Tag: M.W=200-250

Adachi, Kenji published the artcileElectrophilic fluorination with N,N’-difluoro-2,2′-bipyridinium salt and elemental fluorine, Category: pyridine-derivatives, the publication is Journal of Fluorine Chemistry (2003), 120(2), 173-183, database is CAplus.

N,N’-Difluoro-2,2′-bipyridinium bis(tetrafluoroborate) (MEC-31) was shown to be a highly reactive electrophilic fluorinating agent with the highest effective fluorine content in its class. We have developed the perfect recycled fluorination system with MEC-31 for the lower-cost industrial fluorination and for an environment. MEC-31 can be completely recycled including the counter-anion. We found the fluorination of 2-naphthol in liquid CO₂ with MEC-31 in the presence of catalytic amount of NaOTf proceeded quant. without the generation of byproduct. In the fluorination of 1,3-dicarbonyl compounds with elemental fluorine, we found the introduction method of fluorine gas would be very important in order to make a reaction efficient. As fluorination goes on, the quantity of 1,3-dicarbonyl compounds of the starting material is reduced gradually, and therefore the quantity of fluorine must be reduced by the method to control the flow rate or the concentration of fluorine gas diluted with nitrogen, together the fluorination to proceed efficiently.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hong, Junting published the artcileCarboxylation of Alkenyl Boronic Acids and Alkenyl Boronic Acid Pinacol Esters with CO₂ Catalyzed by Cuprous Halide, HPLC of Formula: 844501-00-4, the publication is European Journal of Organic Chemistry (2020), 2020(19), 2813-2818, database is CAplus.

A cuprous halide catalyzed carboxylation of alkenyl boronic acids and alkenyl boronic acid pinacol esters under CO₂, affording the corresponding α,β-unsaturated carboxylic acids in good yield, has been developed. The potassium (E)-trifluoro(styryl)borate is also compatible with this reaction. This simple and efficient copper(I) catalytic system showed good functional group tolerance.

European Journal of Organic Chemistry published new progress about 844501-00-4. 844501-00-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Boronic Acids,Boronic acid and ester, name is (1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)boronic acid, and the molecular formula is C10H18BNO4, HPLC of Formula: 844501-00-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tan, Jing published the artcileMetal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes, Category: pyridine-derivatives, the publication is Organic & Biomolecular Chemistry (2018), 16(23), 4227-4230, database is CAplus and MEDLINE.

Arylacetaldehydes and aliphatic aldehydes underwent oxidative cyclocondensation reactions with aminopyridines mediated by S₈ in cyclohexane/DMSO to yield imidazopyridines without added metal or base.

Organic & Biomolecular Chemistry published new progress about 1174626-28-8. 1174626-28-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Benzene,Ether, name is 2-Amino-6-benzyloxypyridine, and the molecular formula is C20H17FO4S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tagata, Tsuyoshi published the artcilePalladium Charcoal-Catalyzed Suzuki-Miyaura Coupling to Obtain Arylpyridines and Arylquinolines, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2003), 68(24), 9412-9415, database is CAplus and MEDLINE.

A phosphine ligand, such as PPh₃ or 2-(dicyclohexylphosphino)biphenyl, is essential for the Pd/C-catalyzed Suzuki-Miyaura coupling of halopyridines and haloquinolines, although it has been reported that the reaction of Ph chlorides can be catalyzed by non-prereduced Pd/C without any additives. In the reactions of bromopyridines, bromoquinolines, 2-chloropyridines, and 2-chloroquinolines, PPh₃ was effective enough to provide coupling products in good yields. However, in the reactions of 3-chloropyridine, 4-chloropyridine, and 6-chloroquinoline, sterically hindered 2-(dicyclohexylphosphino)biphenyl was indispensable as a ligand.

Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

El Kadib, Abdelkrim published the artcileCross-Coupling in the Preparation of Pharmaceutically Relevant Substrates using Palladium Supported on Functionalized Mesoporous Silicas, Synthetic Route of 89076-64-2, the publication is ChemCatChem (2011), 3(8), 1281-1285, database is CAplus.

Palladium supported on organically functionalized mesoporous silicas is used to catalyze carbon-carbon cross-coupling reactions including Suzuki-Miyaura reaction and Sonogashira reaction. High yields with low to moderate metal contamination were obtained for various substrates including pyridyl substrates, thiophenes, and pharmaceutical precursors. Products were obtained with palladium loadings that were sufficient to pass muster without further scavenging in the case of Suzuki-Miyaura couplings. The secondary scavenging of products from Sonogashira reaction is necessary.

ChemCatChem published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Synthetic Route of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kantak, Abhishek A. published the artcileRegioselective C-H bond amination by aminoiodanes, Category: pyridine-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(17), 3574-3577, database is CAplus and MEDLINE.

A new approach for the direct amination of 2-phenylpyridine derivatives using a diphthalimide-iodane and copper triflate has been developed. A series of different 2-phenylpyridine derivatives were aminated with yields up to 88%. Mechanistic investigations indicate that the reaction proceeds via a copper-mediated single electron transfer.

Chemical Communications (Cambridge, United Kingdom) published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pruschinski, Lucas published the artcileSuzuki-Miyaura Cross-Couplings under Acidic Conditions, Safety of 5-Nitro-2-phenylpyridine, the publication is Synthesis (2020), 52(6), 882-892, database is CAplus.

Suzuki-Miyaura reactions with Pd(PPh₃)₄ had carried out using lithium N-phenylsydnone-4-carboxylate as additive, which gave best yields at pH 5.7 in a mixture of acetic acid, water, and sodium carbonate. Reaction parameters such as the Pd source, the solvent, reaction time and temperature, acid, base and carboxylate have been varied and some representative examples of the Suzuki-Miyaura reaction have been examined

Synthesis published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Safety of 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ivanov, Sergei V. published the artcileFluorination of deltahedral closo-borane and -carborane anions with N-fluoro reagents, Quality Control of 107263-95-6, the publication is Journal of Fluorine Chemistry (1998), 89(1), 65-72, database is CAplus.

The treatment of cesium salts of CB₁₁H₁₂^–, CB₉H₁₀^–, B₁₂H₂^–, and B₁₀H₁₀^2- with the com. available N-fluoro reagent 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA) resulted in the formation of fluorinated derivatives of these 10- and 12-vertex borane and carborane anions. This is the first reported use of an N-fluoro reagent to fluorinate B-H bonds of any type. The effects of changing the solvent, temperature, and reagent stoichiometry were studied. The derivatives 1-B₁₀H₉F²-, 2-B₁₀H₉F^2-, and 1,10-B₁₀H₈F₂^2- are the first fluorinated derivatives of the parent B₁₀H₁₀^2- cluster. For the other three parent anions, reactions with F-TEDA resulted in a higher degree of fluorination than reactions with liquid anhydrous hydrogen fluoride (LAHF) at the same temperature However, F-TEDA was less regioselective than LAHF for B-H B-F transformations.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Quality Control of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rana, Surjyakanta published the artcileOrgano functionalized graphene with Pd nanoparticles and its excellent catalytic activity for Suzuki coupling reaction, Category: pyridine-derivatives, the publication is Applied Catalysis, A: General (2015), 539-547, database is CAplus.

Synthesis of well distributed palladium nanoparticles (3-7 nm) on organo di-amine functionalized graphene is reported, which demonstrated excellent catalytic activity for Suzuki coupling reaction. Organo functionalized graphene support acted as an excellent host which helped in avoiding “Ostwald ripening” i.e., preventing palladium nanoparticle sintering and because of which the catalyst as a whole showed excellent catalytic activity for Suzuki coupling reaction. The catalytic material was characterized by X-ray diffraction (XRD), Fourier-transfer IR spectroscopy (FTIR), Raman spectra, X-ray photoelectron spectra (XPS), and Scanning electron microscope (SEM), Transmittance electron microscopy (TEM) anal. FT-IR revealed that the organic amine functional group was successfully grafted onto the graphene oxide surface. The formation of palladium nanoparticles was confirmed by XPS techniques. The catalytic activity in the coupling reaction using idobenzene was superb with 100% conversion and 98% yield and also activity remained almost unaltered up to six cycles. Typically, an extremely high turnover frequency of 185,078 h-1 or 3,084.64 min-1 is observed in the C-C Suzuki coupling reaction using organo di-amine functionalized graphene as catalyst. Experiments were also conducted under identical conditions to prove heterogeneity of the catalyst.

Applied Catalysis, A: General published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Baudequin, Christine published the artcileEnantioselective electrophilic fluorination: a study of the fluorine-transfer from achiral N-F reagents to cinchona alkaloids, Application In Synthesis of 107263-95-6, the publication is Journal of Fluorine Chemistry (2003), 122(2), 189-193, database is CAplus.

A transfer fluorination on cinchona alkaloids with the aid of achiral N-F fluorine-transfer reagents is described. Ten com. available reagents were evaluated. Selectfluors, Accufluor, N-fluorobenzenesulfonimide (NFSi), and N-fluoro-2,6-dichloropyridinium tetrafluoroborate are effective fluorine-transfer reagents. The N-fluoroammonium salts of cinchona alkaloids thus prepared were employed in the construction of stereogenic fluorinated carbon centers with enantioselectivity as high as 85%. Ionic liquids are effective “green” solvents for the development of this methodol.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Application In Synthesis of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem