Tag: M.W=200-250

Guo, Xuan; Lv, Fang; Zhao, Zifeng; Gu, Jiannan; Qu, Bo; Xiao, Lixin; Chen, Zhijian published the artcile< Spirobifluorene-based oligopyridine derivatives as electron-transporting materials for green phosphorescent organic light-emitting diodes>, Synthetic Route of 329214-79-1, the main research area is spirobifluorene oligopyridine electron transporting material phosphorescent OLED.

The electron-transporting materials (ETMs), 2,7-bis(3,5-di (pyridin-3-yl)phenyl)-9,9′-spirobi [fluorene] (3-4PySF) and 2,7-bis(3,5-di (pyridin-4-yl)phenyl)-9,9′-spirobi [fluorene] (4-4PySF) were designed and synthesized by combining spirobifluorene moiety with di(pyridine-3-yl)phenyl and di(pyridine-4-yl)phenyl, resp. The spirobifluorene moiety improves materials’ rigid twisted structure to ensure the morphol. stability of amorphous film, and pyridine acts as electron acceptor to enhance electron-transporting ability of materials. The dependence of electron-transporting property on the position of substituted pyridine rings was studied. The m.p. (Tm) of 4-4PySF is estimated to be 41°C higher than that of 3-4PySF. And the higher c.d. in the electron only devices exhibited by 4-4PySF revealed the effect of nitrogen atom position on the charge-transporting properties. Green PhOLEDs based on bis(2-phenylpyridine)iridium (III) (2,2,6,6-tetramethylheptane-3,5-diketonate) (Ir (ppy)2tmd) as the emitter and 3-4PySF, 4-4PySF and 1,3,5-tris(N-phenylbenzimid azol-2-yl-benzene (TPBi) as ETMs were fabricated. Compared to the device based on the conventional ETM TPBi, the devices based on new ETMs exhibited a higher maximum external quantum efficiency (EQE) of 20.5% and a lower turn-on voltage (Von) of 2.6 V.

Organic Electronics published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jian-Wei; Xiong, Yuan; Wang, Feng; Zhang, Fu-Mao; Yang, Xiaodi; Lin, Guo-Qiang; Tian, Ping; Ge, Guangbo; Gao, Dingding published the artcile< Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19>, Related Products of 396092-82-3, the main research area is dihydrophenanthrene derivative SARS CoV2 coronavirus 3CLpro inhibitor COVID19; 9,10-Dihydrophenanthrenes; COVID-19; SARS-CoV-2 3CL(pro); Structure-activity relationships.

The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. Herein, we report the discovery of 9,10-dihydrophenanthrene derivatives as non-peptidomimetic and non-covalent inhibitors of the SARS-CoV-2 3CLpro. The structure-activity relationships of 9,10-dihydrophenanthrenes as SARS-CoV-2 3CLpro inhibitors have carefully been investigated and discussed in this study. Among all tested 9,10-dihydrophenanthrene derivatives, C1 and C2 display the most potent SARS-CoV-2 3CLpro inhibition activity, with IC50 values of 1.55 ± 0.21μM and 1.81 ± 0.17μM, resp. Further enzyme kinetics assays show that these two compounds dose-dependently inhibit SARS-CoV-2 3CLprovia a mixed-inhibition manner. Mol. docking simulations reveal the binding modes of C1 in the dimer interface and substrate-binding pocket of the target. In addition, C1 shows outstanding metabolic stability in the gastrointestinal tract, human plasma, and human liver microsome, suggesting that this agent has the potential to be developed as an orally administered SARS-CoV-2 3CLpro inhibitor.

European Journal of Medicinal Chemistry published new progress about Anticoronaviral agents. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Related Products of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yongtao; Luo, Xiaohe; Guo, Qingxiang; Nie, Yongwei; Wang, Tianqi; Zhang, Chao; Huang, Zhi; Wang, Xin; Liu, Yanhua; Chen, Yanan; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong published the artcile< Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetylase 1 (HDAC1) against Malignant Cancer>, Product Details of C10H15N3O2, the main research area is pyrrolopyrimidine preparation CDK4 CDK9 HDAC1 inhibitor treatment malignant cancer.

A series of highly potent, selective inhibitors targeting both CDK4/9 and HDAC1 have been designed and synthesized. N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N8-hydroxyoctanediamide (I) was discovered. The lead compound I with excellent CDK4/9 and HDAC1 inhibitory activity of IC50 = 8.8, 12, and 2.2 nM, resp., can effectively induce apoptosis of cancer cell lines. The kinase profiling of compound I showed excellent selectivity and specificity. Compound I induces G2/M arrest in high concentration and G0/G1 arrest in low concentration to prevent the proliferation and differentiation of cancer cells. Mice bared-breast cancer treated with I showed significant antitumor efficacy. The insight into mechanisms of I indicated that it could induce cancer cell death via cell apoptosis based on CDK4/9 and HDAC1 repression and phosphorylation of p53. The data demonstrated the compound I could be a promising drug candidate for cancer therapy.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Product Details of C10H15N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jian; Jian, Tianying; Guo, Liangqin; Atanasova, Tzvetomira; Nargund, Ravi P. published the artcile< Preparation of 3,4-fused-spiro[furan-5(5H),4'-piperidin]-2-one>, Related Products of 53636-56-9, the main research area is halo heteroaromatic Suzuki coupling iodolactonization dioxaborolanyl pyridine carboxylate; triflate heteroaromatic Suzuki coupling iodolactonization dioxaborolanyl pyridine carboxylate; fused spiro furanone piperidine preparation.

A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-ones with high yield was reported. The formation of spiro[furanone-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction.

Tetrahedron Letters published new progress about Carboxylic esters Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaromatic). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Related Products of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pan, Sheng-Dong; Shen, Hao-Yu; Zhou, Li-Xin; Chen, Xiao-Hong; Zhao, Yong-Gang; Cai, Mei-Qiang; Jin, Mi-Cong published the artcile< Controlled synthesis of pentachlorophenol-imprinted polymers on the surface of magnetic graphene oxide for highly selective adsorption>, Synthetic Route of 14121-36-9, the main research area is pentachlorophenol imprinted polymer surface magnetic graphene oxide adsorption.

A novel, well-designed magnetic graphene oxide sheet embedded with core-shell molecularly imprinted polymer microspheres (MGO@MIP) was controllably synthesized via a reflux-precipitation polymerization and surface imprinting technique. The as-prepared MGO@MIP was fully characterized and the specific selectivity and remarkable adsorption capacity to pentachlorophenol (PCP) are closely related to the synergetic effect of hydrogen bonding and π-π interactions, which are strongly associated with the solution pH and the distribution of magnetic microspheres on the surface of GO sheets. Under the optimal conditions, i.e., pH of 4.0 and a ratio of monomers to Fe3O4 of 15, the maximum adsorption capacity and the imprinting factor (α) of MGO@MIP towards PCP were 789.4 mg g-1 and 4.36, resp. The newly synthesized MGO@MIPs proved to be a great adsorbent for PCP in environmental water.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Adsorption. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Synthetic Route of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Senapak, W.; Saeeng, R.; Jaratjaroonphong, J.; Kasemsuk, T.; Sirion, U. published the artcile< Green synthesis of dipyrromethanes in aqueous media catalyzed by SO3H-functionalized ionic liquid>, Application of C9H13NO3S, the main research area is dipyrromethane green synthesis aldehyde pyrrole ionic liquid catalyst.

A mild, efficient and metal-free method was described for the green synthesis of dipyrromethanes from aldehydes and unsubstituted pyrrole catalyzed by SO3H-functionalized ionic liquids (SO3H-ILs) in aqueous media at room temperature Notably, SO3H-ILs, 1-butylsulfonic-3-methylimidazolium hydrogen sulfate ([bsmim][HSO4]) was the most efficient catalyst for moderate to good yields of the corresponding desired products.

Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Application of C9H13NO3S.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Owada, Tsukasa; Sasabe, Hisahiro; Sukegawa, Yoshihito; Watanabe, Taiki; Maruyama, Tomohiro; Watanabe, Yuichiro; Yokoyama, Daisuke; Kido, Junji published the artcile< A terpyridine-modified chrysene derivative as an electron transporter to improve the lifetime in phosphorescent OLEDs>, SDS of cas: 329214-79-1, the main research area is terpyridine chrysene derivative electron transporter phosphorescent organic LED lifetime.

A terpyridine-modified chrysene derivative, abbreviated as B3TPyC, was designed and developed to be used as electron-transport layers (ETLs) toward the construction of highly stable phosphorescent OLEDs. A green phosphorescent OLED with a B3TPyC ETL exhibited a low turn-on voltage of 2.4 V at 1 cd m-2 and an external quantum efficiency of 17.5% at 1000 cd m-2 with a long operation lifetime at 50% of the initial luminance (LT50) of over 258 h at c.d. 25 mA cm-2 (an initial luminance of ∼12,000 cd m-2), which corresponds to a LT50 of 19,000 h at 1000 cd m-2. This is >1.5 times longer than the time of luminance decay provided by the phenylpyridine counterpart named B3PyPC. These results clearly show the potential and usefulness of terpyridine-based chrysene derivatives to be applied in high-performance OLEDs with high operational stability.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Atomic force microscopy. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, SDS of cas: 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Xiaojie; Popli, Henna; Kwon, Ohyun; Malissa, Hans; Pan, Xin; Park, Bumwoo; Choi, Byoungki; Kim, Sunghan; Ehrenfreund, Eitan; Boehme, Christoph; Vardeny, Z. Valy published the artcile< Isotope Effect in the Magneto-Optoelectronic Response of Organic Light-Emitting Diodes Based on Donor-Acceptor Exciplexes>, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is OLED magneto optoelectronic response donor acceptor exciplex; Rabi oscillations; electrically detected magnetic resonance; exciplexes; magneto-electroluminescence; organic light-emitting diodes (OLEDs); reverse intersystem crossing.

The isotope effect is studied in the magneto-electroluminescence (MEL) and pulsed elec. detected magnetic resonance of organic light-emitting diodes based on thermally activated delayed fluorescence (TADF) from donor-acceptor exciplexes that are either protonated (H) or deuterated (D). It is found that at ambient temperature, the exchange of H to D has no effect on the spin-dependent current and MEL responses in the devices. However, at cryogenic temperatures, where the reverse intersystem crossing (RISC) from triplet to singlet exciplex diminishes, a pronounced isotope effect is observed These results show that the RISC process is not governed by the hyperfine interaction as thought previously, but proceeds through spin-mixing in the triplet exciplex. The observations are corroborated by elec. detected transient spin nutation experiments that show relatively long dephasing time at ambient temperature, and interpreted in the context of a model that involves exchange and hyperfine interactions in the spin triplet exciplex. These findings deepen the understanding of the RISC process in TADF materials.

Advanced Materials (Weinheim, Germany) published new progress about Activation energy (of conductivity). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem