Tag: M.W=200-250

Fu, Bo; Wang, Xiaobei; Chen, Zhengda; Jiang, Nan; Guo, Zhigang; Zhang, Yuhui; Zhang, Shaopeng; Liu, Xiankun; Liu, Li published the artcile< Improved myocardial performance in infarcted rat heart by injection of disulfide-cross-linked chitosan hydrogels loaded with basic fibroblast growth factor>, Reference of 2127-03-9, the main research area is bFGF cardioprotective disulfide crosslinked chitosan hydrogel myocardial infarction.

Myocardial infarction (MI) has been considered as the leading cause of cardiovascular-related deaths worldwide. Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that promotes angiogenesis after MI; however, it has poor clin. efficacy due to proteolytic degradation, low drug accumulation, and severe drug-induced side effects. In this study, an injectable disulfide-cross-linked chitosan hydrogel loaded with bFGF was prepared via a thiol-disulfide exchange reaction for MI treatment. The thiol-disulfide exchange reaction between pyridyl disulfide-modified carboxymethyl chitosan (CMCS-S-S-Py) and reduced BSA (rBSA) was carried out under physiol. conditions (37 °C and pH 7.4). The mech. properties of the disulfide-cross-linked chitosan hydrogel were evaluated based on the molar ratio of the pyridyl disulfide groups of CMCS-S-S-Py and the thiol groups of rBSA. The disulfide-cross-linked chitosan hydrogel showed good swelling performance, rapid glutathione-triggered degradation behavior and well-defined cell proliferation towards NIH 3T3 fibroblast cells. In the process of establishing a rat MI model, the squeezing heart method was used to make the operation more accurate and the mortality of rats was decreased by using a ventilator. The disulfide-cross-linked chitosan hydrogel loaded with bFGF (bFGF-hydrogel) was injected into a peri-infarcted area of cardiac tissue immediately following MI. Echocardiog. demonstrated that the left ventricular functions were improved by the bFGF-hydrogel after 28 days of treatment. Histol. results revealed that the hydrogel significantly reduced the fibrotic area of MI, and this was further improved by the bFGF-hydrogel treatment. TUNEL and immunohistochem. staining results showed that the bFGF-hydrogel had a more synergistic effect on antiapoptosis and proangiogenesis than using either bFGF or the hydrogel alone.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about Angiogenesis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Reference of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wisniewski, Jacek R. published the artcile< Filter Aided Sample Preparation - A tutorial>, Electric Literature of 2127-03-9, the main research area is filter aided sample preparation proteomic ultrafiltration; Detergent removal; Filter Aided Sample Preparation; Lysate preparation; Multi enzyme digestion filter aided sample preparation; Protein digestion conditions; Proteomic sample preparation.

Filter Aided Sample Preparation (FASP) is a widely used protein processing technique in “”bottom-up”” proteomics. Its popularity reflects the key features of the method: its applicability to a variety of sample types and the high quality of the released peptides. Successful application of FASP requires optimized properties of sample lysate and its amount, use of ultrafiltration units with membranes having large mol. mass cut-offs and well selected conditions for protein digestion. In contrast to the majority of sample preparation methods, FASP allows digestion of proteins with a variety of enzymes and a straightforward monitoring of protein-to-peptide conversion. A unique feature of FASP is the possibility to cleave proteins in a consecutive way using several proteases and to sep. peptide fractions. Understanding principles of the method gives guidance in applying FASP to different types of samples in optimization of conditions of the FASP-workflow.

Analytica Chimica Acta published new progress about Critical micelle concentration. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Electric Literature of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Jingcong; Abetz, Volker published the artcile< Double thermoresponsive graft copolymers with different chain ends: feasible precursors for covalently crosslinked hydrogels>, SDS of cas: 2127-03-9, the main research area is graft copolymer covalently crosslinked hydrogel RAFT polymerization thermoresponsive property.

The tailored synthesis of graft copolymers from acrylic and methacrylic monomers can be accomplished solely through photoiniferter reversible addition-fragmentation chain transfer (RAFT) polymerization Samples with poly[oligo(ethylene glycol) methacrylate] (POEGMA) backbones synthesized under green light irradiation and poly(N-isopropylacrylamide) (PNIPAM) side chains growing under blue light irradiation are presented. As monitored by temperature-dependent dynamic light scattering (DLS) measurements and temperature-variable NMR spectroscopy, the architecture of the graft copolymers allows unique two-step lower critical solution temperature (LCST) transitions in aqueous solutions Meanwhile, different end-groups introduced by the corresponding RAFT agents affect the detailed thermoresponsive behavior remarkably. This RAFT strategy shows more advantages when the multiple trithiocarbonate groups are converted into thiol reactive pyridyl disulfide (PDS) groups via a facile post-polymerization modification. The PDS-terminated graft copolymer can then be regarded as a usable precursor for various applications, such as thermoresponsive hydrogels.

Soft Matter published new progress about Hydrodynamic radius. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Koovits, Paul J.; Dessoy, Marco A.; Matheeussen, An; Maes, Louis; Caljon, Guy; Mowbray, Charles E.; Kratz, Jadel M.; Dias, Luiz C. published the artcile< Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi>, COA of Formula: C12H14N2O2, the main research area is azaindole piperidine structure activity relationship trypanosoma cruzi chagas disease; Azaindole; Chagas disease; Drug discovery; Neglected diseases.

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “”Chagas box”” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about Chagas disease. 1018950-15-6 belongs to class pyridine-derivatives, and the molecular formula is C12H14N2O2, COA of Formula: C12H14N2O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iwata, Takahiro; Hirose, Hisaaki; Sakamoto, Kentarou; Hirai, Yusuke; Arafiles, Jan Vincent V.; Akishiba, Misao; Imanishi, Miki; Futaki, Shiroh published the artcile< Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides>, Formula: C10H8N2S2, the main research area is cervical cancer Fc binding ACAL peptide L17E IgG; antibodies; intracellular delivery; liquid droplet; liquid-liquid phase separation (LLPS); peptides.

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E trimer [FcB(L17E)3] was designed for IgG (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 labeled IgG (Alexa488-IgG) with FcB(L17E)3. Droplet contact with the cellular membrane led to spontaneous influx and distribution of Alexa488-IgG throughout cells in serum containing medium. Involvement of cellular machinery accompanied by actin polymerization and membrane ruffling was suggested for the translocation. Alexa488-IgG neg. charges were crucial in liquid droplet formation with pos. charged FcB(L17E)3. Binding of IgG to FcB(L17E)3 may not be necessary. Successful intracellular delivery of Alexa Fluor 594-labeled anti-nuclear pore complex antibody and anti-mCherry-nanobody tagged with supernegatively charged green fluorescence protein allowed binding to cellular targets in the presence of FcB(L17E)3.

Angewandte Chemie, International Edition published new progress about Blood serum. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Parada, Giovanny A.; Goldsmith, Zachary K.; Kolmar, Scott; Pettersson Rimgard, Belinda; Mercado, Brandon Q.; Hammarstroem, Leif; Hammes-Schiffer, Sharon; Mayer, James M. published the artcile< Concerted proton-electron transfer reactions in the Marcus inverted region>, Reference of 396092-82-3, the main research area is concerted proton electron transfer reaction Marcus inverted region.

One of the most counterintuitive features of electron transfer kinetics is the inverted region. As Marcus theory predicts and experiments have borne out, electron transfer slows down once the driving force for it becomes especially favorable. Parada et al. now offer evidence for such inverted behavior in proton-coupled electron transfer. Specifically, they examined a series of compounds with phenol bridging anthracene (electron acceptor) and pyridine (proton acceptor) derivatives Time-resolved spectroscopy and accompanying theory revealed slower rates at higher driving forces in the back reaction that follows light-induced intramol. proton and electron transfer.

Science (Washington, DC, United States) published new progress about Charge separation. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Reference of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trobe, Melanie; Vareka, Martin; Schreiner, Till; Dobrounig, Patrick; Doler, Carina; Holzinger, Ella B.; Steinegger, Andreas; Breinbauer, Rolf published the artcile< A Modular synthesis of teraryl-based α-helix mimetics, part 3: Iodophenyltriflate core fragments featuring side chains of proteinogenic amino acids>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is peptidomimetic helix teraryl amino acid synthesis protein interaction inhibitor; Suzuki Miyaura coupling Wittig reaction iodo salicylic aldehyde amination; Inhibitors; Peptide mimetics; Protein–protein interactions; Suzuki coupling; Triflate.

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for teraryl assembly. In previous publications we have introduced the methodol. of 4-iodophenyltriflates decorated with the side chains of some of the proteinogenic amino acids. We herein report the core fragments corresponding to the previously missing amino acids Arg, Asn, Asp, Met, Trp and Tyr. Therefore, our set now encompasses all relevant amino acid analogs with the exception of His. In order to be compatible with the triflate moiety, some of the nucleophilic side chains had to be provided in a protected form to serve as stable building blocks. Addnl., cross-coupling procedures for the assembly of teraryls were investigated.

European Journal of Organic Chemistry published new progress about Amination. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iddon, Brian; Mack, Arthur G.; Suschitzky, Hans; Taylor, Jack A.; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 42. Carbon-13 NMR spectra of polyhalopyridines and 2-pyrimidines>, Synthetic Route of 14121-36-9, the main research area is carbon NMR polyhalo pyridine pyrimidine; substituent effect NMR halopyridine.

13C NMR spectra are reported for 103 polyhalopyridines and 8 polyhalopyrimidines. Substituent effects were calculated and the results used to assign structures.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about NMR (nuclear magnetic resonance). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Synthetic Route of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xiaolong; An, Hualiang; Zhang, Hongqi; Zhao, Xinqiang; Wang, Yanji published the artcile< n-Butyraldehyde Self-Condensation Catalyzed by Sulfonic Acid Functionalized Ionic Liquids>, Synthetic Route of 21876-43-7, the main research area is butyraldehyde self condensation sulfonic acid functionalized ionic liquid catalyst.

Self-condensation of n-butyraldehyde to 2-ethyl-2-hexenal is one of the important processes for the industrial production of 2-ethylhexanol. In the present work, several sulfonic acid functionalized ionic liquids (SFILs) were synthesized. Their acid strengths were determined by the Hammett method combined with UV-vis spectroscopy, and their catalytic performances in n-butyraldehyde self-condensation were investigated. The results show that the conversion of n-butyraldehyde correlated well with the acid strength of the SFILs with the same cation. The SFILs with triethylammonium cations showed a better catalytic performance than those with imidazolium cations or pyridinium cations, and [HSO3-b-N(Et)3]p-TSA (“”b””, butyl) exhibited the highest selectivity. Under the optimal reaction conditions of the mass ratio of [HSO3-b-N(Et)3]p-TSA to n-butyraldehyde = 0.1, reaction temperature = 393 K, and reaction time = 6 h, the conversion of n-butyraldehyde was 89.7% and the selectivity to 2-ethyl-2-hexenal was 87.8%. [HSO3-b-N(Et)3]p-TSA could be reused four times without a significant loss in its catalytic performance. A kinetic anal. result showed that this is a reversible second-order reaction. Compared with the kinetic parameters from the reaction catalyzed by an aqueous base or acid catalyst, the pre-exponential factor is lower due to the restriction of the high viscosity of [HSO3-b-N(Et)3]p-TSA. Finally, a possible reaction mechanism for n-butyraldehyde self-condensation catalyzed by [HSO3-b-N(Et)3]p-TSA was proposed.

Industrial & Engineering Chemistry Research published new progress about Acidity. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Synthetic Route of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Shaohua; Yang, Xiping; Tong, Yu; Yang, Yuejing; Chen, Quanwei; Wan, Boheng; Wei, Ran; Wang, Yuchen; Zhang, Yanmin; Kong, Bo; Huang, Jianhang; Chen, Yadong; Lu, Tao; Hu, Qinghua; Du, Ding published the artcile< Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis>, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is triazolylpyridinyl indolecarboxamide preparation ASK1 inhibitor ulcerative colitis; structure triazolylpyridinyl indolecarboxamide inhibition ASK1; mol docking pharmacokinetics permeability triazolylpyridinyl indolecarboxamide ASK1 inhibitor; 1H-indole-2-carboxamide derivatives; ASK1 inhibitor; Ulcerative colitis.

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of a hit compound and conduct further structure-activity relationship (SAR) studies that result in the development of the indole-2-carboxamide I. I displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997. Besides improved in vitro activity, I also exhibits an appropriate in vivo PK profile. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), I shows significant anti-UC efficacy and markedly attenuates DSS-induced body weight loss, colonic shortening, elevation in disease activity index (DAI) and inflammatory cell infiltration in colon tissues. Mechanistically, I represses the phosphorylation of ASK1-p38/JNK signaling pathways and suppresses the overexpression of inflammatory cytokines. Together, these findings suggest that ASK1 inhibitors can potentially be used as a therapeutic strategy for UC.

European Journal of Medicinal Chemistry published new progress about Biological permeation. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem