, Wen-Rui published the artcileS=O homolytic bond dissociation enthalpies in sulfones: high-level ab initio and DFT study, Computed Properties of 636-73-7, the publication is Journal of Sulfur Chemistry (2012), 33(5), 541-559, database is CAplus.

The S=O bond dissociation enthalpies (BDE) of sulfone derivatives were calculated using high-level ab initio methods including G3, G3B3, CBS-Q, CBS-4M and MP2. Based on the comparison of these theor. values and exptl. ones, the performances of a number of d. functional theory methods were then assessed. It was found that the KMLYP method gave the lowest root mean square error. We, therefore, used this method to calculate the S=O BDEs of a number of substituted sulfones. The electronic effect of the substituents and the remote substituent effect of aryl-substituted sulfones on S=O BDEs were investigated. In addition, a MO anal. of typical mols. was conducted in order to investigate the electronic effect on S=O BDEs. We also predicted several S=O BDE values of heteroaromatic-substituted sulfones using the KMLYP method.

Journal of Sulfur Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C15H24S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Akiri, Kalyanachakravarthi published the artcileCrystal Structures of Pyridine Sulfonamides and Sulfonic Acids, SDS of cas: 636-73-7, the publication is Crystal Growth & Design (2012), 12(9), 4567-4573, database is CAplus.

Despite the widespread occurrence of pyridinesulfonic acid and pyridinesulfonamide functional groups in drugs and pharmaceuticals, and their use as ligands in metal-organic frameworks, a systematic structural study of their H bonding and mol. packing is lacking. Crystal structures of 2-, 3-, and 4-pyridinesulfonic acids/amides in terms of N⁺-H···O^– H bonds, N-H···O dimer/catemer synthons, and graph set notations are discussed. This model study provides a background for polymorph screening and solid form hunting of pharmacol. active sulfonamides.

Crystal Growth & Design published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Badlueva, T. V. published the artcileNew proton-conductive membrane for fuel cell applications, Quality Control of 636-73-7, the publication is Izvestiya VUZov, Prikladnaya Khimiya i Biotekhnologiya (2014), 15-19, database is CAplus.

Proton conductive membranes based on tetra-Et orthosilicate and pyridine-3-sulfonic acid have been synthesized. The characteristics of the received membranes: proton-conductivity at different temperatures and structure were studied.

Izvestiya VUZov, Prikladnaya Khimiya i Biotekhnologiya published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Quality Control of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lebedeva, O. V. published the artcileHybrid ion-exchange membranes based on heteroaromatic sulfonic acid derivatives, HPLC of Formula: 636-73-7, the publication is Petroleum Chemistry (2015), 55(5), 333-338, database is CAplus.

Membranes exhibiting proton conductivity have been prepared by sol-gel synthesis using tetraethoxysilane and heteroaromatic sulfonic acid derivatives (2-phenyl-5-benzimidazolesulfonic acid and 3-pyridinesulfonic acid) in the presence of phosphoric acid and polyvinyl butyral. The membranes are gels composed of a polyvinyl butyral polymer matrix with uniformly distributed particles of silica containing mols. of heteroaromatic sulfonic acid derivatives mech. incorporated in its network structure. The membranes synthesized from 2-phenyl-5-benzimidazolesulfonic acid or 3-pyridinesulfonic acid exhibit a conductivity of 0.1X10^-2 or 0.55X10^-2 S/cm at 353 K, an ion-exchange capacity of 2.70 or 1.84 mequiv/g, and a proton-transfer activation energy of 24.93 or 21.73 kJ/mol, resp.; at a relative water content of 50%, the tensile strength is 4 or 6 MPa and the elastic modulus is 128 or 191 MPa, resp.

Petroleum Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, HPLC of Formula: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Costanzo, L. L. published the artcileSensitized photoisomerization of pyridylhydrazones, COA of Formula: C11H10N4, the publication is Journal of Photochemistry (1980), 14(2), 125-32, database is CAplus.

The syn–anti isomerizations of benzaldehyde 2-pyridylhydrazone (I) and 2-pyridinecarboxaldehyde 2-pyridylhydrazone (II) by triplet energy transfer were investigated. II underwent reversible isomerization without side reactions; the triplet states implied in the process were quenchable by azulene and their lifetime was determined Isomerization and secondary photolysis reactions occurred simultaneously in I, regardless of the nature of the sensitizer. The pathways of the direct and sensitized isomerizations do not involve intersystem crossing.

Journal of Photochemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Potkin, V. I. published the artcile5-(Naphth-1-yl)- and 5-[(1,1′-biphenyl)-4-yl]isoxazole-3-carbaldehyde oximes: Synthesis, complexes with palladium, and application in catalysis, Safety of 2-Bromopyridin-3-amine, the publication is Russian Journal of General Chemistry (2014), 84(9), 1782-1792, database is CAplus.

1-(Naphth-1-yl)- and 1-(1,1′-biphenyl)-4-yl-3,4,4-trichloro-3-buten-1-ones were synthesized by acylation of naphthalene and biphenyl with 3,4,4-trichloro-3-butenoyl chloride. Further reaction with hydroxylamine led to 5-(naphth-1-yl)- and 5-[(1,1′-biphenyl)-4-yl]isoxazole-3-carbaldehyde oximes. The latter form complexes with palladium, which possess high catalytic activity in the Suzuki reaction in aqueous and aqueous-alc. media.

Russian Journal of General Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Ping published the artcileMicrowave irradiation induced synthesis of 2-amino-4,6-diarylpyridines, HPLC of Formula: 17281-59-3, the publication is Youji Huaxue (2006), 26(12), 1673-1676, database is CAplus.

Under microwave irradiation, N-cyanomethylpyridinium chloride reacted with chalcones in the presence of ammonium acetate and acetic acid to give 2-amino-4,6-diarylpyridines in high yields. 2-Aminoduiarylpyridines can also be prepared from one-pot reactions of N-cyanomethylpyridinium chloride with aromatic aldehydes and substituted acetophones. The structures of the products were characterized with ¹H NMR, IR and HPLC-MS spectra.

Youji Huaxue published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C25H34N4O2S, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Renno, Giacomo published the artcileImidazo[1,5-a]pyridine-Based Fluorescent Probes: A Photophysical Investigation in Liposome Models, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Molecules (2022), 27(12), 3856, database is CAplus and MEDLINE.

In this context, five imidazo[1,5-a]pyridine-based fluorophores were synthesized according to a one-pot cyclization between an aromatic ketone and benzaldehyde in the presence of ammonium acetate and acetic acid. The photophys. features of prepared compounds were investigated in several organic solvents and probes 2-4 exhibited the greatest solvatochromic behavior, resulting in a higher suitability as membrane probes. Their interaction with liposomes as artificial membrane model was tested showing a successful intercalation of the probes in the lipid bilayer. Kinetic experiments were carried out and the lipidic phase influence on the photophys. features was evaluated through temperature-dependent experiments The results herein reported encourage further investigations on the use of imidazo[1,5-a]pyridine scaffold as fluorescent membrane probes.

Molecules published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Picado, Alfredo published the artcileA chemical probe for dark kinase STK17B derives its potency and high selectivity through a unique P-loop conformation, Product Details of C7H8BNO3, the publication is Journal of Medicinal Chemistry (2020), 63(23), 14626-14646, database is CAplus and MEDLINE.

STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the role of STK17B in normal and disease pathol. is poorly defined. Here, we present the discovery of thieno[3,2-d] pyrimidine SGC-STK17B-1 (11s), a high-quality chem. probe for this understudied “dark” kinase. 11S is an ATP-competitive inhibitor that showed remarkable selectivity over other kinases including the closely related STK17A. X-ray crystallog. of 11s and related thieno[3,2-d]pyrimidines bound to STK17B revealed a unique P-loop conformation characterized by a salt bridge between R41 and the carboxylic acid of the inhibitor. Mol. dynamic simulations of STK17B revealed the flexibility of the P-loop and a wide range of R41 conformations available to the apo-protein. The isomeric thieno[2,3-d]pyrimidine SGC-STK17B-1N (19g) was identified as a neg. control compound The >100-fold lower activity of 19g on STK17B was attributed to the reduced basicity of its pyrimidine N1.

Journal of Medicinal Chemistry published new progress about 2682066-26-6. 2682066-26-6 belongs to pyridine-derivatives, auxiliary class Boronic Acids,Boronic acid and ester,Boronic acid and ester, name is (6-Acetylpyridin-3-yl)boronic acid, and the molecular formula is C7H8BNO3, Product Details of C7H8BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem