Tag: M.W=150-200

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Category: pyridine-derivatives.

Song, Wenyue;Rao, Xiaofeng;Bu, Qingqing;Liu, Ning research published 《 Carbazole-bridged NCN-pincer palladium complex catalyzed direct C-H arylation reaction of azoles》, the research content is summarized as follows. A new type of pincer palladium complexes C1∼C6 based on the strong donor strength of carbazoles skeleton were synthesized. The air- and moisture-stable complexes C1∼C6 act as efficient catalysts for the direct arylation of azoles with (hetero)aryl bromides in good to excellent yields with broad substrate scope used KOAc as sole base under aerobic conditions. It was demonstrated that this developed protocol was used as catalytic system for the direct C-H bond arylation of thiazoles under relatively mild reaction conditions at a low catalyst loading of 0.5 mol%.

Category: pyridine-derivatives, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. COA of Formula: C6H4BrNO.

Song, Xiaoxiao;Fan, Yanjun;Zhu, Zhiming;Ni, Qijian research published 《 Chiral Phosphoric Acid-Catalyzed Asymmetric Arylation of Indolizines: Atroposelective Access to Axially Chiral 3-Arylindolizines》, the research content is summarized as follows. A highly straightforward strategy for the synthesis of a new axially chiral 3-arylindolizine I (R = Me, Bn, n-Pr, etc.; R¹ = H, 5-Me, 6-Cl, 8-F, etc.; R² = 2-nitrophenyl, ethoxycarbonyl, (benzyloxy)carbonyl, etc.) and Et 3-[3,6-dihydroxy-2-(methoxycarbonyl)phenyl]indolizine-2-carboxylate scaffold via organocatalytic asym. arylation reactions of indolizinecarboxylates and p-quinone esters and Me 3,6-dioxocyclohexa-1,4-diene-1-carboxylate was reported. Using the chiral phosphoric acid catalyst, a series of axially chiral 3-arylindolizines I was accessed in good to excellent yields and atropo-enantioselectivities. This approach features a broad substrate scope, mild reaction conditions, good scalability, and facile derivatization. Moreover, preliminary investigations based on nonlinear effects and a thermal racemization study demonstrated the intrinsic pathway for the formation of axial chirality and its potential utility.

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reference of 16133-25-8.

Song, Xinning;Jiang, Zhiyang;Li, Jianing;Lu, Xingxing;Han, Qing;Zhu, Kai;Li, Huilin;Ling, Yun;Duan, Hongxia research published 《 Synthesis, antifungal activity, and molecular dynamics study of novel geranyl aromatic sulfonamide compounds as potential complex III inhibitors》, the research content is summarized as follows. Essential oils (EOs), as unique natural products, are promising resources for the discovery of green agrochems. The main ingredient geraniol of citronella oil was found to exhibit substantial antifungal activities in this study. Therefore, a series of novel geranyl aromatic sulfonamide compounds were synthesized and found to display considerable antifungal activities. Two geranyl thiofuran-sulfonamide compounds 4c-1 (median effective concentration (EC50) against Rhizoctonia solani: 24.97 mg/L and EC50 against Sclerotinia sclerotiorum: 27.26 mg/L), 4c-2 (EC50 against S. sclerotiorum: 18.53 mg/L) and one geranyl pyridine-sulfonamide compound 4d-2 (EC50 against R. solani: 29.31 mg/L and EC50 against S. sclerotiorum: 29.98 mg/L) were screened as “star mols.” due to their excellent antifungal activities. The preliminary structure-activity relationship (SAR) study revealed that the introduction of various aromatic heterocycles maybe an efficient protocol to improve the fungicidal activities of geranyl aromatic sulfonamide compounds The mol. mechanisms of the geranyl aromatic sulfonamide compounds were clarified by performing mol. docking and mol. dynamics (MD) simulations. Three “star mols.” of these geranyl aromatic sulfonamide compounds were found to bind to Complex III through several hydrogen bonds and π-interactions with crucial residues TRP17, GLY20 etc. Their binding free energies were calculated to be strong ranging from -50.60 to -39.44 kcal/mol by MM/GBSA method, which suggested the geranyl aromatic sulfonamide compounds were potential Complex III inhibitors. The main component originating from the natural plant EOs ought to be studied in the future to discover novel pathogenic fungicidal candidates.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Reference of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Related Products of 16133-25-8.

Song, Xuyan;He, Yunlu;Wang, Bo;Peng, Sanwen;Pan, Xi;Wei, Min;Liu, Qiang;Qin, Hua-Li;Tang, Haolin research published 《 Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO₂F₂) as fluoride provider》, the research content is summarized as follows. A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO₂F [Ar = 4-MeC₆H₄, 4-PhC₆H₄, 4-ClC₆H₄, etc.] was developed from aryl sulfonyl chlorides using SO₂F₂ as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol.

Related Products of 16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Application In Synthesis of 766-11-0.

Stambirskyi, Maksym V.;Kostiuk, Tetiana;Sirobaba, Serhii I.;Rudnichenko, Alexander;Titikaiev, Dmytro L.;Dmytriv, Yurii V.;Kuznietsova, Halyna;Pishel, Iryna;Borysko, Petro;Mykhailiuk, Pavel K. research published 《 Phosphine Oxides (-POMe₂) for Medicinal Chemistry: Synthesis, Properties, and Applications》, the research content is summarized as follows. A general practical approach to hetero(aromatic) and aliphatic P(O)Me₂-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me₂. The P(O)Me₂ substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Application In Synthesis of 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Application of C6H4BrNO.

Starnovskaya, Ekaterina S.;Kopchuk, Dmitry S.;Khasanov, Albert F.;Tanya, Olga S.;Santra, Sougata;Giri, Kousik;Rahman, Matiur;Kovalev, Igor S.;Zyryanov, Grigory V.;Majee, Adinath;Charushin, Valery N. research published 《 Synthesis and photophysics of new unsymmetrically substituted 5,5′-diaryl-2,2′-bypiridine-based “push-pull” fluorophores》, the research content is summarized as follows. New unsym. substituted 5,5′-diaryl-2,2′-bypiridine “push-pull” fluorophores were prepared in good yields via the “1,2,4-triazine method”/Suzuki coupling reaction sequence. The obtained fluorophores contain the “push-pull” system with donor and acceptor moieties arranged in a D-π-A-π-D fashion, and that provides both the prospective photophys. properties and unique solvatochromic effects for the most representative compounds

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., Application of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Computed Properties of 16133-25-8.

Su, Shijun;Zhou, Qing;Tang, Xuemei;Peng, Feng;Liu, Tingting;Liu, Liwei;Xie, Chengwei;He, Ming;Xue, Wei research published 《 Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate》, the research content is summarized as follows. A series of myricetin derivatives containing sulfonate groups I (R = Ph, 2-chlorophenyl, 2-thienyl, etc.) was designed and synthesized. Preliminary antibacterial activity showed that most of the target compounds I exhibited significant biol. activities against Xanthomonas axonopodis pv. In particular, the EC₅₀ value of compound I (R = 4-nitrophenyl) was 13.76μg/cm³ against Xac, which was better than com. reagents bismerthiazol (50.32μg/cm³) and thiodiazole copper. (83.27μG/cm³), and the EC₅₀ value of compound I (3-chlorophenyl) was 11.92μg/cm³ against Xoo in vitro and the result was better than that of bismerthiazol (72.08μg/cm³) and thiodiazole copper (99.26μg/cm³). Compound I (R = 3-chlorophenyl) displayed the better in vivo activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. Meanwhile, the antibacterial mechanism of compounds I (R = 4-nitrophenyl) and I (R = 3-chlorophenyl) was studied by scanning electron microscope (SEM). These results suggested that myricetin derivatives containing sulfonate I can be considered as new antibacterial reagents.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Computed Properties of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Product Details of C5H4ClNO2S.

Summer, Samantha L.;Kell, Steven A.;Zhu, Zongjian;Moore, Rhonda;Liotta, Dennis C.;Myers, Scott J.;Koszalka, George W.;Traynelis, Stephen F.;Menaldino, David S. research published 《 Di-aryl sulfonamide motif adds π-stacking bulk in negative allosteric modulators of the NMDA receptor》, the research content is summarized as follows. The N-methyl-D-aspartate receptor plays a critical role in central nervous system processes. Its diverse properties, as well as hypothesized role in neurol. disease, render NMDA receptors a target of interest for the development of therapeutically relevant modulators. A number of subunit-selective modulators have been reported in the literature, one of which is TCN-201, a GluN2A-selective neg. allosteric modulator. Recently, it was determined from a cocrystn. study of TCN-201 with the NMDA receptor that a unique active pose exists in which the sulfonamide group of TCN-201 incorporates a π-π stacking interaction between the two adjacent aryl rings that allows it to make important contacts with the protein. This finding led us to investigate whether this unique structural feature of the diaryl sulfonamide could be incorporated into other modulators that act on distinct pockets. To test whether this idea might have more general utility, we added an aryl ring plus the sulfonamide linker modification to a previously published series of GluN2C- and GluN2D-selective neg. allosteric modulators that bind to an entirely different pocket. Herein, we report data suggesting that this structural modification of the NAB-14 series of modulators was tolerated and, in some instances, enhanced potency. These results suggest that this motif may be a reliable means for introducing a π-π stacking element to mol. scaffolds that could improve activity if it allowed access to ligand-protein interactions not accessible from one planar aromatic group.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Product Details of C5H4ClNO2S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Related Products of 5315-25-3.

Sailaja, E.;Bhavani, S.;Rambabu, D.;Basaveswara Rao, M. V.;Pal, Manojit research published 《 A greener approach toward N-1 heteroarylation of indoles: Synthesis and in vitro evaluation of potential anti-proliferative agents》, the research content is summarized as follows. A greener approach was developed to synthesize N-pyridyl indoles e.g., I [R¹ = R² = H, R³ = 2-pyridyl] and N-pyrimidinyl indoles e.g., I [R¹ = R² = H, R³ = 2-pyrimidinyl] via an ultrasound assisted selective N-1 heteroarylation of indoles. This methodol. involved reaction of indoles with heteroaryl halides in PEG-400 under ultrasound irradiation Compound I [R¹ = R² = H, R³ = 2-pyrimidinyl] was benzoylated at C-2 position via palladium-mediated C-H bond activation. All the synthesized N-1 heteroarylindoles were tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Among the tested compounds, compounds I [R¹ = H; R² = 5-OMe; R³ = 2-pyridyl, 5-Me-2-pyridyl, 2-pyrimidinyl] showed promising activity against K562 leukemia cells whereas compound I [R¹ = H, R² = 5-OMe, R³ = 2-pyrimidinyl] showed significant activity against Colo-205 cells. Addnl., none of these N-heteroaryl indoles showed any effect against noncancerous HEK293 cell lines, indicating their selectivity toward cancer cells specifically leukemia.

Related Products of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Name: 5-Bromo-2-fluoropyridine.

Sander, Kerstin;Gendron, Thibault;Yiannaki, Elena;Cybulska, Klaudia;Kalber, Tammy L.;Lythgoe, Mark F.;Arstad, Erik research published 《 Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18》, the research content is summarized as follows. Positron emission tomog. (PET) is unique in that it allows quantification of biochem. processes in vivo, but difficulties with preparing suitably labeled radiotracers limit its scientific and diagnostic applications. Aromatic [¹⁸F]fluorination of drug-like small mols. is particularly challenging as their functional group compositions often impair the labeling efficiency. Herein, we report a new strategy for incorporation of ¹⁸F into highly functionalized aromatic compounds using sulfonium salts as leaving groups. The method is compatible with pharmacol. relevant functional groups, including aliphatic amines and basic heterocycles. Activated substrates react with [¹⁸F]fluoride at room temperature, and with heating the reaction proceeds in the presence of hydrogen bond donors. Furthermore, the use of electron rich spectator ligands allows efficient and regioselective [¹⁸F]fluorination of non-activated aromatic moieties. The method provides a broadly applicable route for ¹⁸F labeling of biol. active small mols., and offers immediate practical benefits for drug discovery and imaging with PET.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Name: 5-Bromo-2-fluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem