Tag: M.W=200-250

Dong, Yuman; Liu, Peng published the artcile< Amphiphilic Triblock Copolymer Prodrug for Tumor-Specific pH/Reduction Dual-Triggered Drug Delivery: Effect of Self-Assembly Behaviors>, SDS of cas: 2127-03-9, the main research area is amphiphilic triblock copolymer prodrug tumor treatment drug delivery system.

Diblock copolymer-based prodrugs have been widely designed for tumor treatment after self-assembly; however, premature drug leakage could not be ignored because their hydrophobic prodrug cores were directly exposed to the media. Here, an amphiphilic triblock copolymer prodrug with a hydrophilic PEG block, a pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) block, and a hydrophobic reduction-cleavable prodrug block was synthesized for tumor-specific pH/reduction dual-triggered drug delivery, via the successive RAFT polymerization of DPA and a DOX-based monomer (MAL-DOX) with a PEG-based macro-CTA. The core-shell and core-shell-corona nanoparticles could be obtained by one-step and two-step self-assembly. With the pH-sensitive gatekeeper formed by the PDPA block, the core-shell-corona nanoparticles possessed a smaller diameter with narrow distribution and better drug release with lower drug leakage. MTT assays demonstrated the selective cytotoxicity of the core-shell-corona nanoparticles to the cancer cells was dose-dependent because of the reduction-cleavable prodrug. The negligible drug leakage and selective cytotoxicity to cancer cells endow the proposed core-shell-corona prodrug nanoparticles with promising potential for tumor treatment without toxic side effects on the normal cells.

Langmuir published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Lichen; Uemura, Nao; Nakao, Yoshiaki published the artcile< meta-Selective C-H Borylation of Benzamides and Pyridines by an Iridium-Lewis Acid Bifunctional Catalyst>, Category: pyridine-derivatives, the main research area is meta selective borylation benzamide pyridine iridium aluminum bifunctional catalyst; borane pyridyl benzamide derivative preparation.

The authors report herein the Ir-catalyzed meta-selective C-H borylation of benzamides by using a newly designed 2,2′-bipyridine (bpy) ligand bearing an alkylaluminum biphenoxide moiety. The authors also demonstrate the Ir-catalyzed C3-selective C-H borylation of pyridine with a 1,10-phenanthroline (Phen) ligand bearing an alkylborane moiety. Probably the Lewis acid-base interaction between the Lewis acid moiety and the aminocarbonyl group or the sp2-hybridized N atom accelerates the reaction and controls the site-selectivity.

Journal of the American Chemical Society published new progress about Benzamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carson, Matthew W.; Giese, Matthew W.; Coghlan, Michael J. published the artcile< An Intra/Intermolecular Suzuki Sequence to Benzopyridyloxepines Containing Geometrically Pure Exocyclic Tetrasubstituted Alkenes>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is bromopyridine alkyne pinacolatodiboron stereoselective diboration; aryloxy bromopyridine vinylpinacol boronic ester intramol Suzuki coupling palladium; benzopyridyloxepine dioxaborolanylethylidene iodoarene Suzuki coupling palladium; benzylidenyl benzopyridyloxepine derivative preparation; palladium Suzuki couplibng catalyst.

A route to enable the preparation of 5-benzylidenyl-benzopyridyloxepine analogs, e.g., I (R1 = Me, Et, i-Pr; R2 = H, F, MeO), was developed to continue our research in the field of nuclear hormone receptor modulators. The key steps are: 1. a syn-stereoselective diboration of a tethered aryl alkyne; 2. an intramol. Suzuki cross-coupling reaction, which forms in a stereo- and regiocontrolled fashion, the 5-exoalkylidenyl 7-membered ring imbedded within the core of the scaffold and; 3. an intermol. Suzuki to furnish the final tetra-substituted olefinic benzopyridyloxepines.

Organic Letters published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (pyridylmethyl). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yi, Sijia; Kim, Sun-Young; Vincent, Michael P.; Yuk, Simseok A.; Bobbala, Sharan; Du, Fanfan; Scott, Evan Alexander published the artcile< Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells>, COA of Formula: C10H8N2S2, the main research area is dendritic peptide polymeric nanovector toxic delivery plasmid DNA; plasmid DNA immune cell nonviral transfection; Biological sciences; Biotechnology; Drug delivery system; Health sciences; Immunology.

Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including “”all-in-one”” CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficiency in immune cell populations. Here, we developed a synthetic non-viral gene delivery platform composed of poly(ethylene glycol)-b-poly(propylene sulfide) copolymers linked to a cationic dendritic peptide (DP) via a reduceable bond, PEG-b-PPS-ss-DP (PPDP). A library of self-assembling PPDP polymers was synthesized and screened to identify optimal constructs capable of transfecting macrophages with small (pCMV-DsRed, 4.6 kb) and large (pL-CRISPR.EFS.tRFP, 11.7 kb) plasmids. The optimized PPDP construct transfected macrophages, fibroblasts, dendritic cells, and T cells more efficiently and with less toxicity than a com. Lipo2K reagent, regardless of pDNA size and under standard culture conditions in the presence of serum. The PPDP technol. described herein is a stimuli-responsive polymeric nanovector that can be leveraged to meet diverse challenges in gene delivery.

iScience published new progress about Blood serum. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, COA of Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fan, Qianqian; Si, Yubing; Guo, Wei; Fu, Yongzhu published the artcile< Insight into Chemical Reduction and Charge Storage Mechanism of 2,2'-Dipyridyl Disulfide toward Stable Lithium-Organic Battery>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is chem reduction dipyridyl disulfide lithium organic redox flow battery.

In lithium-organic batteries, organic cathode materials could dissolve in a liquid electrolyte and diffuse through the porous separator to the active lithium-metal anode, resulting in cycling instability. However, 2,2′-dipyridyl disulfide (PyDS) can be cycled 5 times better than di-Ph disulfide (PDS) although both are soluble We believe this is related to their reactivity with lithium (Li0). Herein, we investigate the chem. reduction of PyDS by lithiated carbon paper (Li-CP) in ether electrolyte. It is found that only 6.3% of PyDS was reduced by Li-CP after 10 days, unlike PDS. Exptl. and computational results show that PyDS mols. are ionized by lithium ions of lithium salts delocalizing the charge on pyridine rings of PyDS, which can momentarily store Li0, thus keeping the S-S bond inert in chem. reaction with Li0. This finding is successfully utilized in a membrane-free redox flow battery with PyDS catholyte, showing long cycle life with high energy d. and energy efficiency. This work reveals the interesting charge storage mechanism and the different activity of organodisulfides toward electrochem. reduction and chem. reduction due to the organic groups, which can provide guidance for the design of stable lithium-organic batteries.

Journal of Physical Chemistry Letters published new progress about Battery capacity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lamola, Jairus L.; Moshapo, Paseka T.; Holzapfel, Cedric W.; Christopher Maumela, Munaka published the artcile< Palladium-catalyzed borylation of aryl bromides and chlorides using phosphatrioxa-adamantane ligands>, Computed Properties of 329214-79-1, the main research area is palladium catalyst borylation aryl bromide chloride phosphatrioxa adamantane; aryl boronate ester preparation.

Catalysts based on the combination of Pd(OAc)2 and the electron-deficient phosphatrioxa-adamantane ligands are described for borylation of aryl bromides and chlorides. Catalytic evaluation of a small library of phosphatrioxa-adamantane ligands provided some insights on the preferred ligand steric profile for borylation reactions. The corresponding aryl boronate esters were accessed under mild conditions (25-70°) and isolated in high yields (up to 96%).

Tetrahedron Letters published new progress about Adamantanes Role: CAT (Catalyst Use), USES (Uses) (phosphatrioxa-). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Computed Properties of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rasina, Dace; Stakanovs, Georgijs; Kanepe-Lapsa, Iveta; Bobrovs, Raitis; Jaudzems, Kristaps; Jirgensons, Aigars published the artcile< Synthesis of 2-aminopyridopyrimidinones and their plasmepsin I, II, IV inhibition potency>, Reference of 870997-85-6, the main research area is aminopyridopyrimidinone preparation antimalarial SAR.

2-Aminoquinazolin-4(3H)-one-based inhibitors, 2-aminopyrido[2,3-d]-, -[3,2-d]-, and -[4,3-d]pyrimidin-4(3H)-ones beared subpocket-specific substituents at position 7 were prepared and tested for their Plm I, II, IV inhibition potency. The position of the nitrogen atom in 2-aminopyridopyrimidinones played significant role in the inhibitory potency against Plms. Pyrido[2,3-d]pyrimidin-4(3H)-one derivatives showed poor inhibitory potency against Plms I, II, IV irresp. of the substituent at position 7. However, pyrido[4,3-d]pyrimidin-4(3H)-ones and pyrido[3,2-d]pyrimidin-4(3H)-ones were more appropriate scaffolds for Plm inhibitor development. Particularly, 2-amino-7-[4-(3-phenylpropyl)phenyl]-3-[(tetrahydrofuran-2-yl)methyl]pyrido[3,2-d]pyrimidin-4(3H)-one showed very high potency against Plm IV subtype and high selectivity against human aspartic protease, cathepsin D.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Antimalarials. 870997-85-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrN2O2, Reference of 870997-85-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gui, Jianzhou; Cong, Xiaohui; Liu, Dan; Zhang, Xiaotong; Hu, Zhide; Sun, Zhaolin published the artcile< Novel Bronsted acidic ionic liquid as efficient and reusable catalyst system for esterification>, Product Details of C9H13NO3S, the main research area is Bronsted acidic ionic liquid efficient reusable catalyst system esterification.

Under mild conditions and without any addnl. organic solvent, esterification of alcs. by carboxylic acids could be carried out in three new halogen-free Bronsted acidic ionic liquids, 1-(4-sulfonic acid) butyl-3-methylimidazolium hydrogen sulfate, 1-(4-sulfonic acid) butylpyridinium hydrogen sulfate and N-(4-sulfonic acid)butyl triethylammonium hydrogen sulfate. Especially for esterification of ethanol by acetic acid, good conversion rate and high selectivity were obtained, and the liquid esters formed a sep. phase that was decanted. The ionic liquid could be reused after removal of water under vacuum.

Catalysis Communications published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses) (catalyst). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Product Details of C9H13NO3S.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem