Tag: M.W=150-200

Mohamad, Ahmad Desoky M. published the artcileTemperature and salt effects of the kinetic reactions of substituted 2-pyridylmethylene-8-quinolyl iron (II) complexes as antimicrobial, anti-cancer, and antioxidant agents with cyanide ions, Product Details of C12H9NO, the publication is Canadian Journal of Chemistry (2021), 99(9), 763-772, database is CAplus.

Kinetics of substitution reaction of three high-spin pyridylmethylene-8-quinolyl iron (II) complexes by CN^– ions were studied spectrophotometrically in various ratios of aqueous-methanol binary mixtures at 298 ± 0.2 K. Kinetics of the substitution reaction follow the rate law (k₂[CN^–][complex]) on applying of the conditions of the pseudo first order reaction. Reactivity of the reaction was investigated in terms of ligand moiety and solvent effects. The rate of the reaction increased as the co-solvent methanol ratio increased. This reactivity trend is predominantly due to increases in the activity coefficient of those hydrophobic complexes in the organic methanol co-solvent, depending upon the hydrophobicity of the substituent groups (R) in the coordinated ligand in the complexes. Reactivity trends of the prepared complexes in the presence of the inserted hydrophobic salts such as tetrabutylammonium bromide (TBAB), tetraethylammonium bromide (TEAB), and tetramethylammonium bromide (TMAB) or hydrophilic salt potassium bromide (KBr) were studied. The observed decrease in the rate constants with increasing salt concentration was due to the cationic character of the reacting complexes. In addition, the synthesized compounds were tested for antimicrobial activity against selected strains of microbes. The results showed that the order of reactivity of the investigated complexes against the selected microbes were as follows: ppaqFe > paaqFe > pmaqFe. In addition, the investigated ligands and their Fe(II) complexes were screened for anticancer activities against several cell lines of cancer. The ppaqFe complex showed the best cytotoxic efficiency against the selected cancer lines (IC₅₀ = 8.75-21.50μg/μl), whereas the pmaq ligand showed the lowest cytotoxic efficiency (IC₅₀ = 58.25- 72.40). Furthermore, the antioxidant potential of the presented compounds was studied by applying DPPH assays and showed a potential activity compared with standard vitamin C. The excellent antimicrobial and anticancer activities of the investigated Fe(II) chelates compared with literature values are promising and deserve further study.

Canadian Journal of Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saifuddin, Mohammad published the artcileWater-accelerated cationic π-(7-endo) cyclization: application to indole-based Peri-annulated polyheterocycles, Quality Control of 39856-58-1, the publication is European Journal of Organic Chemistry (2010), 5108-5117, S5108/1-S5108/27, database is CAplus.

An efficient and versatile method for the synthesis of indole-based polycyclic indolo-benzazepine and its derivatives e. g., I, II through water-accelerated cationic π-cyclization is described. The strategy involves condensation of arylamine moieties linked to C-4 in indole/azaindole systems with arylaldehydes in water containing catalytic amount of Bronsted acids. The C-C bond formation in water is complete within 10-30 min, furnishing the title compounds in excellent yields and purities, whereas in organic solvents 10-12 h are required. Furthermore, aldehydes both with electron-donating and-withdrawing substituents facilitate the π-cyclization equally.

European Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Quality Control of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Linxiao published the artcileSulfate promotion of selective catalytic reduction of nitric oxide by ammonia on ceria, SDS of cas: 636-73-7, the publication is Catalysis Science & Technology (2019), 9(8), 1802-1815, database is CAplus.

NO selective catalytic reduction by NH₃ (NH₃-SCR) is a promising technol. to control NO_x emissions. A recently discovered sulfate promotion effect in this reaction was thoroughly examined over CeO₂. Sulfates from different organic S precursors all exhibited a promoting effect. Mechanistic studies generated a reaction network which included Langmuir-Hinshelwood and Eley-Rideal mechanisms. Sulfates were shown to be versatile promoters with multiple functions: tuning reactant adsorption toward a more balanced intermediate coverage by creating strong Lewis acid sites; facilitating *NH₂ formation; and suppressing NH₃ ammonia oxidation via oxygen deactivation. A comparison between sulfates and the classic inorganic promoter, FeO_x, showed sulfates are more effective, particularly at high temperature This was mainly attributed to the high coverages of Eley-Rideal intermediates and low NH₃ oxidation activity on sulfated CeO₂. This work provided a fundamental understanding of the role of surface sulfates in NH₃-SCR; essential under actual operation conditions. This understanding presents an opportunity to design future catalysts with high durability and low cost.

Catalysis Science & Technology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Iwasawa, Tetsuo published the artcileExperimental and Computational Probes of a Self-Assembled Capsule, Synthetic Route of 85237-71-4, the publication is Organic Letters (2006), 8(14), 2925-2928, database is CAplus and MEDLINE.

This research was undertaken to explore the interior surface of a synthetic receptor 1.1 with arylpyridines as guests. The interior surface differentiates the guests through the recognition of their nitrogen atoms. Exptl. and computational analyses revealed that there is a delicate balance of attractions and repulsions between the host and the lone pairs of guests.

Organic Letters published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Synthetic Route of 85237-71-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kiani, Adeleh published the artcileDirect synthesis of sulfonyl azides from sulfonic acids, Application In Synthesis of 636-73-7, the publication is Journal of Sulfur Chemistry (2014), 35(2), 119-127, database is CAplus.

A one-pot process for the synthesis of various sulfonyl azides (RSO₂N₃) by treating sulfonic acids with PPh₃-trichloroisocyanuric acid-sodium azide at room temperature was described. A wide range of arenesulfonyl and alkanesulfonyl azides was obtained in excellent yields under mild conditions.

Journal of Sulfur Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dropinski, James F. published the artcileSynthesis and biological activities of novel arylindole-2-carboxylic acid analogs as PPARγ partial agonists, Name: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(22), 5035-5038, database is CAplus and MEDLINE.

A series of novel arylindole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chem. synthesis and in vitro activities are discussed. The indole I was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.

Bioorganic & Medicinal Chemistry Letters published new progress about 870459-90-8. 870459-90-8 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, and the molecular formula is C6H5BF3NO2, Name: (4-(Trifluoromethyl)pyridin-2-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hosseini-Sarvari, Mona published the artcileVisible-light assisted of nano Ni/g-C₃N₄ with efficient photocatalytic activity and stability for selective aerobic C-H activation and epoxidation, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Journal of Organometallic Chemistry (2020), 121549, database is CAplus.

A selective, economical, and ecol. protocol has been described for the oxidation of Me arenes and their analogs ArCH₂R (Ar = 3-nitrophenyl, 1-naphthyl, furan-2-yl, etc.; R = H, Me, Ph, pyridin-2-yl) and 9H-fluorene to the corresponding carbonyl compounds ArC(O)R and 9H-fluoren-9-one and epoxidation reactions of alkenes, e.g., 1,3-cyclohexadiene with mol. oxygen (O₂) or air as a green oxygen source, under mild reaction conditions. The nano Ni/g-C₃N₄ exhibited high photocatalytic activity, stability, and selectivity in the C-H activation of Me arenes, methylene arenes, and epoxidation of various alkenes under visible-light irradiation without the use of an oxidizing agent and under base free conditions.

Journal of Organometallic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tavares, Ana Beatriz M. L. A. published the artcileA Quantum Chemistry Approach of Breast Cancer Drugs Bound to Human Serum Albumin, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Advanced Theory and Simulations (2022), 5(5), 2100464, database is CAplus.

The bindings of three different anticancer drugs, Cu(BpT)Br (2-benzoylpyridine thiosemicarbazone copper), NAMI-A (imidazolium trans-imidazoledimethylsulfoxide-tetrachlorido ruthenate), and DOX (doxorubicin), widely used in the breast cancer treatment, to human serum albumin (HSA) are investigated using a quantum chem. approach based on the d. functional theory calculations employing a dispersion corrected exchange-correlation functional within a fragmentation strategy. As a consequence, it is possible to identify the magnitude of the most relevant quantum binding interactions of these supramol. complexes, and thus guide their mol. modification process. The data obtained in this work highlight the power of quantum calculations as an important tool for the drug design process, and pave the way for the use of HSA-ligand interactions during the rational design of new anticancer compounds More important, the results show that HSA/multi-drug complex, formed by the combination of the three individual anticancer drugs [Cu(BpT)Br]-(NAMI-A)-(DOX), increases the targeting ability compared with each single drugs interaction with HSA, in agreement with in vivo predictions.

Advanced Theory and Simulations published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is CBF6K, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Haddad, P. R. published the artcileSpectrophotometric and fluorometric determination of cobalt, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Talanta (1976), 23(4), 275-81, database is CAplus and MEDLINE.

Co(II) reacts with pyridine-2-aldehyde-2-pyridyl hydrazone (L) and eosine (L1) at pH 5.6 to give the ternary complex CoL(HL)L12 which is extracted by CHCl3-Me2CO (7:3) to give a strongly colored, fluorescent extract Linear calibration curves for absorption at 547 nm and fluorescence at 558 nm were obtained for 0.04-0.4 and 0.02-0.2 ppm Co, resp. Relative standard deviations were 2.2 and 6.1% and detection limits were 0.017 and 0.008 ppm Co for absorption and fluorescence, resp. Interferences from Cu(II) were eliminated by electrodeposition of Cu and from Ni, Fe(II), Pd(II), and Hg(II) by ion exchange, giving recoveries of >98%. The method was successfully applied to determination of Co in steels.

Talanta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Name: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Product Details of C6H4BrNO.

Zhang, Ya-Wen;Bai, Sha;Wang, Yao-Yu;Han, Ying-Feng research published 《 A Strategy for the Construction of Triply Interlocked Organometallic Cages by Rational Design of Poly-NHC Precursors》, the research content is summarized as follows. Three-dimensional (3D) triply interlocked catenanes are a family of chem. topologies that consist of two identical, mech. interlocked coordination cage components with intriguingly complex structures. Although only a few successful constructions of 3-dimensional interlocked catenanes were achieved to date via metal-mediated assembly, these complex structures have thus far only been targeted by metal-N/O coordination techniques. Here, taking advantage of rational ligand design, the authors report the efficient construction of 3-dimensional triply interlocked [2]catenanes [Ag₃L₂]₂, wherein the metal ions exclusively form bonds to N-heterocyclic carbene (NHC) units, and their subsequent transmetalation to the corresponding [Au₃L₂]₂ Au analogs. The formation and transmetalation reactions proceed under mild conditions and are generally applicable. Characterization techniques were applied to confirm the formation and structure of the desired 3-dimensional triply interlocked architectures: multinuclear NMR spectroscopy, ESI-MS, and single-crystal x-ray diffraction anal. The solid-state structure of [Ag₃(1a)₂]₂(PF₆)₆ unambiguously confirms the existence of a 3-dimensional catenane that consists of two identical, mech. interlocked trinuclear hexacarbene cage components. The interlocking of two 3-dimensional cages into a [2]catenane is driven by the efficient π···π stacking of triazine-triazine stacks with cooperative interactions between imidazo[1,5-a]pyridine subunits. Notably, the triply interlocked organometallic cages exhibit good stability toward various organic solvents, concentrations, and temperatures, and no disassembly occurred in the presence of coronene or pyrene. The future construction of mech. interlocked architectures using metal-carbene bonds rather than metal-N bonds may provide assemblies with interesting properties for as-yet-unimagined applications in fields such as sensors and mol. elec. conductors.

Product Details of C6H4BrNO, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem