Tag: M.W=200-250

Kashiwagi, Yukiyasu; Kubono, Koji; Tamai, Toshiyuki published the artcile< Crystal structure of catena-poly[[[bis(3-oxo-1,3-diphenylprop-1-enolato-κ2O,O')zinc(II)]- μ2-tris[4-(pyridin-3-yl)phenyl]amine-k2N:N'] tetrahydrofuran monosolvate]>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is crystal coordination polymer structure hydrogen bond geometry; C—H⋯π inter­actions; coordination polymer; crystal structure; tri­aryl­amine; β-diketonato zinc(II).

The reaction of bis(3-oxo-1,3-diphenylprop-1-enolato-k2O,O’)zinc(II), [Zn(dbm)2], with tris[4-(pyridin-3-yl)phenyl]amine (T3PyA) in THF (THF) afforded the title crystalline coordination polymer, {[Zn(C15H11O2)2(C33H24N4)].C4H8O}n. The asym. unit contains two independent halves of Zn(dbm)2, one T3PyA and one THF. Each ZnII atom is located on an inversion center and adopts an elongated octahedral coordination geometry, ligated by four O atoms of two dbm ligands in equatorial positions and by two N atoms of pyridine moieties from two different bridging T3PyA ligands in axial positions. The crystal packing shows a one-dimensional polymer chain in which the two pyridyl groups of the T3PyA ligand bridge two independent Zn atoms of Zn(dbm)2. In the crystal, the coordination polymer chains are linked via C-H…π interactions into a sheet structure parallel to (010). The sheets are crosslinked via further C-H…π interactions into a three-dimensional network. The solvate THF mol. shows disorder over two sets of at. sites having occupancies of 0.631 (7) and 0.369 (7).

Acta Crystallographica, Section E: Crystallographic Communications published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Barroso, Santiago; Joksch, Markus; Puylaert, Pim; Tin, Sergey; Bell, Stephen J.; Donnellan, Luke; Duguid, Stewart; Muir, Colin; Zhao, Peichao; Farina, Vittorio; Tran, Duc N.; de Vries, Johannes G. published the artcile< Improvement in the Palladium-Catalyzed Miyaura Borylation Reaction by Optimization of the Base: Scope and Mechanistic Study>, Synthetic Route of 329214-79-1, the main research area is palladium catalyzed Miyaura borylation aryl halide base optimization; Arylboronic acid ester preparation.

Aryl boronic acids and esters are important building blocks in API synthesis. Pd-catalyzed Suzuki Miyaura borylation is the most common method for their preparation This paper describes an improvement of the current reaction conditions. By using lipophilic bases such as K 2-Et hexanoate, borylation reaction could be achieved at 35° in <2 h with very low Pd loading (0.5 mol %). A preliminary mechanistic study shows a hitherto unrecognized inhibitory effect by the carboxylate anion on the catalytic cycle, whereas 2-Et hexanoate minimizes this inhibitory effect. This improved methodol. enables borylation of a wide range of substrates under mild conditions. Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Watanabe, Hiroyuki; Tatsumi, Haruka; Kaide, Sho; Shimizu, Yoichi; Iikuni, Shimpei; Ono, Masahiro published the artcile< Structure-Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes>, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine, the main research area is structure radioiodinated tricyclic compound Tau imaging probe.

Tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of Alzheimer’s disease (AD). In this study, we designed and synthesized six radioiodinated 6,5,6-tricyclic compounds to explore novel scaffolds for tau imaging probes. On in vitro autoradiog. of AD brain sections, pyridoimidazopyridine and benzimidazopyrimidine derivatives ([125I]21 and [125I]22, resp.) showed selective binding affinity for tau aggregates, whereas carbazole, pyrrolodipyridine, and pyridoimidazopyrimidine derivatives ([125I]10, [125I]12, and [125I]23, resp.) bound β-amyloid aggregates. In a biodistribution study using normal mice, [125I]21 and [125I]22 showed high initial uptakes (5.73 and 5.66% ID/g, resp., at 2 min postinjection) into and rapid washout (0.14 and 0.10% ID/g, resp., at 60 min postinjection) from the brain. Taken together, two novel scaffolds including pyridoimidazopyridine and benzimidazopyrimidine may be applied to develop useful tau imaging probes.

ACS Medicinal Chemistry Letters published new progress about Alzheimer disease (potential diagnosis). 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Tiffany Q.; Pedersen, P. Scott; Dow, Nathan W.; Fayad, Remi; Hauke, Cory E.; Rosko, Michael C.; Danilov, Evgeny O.; Blakemore, David C.; Dechert-Schmitt, Anne-Marie; Knauber, Thomas; Castellano, Felix N.; MacMillan, David W. C. published the artcile< Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids>, Quality Control of 777931-67-6, the main research area is hetero aryl halide preparation photochem; aryl hetero carboxylic acid decarboxylative halogenation copper catalyst.

A general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids RC(O)OH (R = 4-sulfamoylphenyl, 5-methylpyridin-2-yl, isoquinolin-1-yl, etc.) via ligand-to-metal charge transfer was reported. This strategy accommodates an exceptionally broad scope of substrates. An aryl radical intermediate is leveraged toward divergent functionalization pathways: (1) atom transfer to access bromo- or iodo(hetero)arenes or (2) radical capture by copper and subsequent reductive elimination to generate chloro- or fluoro(hetero)arenes. The proposed ligand-to-metal charge transfer mechanism is supported through an array of spectroscopic studies.

Journal of the American Chemical Society published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Quality Control of 777931-67-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Watanabe, Taiki; Sasabe, Hisahiro; Owada, Tsukasa; Maruyama, Tomohiro; Watanabe, Yuichiro; Katagiri, Hiroshi; Kido, Junji published the artcile< Chrysene-based Electron-transporters Realizing Highly Efficient and Stable Phosphorescent OLEDs>, Category: pyridine-derivatives, the main research area is chrysene electron transporter phosphorescence organic light emitting diode.

A series of chrysene-based electron-transporters named BnPyPCs (n = 2, 3, 4) end-capped with two 3,5-di(pyridin-n-yl)phenyl moieties with high thermal and elec. stability were successfully developed. BnPyPCs showed Tm values greater than 390°C and were used for highly efficient green phosphorescent OLEDs with maximum external quantum efficiency values greater than 20% and long operation lifetime at high brightness of approx. 11000 cd m-2 at a c.d. of 25 mA cm-2.

Chemistry Letters published new progress about Density functional theory. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

den Hertog, H. J.; Schogt, J. C. M.; de Bruyn, J.; de Klerk, A. published the artcile< Derivatives of pyridine and quinoline. LXXXIII. Chloropyridines>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is .

2,4,5-Trichloropyridine has been synthesized, 6 other chloropyridines reëxamd., and the m. ps. and b. ps. of 19 chloropyridines determined Nicotinic acid (5 g.) divided in 2 tubes was shaken 4 h. at 250-70° with 42 g. PCl5 and 20 g. POCl3; steam distillation gave an oil and a precipitate which was refluxed 1 h. with 20 mL. 80% H2SO4, diluted with H2O, made basic, and steam-distilled; various fractions m. above 65° [cf. Seyfferth, J. prakt. Chem. 34, 241(1886)], and from the last fraction 2,3,5,6-tetrachloropyridine, m. 90-0.5°, was isolated. 3-Bromo-2,4-dihydroxypyridine (I) (5 g.) and 25 mL. 48% HBr heated 3 h. at 200° in 2 sealed tubes gave, after adding H2O and allowing to stand, 0.5 g. I and from the mother liquor 3.1 g. 5-bromo-2,4-dihydroxypyridine, m. 226.5-7.5°; 1 g. heated 2 h. at 200° with 10 mL. 38% HCl gave 3-chloro-2,4-dihydroxypyridine, decompose about 310°. Et 2,4-dihydroxy-5-pyridinecarboxylate (II) (3 g.) heated 2.5 h. at 115-20° with 18 g. POCl3 gave on steam distillation 90% of the 2,4-di-Cl compound (III), m. 31.5-2°. Saponification with an equivalent amount of dilute NaOH for 0.5 h. gave 80% 2,4-dichloro-5-pyridinecarboxylic acid “”hydrate”” (IV), m. 198° after liquefying at 155° and resolidifying, which could not be dehydrated by recrystallization from EtOH, C6H6, or ligroin, or by sublimation. IV (10 g.) and 10-15 g. POCl3 warmed to 100°, treated gradually with 30 g. PCl5, heated at 140° 0.5 h., evaporated under a vacuum, and the residue dissolved in C6H6 and saturated with NH3 gave 85% 2,4-dichloro-5-pyridinecarboxylic acid, m. 152-3° (from H2O). III (1.7 g.) in 2-3 mL. EtOH with 0.45 g. (NH2)2.H2O let stand 15 min. and a few ml. H2O added gave Et 2-chloro-4-hydrazino-5-pyridinecarboxylate, m. 147-8°; 1 g. suspended in 30 mL. boiling H2O treated dropwise with 35 mL. 10% CuSO4 solution, refluxed 2.5 h., and steam-distilled gave 45-50% Et 2-chloro-5-pyridinecarboxylate (V), saponified to the acid, m. 195° (decomposition) (amide, m. 211°). V (0.25 g.) heated 4 h. at 110° in a sealed tube with 0.1 g. Na in 6 mL. MeOH, diluted with H2O, acidified, and evaporated halfway gave 2-methoxy-5-pyridinecarboxylic acid, m. 171.5-2.5° (from H2O). 2,4-Dichloro-5-pyridinecarboxylic acid (4 g.) and 2 mL. POCl3 warmed to 100°, treated with 13 g. PCl5, warmed 0.5 h. at 140°, evaporated under a vacuum, taken up in C6H6, and saturated with NH3 gave 95% nitrile, m. 136-7°; 0.5 g. with 0.5 mL. Br in 50 mL. 7% KOH at room temperature for a few hrs., then a few hrs. at 70°, acidified, made basic, and extracted with Et2O gave 30-40% 2,4-dichloro-5-aminopyridine (VI), m. 80-1° (from ligroin). VI (0.5 g.) in 10 mL. 38% HCl in an ice-salt bath treated with 1.05 g. NaNO2 in 3 mL. H2O, then with 2.2 g. Cu powder, and steam-distilled gave 40-50% 2,4,5-trichloropyridine (VII), m. 8.5-9° (from aqueous EtOH). Heating 0.1 g. VII 4 h. at 160° with 2 mL. NH4OH (d. 0.9) gave 2,5-dichloro-4-aminopyridine, m. 119-20°; 0.02 g. in 0.5 mL. 38% HCl treated with 0.08 g. H2O2 and evaporated gave 2,3,5-trichloro-4-aminopyridine, m. 147°. NaNO2 with 1 g. 2-chloro-3-aminopyridine gave 0.5 g. 2,3-dichloropyridine, m. 66.5-7°, which with concentrated NH4OH at 190° 36 h. gave 2-amino-3-chloropyridine (VIII), m. 61.5-2°. Heating 0.7 g. 2,4-dihydroxypyridine (IX) with 4 mL. POCl3 2.5 h. at 130-40° gave on making basic, steam-distilling, and extracting with Et2O 60-5% 2,4-di-Cl compound, m. -1 to 0°, b760 189-90°; 0.6 g. with 16 mL. NH4OH heated at 170-80° 4.5 h., made basic, extracted with Et2O, evaporated, and the residue fractionally extracted with 20 mL. ligroin gave 0.05 g. 2-amino-4-chloropyridine, m. 129-30° (picrate, m. 236-43°); after an addnl. extraction with 35 mL. ligroin giving 0.1 g. crystals, 0.1 g. residue remained from which 4-amino-2-chloropyridine, m. 91-1.5°, could be isolated by crystallization 4-Nitraminopyridine (1.8 g.) with 11 mL. 38% HCl heated 10 h. at 100°, made alk., and steam-distilled gave in the 1st fraction (20 mL.) a little 4-chloro- (soluble in dilute HCl), and 10% 3,4,5-trichloropyridine, m. 71.5-2.5°. The 2nd fraction (100 mL.) gave (0.4 g. 4-amino-3,5-dichloropyridine (X), m. 159.5-60.5°. Koenigs, Mields, and Gurlt (C.A. 19, 70) suggested that X was 3,4-dichloropyridine (XII). However, the structure of X was indicated by its isolation in 55-60% yield from 4-aminopyridine by chlorination with HC1 and also from 4-amino-3-chloropyridine (XI). Reduction of 4-chloro-3-nitropyridine with Fe powder and AcOH gave 70% 3-amino-4-chloropyridine, m. 59.5-60.5° (N-Ac derivative, m. 113-13.5°; picrate, m. 181-1.5°); diazotization as before gave XII, m. 23-3.5°, b760 182-3°. XII heated 10 h. at 190° with NH4OH gave XI, m. 60.5-1.5° [picrate, m. 227-9° (decomposition)]; 0.2 g. XII with 0.04 g. Na in 2 mL. EtOH heated 4 h. at 160° gave a residue of 0.175 g. oily 3-chloro-4-ethoxypyridine (picrate, m. 159.5-60°; picrolonate, m. 202-3°). II with HCl and H2O2 gave 70% Et 2,4-dihydroxy-3-chloro-5-pyridinecarboxylate,m. 257-8°; POCl3 then gave 60% Et 2,3,4-trichloro-5-pyridinecarboxylate, m. 34°, 0.07 g. of which was boiled 1.5 h. with 4 mL. 1% NaOH and the Ag salt heated to 230° in a stream of CO2 with distillation, giving 2,3,4-trichloropyridine (XIII), m. 45-6°. IX with HCl and H2O2 gave 3-chloro-2,4-dihydroxypyridine (XIV), decompose about 310°; 0.2 g. I with 5 mL. 38% HCl at 200° 3 h. also gave XIV which was converted to XIII. Et 3-bromo-2,4-dihydroxy-5-pyridinecarboxylate with HCl, then POCl3, gave XIII. 2-Amino-3-chloro-4-bromopyridine (0.14 g.) in 50 mL. EtOH with 0.1 g. NaOH and 10 mg. Pd-Norit catalyst gave impure 2-amino-3-chloropyridine (impure picrate, m. 232-3°). XIII with NH4OH gave by filtration and extraction with ligroin 2-amino-3,4-dichloropyridine, m. 93-5° (picrate, m. 234.5-7°); the crystals less soluble in ligroin were 2,3-dichloro-4-aminopyridine (XV), m. 153.5-4.5° (picrate, m. 198.5-9.5°). XV with HCl and H2O2 gave 2,3,5-trichloro-4-aminopyridine, m. 150-2°. 2,6-Dichloro-4-aminopyridine (XVI) diazotized gave 85% 2,4,6-trichloropyridine (XVII), m. 32.5-3°, b760 217.5-18.5°. XVII with NH4OH gave 2-amino-4,6-dichloro-pyridine (most soluble in ligroin), m. 112.5°, and XVI, m. 170.3°. XVII with NaOMe as before gave 70-5% 2,4,6-trimethoxypyridine, m. 47-8°, which was converted to the 3,5-di-Cl derivative, m. 95.5-6°. 2,4-Dichloro-3-nitropyridine, prepared in 75% yield from IX, was reduced with Fe and AcOH, giving 85-90% 3-amino compound (XVIII), m. 69-9.5° (N-Ac derivative, m. 161-2°). XVIII (0.75 g.) in 15 mL. AcOH saturated with HCl was mixed with 0.7 mL. 30% aqueous H2O2 in 3.3 mL. AcOH, heated 0.5 h. at 80°, and poured into NaOH and Na2SO3 in H2O, giving 3-amino-2,4,6-trichloropyridine (XIX), m. 77.5-8°, and XVIII. Diazotization of XIX gave 75% 2,3,4,6-tetrachloropyridine (XX), m. 37.5-8°, b760 248-9.5°. XVI chlorinated as for XVIII gave 4-amino-2,3,6-trichloropyridine, m. 160-0.5°, which was converted to XX. The substance m. 74-5° [Sell and Dootson, J. Chem. Soc. 73,432(1898)] obtained by the chlorination of pyridine was therefore not XX.

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about 14121-36-9. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Hongyan; Zhao, Qinfu; Wang, Xiudan; Mao, Yuling; Chen, Caishun; Gao, Yikun; Sun, Changshan; Wang, Siling published the artcile< Multi-stimuli responsive mesoporous silica-coated carbon nanoparticles for chemo-photothermal therapy of tumor>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is mesoporous silica carbon nanoparticle delivery chemophotothermal therapy cancer; Carbon dots; Chemo-photothermal synergistic therapy; Controlled release; Mesoporous silica-coated mesoporous carbon; Stimuli-response.

In this work, a traceable dual-porous mesoporous silica-coated mesoporous carbon nanocomposite with high drug loading capacity and high photothermal conversion efficiency (30.5%) was successfully prepared Based on the nanocomposite, a pH/redox/near IR multi-stimuli responsive drug delivery system was constructed to realize the accurate drug delivery, drug controlled release and chemo-photothermal synergistic antitumor therapy. MCN@Si was used as a vehicle to load doxorubicin with a high drug loading efficacy of 48.2% and a NIR absorbance agent for photothermal therapy and NIR thermal imaging. Carbon dots with proper size were covalently attached to the surface of MCN@Si via disulfide bonds to block the mesopores, preventing DOX premature release from DOX/MCN@Si-CDs. DOX was rapidly released at the condition of low pH and high GSH concentration due to the breakage of disulfide bonds and protonation of DOX. Moreover, the local hyperthermia generated by MCN@Si-CDs under NIR irradiation could not only directly kill cells, but also accelerate DOX release and enhance cells sensitivity and permeability. Two-dimensional cells and three-dimensional tumor spheroids assays illustrated that DOX/MCN@Si-CDs + NIR group exhibited thermochemotherapy synergistic treatment effect and combination index was 0.378. All the results demonstrated that DOX/MCN@Si-CDs is a traceable multi-stimuli responsive nanodelivery system and can achieve efficient chemo-photothermal synergistic antitumor therapy.

Colloids and Surfaces, B: Biointerfaces published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Yue; Li, Yang; Zhang, Bohan; Li, Hui; Cheng, Zehong; Shi, Jianqiao; Xiong, Jing; Bai, Yugang; Zhang, Ke published the artcile< Functionalizable, Side Chain-Immolative Poly(benzyl ether)s>, Related Products of 2127-03-9, the main research area is selfimmolative polybenzylether.

Herein, we report a poly(benzyl ether)-based self-immolative polymer (SIP) with pendant pyridine disulfide groups. Cleavage of the side-chain disulfides leads to the formation of phenolates, which initiate depolymerization from the side chain. Due to the higher d. of the disulfide groups compared to that of the chain-end-capping group, which normally is responsible for initiating depolymerization of SIPs, the side chain-immolative polymer (ScIP) can be readily degraded in the solid state where the mobility of polymer chains is substantially limited. The ScIP was also further modified through the thiol-disulfide exchange reaction to prepare ScIP-g-poly(ethylene glycol) graft polymers and organogels, which were also able to undergo complete reductive self-immolative degradation

ACS Macro Letters published new progress about Depolymerization. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duran-Mota, Jose Antonio; Yani, Julia Quintanas; Almquist, Benjamin D.; Borros, Salvador; Oliva, Nuria published the artcile< Polyplex-Loaded Hydrogels for Local Gene Delivery to Human Dermal Fibroblasts>, Application In Synthesis of 2127-03-9, the main research area is polyplex hydrogel fibroblast mRNA wound dressing; gene delivery; human dermal fibroblasts; hydrogel; nanoparticles; poly(β-amino ester)s; polyethylene glycol; skin; wound healing.

Impaired cutaneous healing leading to chronic wounds affects between 2 and 6% of the total population in most developed countries and it places a substantial burden on healthcare budgets. Current treatments involving antibiotic dressings and mech. debridement are often not effective, causing severe pain, emotional distress, and social isolation in patients for years or even decades, ultimately resulting in limb amputation. Alternatively, gene therapy (such as mRNA therapies) has emerged as a viable option to promote wound healing through modulation of gene expression. However, protecting the genetic cargo from degradation and efficient transfection into primary cells remain significant challenges in the push to clin. translation. Another limiting aspect of current therapies is the lack of sustained release of drugs to match the therapeutic window. Herein, we have developed an injectable, biodegradable and cytocompatible hydrogel-based wound dressing that delivers poly(β-amino ester)s (pBAEs) nanoparticles in a sustained manner over a range of therapeutic windows. We also demonstrate that pBAE nanoparticles, successfully used in previous in vivo studies, protect the mRNA load and efficiently transfect human dermal fibroblasts upon sustained release from the hydrogel wound dressing. This prototype wound dressing technol. can enable the development of novel gene therapies for the treatment of chronic wounds.

ACS Biomaterials Science & Engineering published new progress about Fibroblast. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schmid, Lucius; Glaser, Felix; Schaer, Raoul; Wenger, Oliver S. published the artcile< High Triplet Energy Iridium(III) Isocyanoborato Complex for Photochemical Upconversion, Photoredox and Energy Transfer Catalysis>, Quality Control of 396092-82-3, the main research area is photochem upconversion photoredox energy transfer catalysis; High Triplet Energy Iridium Isocyanoborato Complex.

Cyclometalated Ir(III) complexes are often chosen as catalysts for challenging photoredox and triplet-triplet-energy-transfer (TTET) catalyzed reactions, and they are of interest for upconversion into the UV spectral range. However, the triplet energies of commonly employed Ir(III) photosensitizers are typically limited to values around 2.5-2.75 eV. Here, we report on a new Ir(III) luminophore, with an unusually high triplet energy near 3.0 eV owing to the modification of a previously reported Ir(III) complex with isocyanoborato ligands. Compared to a nonborylated cyanido precursor complex, the introduction of B(C6F5)3 units in the second coordination sphere results in substantially improved photophys. properties, in particular a high luminescence quantum yield (0.87) and a long excited-state lifetime (13.0 μs), in addition to the high triplet energy. These favorable properties (including good long-term photostability) facilitate exceptionally challenging organic triplet photoreactions and (sensitized) triplet-triplet annihilation upconversion to a fluorescent singlet excited state beyond 4 eV, unusually deep in the UV region. The new Ir(III) complex photocatalyzes a sigmatropic shift and [2 + 2] cycloaddition reactions that are unattainable with common transition metal-based photosensitizers. In the presence of a sacrificial electron donor, it furthermore is applicable to demanding photoreductions, including dehalogenations, detosylations, and the degradation of a lignin model substrate. Our study demonstrates how rational ligand design of transition-metal complexes (including underexplored second coordination sphere effects) can be used to enhance their photophys. properties and thereby broaden their application potential in solar energy conversion and synthetic photochem.

Journal of the American Chemical Society published new progress about [2+2] Cycloaddition reaction. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Quality Control of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem