Tag: M.W=200-250

Dotson, Jordan J. published the artcileA data-driven approach to the development and understanding of chiroptical sensors for alcohols with remote γ-stereocenters, Quality Control of 1420830-61-0, the publication is Journal of the American Chemical Society (2021), 143(45), 19187-19198, database is CAplus and MEDLINE.

Dynamic covalent chem.-based sensors have recently emerged as powerful tools to rapidly determine the enantiomeric excess of organic small mols. While a bevy of sensors have been developed, those for flexible mols. with stereocenters remote to the functional group that binds the chiroptical sensor remain scarce. In this study, we develop an iterative, data-driven workflow to design and analyze a chiroptical sensor capable of assessing challenging acyclic γ-stereogenic alcs. Following sensor optimization, the mechanism of sensing was probed with a combination of computational parametrization of the sensor mols., statistical modeling, and high-level d. functional theory (DFT) calculations These were used to elucidate the mechanism of stereochem. recognition and revealed that competing attractive noncovalent interactions (NCIs) determine the overall performance of the sensor. It is anticipated that the data-driven workflows developed herein will be generally applicable to the development and understanding of dynamic covalent and supramol. sensors. Dynamic covalent chem.-based sensors have recently emerged as powerful tools to rapidly determine the enantiomeric excess of organic small mols. While a bevy of sensors have been developed, those for flexible mols. with stereocenters remote to the functional group that binds the chiroptical sensor remain scarce. In this study, we develop an iterative, data-driven workflow to design and analyze a chiroptical sensor capable of assessing challenging acyclic γ-stereogenic alcs. Following sensor optimization, the mechanism of sensing was probed with a combination of computational parameterization of the sensor mols., statistical modeling, and high-level d. functional theory (DFT) calculations These were used to elucidate the mechanism of stereochem. recognition and revealed that competing attractive non-covalent interactions (NCIs) determine the overall performance of the sensor. It is anticipated that the data-driven workflows developed herein will be generally applicable to the development and understanding of dynamic covalent and supramol. sensors.

Journal of the American Chemical Society published new progress about 1420830-61-0. 1420830-61-0 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester,, name is [6-Methoxy-5-(trifluoromethyl)pyridin-3-yl]boronic acid, and the molecular formula is C7H7BF3NO3, Quality Control of 1420830-61-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shigehisa, Hiroki published the artcileHydroalkoxylation of Unactivated Olefins with Carbon Radicals and Carbocation Species as Key Intermediates, Application In Synthesis of 107263-95-6, the publication is Journal of the American Chemical Society (2013), 135(28), 10306-10309, database is CAplus and MEDLINE.

A unique Markovnikov hydroalkoxylation of unactivated olefins with a cobalt complex, silane, and N-fluoropyridinium salt is reported. Further optimization of reaction conditions yielded high functional group tolerance and versatility of alc. solvent employed, including methanol, i-propanol, and t-butanol. Use of trifluorotoluene as a solvent made the use of alc. in stoichiometric amount possible. Mechanistic insight into this novel catalytic system is also discussed. Exptl. results suggest that catalysis involves both carbon radical and carbocation intermediates.

Journal of the American Chemical Society published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C8H17Br, Application In Synthesis of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shuman, Robert T. published the artcileAn improved synthesis of homoproline and derivatives, Synthetic Route of 123811-75-6, the main research area is homoproline derivative; proline homo derivative; piperidinecarboxylic acid; benzohomoproline.

Homoproline derivatives I (R = 3-Me, 4-Me, 6-Me, 4-Et, 4-OMe, 4-CMe3) were prepared from the corresponding pyridines II in 4 steps. A key step was the treatment of N-oxides III (R = same) with Me3SiCN and Me2NCOCl in CH2Cl2 to give nitriles IV (R = same). 5,6-Benzohomoprolines V (R1 = H, Me) were also prepared

Journal of Organic Chemistry published new progress about homoproline derivative; proline homo derivative; piperidinecarboxylic acid; benzohomoproline. 123811-75-6 belongs to class pyridine-derivatives, name is 4-(tert-Butyl)picolinic acid hydrochloride, and the molecular formula is C10H14ClNO2, Synthetic Route of 123811-75-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Frydman, Benjamin published the artcilePyrroles from azaindoles. Synthesis of porphobilinogen and related pyrroles, Recommanded Product: Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, the main research area is porphobilinogen pyrrole; pyrrole porphobilinogen.

A new method for the synthesis of 2-aminomethyl-3-pyrroleacetic acids is described. The condensation of 2-methoxy- and 2-benzyloxy-4-methyl-5-nitropyridine with diethyl oxalate afforded the corresponding Et o-nitropyri-dinepyruvates, which on hydrogenation were transformed into the substituted Et 6-azaindole-2-carboxylates. Cleavage of the ethers and hydrogenation of the resulting pyrrolopyridones yielded the corresponding carboxypyrrole lactams which on decarboxylation and hydrolysis gave the 2-aminomethyl-3-pyrroleacetic acids. Substitution at the C-3 position of the 6-azaindole with a propionic acid and acetic asid side chain and repetition of the above sequence gave porphobilinogen and 2-aminomethyl-3,4-pyrrolediacetic acid.

Journal of the American Chemical Society published new progress about porphobilinogen pyrrole; pyrrole porphobilinogen. 3469-63-4 belongs to class pyridine-derivatives, name is Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, and the molecular formula is C11H12N2O3, Recommanded Product: Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ban-Oganowska, Hanna published the artcileSynthesis and some properties of 3-halo-4-nitro-2,6-dimethylpyridine N-oxides, Quality Control of 33259-24-4, the main research area is pyridine oxide halo nitro; substitution halonitropyridine; reduction nitropyridine oxide.

3-Halo-2,6-dimethylpyridines were oxidized by MeCO2OH and nitrated to give the pyridines I (R = Cl, Br, iodo). The substitution of R and NO2 group was investigated. With MeONa, the NO2 group in I was exchanged for OMe, and with PCl3, for Cl. In I (R = iodo) only the NO2 group was reduced by PCl3, and PBr3. Reduction with Fe2+ in AcOH gave amino derivatives

Roczniki Chemii published new progress about pyridine oxide halo nitro; substitution halonitropyridine; reduction nitropyridine oxide. 33259-24-4 belongs to class pyridine-derivatives, name is 3-Bromo-2,6-dimethylpyridin-4-amine, and the molecular formula is C7H9BrN2, Quality Control of 33259-24-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, C. S. published the artcileReaction of dehydroacetic acid with ammonia, Quality Control of 33259-24-4, the main research area is dehydroacetic acid ammonia reaction; nicotinic acid aminodimethyl; pyridone aminodimethyl; lutidine amino.

Dehydroacetic acid reacts with aqueous NH3 at 200° to give the major product 2,6-dimethyl-4-pyridinol and 6 minor by-products, i.e., 4-amino- and 4-hydroxy-2,6-dimethylnicotinic acids, 4-amino-, 4-hydroxy-, and 3-acetyl-4-hydroxy-6-methyl-2-pyridones, and 4-amino-2,6-lutidine. Isolation and synthesis of the by-products, proof of the structures and the mechanistic interpretation of their formation are discussed.

Tetrahedron published new progress about dehydroacetic acid ammonia reaction; nicotinic acid aminodimethyl; pyridone aminodimethyl; lutidine amino. 33259-24-4 belongs to class pyridine-derivatives, name is 3-Bromo-2,6-dimethylpyridin-4-amine, and the molecular formula is C7H9BrN2, Quality Control of 33259-24-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rahimpour, Parivash published the artcileRelationship Between the Parenting Styles and Students’ Educational Performance Among Iranian Girl High School Students, A Cross- Sectional Study., Quality Control of 3469-63-4, the main research area is Authoritarian parenting style; Authoritative parenting styles; Permissive parenting style.

INTRODUCTION: Parenting styles are effective in the educational performance of their child. The present study aimed to investigate the relationship between the parenting styles and students’ educational performance among Iranian girl high school students. MATERIALS AND METHODS: In a cross-sectional survey, female students in high schools of Ilam (Iran) evaluated during the academic year 2014-15. Multistage cluster random sampling was used to select the participants. Data were collected by two demographic and Baumrind’s parenting styles questionnaire. The Cronbach’s alpha coefficient was measured as an index of internal identicalness of the questionnaire to verify its reliability. RESULTS: A total 400 students were studied. The Mean±SD of the students’ age were 14±1.08. The students’ school grades were the first year of high school to pre-university course. The Mean±SD of parenting styles were 35.37±5.8, 34.69±6.34 and 19.17±6.64 for permissive parenting style, authoritarian parenting style and authoritative parenting styles, respectively. There was a significant relationship between the score of permissive parenting style (p= 0.001, r= 0.151), authoritarian parenting style (p= 0.001, r= 0.343) and authoritative parenting style (p=0. 001, r= 0.261) with the students’ average score for studying. CONCLUSION: The results of this study demonstrate that parental influence plays an important role in students’ educational performance.

Journal of clinical and diagnostic research : JCDR published new progress about Authoritarian parenting style; Authoritative parenting styles; Permissive parenting style. 3469-63-4 belongs to class pyridine-derivatives, name is Ethyl 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylate, and the molecular formula is C11H12N2O3, Quality Control of 3469-63-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Van der Lans, H. N. M. published the artcileDidehydrohetarenes. XXIII. Does 2,6-didehydropyridine exist, Recommanded Product: 2-Bromo-4-ethoxypyridine, the main research area is bromo aminopyridine piperidide; bromo aminoquinoline piperidide; pyridines bromo piperidide; quinoline bromo piperidide; didehydropyridine existence.

3-Amino-2-bromopyridine with Li piperidide gave pyrrole-3-carbonitrile; 4-amino-2-bromopyridine gave a ring-opened product (I); 5-amino-2-bromopyridine gave II and III; 6-amino-2-bromopyridine gave IV. 4-Amino-2-bromoquinoline gave V and VI. The intermediacy of 2,6-didehydropyridine in these reactions was discussed.

Tetrahedron Letters published new progress about bromo aminopyridine piperidide; bromo aminoquinoline piperidide; pyridines bromo piperidide; quinoline bromo piperidide; didehydropyridine existence. 17117-13-4 belongs to class pyridine-derivatives, name is 2-Bromo-4-ethoxypyridine, and the molecular formula is C7H8BrNO, Recommanded Product: 2-Bromo-4-ethoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hamed, Ezzat A. published the artcileNucleophilic substitutions at the pyridine ring: kinetics of the reaction of 2-chloro-3-nitro and 2-chloro-5-nitropyridines with piperidine and morpholine in methanol and benzene, Formula: C9H11N3O3, the main research area is nucleophilic substitution chloronitropyridine kinetics mechanism.

The kinetics of the reactions of 2-chloro-3-nitropyridine (ortho-like) and 5-nitro (para-like) isomer with morpholine and piperidine were studied in methanol and benzene at several amine concentrations and at 25-45°. The data show that k3-NO 2/k5-NO2 ratios are less than unity in methanol. The steric hindrance in the transition state of the 3-nitro (ortho-like) isomer retards o-substitution while the stability of p-quinonoid structure of the 5-nitro (para-like) isomer favors p-substitution. In benzene, the k3-NO2/k5-NO2 ratios are greater than unity. The hydrogen bonding formation between the ammonium hydrogen and the ortho-nitro group in the transition state of 3-nitro isomer favors the o-substitution.

International Journal of Chemical Kinetics published new progress about Activation energy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jin, Bo published the artcileSynthesis and biological evaluation of 3-(pyridine-3-yl)-2-oxazolidinone derivatives as antibacterial agents, SDS of cas: 26820-62-2, the main research area is pyridinyl oxazolidinone preparation mol docking antibiofilm antibacterial activity; 3-(pyridine-3-yl)-2-oxazolidinone; antibacterial activity; biofilm formation inhibitory activity; drug resistance development; molecular docking.

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives I [R = (pyridin-3-yl)carbonyl, Me, N-cyclohexylcarbamoyl, etc.], II (X = F, H) was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphol., kinetic studies, and mol. docking. The results demonstrated that compounds II [R = cyclohexanecarbonyl, (2E)-3-(furan-2-yl)prop-2-enoyl (III), (2E)-3-(pyridin-3-yl)prop-2-enoyl, N-(4-chlorophenyl)carbamoyl; X = F] exhibited strong antibacterial activity similar to that of linezolid toward five Gram-pos. bacteria. After observing the effect of the drug on the morphol. and growth dynamics of the bacteria, the possible modes of action were predicted by mol. docking. Furthermore, the antibiofilm activity and the potential drug resistance assay were proceeded. These compounds exhibited universal antibiofilm activity and compound III showed significant concentration-dependent inhibition of biofilm formation. Compound III also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Antibacterial agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, SDS of cas: 26820-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem