Tag: M.W=200-250

Khattab, Sherine N. published the artcileAminolysis of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine, Application of 4-(5-Nitropyridin-2-yl)morpholine, the main research area is hydroxybenzotriazole aminolysis reaction mechanism kinetics solvent effect.

The reaction 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with amines undergoes amination followed by elimination of the 1-hydroxyl benzotriazolyl anion. The kinetic data for the reaction of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with morpholine (Mo), cyclohexylamine (CHA) and aniline (An) in MeOH and acetonitrile (AN) proceeded by uncatalyzed mechanism in which the rate limiting step is the leaving group departure, whereas the reaction with Mo in toluene proceeded by uncatalyzed mechanism in which the formation of the zwitterionic intermediate is the rate determining step. While the reactions of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene with CHA and An and the reaction of 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with CHA in toluene proceeded by the specific base (SB) mechanism in which the rate determining step is the proton transfer process. The reactions of 1-(1-hydroxybenzotriazolyl)-2,4-dinitrobenzene and 2-(1-hydroxybenzotriazolyl)-5-nitropyridine with Mo in the three solvents and with CHA and An in MeOH and AN is greatly dependent on the stability of the zwitterionic intermediate. The effect of ring activation is due to the ground state stabilization and the more efficient delocalization of the neg. charge with a nitro group than with a ring-nitrogen in the transition state. The low activation enthalpies ΔH# and the highly neg. activation entropies ΔS# are due to the intramol. hydrogen bonding with the ammonio hydrogen present in the transition state.

Open Journal of Physical Chemistry published new progress about Activation enthalpy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Application of 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khattab, Sherine N. published the artcileSynthesis and aminolysis of 2,4-dinitrophenyl and 5-nitropyridine N-hydroxy oxime derivatives, Application In Synthesis of 26820-62-2, the main research area is aminolysis dinitrophenyl nitropyridine oxime morpholine nucleophilic aromatic substitution kinetics.

The 2,4-dinitrophenoxy derivatives 12-16 and the 5-nitro-2-pyridyloxy derivatives 18-22 were prepared The products were identified by elemental anal., IR, and NMR. The reaction of 12-16 and 18-22 with morpholine as nucleophile in CH3CN occurs through nucleophilic aromatic substitutions to give N-(2,4-dinitrophenyl)morpholine (23) and N-(5-nitro-2-pyridyl)morpholine (24) resp. Spectrophotometric measurements of the kinetics of these reactions in CH3CN at a range of temperatures indicated that they are not morpholine-catalyzed. The Bronsted-type plots for the reactions of 12-16 and 18-22 with morpholine are linear with slopes, β12-16 = -1.58 ± 0.1 and β18-22 = -1.15 ± 0.25 resp. The relative rate constants compared to the least reactive substrate, as well as the low neg. β values, supported that the decomposition of the zwitterionic intermediate is a slow process. The low activation parameters (ΔH# and ΔS#) are in accordance with the proposed transition state (T#). The expulsion of RO- anion in the rate-determining step is assisted by intramol. hydrogen-bonding with the ammonio-hydrogen present in the intermediate T#.

Bulletin of the Chemical Society of Japan published new progress about Activation enthalpy. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Application In Synthesis of 26820-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gulevskaya, Anna V. published the artcileC-N bond formation by the oxidative alkylamination of azines: comparison of AgPy2MnO4 versus KMnO4 as oxidant, Formula: C9H11N3O3, the main research area is pyridine quinazoline amine oxidative alkylamination permanganate; aminopyridine preparation; aminoquinazoline preparation; permanganate oxidative alkylamination oxidant.

Reports on the successful oxidative alkylamination of azines by the SN-reaction, with the use of alkylamines other than methylamine, are very scarce. Hitherto, the exptl. limitation to extend oxidative amination of azines with NH3/KMnO4 to oxidative alkylamination is solely ascribed to the low solubility of KMnO4 in alkylamines and the increased sensitivity of alkylamines towards oxidation in comparison with ammonia. The exptl. data proved that there is also a substrate dependence in this type of reaction. 2-Alkylamino-5-nitropyridines and 4-alkylaminoquinazolines were smoothly obtained by the treatment of 3-nitropyridine and quinazoline, resp., with alkylamine/AgPy2MnO4. Although KMnO4 still gives moderate to good results with 3-nitropyridine, it is completely useless for reactions with quinazoline with the same alkylamines. The use of AgPy2MnO4 was found to give equal or superior results to those of KMnO4 depending on the alkylamine and the substrate used and therefore seems to be a promising general oxidant for successful oxidative alkylaminations.

European Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tanga, M. J. published the artcileSyntheses of five potential heterocyclic amine food mutagens, Safety of 3-Bromo-2,6-dimethylpyridin-4-amine, the main research area is aminoimidazopyridine trimethyl preparation; imidazopyridine amino trimethyl preparation; food mutagen potential preparation.

The syntheses of the potential heterocyclic amine food mutagens, 3,5,7-trimethyl-2-aminoimidazo[4,5-b]pyridine, 1,4,7-trimethyl-2-aminoimidazo[4,5-c]pyridine, 1,6,7-trimethyl-2-aminoimidazo[4,5-c]pyridine, 3,4,6-trimethyl-2-aminoimidazo[4,5-c]pyridine, and 1,4,6-trimethyl-7-aminoimidazo[4,5-c]pyridine are described.

Journal of Heterocyclic Chemistry published new progress about Mutagens, food Role: SPN (Synthetic Preparation), PREP (Preparation). 33259-24-4 belongs to class pyridine-derivatives, name is 3-Bromo-2,6-dimethylpyridin-4-amine, and the molecular formula is C7H9BrN2, Safety of 3-Bromo-2,6-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Charushin, Valery N. published the artcilePyrimidines. Part 93. Ring transformations of heterocycles. Part 28. Ring transformations of 5-nitropyrimidine via inverse Diels-Alder reactions, Safety of 4-(5-Nitropyridin-2-yl)morpholine, the main research area is nitropyrimidine inverse Diels Alder ketene; nitropyridine; pyrimidine nitro Diels Alder ketene; enamine Diels Alder nitropyrimidine.

5-Nitropyrimidine (I) underwent inverse Diels-Alder cycloaddition reactions with ketene acetals and enamines to give pyridine derivatives Thus, reaction of I with morpholinocyclohexene in EtOH at 70° for 2 h gave 80% pyridine II. 1H NMR studies showed the reaction involves a bicyclic intermediate.

Tetrahedron Letters published new progress about Acetals, ketene Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Safety of 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Walsh, Katie published the artcileAmination of Heteroaryl Chlorides: Palladium Catalysis or SNAr in Green Solvents?, Product Details of C9H11N3O3, the main research area is pyrimidine pyrazine quinazoline preparation; heteroaryl chloride amine SNAr arylation water potassium fluoride; amination; aromatic substitution; green chemistry; nucleophilic substitution.

The reaction of heteroaryl chlorides in the pyrimidine, pyrazine and quinazoline series with amines in water in the presence of KF results in a facile SNAr reaction and N-arylation products, e. g., I. The reaction is less satisfactory with pyridines unless an addnl. electron-withdrawing group is present. The results showed that the transition-metal-free SNAr reaction not only compares favorably to palladium-catalyzed coupling reactions but also operates under environmentally acceptable (“”green””) conditions in terms of the base and solvent.

ChemSusChem published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Product Details of C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duan, Gongping published the artcileSynthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety, Computed Properties of 17117-13-4, the main research area is dithienylethene imidazolidene carbene ruthenium mesitylene half sandwich preparation structure; photochromic mesitylene ruthenium heterocyclic carbene dithienylethene complex; crystal mol structure mesityleneruthenium dithienylethene imidazolidene carbene complex; electrochem redox mesityleneruthenium dithienylethene imidazolidene carbene half sandwich.

A series of half-sandwich type ruthenium(ii) complexes, [(η6-mesitylene)Ru(NHC-L)Cl]PF6 (NHC = N-heterocyclic carbene, L = azole and imine ligand), containing the dithienylethene moiety has been synthesized and characterized by 1H NMR, x-ray crystallog. and electronic absorption spectroscopy. These complexes show photochromic properties upon UV photo-irradiation to generate the closed forms of the dithienylethene moiety.

New Journal of Chemistry published new progress about Crystal structure. 17117-13-4 belongs to class pyridine-derivatives, name is 2-Bromo-4-ethoxypyridine, and the molecular formula is C7H8BrNO, Computed Properties of 17117-13-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Chi-Yu published the artcileSynthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine, the main research area is phenoxybenzamide cycloaliphatic amine preparation human antiproliferative hedgehog signaling inhibitor.

A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety I (R1 = Me, OCF3, OMe, Cl; X = O, CH2), II (R2 = Ph, 3-MeOC6H4, 2-pyridyl, 3,4-Cl2C6H3, etc.) were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacol. data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound I (R1 = OCF3; X = O) showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of I (R1 = OCF3; X = O) showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization.

Chinese Chemical Letters published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Recommanded Product: 4-(5-Nitropyridin-2-yl)morpholine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ding, Huaiwei published the artcileSynthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives, Formula: C9H11N3O3, the main research area is pyridine imidazothiazoleacetamide preparation antitumor.

Novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide (I) and were tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. 2-{6-(4-Chlorophenyl)imidazo[2,1-b]thiazol-3-yl}-N-{6-[4-(4-methoxybenzyl)piperazin-1-yl]pyridin-3-yl}acetamide, with slightly higher inhibition on VEGFR2 than I (5.72 and 3.76% inhibitory rate at 20 μM, resp.), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).

Molecules published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Formula: C9H11N3O3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duan, Gongping published the artcileSynthesis and photochromic studies of η6-mesitylene ruthenium(ii) complexes bearing N-heterocyclic carbene ligands with the dithienylethene moiety, Computed Properties of 17117-13-4, the main research area is dithienylethene imidazolidene carbene ruthenium mesitylene half sandwich preparation structure; photochromic mesitylene ruthenium heterocyclic carbene dithienylethene complex; crystal mol structure mesityleneruthenium dithienylethene imidazolidene carbene complex; electrochem redox mesityleneruthenium dithienylethene imidazolidene carbene half sandwich.

A series of half-sandwich type ruthenium(ii) complexes, [(η6-mesitylene)Ru(NHC-L)Cl]PF6 (NHC = N-heterocyclic carbene, L = azole and imine ligand), containing the dithienylethene moiety has been synthesized and characterized by 1H NMR, x-ray crystallog. and electronic absorption spectroscopy. These complexes show photochromic properties upon UV photo-irradiation to generate the closed forms of the dithienylethene moiety.

New Journal of Chemistry published new progress about Crystal structure. 17117-13-4 belongs to class pyridine-derivatives, name is 2-Bromo-4-ethoxypyridine, and the molecular formula is C7H8BrNO, Computed Properties of 17117-13-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem