Tag: M.W=200-250

Takeuchi, Toshifumi; Mori, Kisho; Sunayama, Hirobumi; Takano, Eri; Kitayama, Yukiya; Shimizu, Taku; Hirose, Yuzuki; Inubushi, Sachiko; Sasaki, Ryohei; Tanino, Hirokazu published the artcile< Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is antibody breast cancer diagnosis extracellular vesicle marker tear.

Small extracellular vesicles (sEVs) are reliable biomarkers for early cancer detection; however, conventional detection methods such as immune-based assays and microRNA analyses are not very sensitive and require sample pretreatments and long anal. time. Here, the authors developed a mol. imprinting-based dynamic molding approach to fabricate antibody-conjugated signaling nanocavities capable of size recognition. This enabled the establishment of an easy-to-use, rapid, sensitive, pretreatment-free, and noninvasive sEV detection platform for efficient sEV detection-based cancer diagnosis. An apparent dissociation constant was estimated to be 2.4 × 10-16 M, which was ~1000 times higher than that of com. immunoassays (anal. time, 5 min/sample). The authors successfully used tears for the first time to detect cancer-related intact sEVs, clearly differentiating between healthy donors and breast cancer patients, as well as between samples collected before and after total mastectomy. The nanoprocessing strategy can be easily repurposed for the specific detection of other types of cancer by changing the conjugated antibodies, thereby facilitating the establishment of liquid biopsy for early cancer diagnosis.

Journal of the American Chemical Society published new progress about Antibodies and Immunoglobulins Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), DGN (Diagnostic Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xuan; McNally, Andrew published the artcile< Cobalt-Catalyzed Alkylation of Drug-Like Molecules and Pharmaceuticals Using Heterocyclic Phosphonium Salts>, Application of C10H6Cl2N2, the main research area is alkylheterocycle regioselective preparation; heterocyclic phosphonium salt preparation organozinc alkylation cobalt catalyst; alkyl Negishi; alkylation; cobalt-catalysis; cross-coupling; late-stage; phosphonium salts; pyridines.

Alkylated pyridines are common in pharmaceuticals, and metal catalysis is frequently used to prepare this motif via Csp2-Csp3 coupling processes. We present a cobalt-catalyzed coupling reaction between pyridine phosphonium salts and alkylzinc reagents that can be applied to complex drug-like fragments and for late-stage functionalization of pharmaceuticals. The reaction generally proceeds at room temperature, and 4-position pyridine C-H bonds are the precursors in this strategy. Given the challenges in selectively installing (pseudo)halides in complex pyridines, this two-step process enables sets of mols. to be alkylated that would be challenging using traditional cross-coupling methods.

ACS Catalysis published new progress about Alkylation. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Futyu, Julia; Ispan, David; Feher, Csaba; Szegedi, Agnes; Juzsakova, Tatjana; Hancsok, Jeno; Skoda-Foldes, Rita published the artcile< Recyclable supported Bronsted acidic ionic liquid catalysts with non-aromatic cations for the oligomerization of isobutene under mild conditions>, COA of Formula: C9H13NO3S, the main research area is bronsted acidic ionic liquid catalyst isobutene oilgomerization jet fuel.

Bronsted acidic ionic liquids with different type of cations (pyridinium, morpholinium, pyrrolidinium, imidazolium), N-sulfoalkyl chain length and different anions (triflate, hydrogensulfate and tetrafluoroborate) were prepared and immobilized on silica by adsorption. The ionic liquids were characterised by NMR and IR. Surface properties and Bronsted/Lewis acidity of the supported catalysts were also determined Their catalytic activity and recyclability were compared in the oligomerisation of isobutene to obtain products that can be used as jet fuel blending components after hydrogenation. The results proved that imidazolium ionic liquids can be replaced by less toxic non-aromatic versions without any loss in their activity and stability. By the introduction of shorter sulfoalkyl chain into the cation, excellent results could be obtained even under milder conditions (lower temperature and shorter reaction time). Catalytic activity was shown to correlate to the Bronsted acidity of the catalyst.

Molecular Catalysis published new progress about Jet aircraft fuels. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, COA of Formula: C9H13NO3S.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Giacobbe, Thomas J.; McGregor, Stanley D.; Beman, Floyd L. published the artcile< Ultraviolet spectra of the chloropyridines and chlorinated pyridines possessing a sulfur (0SR), nitrogen (-NR2), or oxygen (-OR) substituent in either the 2 or 4 position. Convenient method for distinguishing such positional isomers>, Reference of 14121-36-9, the main research area is chloropyridine UV isomerism; pyridine chloro UV.

A correlation is established between the position (2 versus 4) of the S, N, or O substituent on the chlorinated pyridines and their uv spectra. The chlorinated pyridines with S, N, or O substitution at the 2-position give uv spectra whose longest wavelength absorption maxima are enhanced (moved to a greater wavelength and an increased extinction coefficient) when compared to the spectra of the 4-substituted isomers. The number of Cl atoms, and not their position, is the more significant factor in determining the overall character of the spectra.

Journal of Heterocyclic Chemistry published new progress about Isomers. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Reference of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Marcelo, Goncalo A.; Montpeyo, David; Novio, Fernando; Ruiz-Molina, Daniel; Lorenzo, Julia; Oliveira, Elisabete published the artcile< Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is luminescent silicon nanocarrier drug delivery colorectal cancer cell.

Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesized and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesized and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behavior, with a pH 5.0 favoring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.

Dyes and Pigments published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Haixian; Song, Feifei; Dong, Caihong; Yu, Luodan; Chang, Cai; Chen, Yu published the artcile< Co-delivery of nanoparticle and molecular drug by hollow mesoporous organosilica for tumor-activated and photothermal-augmented chemotherapy of breast cancer>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is diethyldithiocarbamate hybrid hollow mesoporous organosilica nanoparticle chemotherapy breast cancer; Breast cancer; Copper; Disulfiram; Mesoporous organosilica; Photothermal.

In comparison with traditional therapeutics, it is highly preferable to develop a combinatorial therapeutic modality for nanomedicine and photothermal hyperthermia to achieve safe, efficient, and localized delivery of chemotherapeutic drugs into tumor tissues and exert tumor-activated nanotherapy. Biocompatible organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) have shown high performance in mol. imaging and drug delivery as compared to other inorganic nanosystems. Disulfiram (DSF), an alc.-abuse drug, can act as a chemotherapeutic agent according to its recently reported effectiveness for cancer chemotherapy, whose activity strongly depends on copper ions. In this work, a therapeutic construction with high biosafety and efficiency was proposed and developed for synergistic tumor-activated and photothermal-augmented chemotherapy in breast tumor eradication both in vitro and in vivo. The proposed strategy is based on the employment of HMONs to integrate ultrasmall photothermal CuS particles onto the surface of the organosilica and the mol. drug DSF inside the mesopores and hollow interior. The ultrasmall CuS acted as both photothermal agent under near-IR (NIR) irradiation for photonic tumor hyperthermia and Cu2+ self-supplier in an acidic tumor microenvironment to activate the nontoxic DSF drug into a highly toxic diethyldithiocarbamate (DTC)-copper complex for enhanced DSF chemotherapy, which effectively achieved a remarkable synergistic in-situ anticancer outcome with minimal side effects. This work provides a representative paradigm on the engineering of combinatorial therapeutic nanomedicine with both exogenous response for photonic tumor ablation and endogenous tumor microenvironment-responsive in-situ toxicity activation of a mol. drug (DSF) for augmented tumor chemotherapy.

Journal of Nanobiotechnology published new progress about Animalia. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hasan, M. Shamim; Chopra, Divykriti; Damm, Anika; Koprivova, Anna; Kopriva, Stanislav; Meyer, Andreas J.; Mueller-Schuessele, Stefanie; Grundler, Florian M. W.; Siddique, Shahid published the artcile< Glutathione contributes to plant defence against parasitic cyst nematodes>, Formula: C10H8N2S2, the main research area is glutathione plant defense parasitic cyst nematode; glutathione; nematode; plant-parasitic nematode; redox; syncytium.

Cyst nematodes (CNs) are an important group of root-infecting sedentary endoparasites that severely damage many crop plants worldwide. An infective CN juvenile enters the host′s roots and migrates towards the vascular cylinder, where it induces the formation of syncytial feeding cells, which nourish the CN throughout its parasitic stages. Here, we examined the role of glutathione (L-γγ-glutamyl-L-cysteinyl-glycine) in Arabidopsis thaliana on infection with the CN Heterodera schachtii. Arabidopsis lines with mutations pad2, cad2, or zir1 in the glutamate-cysteine ligase (GSH1) gene, which encodes the first enzyme in the glutathione biosynthetic pathway, displayed enhanced CN susceptibility, but susceptibility was reduced for rax1, another GSH1 allele. Biochem. anal. revealed differentially altered thiol levels in these mutants that was independent of nematode infection. All glutathione-deficient mutants exhibited impaired activation of defense marker genes as well as genes for biosynthesis of the antimicrobial compound camalexin early in infection. Further anal. revealed a link between glutathione-mediated plant resistance to CN infection and the production of camalexin on nematode infection. These results suggest that glutathione levels affect plant resistance to CN by fine-tuning the balance between the cellular redox environment and the production of compounds related to defense against infection.

Molecular Plant Pathology published new progress about 18S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shen, Ni; Li, Runhan; Liu, Can; Shen, Xuzhong; Guan, Wei; Shang, Rui published the artcile< Photocatalytic Cross-Couplings of Aryl Halides Enabled by o-Phosphinophenolate and o-Phosphinothiophenolate>, Application of C11H16BNO2, the main research area is phosphinophenolate catalyzed cross coupling aryl halide boronate phosphite pyrrole; thiophenolate catalyzed cross coupling aryl halide boronate phosphite pyrrole; arylboronic acid ester preparation; aryl phosphonate preparation; arylpyrrole derivative preparation.

O-Phosphinophenolate and o-phosphinothiophenolate are potent photocatalysts with strong reducing ability to activate aryl chlorides and bromides under visible light for borylation, arylation, and phosphorylation. Exptl. and theor. studies revealed that the o-diphenylphosphino substituent results in a narrow optical gap and facilitates intersystem crossing to access triplet states, which promote phenolate and thiophenolate to function as effective visible-light-photoredox catalysts. The results presented herein suggest promising utility of synthetically modified phenolates and thiophenolates as photoredox catalysts.

ACS Catalysis published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Application of C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ager, Ernest; Chivers, Geoffrey E.; Suschitzky, Hans published the artcile< Polyhalo aromatic compounds. XXVI. Photochemistry of pentachloropyridine and some derivatives>, Related Products of 14121-36-9, the main research area is photochem chloropyridine; pyridine chloro photochem; azabicyclohexenone tetrachloro.

Irradiation of pentachloropyridine in cyclohexane, Et2O, or dioxane gave 2,3,4,6-tetrachloropyridine (I) whereas in C6H6, tetrachloro-3-phenyl-pyridine was formed. Irradiation of pentachloropyridine 1-oxide and tetrachloro-N-methyl-2-pyridone gave CCl2:CClCCl:CClNCO and tetrachloro-2-methyl-2-azabicyclo[2.2.0]hex-5-en-3-one (II) resp. Nucleophilic substitution reactions of I were also examined

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Dechlorination. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Related Products of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Prakash, Muthuraj; Itoh, Yukihiro; Fujiwara, Yoshie; Takahashi, Yukari; Takada, Yuri; Mellini, Paolo; Elboray, Elghareeb E.; Terao, Mitsuhiro; Yamashita, Yasunobu; Yamamoto, Chika; Yamaguchi, Takao; Kotoku, Masayuki; Kitao, Yuki; Singh, Ritesh; Roy, Rohini; Obika, Satoshi; Oba, Makoto; Wang, Dan Ohtan; Suzuki, Takayoshi published the artcile< Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach>, Reference of 329214-79-1, the main research area is fat mass obesity associated protein inhibitor preparation cancer.

Fat mass obesity-associated protein (FTO) is a DNA/RNA demethylase involved in the epigenetic regulation of various genes and is considered a therapeutic target for obesity, cancer, and neurol. disorders. Here, we aimed to design novel FTO-selective inhibitors by merging fragments of previously reported FTO inhibitors. Among the synthesized analogs, compound 11b, which merges key fragments of Hz (3) and MA (4), inhibited FTO selectively over alkylation repair homolog 5 (ALKBH5), another DNA/RNA demethylase. Treatment of acute monocytic leukemia NOMO-1 cells with a prodrug of 11b decreased the viability of acute monocytic leukemia cells, increased the level of the FTO substrate N6-methyladenosine in mRNA, and induced upregulation of MYC and downregulation of RARA, which are FTO target genes. Thus, Hz (3)/MA (4) hybrid analogs represent an entry into a new class of FTO-selective inhibitors.

Journal of Medicinal Chemistry published new progress about Acute monocytic leukemia. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Reference of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem