Tag: M.W=150-200

Berseneva, V. S. published the artcileSynthesis and properties of [(thiocarbamoyl)methyl]pyridinium (isoquinolinium) ylides, Name: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1989), 1639-43, database is CAplus.

Treating pyridinium or isoquinolinium ylides I (R = CN) with H₂S in EtOH containing NaOEt gave ylides I (R = CSNH₂). The isoquinoline derivatives were cyclized by 1-chloro-2,4-dinitrobenzene to give 32% imidazoloisoquinoline II. Addnl. obtained from I were 15 and 30% imidazolopyridine and isoquinolines III, resp.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Name: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ghalehshahi, Hajar G. published the artcileSynthesis, CYP 450 evaluation, and docking simulation of novel 4-aminopyridine and coumarin derivatives, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(3), n/a, database is CAplus and MEDLINE.

Four series of novel compounds based on 4-aminopyridine, glatiramer acetate, pyrone, and coumarin backbones were sufficiently synthesized and identified by spectroscopic methods. CYP enzyme inhibition assays of five predominate human P 450 isoenzymes indicate that all compounds, except for 4-hydrazide pyridine 1c, seem to be less toxic than 4-aminopyridine. Further investigation of the compounds using mol. docking experiments revealed different, the same, or stronger binding modes for most of the synthesized compounds, with both polar and hydrophobic interactions with the 1WDA and 1J95 receptors compared to benzoyl L-arginine amide and 4-aminopyridine, resp. These results introduce the synthesized compounds as K⁺ channel blockers that could be considered for in vivo CNS disease studies.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Recommanded Product: 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Siddle, Jamie S. published the artcileDivergent synthesis of arylated pyridin-2(1H)-one derivatives via metal-catalysed cross-coupling processes, Formula: C5H5BrN2, the publication is Tetrahedron (2010), 66(32), 6138-6149, database is CAplus.

1,5-Di(hetero)arylated-pyridin-2(1H)-one derivatives, e.g. I, have been readily obtained in good yields starting from 2-fluoro-5-pyridylboronic acid. The sequence comprises three steps: (i) palladium-catalyzed Suzuki-Miyaura reaction; (ii) base-catalyzed hydrolysis; (iii) copper-catalyzed C-N coupling. X-ray crystal structures are reported for selected pyridin-2(1H)-one derivatives These compounds are of interest as new scaffolds for drug discovery.

Tetrahedron published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C10H2F12NiO4, Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mushrush, George W. published the artcileChemical basis of middle-distillate fuel instability – interactive effects of selected nitrogen heterocycles with organic acids and bases in a shale-derived diesel fuel, Formula: C5H5NO3S, the publication is Oil Shale Symposium Proceedings (1991), 74-81, database is CAplus.

Fuel-instability reactions with increasing time in storage usually are defined in terms of the formation of deleterious products, such as filterable sediment and peroxides. These detrimental products of long-term storage continue to be a problem in the utilization of middle-distillate fuels. Gravimetric stability tests have been carried out at 80° by using 2 model N heterocycles: 2,5-dimethylpyrrole (DMP) and 3-methylindole (3-MI) in an otherwise stable shale-derived diesel fuel. Potential interactive effects for these N heterocycles in this stable middle-distillate fuel have been described by the presence of organic acid and base co-dopants. Organic acid co-dopants included hexanoic acid, acetic acid, dodecylbenzene sulfonic acid, and p-toluene sulfonic acid; organic bases employed included tri-n-butylamine, N,N-di-Me aniline, and 4-dimethylamino pyridine. Co-dopants were selected on the number of polar species present in a shale-derived diesel fuel. The fuel matrix containing the co-dopants, 2,5-dimethylpyrrole and dodecylbenzene sulfonic acid, generated the largest quantity of filterable sediment yet observed in any of the stability tests. Simple organic amines exerted only minor interactive effects, usually an increase in filterable sediment of 5-15%. However, the diamine species, 4-dimethylamino pyridine, interacted in a strongly pos. fashion to generate increased amounts of sediment. Hydroperoxide levels were monitored for each reaction mixture Co-dopants had a drastic beneficial effect on observed hydroperoxide concentration

Oil Shale Symposium Proceedings published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Baus Topic, Nea published the artcileHalogen-Bonded Cocrystals of 1,3,5-Triiodo-2,4,6-trifluorobenzene and Structural Isomers of Benzoylpyridine, Computed Properties of 91-02-1, the publication is Crystal Growth & Design (2022), 22(6), 3981-3989, database is CAplus.

Six novel halogen-bonded cocrystals of 1,3,5-triiodo-2,4,6-trifluorobenzene with three structural isomers of benzoylpyridine have been synthesized mechanochem. and by crystallization from solution, five of which were structurally characterized. In four cocrystals, benzoylpyridine is a ditopic halogen-bond acceptor participating in halogen bonding with both pyridine nitrogen and carbonyl oxygen atoms, while in one cocrystal, only the I···N halogen bond has formed. In general, the I···N halogen bonds are shorter than I···O interactions, except in the cocrystals with 2-benzoylpyridine. The N and O halogen-bond acceptor sites were evaluated using calculated mol. electrostatic potentials (MEPs) and binding energies of both I···N and I···O halogen-bonded dimers in the gas phase.

Crystal Growth & Design published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Quddus, M. A. published the artcileExtraction of zinc by pyridine 2-carboxaldehyde 2-pyridylhydrazone (PAPHY) in chloroform, SDS of cas: 2215-33-0, the publication is Journal of Inorganic and Nuclear Chemistry (1971), 33(7), 2001-7, database is CAplus.

The distribution of Zn between aqueous solutions and pyridine 2-carboxaldehyde 2-pyridylhydrazone (PAPHY) in CHCl3 has been studied as a function of the pH of the aqueous phase and the concentration of PAPHY. Stability and acid dissociation constants of the complex ions have been determined as well as the partition coefficients of the ligand and its extractable Zn complex. An equation has been proposed to represent the extraction equilibrium and its essential correctness verified.

Journal of Inorganic and Nuclear Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, SDS of cas: 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wood, Aaron published the artcileCoordinated Hydrazone Ligands as Nucleophiles: Reactions of Fe(papy)₂, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Inorganic Chemistry (2004), 43(26), 8355-8360, database is CAplus and MEDLINE.

The diamagnetic Fe(II) complexes of the hydrazone ligand pyridinecarboxaldehyde-2′-pyridylhydrazone (papyH) were characterized by NMR, IR, UV-visible, and electrochem. The dication Fe(papyH)₂²⁺ undergoes reversible 1-electron oxidation at 0.66 V vs. internal ferrocene and shows a strong metal-ligand charge-transfer band in the visible region at 524 nm. Deprotonation with NaOH gives diamagnetic, neutral Fe(papy)₂ with an oxidation potential of -0.25 V vs. internal ferrocene and a charge-transfer band at 603 nm. Fe(papy)₂ reacts with active alkylating agents to give dialkyl complexes Fe(papyR)₂²⁺ with spectroscopic properties similar to those of Fe(papyH)₂²⁺. Monitoring the alkylation by UV-visible reveals the intermediacy of a monoalkylated species.

Inorganic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C10H14O, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Carmona-Vargas, Christian C. published the artcileDetermination of the binding constants of propeller-like metal complexes of picolinaldehyde-2-pyridylhydrazone, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Inorganica Chimica Acta (2019), 275-280, database is CAplus.

Herein, the authors determined the binding constants for transition metal complexes of Cu²⁺, Co²⁺, Fe²⁺, Ni²⁺, and Zn²⁺ ions formed with the ligand picolinaldehyde-2-pyridylhydrazone (PapyH) using the Benesi-Hildebrand method. Stoichiometry 2:1 (ligand: metal) was previously determined by the Job’s method and confirmed by single-crystal x-ray diffraction finding a propeller-like structure of the [Fe(Papy)₂] compound PapyH and the metal complexes were characterized by ¹H NMR and UV-visible spectroscopy, resp. The Cu²⁺ complex exhibited the highest stability constant, which was confirmed by competitive reaction of different metal ions with the ligand PapyH.

Inorganica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cao, Dawei published the artcileLight-driven transition-metal-free direct decarbonylation of unstrained diaryl ketones via a dual C-C bond cleavage, Formula: C12H9NO, the publication is Nature Communications (2022), 13(1), 1805, database is CAplus and MEDLINE.

An efficient light-driven transition-metal-free strategy for decarbonylation of unstrained diaryl ketones R¹C(O)R² (R¹ = Ph, 2H-1,3-benzodioxol-5-yl, thiophen-2-yl, etc.; R² = Ph, 4-methoxyphenyl, pyridin-2-yl, etc.) to construct biaryl compounds R¹R² through dual inert C – C bonds cleavage was reported. This reaction featured mild reaction conditions, easy-to-handle reactants and reagents, and excellent functional groups tolerance. The mechanistic investigation and DFT calculation suggest that this strategy proceeds through the formation of dioxy radical intermediate via a single-electron-transfer (SET) process between photo-excited diaryl ketone and DBU mediated by DMSO, followed by removal of CO₂ to construct biaryl compounds

Nature Communications published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Law, Robert P. published the artcileDiscovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain, Safety of 3-Methoxypyridine-4-boronic acid, the publication is Journal of Medicinal Chemistry (2018), 61(10), 4317-4334, database is CAplus and MEDLINE.

The bromodomain and extra-terminal domain (BET) family of proteins bind acetylated lysine residues on histone proteins. The four BET bromodomains-BRD2, BRD3, BRD4, and BRDT-each contain two bromodomain modules. BET bromodomain inhibition is a potential therapy for various cancers and immunoinflammatory diseases, but few reported inhibitors show selectivity within the BET family. Inhibitors with selectivity for the first or second bromodomain are desired to aid investigation of the biol. function of these domains. Focused library screening identified a series of tetrahydroquinoxalines with selectivity for the second bromodomains of the BET family (BD2). Structure-guided optimization of the template improved potency, selectivity, and physicochem. properties, culminating in potent BET inhibitors with BD2 selectivity.

Journal of Medicinal Chemistry published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, Safety of 3-Methoxypyridine-4-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem