Tag: M.W=200-250

Du, Zhengyin; Li, Zuopeng; Deng, Youquan published the artcile< Synthesis and characterization of sulfonyl-functionalized ionic liquids>, Computed Properties of 21876-43-7, the main research area is ionic liquid sulfonyl functionalized preparation media catalyst.

Novel sulfonyl-functionalized ionic liquids with -SO3H and -SO2Cl groups were designed, synthesized, and characterized. Being strong acidic substances, these ionic liquids have great potential as media and catalysts in many acid-catalyzed reactions.

Synthetic Communications published new progress about Imidazolium compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Computed Properties of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Mingzhong; Luo, Chengkai; Xu, Caifeng; Huang, Bin published the artcile< Recyclable Pd2dba3/XPhos/PEG-2000 System for Efficient Borylation of Aryl Chlorides: Practical Access to Aryl Boronates>, Computed Properties of 329214-79-1, the main research area is green palladium xphos polyethylene glycol catalyst borylation aryl chloride; aryl boronate preparation green.

Pd2dba3/XPhos in poly(ethylene glycol) (PEG-2000) is shown to be a highly stable and efficient catalyst for the borylation of aryl chlorides with bis(pinacolato)diboron. The borylation reaction proceeds smoothly at 110°, delivering a wide variety of aryl boronates in good to excellent yields with high functional group tolerance. The crude products were easily isolated via simple extraction of the reaction mixture with cyclohexane. Moreover, both expensive Pd2dba3 and XPhos in PEG-2000 system could be readily recycled and reused more than six times without loss of catalytic efficiency.

Synthesis published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Computed Properties of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Bo; Bi, Xiuru; Zhou, Jinbo; Li, Changming; Zhao, Peiqing; Meng, Xu published the artcile< Synthesis of Crystalline OMS-2 with Urea Hydrogen Peroxide and its Application in Aerobic Oxidation Reactions>, Category: pyridine-derivatives, the main research area is cryptomelane type manganese oxide preparation pore size crystallinity recyclability; alkane manganese oxide catalyst selective oxidation; ketone preparation; thiol manganese oxide catalyst selective oxidation; disulfide preparation.

Cryptomelane-type manganese oxide (OMS-2) was synthesized successfully using urea hydrogen peroxide (urea.H2O2) as the reductant in an acidic buffer solution As-prepared crystalline material was fully characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller method (BET), XPS, SEM (SEM) and high resolution transition electron microscopy(HRTEM). The results demonstrate that OMS-2 has nanofiber with short nanorod morphologies, very rich oxygen vacancy defected and more exposed crystal facets compared with ones synthesized with other H2O2-containing reductants. These unique properties made nanostructural OMS-2 an excellent heterogeneous catalyst in aerobic oxidation reactions, such as selective oxidation of mercaptan and oxygenation of alkylarenes.

ChemistrySelect published new progress about Crystallinity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Qiqiang; Dong, Guangbin published the artcile< Programmable Ether Synthesis Enabled by Oxa-Matteson Reaction>, Formula: C11H16BNO2, the main research area is boronate alkyl aryl oxa Matteson oxygen carbenoid insertion reaction; boron substituted ether product preparation.

The Matteson-type reactions have received increasing interest in constructing complex organic mols. via iterative synthetic strategies; however, the current tactics are almost exclusively based on homologation of pure C chains. Here, the authors report the development of the oxa-Matteson reaction that enables sequential O and carbenoid insertions into diverse alkyl- and arylboronates. It offers a distinct entry to a wide range of B-substituted ethers. The utilities of this method are demonstrated in the preparation of various functional ethers, the asym. synthesis of an acetyl-CoA-carboxylase inhibitor, and the programmable construction of polyethers.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent) (alkyl and aryl). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Katsuya, Ken; Oikawa, Daisuke; Iio, Kiyosei; Obika, Shingo; Hori, Yuji; Urashima, Toshiki; Ayukawa, Kumiko; Tokunaga, Fuminori published the artcile< Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-kB signaling>, Synthetic Route of 329214-79-1, the main research area is LUBAC HOIPIN nuclear factor signalling; Cytokine; Enzyme inhibitor; Inflammation; NF-κB; Ubiquitin.

Nuclear factor-kB (NF-kB) is a crucial transcription factor family involved in the regulation of immune and inflammatory responses and cell survival. The linear ubiquitin chain assembly complex (LUBAC), composed of the HOIL-1L, HOIP, and SHARPIN subunits, specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway. We recently identified a chem. inhibitor of LUBAC, which we named HOIPIN-1 (HOIP inhibitor-1). To improve the potency of HOIPIN-1, we synthesized 7 derivatives (HOIPIN-2~8), and analyzed their effects on LUBAC and NF-kB activation. Among them, HOIPIN-8 suppressed the linear ubiquitination activity by recombinant LUBAC at an IC50 value of 11 nM, corresponding to a 255-fold increase over that of HOIPIN-1. Furthermore, as compared with HOIPIN-1, HOIPIN-8 showed 10-fold and 4-fold enhanced inhibitory activities on LUBAC- and TNF-a-induced NF-kB activation resp., without cytotoxicity. These results indicated that HOIPIN-8 is a powerful tool to explore the physiol. functions of LUBAC.

Biochemical and Biophysical Research Communications published new progress about Animal gene, ICAM1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Inai, Makoto; Hamashima, Yoshitaka; Kan, Toshiyuki published the artcile< Practical Total Syntheses of Acromelic Acids A and B>, Computed Properties of 777931-67-6, the main research area is acromelic acid A B total synthesis; asym conjugate addition intramol reductive amination epimerization.

Practical total syntheses of acromelic acids A (I) and B (II), which have potent neuro-excitatory activity, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), resp., from 2,6-dichloropyridine. Regioselective transformation of sym. 2,6-dichloropyridine provided nitroalkenes III and IV. The pyrrolidine ring was efficiently constructed by Ni-catalyzed asym. conjugate addition followed by intramol. reductive amination.

Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Computed Properties of 777931-67-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gao, Jian; Zhu, Yafeng; Liu, Wenqi; Jiang, Suyu; Zhang, Jie; Ma, Wei published the artcile< Hydrogen Bonds in Disulfonic-Functionalized Acid Ionic Liquids for Efficient Biodiesel Synthesis>, Reference of 21876-43-7, the main research area is biodiesel synthesis ionic liquid catalyst hydrogen bond.

Regulating the states of hydrogen bonds in ionic liquids (ILs) is an effective way to improve their catalytic performance. In this paper, disulfonic-functionalized acidic ionic liquids (DSFAILs) were synthesized successfully, including novel SO3H-functionalized binuclear IL (bis[3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2). For the biodiesel synthesis, compared with the traditional ILs catalysts, DSFAILs bis[(3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2, [Im(N (CH2)3SO3H)2][HSO4]) had higher catalytic activity even under mild reaction conditions. Using the d. functional theory (DFT) method, the role of hydrogen bonds in different SO3H-functionalized acidic ionic liquids (SFAILs) was explored. The forms of hydrogen bonds existing in different ILs directly determine their acidity. It suggested that the forming status of the active sites (hydrogen bonds) were diverse in different SFAILs. Also, deep ionization of the hydrogen atoms from the cation-anion strong interaction could increase the acidity and catalytic performance of SFAILs. From this, the structure-activity relationship between the SFAILs structures and the catalytic activity of Me oleate synthesis was proposed. Besides, the exptl. results also showed that bis[3-(CH2)3SO3H-1-(CH2)2-Im][HSO4]2 catalyst had a high catalytic activity to obtain Me oleate and the catalyst could be separated easily owing to its larger mol. weight However, [Im(N(CH2)3SO3H)2][HSO4] had a stronger acidity and a lower steric hindrance and thus a higher catalytic activity and was the optimal catalyst for the Me oleate synthesis. In the presence of a small amount of catalyst (6 wt %) and at low reaction temperature (353 K), the Me oleate yield could reach up to 93%. After six recycles of the catalyst, the Me oleate yield remained at 90%.

ACS Omega published new progress about Acidity. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Reference of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Peng, Ling; Yao, Jing-Wen; Wang, Mei; Wang, Lin-Ye; Huang, Xiao-Lan; Wei, Xin-Feng; Ma, Dong-Ge; Cao, Yong; Zhu, Xu-Hui published the artcile< Efficient soluble deep blue electroluminescent dianthracenylphenylene emitters with CIE y (y ≤ 0.08) based on triplet-triplet annihilation>, Formula: C11H16BNO2, the main research area is deep blue electroluminescent dianthracenylphenylene emitter triplet annihilation.

It has been challenging to develop deep blue organic mol. fluorescent emitters with CIE y (y ≤ 0.08) based on triplet-triplet annihilation (TTA). Here, we report facilely available dianthracenylphenylene-based emitters, which have a 3,5-di(4-t-butylphenyl)phenyl moiety at the one end and 4-cyanophenyl or 3-pyridyl at the other end, resp. Both fluorophores show a high glass transition temperature of over 220°C with a thermal decomposition temperature of over 430°C at an initial weight loss of 1%. The preliminary characterizations of the organic light-emitting diodes (OLEDs) that utilized these nondoped emitters provided high EQEs of 4.6%-5.9% with CIE coordinates (0.15, 0.07-0.08). The anal. of the EL transient decay revealed that TTA contributed to the observed performance. The results show that the new emitters are attractive as a potential TTA-based host to afford stable deep blue fluorescent OLEDs.

Science Bulletin published new progress about Electric current-potential relationship. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Shuguang; Chen, Liang; Zhou, Xiaojun; Sun, Ping; Fu, Liwen; You, Yanling; Xu, Man; You, Zhengwei; Kai, Guoyin; He, Chuanglong published the artcile< Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics>, Category: pyridine-derivatives, the main research area is tumor targeting biodegradable multifunctional nanoparticle cancer theranostic.

Mesoporous silica nanoparticles (MSN) attract extensive attention in area of cancer diagnosis and therapy because of their controllable nanostructures, easy surface modification and stable synthesis methods. However, their biodegradability was still controversial. This work explored the degradation effect of a type of biodegradable MSN (bMSN) in different environments and simultaneously endowed it with imaging functions and high-efficiency targeting effect on cancer cell, thus forming a multifunctional biodegradable drug carrier (bMSN-ss-GABA) for cancer theranostics. The bovine serum albumin-based Gd/Au complex (BSA-Gd/Au) was wrapped on the surface of bMSN through disulfide linkage, acting as contrast agent for magnetic resonance (MR) and fluorescence imaging, and then folate (FA), whose receptor (FR) is overexpressed in KB human oral epidermoid carcinoma cells, was modified on the nanocarriers as a targeting ligand. TEM revealed the degradation process of bMSN and a series of characterization methods verified the successful construction of bMSN-ss-GABA. Doxorubicin hydrochloride (DOX) loaded bMSN-ss-GABA (DOX@bMSN-ss-GABA) was proved with redox-responsiveness, thereby triggering rapid drug release under specific tumor microenvironment of high glutathione concentration Further, the excellent imaging capability was also fully inspected. What’s more, the results of endocytosis and tumor growth inhibition of DOX@bMSN-ss-GABA demonstrated the highly effective targeting effect of hybrid nanocarriers. Therefore, the prepared DOX@bMSN-ss-GABA might be used as a promising nanotheranostic agent for KB human oral epidermoid carcinoma.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Eastman, Kyle J.; Parcella, Kyle; Yeung, Kap-Sun; Grant-Young, Katharine A.; Zhu, Juliang; Wang, Tao; Zhang, Zhongxing; Yin, Zhiwei; Beno, Brett R.; Sheriff, Steven; Kish, Kevin; Tredup, Jeffrey; Jardel, Adam G.; Halan, Vivek; Ghosh, Kaushik; Parker, Dawn; Mosure, Kathy; Fang, Hua; Wang, Ying-Kai; Lemm, Julie; Zhuo, Xiaoliang; Hanumegowda, Umesh; Rigat, Karen; Donoso, Maria; Tuttle, Maria; Zvyaga, Tatyana; Haarhoff, Zuzana; Meanwell, Nicholas A.; Soars, Matthew G.; Roberts, Susan B.; Kadow, John F. published the artcile< The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase>, Application In Synthesis of 777931-67-6, the main research area is hepatitis C virus NS5B polymerase 7 azabenzofuran.

The development of a series of novel 7-azabenzofurans exhibiting pan-genotype inhibition of HCV NS5B polymerase via binding to the primer grip site is presented. Many challenges, including poor oral bioavailability, high clearance, bioactivation, high human serum shift, and metabolic stability were encountered and overcome through SAR studies. This work culminated in the selection of BMS-986139 (43) as a preclin. candidate.

MedChemComm published new progress about Blood serum. 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Application In Synthesis of 777931-67-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem