Tag: M.W=200-250

Pandopulos, Aaron J.; Gerber, Cobus; Tscharke, Benjamin J.; O’Brien, Jake; White, Jason M.; Bade, Richard published the artcile< A sensitive analytical method for the measurement of neurotransmitter metabolites as potential population biomarkers in wastewater>, Application of C10H8N2S2, the main research area is neurotransmitter metabolite determination wastewater analysis; liquid chromatog tandem mass spectrometry neurotransmitter metabolite determination wastewater; population biomarker wastewater epidemiol neurotransmitter metabolite determination; hydroxyindoleacetic acid vanillylmandelic acid homovanillic acid neurotransmitter metabolite biomarker; 5-hydroxyindoleacetic acid; Homovanillic acid; Mass spectrometry; Population biomarker; Vanillylmandelic acid; Wastewater-based epidemiology.

Wastewater-based epidemiol. is a growing research field which provides valuable information on community drug use and chem. exposure. One parameter critical to estimate drug use is catchment area population. A population biomarker could provide this information. This work evaluated the anal. suitability of three human activity endogenous biomarkers: the previously proposed serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA); and two other candidates, the catecholamine metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA). A derivatization-involved anal. method was developed and validated for 5-HIAA and HVA: liquid chromatog./mass spectrometry. Best performance was obtained for VMA as an underivatized analyte. Derivatized extracts produced 100 times better sensitivity. The three neurotransmitter metabolites were evaluated as population biomarkers in wastewater. All were stable, not lost upon filtration, and displayed stable inter-day mass loads over seven days for a metropolitan wastewater treatment facility. When used for a small community during a festival, mass HVA and VMA loads reflected an increase in catchment population; 5-HIAA was more variable.

Journal of Chromatography A published new progress about Biomarkers (endogenous human activity neurotransmitter metabolite). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ishigeev, Roman S.; Potapov, Vladimir A.; Shkurchenko, Irina V.; Zinchenko, Sergey V.; Amosova, Svetlana V. published the artcile< Two types of products in the reactions of 2-pyridinesulfenyl halides with cycloalkenes and cycloalkadienes: synthesis of novel [1,3]thiazolo[3,2-a]pyridinium derivatives>, Computed Properties of 2127-03-9, the main research area is thiazolopyridinium compound preparation; pyridinesulfenyl halide cycloalkene cyclocondensation; cycloalkenyl sulfanylpyridine preparation; cycloalkene pyridinesulfenyl halide electrophilic addition.

The reactions of 2-pyridinesulfenyl halides like 2-pyridinesulfenyl chloride and 2-pyridylsulfenyl bromide with cyclopentene, 1,4-cyclohexadiene, 1,5-cyclooctadiene, 1,3-cyclooctadiene, and norbornene, depending on the structure of the alkene, the nature of the halogen, and the duration of the process, lead to the formation of two types of adducts, electrophilic addition products, e.g., I or condensed compounds, [1,3]thiazolo[3,2-a]pyridinium derivatives, e.g., II in high yields.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Cycloalkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Computed Properties of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Min-Young; Hwang, Ji Yeon; Bae, Eun Ji; Kim, Saesbyeol; Kang, Hye-Min; Kim, Yong Jun; Park, Chan; Park, Kang-Sik published the artcile< Tyrosine phosphorylation of the Kv2.1 channel contributes to injury in brain ischemia>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is tyrosine phosphorylation potassium channel brain ischemia injury; Kv2.1; brain ischemia; oxidative stress; tyrosine phosphorylation.

In brain ischemia, oxidative stress induces neuronal apoptosis, which is mediated by increased activity of the voltage-gated K+ channel Kv2.1 and results in an efflux of intracellular K+. The mol. mechanisms underlying the regulation of Kv2.1 and its activity during brain ischemia are not yet fully understood. Here this study provides evidence that oxidant-induced apoptosis resulting from brain ischemia promotes rapid tyrosine phosphorylation of Kv2.1. When the tyrosine phosphorylation sites Y124, Y686, and Y810 on the Kv2.1 channel are mutated to non-phosphorylatable residues, PARP-1 cleavage levels decrease, indicating suppression of neuronal cell death. The tyrosine residue Y810 on Kv2.1 was a major phosphorylation site. In fact, cells mutated Y810 were more viable in our study than were wild-type cells, suggesting an important role for this site during ischemic neuronal injury. In an animal model, tyrosine phosphorylation of Kv2.1 increased after ischemic brain injury, with an observable sustained increase for at least 2 h after reperfusion. These results demonstrate that tyrosine phosphorylation of the Kv2.1 channel in the brain may play a critical role in regulating neuronal ischemia and is therefore a potential therapeutic target in patients with brain ischemia.

International Journal of Molecular Sciences published new progress about Apoptosis. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rangasami, Vignesh K.; Nawale, Ganesh; Asawa, Kenta; Kadekar, Sandeep; Samanta, Sumanta; Nilsson, Bo; Ekdahl, Kristina N.; Miettinen, Susanna; Hilborn, Jons; Teramura, Yuji; Varghese, Oommen P.; Oommen, Oommen P. published the artcile< Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells>, Application In Synthesis of 2127-03-9, the main research area is Pluronic micelle tissue factor silencing hemocompatibility mesenchyme stem cell.

Mesenchymal stem/stromal cells (MSCs) evoke great excitement for treating different human diseases due to their ability to home inflamed tissues, suppress inflammation, and promote tissue regeneration. Despite great promises, clin. trial results are disappointing as allotransplantation of MSCs trigger thrombotic activity and are damaged by the complement system, compromising their survival and function. To overcome this, a new strategy is presented by the silencing of tissue factor (TF), a transmembrane protein that mediates procoagulant activity. Novel Pluronic-based micelles are designed with the pendant pyridyl disulfide group, which are used to conjugate TF-targeting siRNA by the thiol-exchange reaction. This nanocarrier design effectively delivered the payload to MSCs resulting in ~72% TF knockdown (KD) without significant cytotoxicity. Hematol. evaluation of MSCs and TF-KD MSCs in an ex vivo human whole blood model revealed a significant reduction in an instant-blood-mediated-inflammatory reaction as evidenced by reduced platelet aggregation (93% of free platelets in the TF-KD group, compared to 22% in untreated bone marrow-derived MSCs) and thrombin-antithrombin complex formation. Effective TF silencing induced higher MSC differentiation in osteogenic and adipogenic media and showed stronger paracrine suppression of proinflammatory cytokines in macrophages and higher stimulation in the presence of endotoxins. Thus, TF silencing can produce functional cells with higher fidelity, efficacy, and functions.

Biomacromolecules published new progress about Cell differentiation. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Peiru; Wang, Dali; Wang, Yuyan; Zhang, Lei; Wang, Qiwei; Liu, Lanxia; Li, Jiahe; Sun, Xin; Ren, Mengqi; Wang, Ruoxuan; Fang, Yang; Zhao, Jean J.; Zhang, Ke published the artcile< Maximizing TLR9 Activation in Caner Immunotherapy with Dual-Adjuvanted Spherical Nucleic Acids>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is cancer immunotherapy dual adjuvanted spherical nucleic acid TLR9; CpG oligonucleotides; DNA amphiphiles; cancer vaccines; spherical nucleic acids.

Nucleic-acid-based immune adjuvants have been extensively investigated for the design of cancer vaccines. However, nucleic acids often require the assistance of a carrier system to improve cellular uptake. Yet, such systems are prone to carrier-associated adaptive immunity, leading to difficulties in a multidose treatment regimen. Here, we demonstrate that a spherical nucleic acid (SNA)-based self-adjuvanting system consisting of phosphodiester oligonucleotides and vitamin E can function as a potent anticancer vaccine without a carrier. The two functional modules work synergistically, serving as each other′s delivery vector to enhance toll-like receptor 9 activation. The vaccine rapidly enters cells carrying OVA model antigens, which enables efficient activation of adaptive immunity in vitro and in vivo. In OVA-expressing tumor allograft models, both prophylactic and therapeutic vaccinations significantly retard tumor growth and prolong animal survival. Furthermore, the vaccinations were also able to reduce lung metastasis in a B16F10-OVA model.

Nano Letters published new progress about Adaptive immunity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guzyr, Olexandr I.; Kozel, Volodymyr N.; Rusanov, Eduard B.; Rozhenko, Olexandr B.; Fetyukhin, Volodymyr N.; Shermolovich, Yuriy G. published the artcile< Enhanced preparation of aryl and heteryl sulfur pentafluorides using mercury (II) oxide - hydrogen fluoride media as a fluorinating reagent>, Product Details of C10H8N2S2, the main research area is aryl sulfur pentafluoride preparation DFT.

An enhanced method for the synthesis of aryl sulfur pentafluorides ArSF5 [Ar = Ph, 2-pyridyl, 3H-1,3-benzothiazol-2-yl, etc.] from chlorotetrafluorides using mercury oxide-hydrogen fluoride and mercury oxide-pyridinium poly(hydrogen fluoride) media as the fluorinating reagents was developed at low temperature and in good yield. X-Ray crystallog. anal. of compounds ArSF5 [Ar = 3H-1,3-benzothiazol-2-yl, pyrimidin-2-yl] showed distorted octahedral environment of sulfur atom and elongated C-S bond length for pyrimidinium compound

Journal of Fluorine Chemistry published new progress about Aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem