Tag: M.W=150-200

Yang, Qin; Lei, Xiaoli; Yin, Zhijian; Deng, Zhihong; Peng, Yiyuan published the artcile< Copper-Catalyzed NaBAr4-Based N-Arylation of Amines>, Synthetic Route of 22961-45-1, the main research area is arylamine preparation; amine tetraaryl borate Cham Lam cross coupling copper catalyst.

NaBAr4 Based Cham-Lam cross-coupling of amines for the synthesis of arylamines RNHAr [R = n-Bu, Ph, benzyl, etc.; Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.] in the presence of catalytic copper (II) acetate monohydrate in acetonitrile at room temperature under air was described. In particular, the reaction of alkylamine and NaBAr4 proceeded smoothly to offered the corresponding products in good to excellent yields.

Synthesis published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Synthetic Route of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yue, Cheng-Yang; Yue, Yun-Di; Sun, Hai-Xiao; Li, Dong-Yang; Lin, Na; Wang, Xin-Ming; Jin, Ying-Xue; Dong, Yu-Han; Jing, Zhi-Hong; Lei, Xiao-Wu published the artcile< Transition metal complex dye-sensitized 3D iodoplumbates: syntheses, structures and photoelectric properties>, Electric Literature of 366-18-7, the main research area is bipyridine iron cobalt nickel manganese iodoplumbate preparation crystal structure; photoelec property dye sensitized iodoplumbate.

Here, authors prepared the first series of 3D hybrid iodoplumbates with novel porous frameworks of [Pb8I21]5- directed by transition metal complex (TMC) cationic dyes of [TM(2.2-bipy)3]2+. The microporous materials exhibit outstanding visible light-driven photoelec. properties due to the effective photosensitization of the TMC dyes. The coexistence of stronger face- and weaker corner-shared connecting manners affords the feasibility of tailoring the 3D framework into low-dimensional skeletons, which provide a new structural prototype to modify the semiconducting properties similar to those of classic perovskites.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cationic dyes. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Lijuan; Wu, Xiaoyun; Shi, Chuanling; Wen, Haoyu; Wu, Shouhai; Chen, Jing; Huang, Chunxia; Wang, Yi; Liu, Yunjun published the artcile< Synthesis and characterization of polypyridine ruthenium(II) complexes and anticancer efficacy studies in vivo and in vitro>, Application of C10H8N2, the main research area is Apoptosis; Cell cytotoxicity; Mitochondria; Ruthenium(II) complexes; Toxic activity in vivo.

In this article, ligand IPP (IPP = 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline) and its three Ru(II) complexes: [Ru(bpy)2(IPP)](ClO4)2 (1) (bpy = 2,2′-bipyridine), [Ru(dmbpy)2(IPP)](ClO4)2 (2) (dmbpy = 4,4′-dimethyl-2,2′-bipyridine), and [Ru(phen)2(IPP)](ClO4)2 (3) (phen = 1,10-phenanthroline) were synthesized and characterized. The anticancer activity in vitro of the complexes was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The scratching and colony-forming experiments confirmed the complexes 1, 2, 3 interfered with the proliferation and migration ability of cells. The accumulation of the complexes in cells was researched and we found that these complexes directly accumulated in mitochondria, then the complexes cause a decline of the mitochondrial membrane potential and induce an increase of intracellular reactive oxygen species (ROS) levels. The growth of B16 cells were inhibited by 1, 2 and 3 at G0/G1 phase. Apoptosis was induced through mitochondrial pathway and the expression of apoptosis-related factors was regulated. In addition, the complexes promoted the transition of poly(ADP-ribose)polymerase (PARP) into the cleaved form (Cleaved PARP), downregulated the anti-apoptotic proteins, and upregulated the pro-apoptotic proteins. Consequently, complexes 1, 2 and 3 exerted their anticancer activity by regulating B-cell lymphoma-2 (Bcl-2) family proteins. Complex 2 showed excellent antitumor effects with a high inhibitory rate of 65.95% in vivo. Taken together, the complexes cause apoptosis in B16 cells through a ROS-mediated mitochondrial dysfunction pathway.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vasbinder, Melissa M.; Alimzhanov, Marat; Augustin, Martin; Bebernitz, Geraldine; Bell, Kirsten; Chuaqui, Claudio; Deegan, Tracy; Ferguson, Andrew D.; Goodwin, Kelly; Huszar, Dennis; Kawatkar, Aarti; Kawatkar, Sameer; Read, Jon; Shi, Jie; Steinbacher, Stefan; Steuber, Holger; Su, Qibin; Toader, Dorin; Wang, Haixia; Woessner, Richard; Wu, Allan; Ye, Minwei; Zinda, Michael published the artcile< Identification of azabenzimidazoles as potent JAK1 selective inhibitors>, Recommanded Product: 4,5-Dichloropyridin-2-amine, the main research area is azabenzimidazoles screening JAK1 selective inhibitor STAT3; Azabenzimidazoles; JAK selectivity; JAK1; JAK1 inhibitors.

We have identified a class of azabenzimidazoles as potent and selective JAK1 inhibitors. Investigations into the SAR are presented along with the structural features required to achieve selectivity for JAK1 vs. other JAK family members. An example from the series demonstrated highly selective inhibition of JAK1 vs. JAK2 and JAK3, along with inhibition of pSTAT3 in vivo, enabling it to serve as a JAK1 selective tool compound to further probe the biol. of JAK1 selective inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug screening. 188577-68-6 belongs to class pyridine-derivatives, and the molecular formula is C5H4Cl2N2, Recommanded Product: 4,5-Dichloropyridin-2-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wandas, M.; Talik, Z. published the artcile< Theoretical and experimental NMR data of 3,5-dinitro-2-(2-phenylhydrazinyl)pyridine and of its 4- and 6-methyl derivatives>, Synthetic Route of 21901-29-1, the main research area is methyldinitrophenylhydrazinylpyridine dinitrophenylhydrazinylpyridine NMR mol structure.

3,5-Dinitro-2-(2-phenylhydrazinyl)pyridine and its Me derivatives: 4-methyl-3,5-dinitro-2-(2-phenylhydrazinyl)pyridine and 6-methyl-3,5-dinitro-2-(2-phenylhydrazinyl)pyridine were synthesized and characterized by 1H NMR and 13C NMR. Calculations were also performed where the above mols. were optimized using the methods of d. functional theory (DFT) with 6-31G(d,p) and 6-311G(d,p) basis sets. For all mols. studied, the lowest energy was obtained using the 6-311G(d,p) basis set. The GIAO/DFT (Gauge Invariant AOs/D. Functional Theory) calculations on the 6-311G and 6-311++G and 6-311G** basis sets were carried out to determine proton and carbon chem. shifts and to find they were close to the exptl. values. It has been also found that intramol. hydrogen bonding exists between hydrogen atom (in 2-NH group) and oxygen atom (pyridine-3-NO2). Moreover, resonances between pyridine ring and electron withdrawing 3-nitro group as well between that ring and the lone electron pair of NH group favor a co-planarity of the structure; this means a chelate ring created by above-mentioned intramol. hydrogen bond is almost co-planar with pyridine ring.

Journal of Molecular Structure published new progress about Atomic charge. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lougiakis, Nikolaos; Marakos, Panagiotis; Pouli, Nicole; Balzarini, Jan published the artcile< Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides [Erratum to document cited in CA149:402608]>, Quality Control of 22280-62-2, the main research area is erratum pyrazolopyridine acyclonucleoside preparation antiviral antitumor.

On page 775, in the author list, the third author, Nicole Pouli, was incorrectly given as “”Nicole Poul””.

Chemical & Pharmaceutical Bulletin published new progress about Acyclonucleosides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Quality Control of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sepiol, Jadwiga; Tomasik, Piotr published the artcile< Syntheses with aromatic nitramines. VI. Substituent effect in the photolytic rearrangement of nitraminopyridines>, Application In Synthesis of 21901-29-1, the main research area is photochem rearrangement nitraminopyridine; aminonitropyridine; photolytic rearrangement nitraminopyridine; regiochem photochem rearrangement nitraminopyridine; substituent effect photochem rearrangement nitraminopyridine.

Isomeric 2-nitraminopyridines I (R = 3-Me, 4-Me, 5-Me, 6-Me, 3-NO2, 5-NO2, 5-Cl, 3-CO2H) as well as 3,5-dibromo-2-nitraminopyridine (II, R1 = NO2) rearranged on irradiation with a low pressure Hg lamp (253.7 nm) in MeOH. Preference was generally noted for the migration of the side-chain NO2 group to the vicinal β-position. II (R1 = NO2) gave both II (R1 = H) and the pyridone III. The ratio of the preparative and quantum yields of the two products were 2.5 and 3.0, resp.

Acta Chimica Hungarica published new progress about Photorearrangement. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application In Synthesis of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Skepper, Colin K.; Moreau, Robert J.; Appleton, Brent A.; Benton, Bret M.; Drumm, Joseph E.; Feng, Brian Y.; Geng, Mei; Hu, Cheng; Li, Cindy; Lingel, Andreas; Lu, Yipin; Mamo, Mulugeta; Mergo, Wosenu; Mostafavi, Mina; Rath, Christopher M.; Steffek, Micah; Takeoka, Kenneth T.; Uehara, Kyoko; Wang, Lisha; Wei, Jun-Rong; Xie, Lili; Xu, Wenjian; Zhang, Qiong; de Vicente, Javier published the artcile< Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity>, Category: pyridine-derivatives, the main research area is triazolopyrimidinone azabenzimidazole preparation phosphopantetheine adenylyltransferase inhibitor antibacteria Escherichia.

In the preceding manuscript the authors described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Following several rounds of optimization two promising lead compounds were identified: triazolopyrimidinone (I) and 4-azabenzimidazole (II). Here the authors disclose the efforts to further optimize these two leads for on-target potency and Gram-neg. cellular activity. Enabled by a robust x-ray crystallog. system, the authors’ structure-based inhibitor design approach delivered compounds with biochem. potencies 4-5 orders of magnitude greater than their resp. fragment starting points. Addnl. optimization was guided by observations on bacterial permeability and physicochem. properties, which ultimately led to the identification of PPAT inhibitors with cellular activity against wild-type E. coli.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Runbin; Wei, Ming; Wang, Xuerong; Chen, Yushou; Xiong, Yanshi; Cheng, Jianxin; Tan, Yanhui; Liao, Xiangwen; Wang, Jintao published the artcile< Synthesis of ruthenium polypyridine complexes with benzyloxyl groups and their antibacterial activities against Staphylococcus aureus>, COA of Formula: C10H8N2, the main research area is Antibacterial activity; Antibacterial adjuvants; Biofilm; Membrane disruption; Ruthenium complex; Synergistic effect.

Four new ruthenium polypyridyl complexes, [Ru(bpy)2(BPIP)](PF6)2 (Ru(II)-1), [Ru(dtb)2(BPIP)](PF6)2 (Ru(II)-2), [Ru(dmb)2(BPIP)](PF6)2 (Ru(II)-3) and [Ru(dmob)2(BPIP)](PF6)2 (Ru(II)-4) (bpy = 2,2′-bipyridine, dtb = 4,4′-di-tert-butyl-2,2′-bipyridine, dmb = 4,4′-dimethyl-2,2′-bipyridine, dmob = 4,4′-dimethoxy-2,2′-bipyridine and BPIP = 2-(3,5-bis(benzyloxyl)phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) had been synthesized and characterized. Their antimicrobial activities were investigated against Staphylococcus aureus (S. aureus) and four complexes showed obvious antibacterial effect, especially the min. inhibition concentration (MIC) value of Ru(II)-3 was only 4 μg/mL. In addition, Ru(II)-3 was able to kill bacteria quickly and inhibit the formation of biofilm. Meanwhile, the cooperative effect between Ru(II)-3 and general antibiotics were tested and the results showed that Ru(II)-3 could enhance the susceptibility of S. aureus to different types of antibiotics. Most importantly, Ru(II)-3 hardly showed cytotoxicity to mammalian erythrocytes both in homelysis experiment and G. mellonella model. After being injected with high doses of the Ru(II)-3in vivo, the G. mellonella worms still exhibited high survival rates. Finally, a mouse skin infection model and G. mellonella infection model was built to determine the antibacterial activity of Ru(II)-3in vivo. The antibacterial mechanism of Ru(II)-3 was probably related to the membrane-disruption. Taken together, ruthenium polypyridine complexes with benzyloxyl groups had the potential to develop an attractive and untraditional antibacterial agent with new mode of action.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sanchez Delgado, Giset Y.; Ferreira, Frederico Henrique do C.; Paschoal, Diego F. S.; Dos Santos, Helio F. published the artcile< The role of tridentate ligands on the redox stability of anticancer gold(III) complexes>, Reference of 366-18-7, the main research area is Chelating effect; DFT; Gold(III) complexes; Redox stability; VT-HAA; VT-HXAA.

Gold(III) complexes are promising compounds for cancer chemotherapy, whose action depends on their redox stability. In this context, the choice of ligands is crucial to adjust their reactivity and biol. response. The present study addressed the effect of the gold coordination sphere on the reduction potential (Eo) for ten gold(III) complexes containing five or six-membered rings tridentate ligands – [AuIII(trident)Cl]3+n (trident = NN̂N̂, CN̂N̂, CĈN̂, CN̂Ĉ, and NĈN̂). The calculated Eo covered a broad range of 2500 mV with the most stable complexes containing two Au-C bonds (Eo = -1.85 V for [AuIII(CĈN̂)Cl] – f). For complexes with one Au-C bond, the NĈN̂ ligands stabilize the gold(III) complex more efficiently than NN̂Ĉ; however, the inclusion of the non-innocent ligand bipy (2,2′-bipyridine) in NN̂ portion provides an extra stabilization effect. Among the derivatives with one Au-C bond, [AuIII(NN̂Ĉ)Cl]+ (NN̂ = bipy) (a) showed Eo = -1.20 V. For the complexes with NN̂N̂ ligands, Eo was pos. and almost constant (+0.60 V). Furthermore, the kinetics for ligand exchange reactions (Cl-/H2O, H2O/Cys and Cl-/Cys) were monitored for the most stable compounds and the energy profiles compared to the reduction pathways.

Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Reference of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem