Tag: M.W=200-250

Qiu, Xu; Yang, Xiaoxue; Zhang, Yiqun; Song, Song; Jiao, Ning published the artcile< Efficient and practical synthesis of unsymmetrical disulfides via base-catalyzed aerobic oxidative dehydrogenative coupling of thiols>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is disulfide green preparation; thiol oxidative dehydrogenative coupling base catalyst.

An efficient M2CO3-catalyzed (M = K or Cs) aerobic cross dehydrogenative coupling reaction of thiols to afford unsym. disulfides RSSR1 [R = 4-MeC6H4, 2-pyridyl, 4-ClC6H4CH2, etc.; R1 = t-Bu, Bn, 2-naphthyl, etc.] was described. The high atom-economy, easy accessibility of catalyst, O2 as the ideal green oxidant, mild reaction conditions and broad substrate scope demonstrated that the present methodol. as a green, attractive and practical approach to disulfides.

Organic Chemistry Frontiers published new progress about Disulfides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bratt, Jack; Iddon, Brian; Mack, Arthur G.; Suschitzky, Hans; Taylor, Jack A.; Wakefield, Basil J. published the artcile< Polyhaloaromatic compounds. Part 41. Photochemical dehalogenation and arylation reactions of polyhaloaromatic and polyhaloheteroaromatic compounds>, Recommanded Product: 2,3,4,6-Tetrachloropyridine, the main research area is photochem dehalogenation arylation haloarom compound; photocyclization thiopyridine; halobenzene poly photochem dehalogenation arylation; pyridine halo dehalogenation arylation.

Photolysis of pentachloro- and pentabromopyridine in Et2O led to β-halogen loss and the formation of a product of attack by Et2O, I (R = Cl, Br, resp.). Both 4-bromo- and 4-iodotetrachloropyridines underwent exclusive loss of Br and iodine, resp. Perhalothiophenes, tetrachloropyrimidine and C6Cl6 underwent similar dehalogenation reactions. Photolysis of C6Cl5I (II), tetrachloroiodopyridines and trichloro-5-iodothiophene in C6H6 gave the corresponding polychloroaryl- or polychloroheteroarylbenzenes. E.g., II underwent photolysis in C6H6 to give 95% 2,3,4,5,6-pentachlorobiphenyl. Photolysis of the pyridines III (R1 = SPh, SC6Cl5) gave the corresponding photocyclization products IV (R2 = H, Cl) resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Photochemical arylation. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Recommanded Product: 2,3,4,6-Tetrachloropyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oka, Naoki; Yamada, Tsuyoshi; Sajiki, Hironao; Akai, Shuji; Ikawa, Takashi published the artcile< Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki-Miyaura Coupling Conditions>, Category: pyridine-derivatives, the main research area is aryl boronic ester bromoarene palladium Suzuki Miyaura coupling; biaryl preparation.

A wide range of aryl boronic 1,1,2,2-tetraethylethylene glycol esters [ArB(Epin)s] were readily synthesized. Purifying aryl boronic esters by conventional silica gel chromatog. is generally challenging; however, these introduced derivatives were easily purified on silica gel and isolated in excellent yields. The purified ArB(Epin) was subjected to Suzuki-Miyaura couplings, which provided higher yields of the desired biaryl products than those obtained using the corresponding aryl boronic acids or pinacol esters.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ya-Lan; Pang, Jin-Yu; Lou, Ji-Cong; Sun, Wen-Wu; Liu, Ji-Kai; Wu, Bin published the artcile< Chemo- and Site-Selective Fischer Esterification Catalyzed by B(C6F5)3>, SDS of cas: 53636-56-9, the main research area is ester preparation chemoselective; carboxylic acid alc Fischer esterification tris pentafluorophenyl borane catalyst.

A direct and catalytic dehydrative esterification of carboxylic acids RC(O)OH [R = hept-1-yn-1-yl, 2-(naphthalen-2-yl)ethyl, (1-methyl-1H-indol-3-yl)methyl, 1-([(benzyloxy)carbonyl]amino)ethyl, etc.] with alcs. R1OH (R1 = Et, cyclohexyl, 2,3-dihydroxypropyl, etc.) is described. B(C6F5)3 is shown to be a highly effective catalyst for the Fischer esterification, providing esters RC(O)OR1 in high to excellent yields. This esterification shows excellent chemo- and site-selective monoesterification of various polyols R1OH without any protection step, including bio-derived mol. glycerol.

Asian Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, SDS of cas: 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuehn, Laura; Huang, Mingming; Radius, Udo; Marder, Todd B. published the artcile< Copper-catalysed borylation of aryl chlorides>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is catalytic borylation aryl chloride preparation arylboronic acid copper NHC; copper NHC catalyst borylation aryl chloride pinacoldiboronate.

We report herein the first Cu-catalyzed borylation of a wide range of aryl chlorides with different electronic and steric properties using a readily prepared NHC-stabilized Cu catalyst and KOtBu as the base with B2pin2 (pin = pinacolato) as the boron reagent. The aryl chlorides are converted into their corresponding arylboronic esters in good yields. The new procedure shows broad functional group tolerance, and B2neop2 (neop = neopentyl glycolato) can also be applied as the boron reagent.

Organic & Biomolecular Chemistry published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bej, Raju; Ghosh, Suhrit published the artcile< Glutathione Triggered Cascade Degradation of an Amphiphilic Poly(disulfide)-Drug Conjugate and Targeted Release>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is glutathione cascade amphiphile polydisulfide drug conjugate targeting.

A bioreducible poly(disulfide)-derived amphiphilic block copolymer-drug conjugate (loading content 31%) was synthesized by post-polymerization modification. It shows redox-responsive polymersome assembly in water with aggregation induced emission property arising from the appended Camptothecin (CPT) drug. Glutathione (GSH), a tripeptide overexpressed in cancer cells, triggers a cascade reaction resulting in simultaneous degradation of the polymer backbone (consisting of disulfide linkage) and the release of the pendant drug. The cascade reaction involves GSH trigger cleavage of the backbone disulfide bond producing free thiol followed by its intrachain nucleophilic attack to the adjacent carbonate group that links the appended drug mol. The polymeric pro-drug exhibits killing efficiency to a cancer cell with remarkably low IC50 value of 3.1μg/mL (based on the CPT concentration) while it shows negligible toxicity to a normal cell up to polymer concentration 300μg/mL.

Bioconjugate Chemistry published new progress about Aggregation-induced emission. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Penning, Miriam; Christoffers, Jens published the artcile< Synthesis of Regioisomeric Pyrido[c]azocanones from Azaindanone Derivatives>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is pyridoazocanone regioisomer preparation.

A ring enlargement reaction with methylamine gave new pyrido[2,3-c]-, pyrido[3,4-c]- and pyrido[3,2-c]azocanone derivatives from cyclic β-oxo esters with a cyclopentapyridine skeleton and a 1,4-diketone moiety. The starting materials for this ring transformation were either prepared from halogenopyridine carboxylates by Heck reaction and subsequent hydrogenation, or (halogenomethyl)pyridine carboxylates were submitted to SN reaction with di-Et malonate. Both routes were completed by Dieckmann condensation to build the cyclic β-oxo ester structure and alkylation with phenacylbromide to install the 1,4-diketone motif.

European Journal of Organic Chemistry published new progress about Heterocyclic compounds, nitrogen Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Xianwei; Admane, Prasad; Starosolski, Zbigniew A.; Eriksen, Jason L.; Annapragada, Ananth V.; Tanifum, Eric A. published the artcile< 1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates>, Formula: C11H16BNO2, the main research area is Parkinson Alzheimer disease brain alpha synuclein SAR indandione; α-synuclein flurescent probes; α-synuclein imaging probes; α-synuclein ligands; α-synuclein selective molecules.

The development of imaging agents for in vivo detection of alpha-synuclein (α-syn) pathologies faces several challenges. A major gap in the field is the lack of diverse mol. scaffolds with high affinity and selectivity to α-syn fibrils for in vitro screening assays. Better in vitro scaffolds can instruct the discovery of better in vivo agents. We report the rational design, synthesis, and in vitro evaluation of a series of novel 1-indanone and 1,3-indandione derivatives from a Structure-Activity Relationship (SAR) study centered on some existing α-syn fibril binding ligands. Our results from fibril saturation binding experiments show that two of the lead candidates compounds 8 and 32 bind α-syn fibrils with binding constants (Kd) of 9.0 and 18.8 nM, resp., and selectivity of greater than 10x for α-syn fibrils compared with amyloid-β (Aβ) and tau fibrils. Our results demonstrate that the lead ligands avidly label all forms of α-syn on PD brain tissue sections, but only the dense core of senile plaques in AD brain tissue, resp. These results are corroborated by ligand-antibody colocalization data from Syn211, which shows immunoreactivity toward all forms of α-syn aggregates, and Syn303, which displays preferential reactivity toward mature Lewy pathol. Our results reveal that 1-indanone derivatives have desirable properties for the biol. evaluation of α-synucleinopathies.

ChemMedChem published new progress about Alzheimer disease. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Husain, Sajid; Krishnamurthy, A. S. R.; Sarma, P. Nageswara published the artcile< Separation and identification of chloropyridine isomers and quantitative determination of pentachloropyridine in chlorinated pyridine residues by gas chromatography-mass spectrometry>, Formula: C5HCl4N, the main research area is chloropyridine gas chromatog mass spectrometry.

Chloropyridine isomers (2,3,5-trichloropyridine 2,4,6-trichloropyridine, 2,3,4,6-tetrachloropyridine. 2,3,5,6-Tetrachloropyridine, and pentachloropyridine) were separated and identified by gas chromatog.-mass spectrometry in chlorinated pyridine residue. Stainless steel columns packed with 3% or 10% DEGA on Chromosorb WAW or PAW were used. Chloropyridine are intermediates in the preparation of pesticides, herbicides, dyes, pharmaceuticals, and plastics.

Journal of Chromatography published new progress about 14121-36-9. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Formula: C5HCl4N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Karges, Johannes; Kalaj, Mark; Gembicky, Milan; Cohen, Seth M. published the artcile< ReI tricarbonyl complexes as coordinate covalent inhibitors for the SARS-CoV-2 main cysteine protease>, Product Details of C10H6Cl2N2, the main research area is rhenium tricarbonyl complex coordinate inhibitor main protease SARS CoV2; synthesis crystal structure rhenium tricarbonyl complex protease inhibitor 3CLpro; SARS-CoV-2; antiviral agents; bioinorganic chemistry; medicinal inorganic chemistry; protease inhibitor.

Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CLpro), which is also known as the main protease, is considered among the most important pharmacol. targets. The vast majority of investigated 3CLpro inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. ReI tricarbonyl complexes were identified that demonstrate coordinate covalent enzymic inhibition of 3CLpro. Preliminary studies indicate the selective inhibition of 3CLpro over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CLpro cysteine protease.

Angewandte Chemie, International Edition published new progress about Anticoronaviral agents. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Product Details of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem